• Title, Summary, Keyword: Pancreas

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Pancreatic lesions of pigs with post-weaning multisystemic wasting syndrome

  • Jung, Ji-Youl;Kang, Sang-Chul;Park, Bong-Kyun;Hwang, Eui-Kyung;Kim, Dae-Yong;Kim, Jae-Hoon
    • Korean Journal of Veterinary Research
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    • v.50 no.4
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    • pp.265-271
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    • 2010
  • Post-weaning multisystemic wasting syndrome (PMWS) is a new emerging disease affecting nursery and growing pigs in worldwide. Porcine circovirus type 2 (PCV-2) is a most important pathogen associated with PMWS. This study was carried out to investigate the pathological changes in the pancreas of pigs diagnosed as PMWS. To detect the PCV-2 antigen and nucleic acid in the tissue, immunohistochemistry and polymerase chain reaction (PCR) was conducted, respectively. 24 pigs of 4-10 weeks old showed clinical signs of PMWS such as chronic wasting, respiratory distress and diarrhea were examined. Histopathologically, interstitial and periductular mononuclear cells infiltration were observed in pancreas. Multifocal to diffuse necrosis of acinar tissues or necrotizing to granulomatous pancreastitis with numerous syncytial cells infiltration were examined in severe cases. PCV-2 nucleic acid was detected from all tested pancreas using PCR. The PCV-2 antigen in 12 pancreas sections was detected by immunohistochemical staining. PCV-2 has a tropism for vascular endothelial cells and infiltrated macrophages. Although gross lesions are uncommon in the pancreas of pigs with PMWS, histopathological changes and the presence of PCV-2 in this tissue may be related to clinical signs associated with digestive disorders.

Case of Solitary Pancreatic Metastasis from Small Cell Lung Cancer

  • Park, Chul;Kim, Tae Hyeon;Yun, Ki Jung;Choi, Soon Ho;Lee, Sam Youn;Lee, Mi Kyung;Ryu, Dae Woong;Yang, Sei Hoon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.26 no.6
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    • pp.980-982
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    • 2012
  • Metastasis to the pancreas from extra-pancreatic primary cancers are rare; they commonly present as a manifestation of widespread disease and rarely as an isolated mass of the pancreas. Examinations showed a pancreatic tumor infiltrating the pancreas tail portion and an endoscopic ultrasound guided percutaneous biopsy proved that the lesion was metastatic from the lung carcinoma. Most metastatic cases of the pancreas tend to be discovered in patients with widely disseminated malignant disease. In addition, patients with pancreatic metastasis are often asymptomatic, the metastatic lesions are found incidentally, and are misdiagnosed as primary pancreatic tumors. This report that patient undergoing chemotherapy for a small cell lung cancer, who 1 year and 3 months later, accidentally diagnosed of solitary pancreas metastasis and confirmed histology by needle biopsy using endoscopic ultrasound.

Squamous Cell Carcinoma of the Pancreas: A Case Report (췌장의 편평세포암: 증례 보고)

  • Park, Se Hoon;Choi, Ju Wan;Shin, Ji Yeol;Kim, Seong Hoon
    • Journal of the Korean Society of Radiology
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    • v.79 no.4
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    • pp.191-195
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    • 2018
  • Squamous cell carcinoma (SCC) of the pancreas is an extremely rare subtype of pancreatic cancer. To our best knowledge, magnetic resonance imaging findings, including diffusion weighted images and the non-hypervascular feature on computed tomography, in patients with SCC of the pancreas have not been reported previously. We present the computed tomography and magnetic resonance imaging findings of SCC of the pancreas in a 63-year-old male patient with no specific past history.

Management of Traumatic Pancreas Injury in Multiple Trauma - Single Center Experience (다발성 외상 환자에서 췌장 손상 치료 경험)

  • Jang, Hyun-A;Shim, Hong-Jin;Cha, Sung-Whan;Lee, Jae-Gil
    • Journal of Trauma and Injury
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    • v.24 no.2
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    • pp.111-117
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    • 2011
  • Purposes: Pancreatic injury is rare in abdominal trauma patients (3%~12%). but it could result in significant morbidity and even mortality. Early and adequate decision making are very important in the management of patients with traumatic pancreatic injury. The purpose of this study was to assess the kinds of management and outcome through the review of our experience of pancreatic injury with multiple trauma. Methods: We reviewed 17 patients with traumatic pancreas injury via electronic medical records from Jan. 2002 and April. 2011. We collected demographic findings; the type, location and grade of pancreas injury, the treatment modality, and patient's outcomes, such as complications, length of hospital stay (LOS), and mortality. Results: Total 17 patients were reviewed, and man was 13 (88%). Traffic accident was the most common cause of injury. Pancreas neck was the most common injured site, and occured in 5 patients. Ductal injury was detected in 7 cases. Eleven patients were treated by surgical procedure, and in this group, 3 patients underwent the endoscopic retrograde pancreas drainage procedure coincidently. ERPD was tried in 8 patients, and failed in 2 patients. The major complications were post-traumatic fluid collection and abscess which accounted for 70 % of all patients. The hospital stay was 35.9 days, and it was longer in patient with ductal injury ($38.0{\pm}18.56$ vs. $34.5{\pm}33.68$ days). Only one patient was died due to septic shock associated with an uncontrolled retroperitoneal abscess. Conclusion: Early diagnosis is the most important factor to apply the adequate treatment option and to manage the traumatic pancreas injury. Aggressive treatment should be considered in patients with a post-operative abscess.

Anti-oxidant Effect of Hyangsayangyi-tang Decoction in Stomach, Spleen and Pancreas Cell of SD Rats (향사양위탕(香砂養胃湯) 전탕액이 노화주의 비장, 췌장, 위장 세포의 항산화능에 미치는 영향)

  • Choi, Byoung-Chol;Ahn, Taek-Won
    • Journal of Sasang Constitutional Medicine
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    • v.20 no.2
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    • pp.72-84
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    • 2008
  • 1. Objectives The purpose of this study was to observe the anti-oxidant effects of Hyangsayangyi-tang(HY) in SD rats. 2. Methods This experiment was used the tissue of stomach, spleen and pancreas cells of 6, 52 and 68 weeks old SD rats. Each age group was again divided into three groups. One group, as normal group, was not-treated cells, another group, as control group, was saline-treated cells, and the last group, as experimental group, was HY-treated cells. After culture for 48 hours, each groups measured the level of SOD, GSH, MDA and NO in the tissue of stomach, spleen and pancreas cells. 3. Results and Conclusions The activity of SOD were significantly increased in spleen cell of 52, 68 w-HY group, pancreas cell of 68 w-HY group and in stomach cell of 52, 68 w-HY group compared with those of the normal and the control groups. The level of GSH were significantly increased in spleen cell of 52, 68w-HY group and in pancreas cell of 68w-HY group compared with those of the normal and the control groups. The level of MDA were significantly decreased in pancreas cell of 68 w-HY group compared with those of the normal and the control groups. The level of NO were significantly decreased in spleen cell of 68 w-HY group, pancreas cell of 52, 68w-HGD groups compared with those of the control groups. According to results, HY showed anti-oxidant effect. Investigation into the clinical use of the HY is suggested for future research.

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A Case of Solid and Papillary Epithelial Neoplasm in Head of Pancreas in a 11-year-old Female (11세 소아에서 췌장 두부에서 발생한 고형성 및 유두상 상피성 종양 1례)

  • Jeong, Jong-Su;Cho, Jai-Il;Kim, Hwan-Il;Kim, Kil-Seo;Seong, Hun;Lee, Chae-Won
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.3 no.1
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    • pp.116-121
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    • 2000
  • Solid and Papillary epithelial neoplasm of pancreas is a rare and low grade malignant tumor. It develops in 2nd or 3rd decades of young female and located in tail of pancreas predominantly. Prognosis is good despite its various histologic features, which suggest a malignant appearance. We report one case of solid and papillary epithelial neoplasm in head of pancreas in a 11-year-old girl who had been suffered from vomiting and right upper abdominal pain for 3 weeks.

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Gage R&R Study on Abdominal Sonography for Measuring Distance from Sangwan (CV13) to Pancreas - A Pilot Study - (복부초음파를 이용한 상완혈(上脘穴)-췌장 수직거리 측정시스템의 재현성 반복성 평가실험-A Pilot Study-)

  • Nam, Dong-Hyun
    • The Journal of the Korean Medicine Diagnostics
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    • v.14 no.2
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    • pp.75-84
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    • 2010
  • Objectives: The objective of the current study is to determine whether an ultrasound device system is adequate for measuring distance from Sangwan (CV13) to pancreas. Methods: We recruited 3 healthy young male subjects and 2 sonographers. The each sonographer measured vertical shortest distance from CV13 to pancreas with a ultrasound device three times in random order. Because the total variation could be divided into repeatability, reproducibility and subject-to-subject variation in Gage R&R method, we compared the sources of variation associated with the measurement system with an analysis of variance model. Results & Conclusions: Number of distinct categories is calculated on the basis of standard deviation of subject-to-subject divided by standard deviation of total Gage R&R. If the number of categories is five or more, the measurement system may be acceptable for the analysis of the process. The number of distinct categories of the ultrasound device system for measuring distance from CV13 to pancreas was 6.29. So we concluded that repeatability and reproducibility of the ultrasound device system for measuring distance from CV13 to pancreas was acceptable.

Prevention of Alloxan-induced Diabetes by Se-Methylselenocysteine Pretreatment in Rats: The Effect on Antioxidant System in Pancreas

  • Nam, Tack-Il;Park, Jung-Jin;Choi, Eun-Mi
    • Preventive Nutrition and Food Science
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    • v.14 no.2
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    • pp.95-101
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    • 2009
  • In this study, we assessed the effects of Se-methylselenocysteine (MSC) pretreatment on the antioxidant system in the pancreas and the development of alloxan-induced diabetes in rats. The rats were treated with MSC at a dose of 0.75 mg/rat/day for 2 weeks. The MSC-treated rats evidenced significantly increased glutathione content, GSH/GSSG ratio, and glutathione peroxidase (GPx) and glutathione reductase (GRd) activities in the pancreas. Diabetes was induced via alloxan injection. The alloxan-diabetic rats evidenced significantly reduced glutathione content and glucose 6-phosphate dehydrogenase (G6PD) activity and increased catalase activity in the pancreas, when measured 3 days after the alloxan injection. 2-week MSC pretreatment was shown to prevent the alloxan-induced hyperglycemia as well as changes in glutathione content, G6PD activity, and catalase activity. The results of this study indicate that the prevention of alloxan-diabetes by MSC pretreatment is associated with its effects on antioxidants in the pancreas, namely, the increase in cellular content and the reduction of glutathione by the facilitation of glutathione recycling induced via increased GPx, GRd, and G6PD activities.

A Case of Pseudocyst Originated from Ectopic Pancreas in the Transverse Mesocolon Associated with Colonic Duplication (대장중복증과 동반된 횡행결장간막의 이소성 췌장에서 유래된 가성낭종 1예)

  • Kim, In-Gyu;Han, Seok-Joo;Yang, Kyung-Mu;Kim, Ho-Geun;Kim, Myung-Joon;Oh, Jung-Tak;Hwang, Eui-Ho
    • Advances in pediatric surgery
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    • v.4 no.1
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    • pp.79-84
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    • 1998
  • We have treated a case of pseudocyst of transverse mesocolon in 3-year-old male child. Operative findings demonstrated that the pseudocyst originated in the transverse mesocolon, and was not connected to the pancreas. A colonic duplication was found incidentally near the pseudocyst. On microscopic examination, ectopic pancreatic tissue was noted in the transverse mesocolon. This pseudocyst was thought to have originated from the ectopic pancreas of the transverse mesocolon. This is the first reported case of pseudocyst originated from ectopic pancreas of the transverse mesocolon, combined with a colonic duplication. The pathogenesis is discussed.

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A Case of Intussusception Arising from Heterotopic Pancreas in Ileum (회장에 발생한 이소성 췌장에 의한 장중첩증 1례)

  • Rhim, Jung Woo;Koh, Eun Suk;Park, Jae Ock
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.7 no.2
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    • pp.274-277
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    • 2004
  • The heterotopic pancreas is defined as the presence of pancreatic tissue lacking anatomical and vascular continuity from the main body of pancreas. Its incidence has been reported as widely ranging from 0.55~13.7% in autopsy studies and 0.2% in upper abdominal laparotomies. The most common sites are the antrum of stomach, duodenum and proximal jejunum. But, lesions have also been found in the ileum, Meckel diverticulum, common bile duct and the esophagus. Most cases are incidentally encountered during surgery, and on rare occasions, epigastric pain, hemorrhage, gastric outlet obstruction and intussusception have been directly attributable to the presence of the heterotopic pancreas. A 3-month-old boy presented with 1-day history of vomiting and irritability. Intussusception was confirmed on ultrasound scan. At laparotomy there was an irreducible ileoileal intussusception, the intussuscepted portion of ileum was resected and end to end anastomosis was performed. Histologically, the mass was found to be composed of pancreatic tissue.

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