• Title, Summary, Keyword: Polygonatum sibiricum

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Dereplication and Quantification of Steroidal Saponins in Polygonatum Species Using LC-MS

  • Kim, Jin-Woong;Ahn, Mi-Jeong
    • Proceedings of the PSK Conference
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    • pp.66.1-66
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    • 2003
  • Rhizomes of Polygonatum species belong to Liliaceae are important herbal drugs in the traditional medical practice of Asian region. Two representative Chinese drugs derived from this genus are Hwangjeong and Okjuk. Though botanical origins of these drugs are officially listed as P. falcatum, P. sibiricum and P. kingianum for Hwangjeong and P. odoratum var. pluriflorum for Okjuk in the Korean Pharmacopoeia and Korean Herbal Pharmacopoeia, respectively, they are often sold as a mixture of several different species in the market. (omitted)

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Inhibitory Effects of Herbal Medicines on the Platelet-Activating Factor(PAF) Receptor Binding

  • Kang, Young-Hwa
    • Natural Product Sciences
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    • v.11 no.3
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    • pp.131-135
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    • 2005
  • Methanolic extracts of ninety-five medicinal plants were screened for platelet-activating factor (PAF) receptor binding inhibitory activity using rabbit platelet. Alpinia officinarum, Belamcanda chinensis, Leonurus heterophyllus, Pinus densiflora, Polygonatum sibiricum and Sambucus williamsii showed significant inhibitory effects on the platelet-activating factor (PAF) receptor binding.

Effects of Polygonatum sibiricum rhizome extract on lipid and energy metabolism in high-fat diet-induced obese mice (고지방 식이 유도 비만 마우스 모델에서 황정 추출물의 지방질 및 에너지 대사 관련 유전자에 대한 효능 연구)

  • Jeon, Woo-Jin;Kim, Ji-Young;Oh, Ik-Hoon;Lee, Do-Seop;Shon, Suh-Youn;Seo, Yun-Ji;Yeon, Seung-Woo;Kang, Jae-Hoon
    • Korean Journal of Food Science and Technology
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    • v.49 no.2
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    • pp.192-202
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    • 2017
  • In this study, factors involved in lipid and energy metabolism following treatment with ethanolic extract of the Polygonatum sibiricum rhizome (ID1216) were evaluated in high-fat diet-induced obese mice. ID1216-treated mice showed a significant reduction in weight gain compared to non-treated mice. ID1216 treatment increased the protein levels of AMP-dependent protein kinase, sirtuin1, peroxisome proliferator-activated receptor ${\gamma}$ coactivator 1-${\alpha}$ ($PGC1{\alpha}$), peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) and uncoupling proteins in the adipose tissue, liver and muscle compared to vehicle treatment. Analysis of downstream signals of the sirtuin1 $PGC1{\alpha}$-$PPAR{\alpha}$ pathway showed that ID1216 regulates the expression of ${\beta}$-oxidation related genes such as acyl-CoA oxidase, carnitine palmitoyltransferase1, acyl-CoA dehydrogenase and adipocyte protein 2. In addition, ID1216 increased the expression of adipose triglyceride lipase. These results suggest that ID1216 has anti-obesity effects by regulating the genes involved thermogenesis, ${\beta}$-oxidation and lipolysis in a diet-induced obesity model.

Effects of ethanol extract of Polygonatum sibiricum rhizome on obesity-related genes (황정 에탄올 추출물의 비만 조절 유전자에 대한 효과)

  • Jeon, Woo-Jin;Lee, Do-Seop;Shon, Suh-Youn;Seo, Yun-Ji;Yeon, Seung-Woo;Kang, Jae-Hoon
    • Korean Journal of Food Science and Technology
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    • v.48 no.4
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    • pp.384-391
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    • 2016
  • In previous studies, we confirmed that the ethanol extract of Polygonatum sibiricum (ID1216) has anti-obesity effects on high-fat diet-fed mice. To identify the obesity-related genes affected by ID1216, we studied its effects both in vivo and in vitro. In mice, single administration of ID1216 increased the expression of obesity-related genes including sirtuin1 (SIRT1), peroxisome proliferator-activated receptor ${\gamma}$ coactivator $1{\alpha}$ ($PGC1{\alpha}$) and peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) compared to that in mice administered the vehicle; their downstream genes (uncoupling proteins, acyl-CoA oxidase, adipocyte protein 2, and hormone-sensitive lipase) were also increased by ID1216. In fully differentiated 3T3-L1 adipocytes, ID1216 showed the same effects on anti-obesity genes as those in the animal model. Based on these results, we propose that ID1216 has anti-obesity effects by regulating the $SIRT1-PGC1{\alpha}-PPAR{\alpha}$ pathway and their downstream genes, thereby controlling energy and lipid metabolisms.

Morphological Characteristics and Phylogenetic Analysis of Polygonatum Species Based on Chloroplast DNA Sequences (한국산 둥굴레속 식물의 형태적 특성 및 엽록체 DNA 염기서열을 이용한 유연관계 분석)

  • Kim, Jeong Hun;Seo, Jae Wan;Byeon, Ji Hui;Ahn, Young Sup;Cha, Seon Woo;Cho, Joon Hyeong
    • Korean Journal of Medicinal Crop Science
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    • v.22 no.6
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    • pp.489-496
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    • 2014
  • Polygonatum is a genus placed in the family Liliaceae, distributed throughout the Northern Hemisphere and 16 of the species are grown naturally in Korea. In oriental medicine, the rhizomes of Polygonatum have been used as two different medicines, Okjuk (Polygonati odorati Rhizoma) and Hwangjeong (Polygonati Rhizoma). However, it is difficult to identify the morphological and chemical differences between the medicinal groups and thus easy to confuse the one with the other. Therefore, a clear classification standard needs to be established so as to be able to discriminate between them. In the study, the morphological characteristics of the plants, Polygonatum spp., were examined. Then, the differences in SNPs among the DNA sequences of 7 of the Polygonatum spp. and 1 of the Disporum spp. were analyzed by DNA barcoding with rpoC1, rpoB2, matK, and psbA-trnH of the cpDNA region. In the results, three regions, rpoC1, rpoB2, and matK were useful for discriminating the species, P. stenophyllum and P. sibiricum. Furthermore, it was possible to discriminate the individual germplasm within the species by using the combination of the results obtained from rpoB2, rpoC1, and matK.

Reexamination of plant names in the literature published during the Japanese Imperialism Period with special reference to Hwangjeong and Wiyu (일제 강점기 문헌에 나오는 식물명의 재검토: 황정(黃精)과 위유(萎蕤)를 중심으로)

  • SHIN, Hyunchur
    • Korean Journal of Plant Taxonomy
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    • v.49 no.3
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    • pp.253-260
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    • 2019
  • The plant names Hwangjeong and Wiyu were written in Chinese characters in Hyang-yak-jib-seong-bang during the early Chosen dynasty. However, soon after, Hwangjeong and Wiyu were written in Korean characters as Jukdae and Dung-gul-re, respectively. However, since under the Japanese imperialist period in Korea, the taxonomic identities of these two Korean names have been incorrectly understood, with scientific names incorrectly assigned as well to these two names thus far. The results of the present study prove that Hwangjeong is Polygonatum sibiricum and that its Korean name should be Jukdae, its initial Korean name, and not Cheung-cheung-gal-go-ri-dung-gul-re, as used recently. Meanwhile, during the Japanese imperialist period, Wiyu was termed P. officinale or P. japonicum with the Korean name of Dung-gul-re. However, the correct scientific names were shown to be synonyms of P. odoratum.

Genetic Analysis of Polygonati Rhizoma and Polygonati odorati Rhizoma using Random Amplified Microsatellite Polymorphism (RAMP를 이용한 황정과 위유의 유전적 분석)

  • An, Sun-Min;Ryuk, Jin-Ah;Kim, Young-Hwa;Chae, Byoung-Chan;Kim, Hong-Jun;Kim, Ki-Hoon;Kang, Kwon-Kyoo;Ko, Byong-Seob;Lee, Mi-Young
    • Korean Journal of Medicinal Crop Science
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    • v.14 no.3
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    • pp.125-129
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    • 2006
  • Two herbal medicines of the Polygonatum genus, namely Polygonati Rhizoma and Polygonati Odorati Rhizoma, are difficult to distinguish from each other through exterior morphologic aspects. Furthermore, because the standard components for physiochemical distinction have not yet been standardized, the identification of these medicines through botanic taxology is based on genetic methods of random amplified microsatellite polymorphism (RAMP). For the RAMP evaluation, we used five sets of UBC microsatellite primers 811, 818, 834, 836, 842 and random primer M1. Although no specific band that could clearly distinguish Polygonati Rhizoma from Polygonati Odorati Rhizoma was found, 11 Polygonatum plants could be divided into two groups by this method. P. sibiricum and P. stenophyllum were classified to group I and the others were to group II. As P. sibiricum and P. stenophyllum were very similar in genetic and morphologic perspective, the results suggest that P. stenophyllum belongs to the Polygonati Rhizoma family.

Classification of Polygonatum spp. Collections Based on Multivariate Analysis (다변량 분석에 의한 둥굴레속 식물의 분류)

  • Yun, Jong-Sun;Son, Suk-Yeong;Kim, Ik-Hwan;Hong, Eui-Yon;Yun, Tae;Lee, Cheol-Hee;Jong, Seung-Keun;Park, Sang-Il
    • Korean Journal of Medicinal Crop Science
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    • v.10 no.5
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    • pp.333-339
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    • 2002
  • This study was conducted to obtain the basic data for practical use of the Polygonatum genetic resources. The 20 collections were analyzed by principal component analysis of 8 characters and cluster analysis. In the principal analysis, the first, the second and the third components contributed 54.10%, 18.95% and 11.62% of the variations, respectively. The cumulative contribution from the first to the third principal components was 84.68%. The first principal component was related to shape and size of plant, and assimilatory, reserve and reproductive organs. The second principal component was related to growth and development of plant, and reserve organ. And the third principal component was related to growth and development of plant. Based on cluster analysis, the 20 collections were classified into 4 distinct groups with the average distance greater than 0.7 between groups. Group I was Polygonatum sibiricum $D_{ELAR}$ and Group II included P. odoratum var. pluriflorum $O_{HWI}$, P. odoratum var. pluriflorum $O_{HWI}$ for 'Variegatum' Y. Lee, for. nov., P. odoratum var. thunbergii $H_{ARA}$ and P. odoratum var. maximowiczii $K_{OIDZ}$. GroupIII was P. involucratum $M_{AXIM}$, P. desoulavyi $K_{OMAROV}$ and P. humile $F_{ISHER}$ ex. $M_{AXIM}$. And GroupIV included P. lasianthum var. coreanum $N_{AKAI}$ and P. inflatum $K_{OMAROV}$.

Classification of Korean Polygonatum Collections Based on Cluster Analysis (군집분석에 의한 한국 자생 둥글레속 수집종의 분류)

  • Yoon, Jong-Sun;Son, Seok-Yong;Hong, Eui-Yeon;Kim, Ik-Hwan;Yoon, Tae;Lee, Chul-Hee;Lee, Chul-Hee
    • Korean Journal of Plant Resources
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    • v.15 no.3
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    • pp.260-268
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    • 2002
  • Morphological characteristics and growth patterns of 20 Polygonatum collections indigenous to Korea were examined and the collections were classified to obtain the basic data for practical use of Polygonatum genetic resources. Based on the cluster analysisi 20 collections were distinctly classified into seven groups with average distance greater than 0.6 between groups. Group I was p. sibiricum Delar, and group II included p. odoratum var. pluriforum Ohwi, P. odoratum var. pturiforum Ohwi 'Variegata' and P. odoratum var. maximowiczii Koidz.. Group III was P. odoratum var. thunbergii Hara, group IV included P. lasianthum var. coreanum Nakai, and group V was P. involucratum Maxim. and P. desoulavyi Komarov. group Ⅵ was P. inflatum Komarov and group Ⅶ was P. humile Fischer ex. Maxim. Morphologically, group I was larger than the other groups, group II and III were medium, and group IV to Ⅶ were small. In the classification of genus Polyognatum, stem length, stem habit, phyllotaxis, stem angularity, petiole, inflorescence, perianth, bract and rhizome were particularly important characters. Group I to III were thought to be useful as the edible and medicinal resources plants, and group IV to Ⅶ were thought to be useful as ornamental plants.

Screening and Evaluation of the Anti-allergic Effect of Korean Medicinal Plant Extracts (한국 약용식물자원 추출물의 항알레르기 활성 평가 및 선발)

  • Kim, Nan Sol;Choi, Doo Jin;Choi, Eun Ju;Lee, Jeong Hoon;Park, Saetbyul;Lee, Young Sup;Lee, Jae Won;Lee, Dae Young;Kim, Geum Sook;Lee, Seung Eun
    • Korean Journal of Medicinal Crop Science
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    • v.26 no.1
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    • pp.42-54
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    • 2018
  • Background: Allergic diseases like such as atopic dermatitis, asthma, and rhinitis have recently increased both domestically and globally. The present study was undertaken to select candidates with anti-allergic activity from plant resources. Methods and Results: Fifty-six plant extracts at $20{\mu}g/m{\ell}$ were screened against ${\beta}$-hexosaminidase production and interleukin (IL)-4 release in degranulated rat basophilic leukemia (RBL)-2H3 cells. The anti-allergy activity of three plant extracts selected from the preliminary screening experiment, Polygonatum sibiricum F. Delaroche (root), Pyrus pytifolia var. culta (Makino) Nakai (leaf), and Rehmannia glutinosa (Gaertn.) Libosch. ex Steud (root) were measured at concentrations of $2-250{\mu}g/m{\ell}$ in three cell lines as RBL-2H3, HaCaT and Jurkcat T cells. The assay showed the root extract of R. glutinosa to have an inhibitory activity of 4.2% - 28.6% on ${\beta}$-hexosaminidase production from IgE-sensitized RBL-2H3 cells. Each extract of P. sibiricum and R. glutinosa reduced IL-4 release in IgE-sensitized RBL-2H3 cells, respectively. The leaf extract of P. pyrifolia var. culta showed a significantly potent suppressive effect of 10.2% - 74.7% on the mRNA expression of tumor necrosis factor (TNF)-${\alpha}$ in HaCaT cells sensitized with TNF-a and INF-g, and showed inhibitory effect of -8.6% - 90.9% on the mRNA expression of IL-2 in Jurkat T cells sensitized with PMA and A23187. Conclusions: The results showed that the root of R. glutinosa and leaf of P. pyrifolia var. culta could be useful candidates as antiallergy materials.