• Title, Summary, Keyword: Pancreas

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Perilesional Steatosis in Ectopic Pancreas Mimicking Exogastric Mass : A Case Report (주변부 지방침윤으로 인해 외위장 종괴로 보이는 이소성 췌장: 증례 보고)

  • Nam, Mi Yeon;Kim, Mi Young;Kim, Yeo Ju;Suh, Chang Hae;Choi, Suk Jin;Cho, Jae Sung
    • Investigative Magnetic Resonance Imaging
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    • v.17 no.2
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    • pp.154-157
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    • 2013
  • We report an unusual case of ectopic pancreas that appeared on radiologic images as a lobulated, submucosal mass enclosed by fat component in the gastric lower body. Although, ectopic pancreas including fat component is extremely rare, in the setting of gastric submucosal mass with containing perilesional fat, these findings should be considered in ectopic pancreas as part of the differential diagnosis.

Two Cases of Papillary Cystic Neoplasm of the Pancreas (췌장의 유두상 낭성암 2예 보고)

  • Choi, Seung-Hoon;Hwang, Eui-Ho
    • Advances in pediatric surgery
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    • v.1 no.1
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    • pp.79-84
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    • 1995
  • Two cases with papillary cystic neoplasm of the pancreas are reviewed and discussed. Up to recently, the tumors have been misclassified as nonfunctioning islet cell tumor or carcinoma, acinar cell carcinoma, papillary cystadenocarcinoma, or pancreatoblastoma. It frequently has been managed with aggressive surgery such as pancreatoduodenectomy. The tumors are well encapsulated and the cut surfaces are characteristically solid and hemorrhagic. Ultrasonography and CT scan are the most useful tools for the diagnosis. The neoplasms usually behave like a very low grade malignancy, so complete removal is the treatment of choice for the tumor arising anywhere in the pancreas. We have a boy and a girl who have papillary cystic neoplasm. The boy was 12 years old and the girl was 14 years old. Both underwent distal pancreatectomy and the progress were uneventful. We have a boy and a girl who have papillary cystic neoplasm. The boy was 12 years old and the girl was 14 years old. Both underwent distal pancreatectomy and the progress were uneventful.

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Solid and Papillary Epithelial Neoplasm of the Pancreas in Children (소아에서의 췌장의 고형유두상 상피성 종양)

  • Yoon, Hyuk-Jin;Park, Jin-Young
    • Advances in pediatric surgery
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    • v.12 no.1
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    • pp.32-40
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    • 2006
  • Four children with solid and papillary epithelial neoplasm of the pancreas are reported. Three were girls. Mean age at operation was 12 years and 7 months (10-13 years). Clinical presentation included nausea, vomiting, and apalpable mass. One had hemoperitoneum due to tumor rupture. In two cases, tumors were in the body of the pancreas, and one the body and tail, and in one,the tail. Mean diameter of the tumors was 10.8 cm (8-15cm). Surgical procedures were distal pancreatectomy and splenectomy in 2 cases, distal pancreatectomy in one, and subtotal pancreatectomy and splenectomy in one. Mean follow-up period was 61 months (6-121 months). Three patients are still alive without any recurrence. However, in the one case of ruptured tumor, portal vein thrombosis and liver metastasis developed after subtotal pancreatectomy and splenectomy during the course of postoperative adjuvant chemotherapy.

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Cystic duct variation detected by near-infrared fluorescent cholangiography during laparoscopic cholecystectomy

  • Kim, Nam Seok;Jin, Hyeong Yong;Kim, Eun Young;Hong, Tae Ho
    • Annals of Surgical Treatment and Research
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    • v.92 no.1
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    • pp.47-50
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    • 2017
  • Near-infrared fluorescent cholangiography (NIRFC) is an emerging technique for easy intraoperative recognition of biliary anatomy. We present a case of cystic duct variation detected by NIRFC which had a potential risk for biliary injury if not detected. A 32-year-old female was admitted to the Seoul St. Mary's Hospital for surgery for an incidental gallbladder polyp. We performed laparoscopic cholecystectomy with NIRFC. In fluorescence mode, a long cystic duct and an accessory short hepatic duct joining to the cystic duct were found and the operation was completed safely. The patient recovered successfully. NIRFC is expected to be a promising procedure that will help minimize biliary injury during laparoscopic cholecystectomy.

Immunohistochemistry of Glucagon- immunoreactive Cells in the Developing Pancreas of the Korean Native Goat (Capra hircus)

  • Sae-Kwang Ku;Hyeung-Sik Lee;Jae-Hyun Lee
    • Animal cells and systems
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    • v.3 no.2
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    • pp.187-191
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    • 1999
  • The distribution of glucagon-immunoreactive cells in the pancreas during various developmental stages (fetus, neonate, 1-month-old, 6-month-old and adult) of the Korean native goat was investigated by immunohistochemical methods. The varying distribution and frequency of glucagon-immunoreactive cells in the pancreas of the Korean native goat were observed. The glucagon-immunoreactive cells were detected in both exocrine and endocrine portions (pancreatic islets) at all developmental stages and also in ducts of the 6-month-old and adult. The relative frequencies of glucagon-immunoreactive cells increased in the pancreatic islets and ducts with age, but decreased in the exocrine portions. Generally, they were distributed in the interacinar spaces or marginal zone of the pancreatic islets during all stages of development. However, the cell distributions of the pancreatic islets in the neonate divided into two types: 1) ones which were distributed in the inner zone, and 2) others in the peripheral zone.

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Anatomical and histological studies on the developing pancreas of chincken embryos (일령에 따른 닭 태자 췌장의 해부학적 및 조직학적 연구)

  • Ku, Sae-kwang;Lee, Jae-hyun;Lee, Hyeung-sik
    • Korean Journal of Veterinary Research
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    • v.39 no.6
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    • pp.1049-1056
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    • 1999
  • Anatomical and histological changes were studied in the dorsal, ventral, third and splenic lobes of the pancreas of the chicken embryos (8 days of incubation, 10 days of incubation to hatching). From 13 days of incubation, all four pancreatic lobes, namely, dorsal, ventral, third and splenic lobes were observed. Histologically, the pancreas of 10-14 days of incubation were consisted of mesenchymal tissue, exocrine acini and pancreatic islets. But mesenchymal tissues were disappeared from 15 days of incubation. The pancreatic ducts were observed from 14 days of incubation. The dark and light typed pancreatic islets were observed in splenic lobe from 13 days of incubation, in the third lobe from 11 days of incubation, and in the dorsal lobe from 13 days of incubation. But no dark typed islets were observed in the ventral lobes.

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An immunohistochemical study of endocrine cells in the alimentary tract and pancreas of the toad, Bufo bufo gargarizans Cantor (두꺼비(Bufo bufo gargarizans cantor)에서 위장췌내분비세포의 면역조직화학적 연구)

  • Lee, Hyeung-sik;Ku, Sae-kwang;Park, Ki-dae;Lee, Jae-hyun
    • Korean Journal of Veterinary Research
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    • v.40 no.1
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    • pp.17-26
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    • 2000
  • The regional distribution and relative frequencies of endocrine cells were studied immunohistochemically (PAP methods) in the alimentary tract and pancreas of the toad, Bufo bufo gargarizans Cantor using specific antisera against bovine Sp-1/chromogranin (BCG), serotonin, bombesin, gastrin, substance P (SP), somatostatin, insulin, glucagon, pancreatic polypeptide (PP), vasoactive intestinal polypeptide (VIP) and secretin. Nine kinds of endocrine cells were identified in this study. Spherical or spindleshaped immunoreactive (IR) cells were located in the gastric glands of stomach regions, in the basal portion of the epithelium of intestinal tract or esophagus, and in the exocrine or pancreatic islets with variable frequencies. In the alimentary tract, BCG-IR cells were found in the fundus and pylorus with rare and a few frequencies, respectively. Serotonin-IR cells were demonstrated in the whole alimentary tract including the esophagus. Bombesin- and SP-IR cells were restricted to the stomach regions and gastrin-IR cells were restricted to the pylorus. Somatostatin-IR cells were detected throughout the whole alimentary tract except for the large intestine, However, insulin-, glucagon-, PP-, VIP- and secretin-IR cells were not detected in the alimentary tract. In the pancreas of toad, the distribution and relative frequency of endocrine cells were similar to those of other mammals. Insulin-IR cells were located in the central portion of the pancreatic islets and interspaces of exocrine portions, and glucagon-, somatostatin- and PP-IR cells were detected in the marginal regions of the pancreatic islets and interspaces of exocrine. However, other IR cells were not found in the pancreas. In conclusion, the regional distribution and relative frequency of the endocrine cells in the alimentary tract and pancreas of the toad were similar to other anuran species but some differences which might be caused by feeding habits and species specification were also observed.

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Effects of ${\gamma}-Aminobutyric$ Acid on Intrinsic Cholinergic Action in Exocrine Secretion of Isolated, Perfused Rat Pancreas

  • Park, Yong-Deuk;Park, Hyung-Seo;Cui, Zheng-Yun;Park, Hyoung-Jin
    • The Korean Journal of Physiology and Pharmacology
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    • v.7 no.3
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    • pp.169-174
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    • 2003
  • ${\gamma}$-Aminobutyric acid (GABA) has been reported to enhance exocrine secretion evoked not only by secretagogues but also by intrinsic neuronal excitation in the pancreas. The pancreas contains cholinergic neurons abundantly that exert a stimulatory role in exocrine secretion. This study was undertaken to examine effects of GABA on an action of cholinergic neurons in exocrine secretion of the pancreas. Intrinsic neurons were excited by electrical field stimulation (EFS; 15 V, 2 msec, 8 Hz, 45 min) in the isolated, perfused rat pancreas. Tetrodotoxin or atropine was used to block neuronal or cholinergic action. Acetylcholine was infused to mimic cholinergic excitation. GABA $(30{\mu}M)$ and muscimol $(10{\mu}M)$, given intra-arterially, did not change spontaneous secretion but enhanced cholecystokinin (CCK; 10 pM)-induced secretions of fluid and amylase. GABA (3, 10, $30{\mu}M$) further elevated EFS-evoked secretions of fluid and amylase dose-dependently. GABA (10, 30, $100{\mu}M$) also further increased acetylcholine $(5{\mu}M)$-induced secretions of fluid and amylase in a dose-dependent manner. Bicuculline $(10{\mu}M)$ effectively blocked the enhancing effects of GABA $(30{\mu}M)$ on the pancreatic secretions evoked by either EFS or CCK. Both atropine $(2{\mu}M)$ and tetrodotoxin $(1{\mu}M)$ markedly reduced the GABA $(10{\mu}M)$-enhanced EFS- or CCK-induced pancreatic secretions. The results indicate that GABA enhances intrinsic cholinergic neuronal action on exocrine secretion via the $GABA_A$ receptors in the rat pancreas.

Exocrine Secretory Responsiveness of Dispersed Pancreatic Acini to Secretagogues in Camostat-treated Rats (Camostat 투여 흰쥐 이자 외분비선의 분비자극물질에 대한 반응성)

  • Kim, Chul;Kim, Dong-Goo;Kim, Kyung-Hwan
    • The Korean Journal of Pharmacology
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    • v.30 no.2
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    • pp.205-215
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    • 1994
  • It is well known that chronic stimulation with CCK gives rise to growth of exocrine pancreas and to increased content of enzyme proteins in pancreas. However, littls Is known about changes of the secretory function of exocrine pancreas which has been chronically stimulated with CCK, especially about the responsiveness to secretagogues such as CCK, caerulein and carbachol. The present study was performed to investigate the effect of camostat on secretory profiles and the responsiveness to secretagogues of exocrine pancreas by observing in vitro amylase release stimulated by cholecystokinin-octapeptide(CCK-8) and carbachol in dispersed isolated pancreatic acini from camostat-treated rats for 4 or 10 days. The results summarized as follows : 1) The maximal effective concentration of CCK-8 in amylase release in the camostat treated group was greater than control group, but that of carbachol was not different between groups. 2) Analysis of the stimulated amylase release as the percentage of the maximal response revealed that camostat treatment caused right-shift of the dose-response curve of CCK-8. Camostat did not cause significant changes in the dose-response curve of carbachol. 3) There were considerable increases in the amylase release in the camostat-treated group, compared to the control when acini were stimulated with CCK-8 $10^{-9}\;M$ and carbaochol $10^{-6}\;M$, and higher concentrations. 4) There was a reverse correlation between the tissue content and the maximal release(percent of the total content) of amylase. These results suggest that chronic exposure of exocrine pancreas to increased endogenous CCK can enhance the responsiveness of exocrine enzyme secretion to secretagogues, especially at higher concentrations of CCK and carbachol.

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