• Title, Summary, Keyword: Probiotics

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The Role and Clinical Value of Probiotics (Probiotics의 역할과 임상적 가치)

  • Rheu, Kyoung-Hwan;Yoon, Seoung-Woo
    • Journal of Korean Traditional Oncology
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    • v.10 no.1
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    • pp.75-86
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    • 2005
  • Disease associated with microorganisms are far from resolved by current therapeutics. One of effective approach to health maintenance and disease control is the use of dietary bacterial and carbohydrate supplements. This comprises use of probiotics and prebiotics. Probiotics mean the live microorganisms, which when administered in adequate amounts confer a health benefit on the host. Prebiotics mean a nondigestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria that can Improve the host health. Especially, probiotics has the relation which is close with innate immunity and adaptive immunity. And probiotics has the clinical value with many disease like lactose intolerance, constipation, acute gastroenteritis, food hypersensitivity and allergy, atopic dermatitis, crohn's disease, rheumatoid arthritis, pelvic radiotherapy, intestinal inflammation and chemical exposure, colon cancer, inhibitory effect of Helicobacter pylori and lowering the level of cholesterol. We use jointly korean medicine and probiotics and it has the more therapeutic effect in the many disease.

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Effects of Dietary Supplementation of Complex Probiotics and Enzyme on Improvement of Farm Environment and Performance of Finishing Pigs (복합생균효소제 급여가 돈사 환경개선과 비육돈 생산성에 미치는 영향)

  • Kim D.H.;Kim H.R.
    • Journal of Animal Environmental Science
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    • v.12 no.2
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    • pp.67-74
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    • 2006
  • This experiment was carried out to investigate the effect of dietary supplementation of complex probiotics and enzyme on air quality in finishing pig building and the performance of finishing pigs. A total 117 crossbred $[(Landrace{\times}Yorkshire){\times}Duroc]$ pigs were randomly arranged into nine groups and assigned to three treatments. Pigs were fed a basal diet supplemented with 0, 0.1% level of probiotics and 0.1% level of complex probiotics and enzyme until the market weight for 42 days of the experimental period. Ammonia and hydrogen sulfide concentrations in the finishing pig building were significantly (p<0.05) decreased by dietary supplementation of complex probiotics and enzyme compared with those of control, however, indoor carbon dioxide concentration was not affected by dietary supplementation of probiotics or complex probiotics and enzyme. Average daily feed intake and feed conversion ratio were significantly improved (p<0.05) with dietary supplementation of 0.1% complex probiotics and enzyme; however, average daily gain was not affected by dietary supplementation of probiotics or complex probiotics and enzyme. In conclusion, the results obtained from this experiment suggest that the dietary supplementation of complex probiotics and enzyme for finishing pigs may improve air quality in the finishing pig building and the performance.

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Effects of Dietary Complex Probiotics on Growth Performance Nutrient Digestibility and Blood Characteristics in Growing Pigs (육성돈에 있어 복합생균제 첨가가 생산성, 영양소 소화율, 혈액성상 및 분뇨내 악취물질 발생량에 미치는 효과)

  • Yoo, Jong-Sang;Chen, Ying-Jie;Kim, In-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.8 no.5
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    • pp.1266-1272
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    • 2007
  • The current study was conducted to investigate the effects of dietary complex probiotics supplementation on growth performance, nutrient digestibility, blood characteristics and noxious gas emission of manure slurry in growing pigs. A total of forty eight pigs with an initial body weight of 20.12 kg were allotted to three dietary treatments (two pigs per pen with eight pens per treatment). Dietary treatment included: 1) CON (basal diet), 2) Pro1 (basal diet + 0.1% complex probiotics) and 3) Pro2 (basal diet + 0.2% complex probiotics). The experiment was lasted six weeks. Through the entire experimental period, ADG was increased with the increased complex probiotics supplementation level (linear effect, P<0.05). However, neither ADFI nor gain/feed was influenced by the dietary treatments. Complex probiotics supplementation increased DM digestibility (linear effect, P<0.05). Also, the N digestibility was improved, with the Pro1 treatment showed highest value (linear and quadratic effect, P<0.05). Supplementation of complex probiotics did not affect the WBC, RBC, lymphocyte and BUN concentrations in blood. The $NH_3-N$ emission from manure slurry was decreased with the increased level of complex probiotics supplementation (linear and quadratic effect, P<0.05). Similarly, $H_2S$ emission of manure slurry was also decreased significantly when complex probiotics was included in diet (linear effect, P<0.05). In conclusion, dietary supplementation of Complex probiotics can increase growth performance and decrease noxious gas emission of manure slurry in growing pigs.

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Analysis of Health-related Microbes by Capillary Electrophoresis

  • Moon, Byoung-Geoun;Kim, Yong-Seong
    • Bulletin of the Korean Chemical Society
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    • v.24 no.8
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    • pp.1203-1206
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    • 2003
  • Analysis of health-related microbes called probiotics was performed by capillary electrophoresis. A rapid and easy characterization for two important probiotics, Saccharomyces cerevisiae and Enterococcus feacalis, was obtained in the running buffer containing poly(ethylene oxide). Quantitation of probiotic (Saccharomyces cerevisiae) shows a good linearity between the peak area versus the concentration of microbe. From the comparison of electropherograms of antidiarrhea, it was found that capillary electrophoresis could be employed for the quality control and quality assurance for the production of a medicine containing the probiotics.

Effects of probiotics on growth and immune responses in olive flounder, Paralichthys olivaceus and on water quality parameters of recirculating rearing system

  • Yousuke Taoka;Jo, Jae-Yoon;Hiroto Maeda;Sungchul C. Bai;Lee, Won-Jae
    • Proceedings of the Korean Society of Fisheries Technology Conference
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    • pp.201-202
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    • 2003
  • Recently, probiotics is applied for aquaculture management as an alternative method of antibiotics. Probiotics is defined as a live microbial feed supplement which a good effect to the host animal by improving its microbial condition of gastrointestinal tract (Fuller, 1989). Generally, probiotics affect growth and survival of cultured fish, water quality, immune system and so on (Rengpipat et al, 2000, Robertson et al, 2000). (omitted)

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Effect of probiotics and xylo-oligosaccharide supplementation on nutrient digestibility, intestinal health and noxious gas emission in weanling pigs

  • Liu, JB;Cao, SC;Liu, J;Xie, YN;Zhang, HF
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.10
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    • pp.1660-1669
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    • 2018
  • Objective: This study was conducted to evaluate the effect of probiotics (Bacillus subtilis and Enterococcus faecium) and xylo-oligosaccharide (XOS) supplementation on growth performance, nutrient digestibility, serum profiles, intestinal health, fecal microbiota and noxious gas emission in weanling pigs. Methods: A total of 240 weanling pigs ([Yorkshire${\times}$Landrace]${\times}$Duroc) with an average body weight (BW) of $6.3{\pm}0.15kg$ were used in this 28-day trial. Pigs were randomly allocated in 1 of the following 4 dietary treatments in a $2{\times}2$ factorial arrangement with 2 levels of probiotics (0 and 500 mg/kg probiotics) and XOS (0 and 200 mg/kg XOS) based on the BW and sex. Results: Administration of probiotics or XOS improved average daily gain (p<0.05) during 0 to 14 d and the overall period, while pigs that were treated with XOS had a greater average daily gain and feed efficiency (p<0.05) compared with unsupplemented treatments throughout 15 to 28 d and the whole experiment. Either probiotics or XOS treatments increased the apparent total tract digestibility of nutrients (p<0.05) during 0 to 14 d. No effects on serum profiles were observed among treatments. The XOS increased villus height: crypt depth ratio in jejunum (p<0.05). The supplementation of probiotics (500 mg/kg) or XOS (200 mg/kg) alone improved the apparent total tract digestibility of dry matter, nitrogen and gross energy on d 14, the activity of trypsin and decreased fecal NH3 concentration (p<0.05). Administration of XOS decreased fecal Escherichia coli counts (p<0.05), while increased lactobacilli (p<0.05) on d 14. There was no interaction between dietary supplementation of probiotics and XOS. Conclusion: Inclusion of XOS at 200 mg/kg or probiotics (Bacillus subtilis and Enterococcus faecium) at 500 mg/kg in diets containing no antibiotics significantly improved the growth performance of weanling pigs. Once XOS is supplemented, further providing of probiotics is not needed since it exerts little additional effects.

Impact of Feeding Multiple Probiotics on Productivity, Intestinal Microflora and Fecal Noxious Gas Emission in Broiler Chicks (혼합생균제 급여가 육계의 생산성, 장내 미생물 및 계분 유해가스 발생에 미치는 영향)

  • 박재홍;류명선;김종설;김상호;이동호;리홍룡;류경선
    • Korean Journal of Poultry Science
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    • v.30 no.3
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    • pp.203-209
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    • 2003
  • This experiment was conducted to investigate the influence of dietary supplementation of two different types of multiple probiotics in broiler chicks. Four hundred one day old male broiler chicks(Ross ${\times}$ Ross) were raised in the floor pen with five treatments(0, A: 0.10, 0.20%, B: 0.10, 0.20% of probiotics), consisting of 5 replicates for 5 weeks. Weight gain, feed intake and feed conversion were measured weekly, Total Lactobacillus, yeast, E. coli, Salmonella were examined from ileum and cecum at the end of experiment. Sera protein, cholesterol and ND vaccine titer were measured and fecal COD, CO$_2$ and NH$_3$ were detected in 24 hours after collection. Weight gain of chickes fed both types of probiotics increased for the first three weeks and showed significantly higher for the rest two weeks. Feed intake tended to be high in probiotics treatments compared with contro(P<0.05)1. Feed conversion improved significantly in B types of 0.2% probiotics compared with control. Total number of Salmonella was not consistent in ileum among treatments, whereas E. coli tended to be decreased in both types of probiotics compared with control. NH$_3$ and CO$_2$ emission of feces were decreased in both types of probiotics, but it was not statistically different(p>0.05). COD of chicks fed both probiotics was lower than control. There were no significantly different breast meat(P>0.05). Total cholesterol decreased in probiotics groups regardless of it's type. ND antibody vaccine titer was prone to be a small increments.

Study on the Development of a Probiotics Complex for Weaned Pigs

  • Xuan, Z.N.;Kim, J.D.;Heo, K.N.;Jung, H.J.;Lee, J.H.;Han, Y.K.;Kim, Y.Y.;Han, In K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.14 no.10
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    • pp.1425-1428
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    • 2001
  • This study was conducted to investigate the effects of supplementation of a probiotics complex on growth performance, nutrient digestibility, diarrhea score and microbial population in pigs weaned at 21 days of age. Treatments were 1) control A (0.2% antibiotics, Avilamycin), 2) control B (0.1 % $Ractocom^{(R)}$), 3) 0.1%, 4) 0.2% and 5) 0.3% probiotics complex; 80 pigs were used and each treatment had 4 replicates with 4 pigs per replicate (16 pigs per treatment). During phase I period (d 0 to 14), although there was no significant difference, pigs fed control B diet showed higher ADG (average daily gain) and better F/G (feed/gain) than any other treatments. During late experimental period (d 15 to 28), pigs fed diet supplemented with 0.2% probiotics complex showed slightly higher ADG. Overall (d 0 to 28) the diet that contained 0.2% probiotics complex gave slightly higher ADG and ADFI (average daily feed intake) than the other diets. In a metabolic trial using 20 piglets, nutrient digestibility showed the best results in pigs fed 0.2% probiotics complex diet, but not significantly different from other groups. Diarrhea score and microbial population status in intestine, colon and feces were not affected by dietary treatments. In conclusion, this study suggested that a newly developed probiotics complex can replace antibiotics in weaned pigs.

Probiotics Inhibit Lipopolysaccharide-Induced Interleukin-8 Secretion from Intestinal Epithelial Cells

  • Oh, Hyun-Wook;Jeun, Gi-Hoon;Lee, Jin;Chun, Tae-Hoon;Kim, Sae-Hun
    • Food Science of Animal Resources
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    • v.32 no.4
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    • pp.434-440
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    • 2012
  • It has been suggested that probiotics could be useful for the prevention of symptomatic relapse in patients with inflammatory bowel disease (IBD). Interleukin (IL)-8 has been well recognized as one of the pro-inflammatory cytokines that could trigger inflammation and epithelial barrier dysfunction. In this study, the anti-inflammatory effects of probiotics were investigated using a human epithelial cell line (HT-29). Probiotics from infant feces and kimchi were tested for their cytotoxicity and effects on adhesion to epithelial cells. The present results show that seven strains could form 70 % adhesion on HT-29. The probiotics used in this study did not affect HT-29 cell viability. To screen anti-inflammatory lactic acid bacteria, HT-29 cells were pretreated with live and heat-killed probiotics, and lipopolysaccharide (LPS) ($1{\mu}g/mL$) was then added to stimulate the cells. The cell culture supernatant was then used to measure IL-8 secretion by ELISA, and the cell pellet was used to determine IL-8 and toll-like receptor (TLR-4) mRNA expression levels by RT-PCR. Some probiotics (KJP421, KDK411, SRK414, E4191, KY21, and KY210) exhibited anti-inflammatory effects through the repression of IL-8 secretion from HT-29 cells. In particular, Lactobacillus salivarius E4191, originating from Egyptian infant feces, not only decreased IL-8 mRNA expression, but also decreased TLR-4 expression. These results indicate that Lactobacillus salivarius E4191 may have a protective effect in intestinal epithelial cells.

Clinical efficacy and mechanism of probiotics in allergic diseases

  • Kim, Ha-Jung;Kim, Hyung Young;Lee, So-Yeon;Seo, Ju-Hee;Lee, Eun;Hong, Soo-Jong
    • Korean Journal of Pediatrics
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    • v.56 no.9
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    • pp.369-376
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    • 2013
  • A complex interplay between genetic and environmental factors partially contributes to the development of allergic diseases by affecting development during prenatal and early life. To explain the dramatic increase in the prevalence of allergic diseases, the hygiene hypothesis proposed that early exposure to infection prevented allergic diseases. The hygiene hypothesis has changed to the microbial hypothesis, in which exposure to microbes is closely linked to the development of the early immune system and allergic diseases. The intestinal flora may contribute to allergic disease through its substantial effect on mucosal immunity. Based on findings that exposure to microbial flora early in life can change the Th1/Th2 balance, thus favoring a Th1 cell response, probiotics may be beneficial in preventing allergic diseases. However, evidence from clinical and basic research to prove the efficacy of probiotics in preventing allergy is lacking. To date, studies have yielded inconsistent findings on the usefulness of probiotics in allergic diseases. It is difficult to demonstrate an exact effect of probiotics on asthma, allergic rhinitis, and food allergy because of study limitations, such as different first supplementation period, duration, different strains, short follow-up period, and host factors. However, many studies have demonstrated a significant clinical improvement in atopic dermatitis with the use of probiotics. An accurate understanding of the development of human immunity, intestinal barrier function, intestinal microbiota, and systemic immunity is required to comprehend the effects of probiotics on allergic diseases.