• Title, Summary, Keyword: Probiotics

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Functionality and Safety of Probiotics (프로바이오틱스의 기능성과 안전성)

  • Seo, Yeongeun;Yoon, Yohan;Kim, Sejeong
    • Journal of Dairy Science and Biotechnology
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    • v.37 no.2
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    • pp.94-101
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    • 2019
  • Probiotics stabilize intestinal microflora, reduce constipation, reduce decay by inhibiting harmful bacteria, and prevent diseases. Probiotics have also been studied for their possible roles in immune activation, treatment of cancer, remediation of cholesterol, treatment of diabetes, alleviation of allergies, and relief of lactose intolerance. However, recent data concerning the side effects of probiotics have prompted debate regarding their efficacy and safety. Major adverse events associated with probiotics are gastrointestinal symptoms, such as diarrhea, gastrointestinal disorders, and vomiting, along with skin rash and urticaria. Probiotics occasionally cause sepsis in infants with poor immunity and elderly people with severe diseases. In contrast to previous studies that described the efficacy of probiotics in intestinal regulation, some recent studies have reported that the activity of intestinal microbes becomes weak as a result of the influx of probiotics. The data indicate that the safety of probiotics is not guaranteed and that further investigations are needed.

Probiotics as a Potential Immunomodulating Pharmabiotics in Allergic Diseases: Current Status and Future Prospects

  • Sharma, Garima;Im, Sin-Hyeog
    • Allergy, Asthma & Immunology Research
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    • v.10 no.6
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    • pp.575-590
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    • 2018
  • The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases etc., dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector metabolites or component of them in a bacterial species can affect the efficacy of those as probiotics. On the other hand, host variations like geographical locations, food habits etc. could also affect the expected results from probiotic usage. Thus, there is a glaring deficiency in our approach to establish probiotics as an irrefutable treatment avenue for suitable disorders. In this review, we explicate on the reported probiotics and their effects on certain allergic diseases like atopic dermatitis, food allergy and asthma to establish their utility. We propose possible measures like elucidation of effector molecules and functional mechanisms of probiotics towards establishing probiotics for therapeutic use. Certain probiotics studies have led to very alarming outcomes which could have been precluded, had effective guidelines been in place. Thus, we also propose ways to secure the safety of probiotics. Overall, our efforts tend to propose necessary discovery and quality assurance guidelines for developing probiotics as potential immunomodulatory 'Pharmabiotics.'

Oral Delivery of Probiotics in Poultry Using pH-Sensitive Tablets

  • Jiang, Tao;Li, Hui-Shan;Han, Geon Goo;Singh, Bijay;Kang, Sang-Kee;Bok, Jin-Duck;Kim, Dae-Duk;Hong, Zhong-Shan;Choi, Yun-Jaie;Cho, Chong-Su
    • Journal of Microbiology and Biotechnology
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    • v.27 no.4
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    • pp.739-746
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    • 2017
  • As alternatives to antibiotics in livestocks, probiotics have been used, although most of them in the form of liquid or semisolid formulations, which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for livestocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxypropyl methylcellulose phthalate 55 (HPMCP 55) as a tablet-forming matrix to develop probiotics in a tablet form for poultry. Here, we made three different kinds of probiotics-loaded tablet under different compression forces and investigated their characteristics based on their survivability, morphology, disintegration time, and kinetics in simulated gastrointestinal fluid. The results indicated that the probiotics formulated in the tablets displayed higher survival rates in acidic gastric conditions than probiotics in solution. Rapid release of the probiotics from the tablets occurred in simulated intestinal fluid because of fast swelling of the tablets in neutral pH. As a matrix of tablet, HPMCP 55 provided good viability of probiotics after 6 months under refrigeration. Moreover, after oral administration of probiotics-loaded tablets to chicken, more viable probiotics were observed, than with solution type, through several digestive areas of chicken by the tablets.

Trends in probiotics product (국내외 프로바이오틱스 제품 개발 현황)

  • Seong, Yeong-Je;Park, Myeong Soo
    • Food Science and Industry
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    • v.52 no.3
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    • pp.229-240
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    • 2019
  • Ever since the definition "live microorganisms which when administered in adequate amounts confer a health benefit on the host"and guidelines of probiotics by the Food and Agriculture Organization of the United Nations and the WHO were announced, the research and product development using probiotics has been hugely successful. As a result, probiotics products become an important part of the functional food market. Recently, thanks to rapidly growing microbiome research, more diverse roles and health benefits of probiotics are being elucidated. Based on those results, pharmabiotics using probiotics are anticipated. In addition, in order to be internationally competitive and distributed, efforts should be made for certification such as GRAS/NDI notification through quality control that meets global standards. In this paper, we reviewed several aspects of probiotics concerning recently amended definition of probiotics, the regulation of probiotics, the strain specificity of efficacy, the association with microbiome research, and the market trends.

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Prevention of Obesity and Type 2 Diabetes by Using Probiotics (프로바이오틱스 섭취를 통한 비만 및 제2형 당뇨의 완화)

  • Eor, Ju Young;Park, Mi Hyun;Kim, Sae Hun
    • Journal of Dairy Science and Biotechnology
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    • v.33 no.4
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    • pp.231-235
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    • 2015
  • The beneficial effects of probiotics on human health have been extensively studied. Strains of Lactobacillus and Bifidobacterium have gained considerable attention, as they are major groups of probiotic bacteria that improve gastrointestinal health. Recently, probiotics have been found to have positive effects on obesity and type 2 diabetes mellitus (T2D) that go beyond the improvement of gut health. Probiotics can alter the secretion of substances such as leptin and adiponectin from white adipose tissue via certain mechanisms. Additionally, probiotics can modulate the adaptive immune system against low-grade inflammation caused by obesity. The potential role of probiotics in the treatment of T2D has garnered interest because of increasing evidence of the anti-diabetic effect of probiotics. In this review, we discuss the results of in vivo studies that have examined the use of probiotics to prevent obesity and T2D, while primarily focusing on the studies that explore the cellular and molecular mechanisms underlying the activity of promising probiotic strains. The conclusions of this review could be of help to researchers who are investigating the effects of probiotics on obesity or T2D, and to patients with these diseases.

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Comparison of Perception on Probiotics and Dietary Behavior according to the Probiotics Ingestion Experience - focus on Consumers in Metropolitan Areas - (프로바이오틱스 섭취경험에 따른 제품인식 및 식행동 비교 - 수도권 지역 소비자를 중심으로 -)

  • Cho, Wookyoun;Yeom, Ok Kyoung;Lee, Kyung-Ran
    • Journal of the Korean Society of Food Culture
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    • v.33 no.6
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    • pp.567-579
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    • 2018
  • This study analyzed consumers' recognition and demand for probiotic products and dietary and living habits according to their probiotics ingestion experience to provide information on the development of probiotic products and marketing strategies in the health functional food-related industry. A total of 280 consumers living in Seoul, Incheon and Kyeonggi-do area were enrolled in this study. The consumers expected mostly intestinal health (80.4%) after ingesting probiotics. The appropriate price level for purchasing probiotics was between 20,000-50,000 won (58.2%), preferring a price range of 50,000 won or less (77.1%). There was a significant difference in the dietary habits depending on the experience of probiotics ingestion, but there was no difference in the living habit. Consumers took Vitamin C, red Ginseng and Ginseng the most instead of probiotics as health functional foods. Based on the results, a marketing strategy could be established to meet the consumer's needs, such as focusing on the effects of probiotics, building up various price policies and the development of new products mixing with other commonly consumed health supplements.

Efficacy of antibacteriocidal yeast that producing bacteriocin OR-7 in pig (박테리오신 OR-7을 생산하는 항균 효모의 양돈에서의 사양시험 효과)

  • Cho, Dong-In;Kang, Sang-Mo;Lee, Jae-Hwa;Lee, Sang-Hyeon;Jang, Min-Kyung;Kim, Ki-seuk
    • Korean Journal of Veterinary Research
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    • v.50 no.4
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    • pp.297-302
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    • 2010
  • This study was conducted to investigate the effects of feeding probiotics (gene modified yeast) on the growth performances in pigs. In pigs, this study investigated the effects of dietary probiotics which contained antibacterial probiotics (OR-7, bacteriocin, gene modified yeast) on growth performances and feed efficiency in pig farm. A total of 150 pigs were studied. The treatments are probiotics yeast (PY) 0.3% (basal diet + 0.3% plasmid modified probiotics), PY 0.5% (basal diet + 0.5% plasmid modified probiotics), yeast (Y) 0.3% (basal diet + 0.3% probiotics), Y 0.5% (basal diet + 0.5% probiotics) and control (basal diet). Weight gain, feed intake and feed efficiency were periodically recorded for 90 days. The treatment group trended higher weight gain, feed intake and feed efficiency than control. And, the PY group trended higher weight gain, feed intake and feed efficiency than Y group.

Prevention of Inflammatory Bowel Disease using Fermented Milk Including Probiotics (프로바이오틱스 섭취를 통한 염증성 장 질환의 완화)

  • Lee, Jin;Yun, Hyun-Sun;Kim, Sae-Hun;Jeon, Woo-Min
    • Journal of Dairy Science and Biotechnology
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    • v.28 no.2
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    • pp.25-30
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    • 2010
  • For centuries, probiotics have been known to promote health and prevent diseases. In recent times, modulation of diseases related to the immune function by probiotics has been recognized as very important to the health of the host's gut. Inflammatory bowel diseases (IBDs) are the most frequently studied diseases in which probiotic administration has been tested as a potential therapy. Various in vitro and in vivo studies have been performed. The studies discussed in this review suggest several mechanisms: probiotics could modulate the gut microflora by competing with disease-causing pathogenic bacteria and could directly regulate the mucosal immune system, which activates the innate and adaptive immune systems. In addition, human clinical trials have shown alleviation of disease symptoms of ulcerative colitis (UC), Crohn's disease, etc. This study aimed to understand the molecular mechanisms underlying immune modulation by probiotics and review studies on the functional aspect of IBD alleviation by probiotics. With more scientific studies confirming the effect of probiotics, this therapy holds promise for use in alternative medicine and/or pharmaceutical preparations, given the long history of safe consumption of probiotics.

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The effects of Lactobacillus reuteri-containing probiotics on the viability and biofilm formation of oral microorganisms (Lactobacillus reuteri 함유 Probiotics가 구강미생물의 생존 및 biofilm 형성에 미치는 영향)

  • Lee, Su-Bin;Lee, Kyung-Hee
    • Journal of Korean society of Dental Hygiene
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    • v.20 no.3
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    • pp.387-397
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    • 2020
  • Objectives: This study aimed to evaluate the inhibitory effects of probiotics containing Lactobacillus reuteri on Streptococcus mutans and Aggregatibacter actinomycetemcomitans. In addition, the degree of biofilm formation, initial acidity, buffering ability, and acid production performance were measured to confirm the dental caries-inducing ability. Methods: S. mutans (KCTC3065) and A. actinomycetemcomitans (KCTC2581) were used as experimental strains. The number of viable cells, degree of biofilm formation, initial pH, buffering capacity, and production performance were measured for comparing L. reuteri-containing probiotics and Bulgaris. Results: The viability of S. mutans in the groups was reduced in the following order: Bulgaris, probiotics, control. The degree of biofilm formation was significantly higher at 0% and gradually reduced at different concentrations (p<0.01). At 2.5%, the absorbance of the probiotics and Bulgaris groups differed significantly (p<0.01). The acid formation ability differed significantly based on the performance of S. mutans in each product (p<0.05). The absorbance of the probiotics group was significantly lower than that of the Bulgaris group (p<0.01). Conclusions: This study suggests that the use of L. reuteri-containing probiotics as an adjuvant for the prevention and decreasing of oral diseases may reduce their incidence, which can be considered one of the benefits of using probiotics.

Effect of Bacillus subtilis PNG-4 with or without Lactobacillus acidophilus on malodorous gas emission of excreta in laying hens (Bacillus subtilis PNG-4의 단독 및 Lactobacillus acidophilus와의 혼합 사용이 산란계의 건물소화율, 혈액성상 및 계분의 악취 발생에 미치는 영향)

  • Kim, Lee-Su;Cha, Sang-Woo;Cho, Sung-Kyung;Kim, Sung-Bok;Lee, Bong-Duk;Lee, Soo-Kee
    • Korean Journal of Agricultural Science
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    • v.37 no.1
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    • pp.53-60
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    • 2010
  • Two experiments were conducted to investigate the effect of probiotics on the malodor removal. In experiment 1, dietary effects (several malodorous gas concentration of excreta, dry matter metabolizability, and blood profiles) were determined using laying hens. A total of 30 Hy-line brown layers, 68-wk of age, were randomly allocated into 5 groups with 3 replicates of 2 birds each. The treatments were probiotics free, 0.2% and 0.4 % addition of mixed probiotics (Bacillus subtilis PNG-4 +Lactobacillus acidophilus LAS), and 0.2 and 0.4 % addition of single probiotics (Bacillus subtilis PNG-4). In experiment 2, the effects of mixing of probiotics into the excreta on the malodorous gas removal was investigated. There were three treatments (probiotics free, Bacillus subtilis PNG-4 +Lactobacillus acidophilus LAS, and Bacillus subtilis PNG-4) with three replicates. The malodorous gas concentrations were detected at 0, 3, 7 and 14 day of incubation. In experiment 1, ammonia concentration was significantly decreased by feeding mixed probiotics at 14th day of incubation. However, amines, hydrogen sulfide, ethylmercapthan, and methylmercapthan were not significantly affected by mixed probiotics. Dry matter metabolizability was significantly increased by feeding probiotics, but no significant differences between single and mixed probiotics. There was no significant differences in blood profiles. In experiment 2, mixing of probiotics into the excreta did not affect the concentration of ammonia, amines, hydrogen sulfide, ethylmercapthan, and methylmercapthan. Therefore, these experiments suggested that Bacillus subtilis PNG-4 + Lactobacillus acidophilus LAS supplementations could improve ammonia gas removal, and dry matter metabolizability in layers. Also, decrease of ammonia concentration was higher in mixed probiotics group compare to the single probiotics group. On the other hand, mixing of probiotics into the excreta appeared not to be a useful method.