• Title, Summary, Keyword: Pancreas

Search Result 766, Processing Time 0.032 seconds

A Study on Pancreas Scanning with $Selenium^{75}$-Selenomethionine ($^{75}Se$-Selenomethionine 을 이용(利用)한 췌장주사(膵臟走査)에 관(關)한 연구(硏究))

  • Shin, Hyun-Chan;Toh, Sang-Hee;Ra, Woo-Youn;Suh, Chul-Sung
    • The Korean Journal of Nuclear Medicine
    • /
    • v.2 no.1
    • /
    • pp.21-25
    • /
    • 1968
  • Radiographic visualization of the pancreas is a difficult problem, but the direct visualization of the pancreas is possible by the injection of the amino-acid methionine tagged with $selenium^{75}$75 ($Se^{75}$). In order to know the diagnostic value of pancreas scanning, scans were performed on 23 cases using $selenium^{75}$-selenomethionine. These cases were also given egg white, probanthine and morphine. 1. Good visualization of the pancreas scanning was observed on 19 cases, presumably with normal pancreas. 2. A case which showed diffusely decreased uptake on pancreas scanning was proven to have lesions in the bile duct and the gall bladder. 3. Of those two cases which showed localized cold area, one had pancreas cyst and the other one was not explored. 4. A case which showed no visualization of the pancreas was proven to have pancreatic carcinoma. 5. Two cases which showed widened duodenal loop by upper gastro-intestinal series revealed normal pancreas scanning, and no pancreatic disease was found in both cases.

  • PDF

Automatic Pancreas Detection on Abdominal CT Images using Intensity Normalization and Faster R-CNN (복부 CT 영상에서 밝기값 정규화 및 Faster R-CNN을 이용한 자동 췌장 검출)

  • Choi, Si-Eun;Lee, Seong-Eun;Hong, Helen
    • Journal of Korea Multimedia Society
    • /
    • v.24 no.3
    • /
    • pp.396-405
    • /
    • 2021
  • In surgery to remove pancreatic cancer, it is important to figure out the shape of a patient's pancreas. However, previous studies have a limit to detect a pancreas automatically in abdominal CT images, because the pancreas varies in shape, size and location by patient. Therefore, in this paper, we propose a method of learning various shapes of pancreas according to the patients and adjacent slices using Faster R-CNN based on Inception V2, and automatically detecting the pancreas from abdominal CT images. Model training and testing were performed using the NIH Pancreas-CT Dataset, and intensity normalization was applied to all data to improve pancreatic detection accuracy. Additionally, according to the shape of the pancreas, the test dataset was classified into top, middle, and bottom slices to evaluate the model's performance on each data. The results show that the top data's mAP@.50IoU achieved 91.7% and the bottom data's mAP@.50IoU achieved 95.4%, and the highest performance was the middle data's mAP@.50IoU, 98.5%. Thus, we have confirmed that the model can accurately detect the pancreas in CT images.

Clinical Application of $^{18}F-FDG$ PET in Pancreas Cancer (췌장암에서 $^{18}F-FDG$ PET의 임상 이용)

  • Kang, Won-Jun
    • Nuclear Medicine and Molecular Imaging
    • /
    • v.42 no.sup1
    • /
    • pp.71-75
    • /
    • 2008
  • The prevalence of pancreas cancer is increasing. Due to difficulty in detecting early stage disease, the prognosis of pancreas cancer is known to be poor. Clinical use of FDG PET in pancreas has been reported. FDG PET showed good performance in diagnosing pancreas cancer, and is expected to be useful in staging and detecting recurrence.

Immunohistochemistry of the Pancreatic Endocrine Cells of the Red-eared Slider (Trachemys scripta elegans)

  • Ku, Sae-Kwang;Lee, Hyeung-Sik;Lee, Jae-Hyun;Park, Ki-Dae
    • Animal cells and systems
    • /
    • v.4 no.2
    • /
    • pp.187-193
    • /
    • 2000
  • Regional distribution and relative frequency of endocrine cells in the pancreas of the red-eared slider, Trachemys scripta elegans, were investigated by immunohistochemical methods. Chromogranin (Cg) A-, serotonin-, insulin-, glucagon-, somatostatin-, bovine pancreatic polypeptide (BPP)- and human pancreatic polypeptede (HPP)-immunoreactive cells were identified in this study. Most of immunoreactive cells in the exocrine and endocrine pancreas (Langerhans islet) were generally spherical or spindle-shaped (open-typed cell), while occasionally cells round in shape (close-typed cell) were found in the basal portion or interepithelial regions of the pancreatic duct. These immunoreactive cells were located in the exocrine, endocrine pancreas and/or basal or interepithelial portion of the pancreatic duct. Serotonin-immunoreactive cells were found in the basal portion of epithelia of the pancreatic duct at a low frequency and interacinar region of the exocrine at a moderate frequency. Insulin-immunoreactive cells were found in the central portion of the endocrine pancreas, interacinar regions of the exocrine pancreas and basal portion of the epithelia of the pancreatic duct at high, moderate and low frequencies, respectively. Glucagon-immunoreactive cells were detected in the periphery of the endocrine pancreas, interacinar region of the exocrine pancreas and basal portion of the epithelia or interepithelia of the pancreatic duct at high, moderate and moderate frequencies, respectively. Somatostatin-immunoreactive cells were dispersed in the whole area of the endocrine pancreas, interacinar regions of exocrine pancreas and basal portion of the epithelia or interepithelia of the pancreatic duct at a moderate frequency. BPP- and HPP-immunoreactive cells were detected in the iinteracinar region of the exocrine pancreas at moderate and hige frequencies, respectively. However, no Cg A- and motilin-immunoreactive cells were detected in this study.

  • PDF

Significance of Caveolin-1 Regulators in Pancreatic Cancer

  • Chen, Tao;Liu, Liang;Xu, Hua-Xiang;Wang, Wen-Quan;Wu, Chun-Tao;Yao, Wan-Tong;Yu, Xian-Jun
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.14 no.8
    • /
    • pp.4501-4507
    • /
    • 2013
  • Caveolin-1 is a scaffold protein on the cell membrane. As the main component of caveolae, caveolin-1 is involved in many biological processes that include substance uptake and transmembrane signaling. Many of these processes and thus caveolin-1 contribute to cell transformation, tumorigenesis, and metastasis. Of particular interest are the dual rolesof tumor suppressor and oncogene that caveolin-1 appear to play in different malignancies, including pancreatic cancer. Therefore, analyzing caveolin-1 regulators and understanding their mechanisms of actionis key to identifying novel diagnostic and therapeutic tools for pancreatic cancer. This review details the mechanisms of action of caveolin-1 regulators and the potential significance for pancreatic cancer treatment.

Focal change of the pancreatic texture using a direct injection mixture of N-butyl cyanoacrylate and lipiodol in the pig model: a strategy for preventing pancreatic leakage during pancreatic surgery

  • Kim, Eun Young;Hong, Tae Ho
    • Annals of Surgical Treatment and Research
    • /
    • v.95 no.4
    • /
    • pp.175-182
    • /
    • 2018
  • Purpose: A soft texture of the pancreas is one of the most important predisposing factors for a pancreatic fistula. Thus, in a porcine model, we investigated a method to harden the pancreas locally by directly injecting an artificial material. Methods: During the laparotomy, 51 samples from 17 pigs, including 13 survival models, were randomly divided into 3 groups and either received a direct injection into the pancreas of MHL (1:4 mixture of histoacryl [n-butyl cyanoacrylate] and lipiodol) (group E) or saline (group C) or only received a pinprick into the pancreas without injecting a substance (sham). We measured the change in the pancreatic hardness after the injection using a durometer and examined the histological change of the pancreas using the fibrosis grade in the survival model. Results: The postinjection hardness of the pancreas was significantly increased in group E compared to group C and the sham group (P < 0.001). Pathologically, all cases in group E showed a severe fibrotic change, whereas the other groups demonstrated mild to no fibrosis (P < 0.001). The fibrosis in group E was localized to the area of the injection, while the surrounding areas were preserved. Conclusion: The direct injection of MHL could induce focal hardening and fibrotic changes in the pancreas of the porcine model.

Nonfunctioning Neuroendocrine Tumor of the Pancreas in a 15-year-old Girl - a Case Report - (15세 여아에서 발생한 췌장의 비기능성 신경내분비종양 - 1예 보고 -)

  • Lee, Kyung-Keun;Park, Jin-Young
    • Advances in pediatric surgery
    • /
    • v.15 no.2
    • /
    • pp.180-185
    • /
    • 2009
  • We report a case of nonfunctioning neuroendocrine tumor of the pancreas in a 15-year-old girl who presented with back pain. On physical examination, there was mild tenderness in the left upper quadrant of the abdomen. The patient had no pancreatic hormone-associated symptoms. An abdominal ultrasonography showed a well-demarcated hypervascular solid mass with calcification in the tail of the pancreas. An abdominal computed tomography scan showed a $6{\times}5cm$ sized well-encapsulated enhancing solid mass with cystic component in the tail of the pancreas. Distal pancreatectomy was performed. Pathology revealed awelldifferentiated nonfunctioning low grade malignant neuroendocrine tumor of the pancreas. The postoperative course was uneventful.

  • PDF

Oral contrast media for computed tomography of canine pancreas

  • Choi, Jihye;Chang, Jinhwa;Oh, Sunkyoung;Yoon, Junghee
    • Korean Journal of Veterinary Research
    • /
    • v.51 no.2
    • /
    • pp.165-169
    • /
    • 2011
  • Barium suspension, oral iodine contrast medium and water were applied in eight dogs to evaluate (1) distension of gastrointestinal tract, (2) the effect of the oral contrast media on the identification of the pancreas from surrounding organs, and (3) image quality and the presence of artifacts in canine pancreas computed tomography (CT) images. Oral iodine contrast medium, gastrografin, produced significant artifacts that deteriorated the CT images of the pancreas. The use of water did not provide the fullness of the gastrointestinal lumens. Barium suspension was effective for the identification of the pancreas from the surrounding gastrointestinal tract, without significantly increasing image noise. Barium suspension can be used as an optimal contrast medium that will not cause an adverse effect on the pancreatic density and image quality.

Distribution, Content and Molecular Heterogeneity of Gastrin-Releasing Peptide in Rat Pancreas

  • Park, Hyung-Seo;Park, Hyoung-Jin
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.3 no.4
    • /
    • pp.427-432
    • /
    • 1999
  • Although importance of intrapancreatic neurons containing gastrin-releasing peptide (GRP) in control of exocrine secretion has been raised, the nature of GRP in the pancreas is unclear. Thus, the present study was undertaken to see distribution, content and molecular heterogeneity of immunoreactive GRP in the rat pancreas. Content of immunoreactive GRP in the rat pancreas was $2.99\;{\pm}\;0.66$ ng/g wet tissues determined by radioimmunoassay. Immunoreactive GRP was most abundantly expressed in the duodenal part among 3 parts of the pancreas; duodenal, body and splenic part. Vagotomy failed to change the content of immunoreactive GRP in the pancreas. Three distinct forms of immunoreactive GRP, very identical to GRP-27, bombesin-24 and neuromedin C, were observed in the rat pancreas by using reversed phase $C_{18}$ HPLC and Sephadex G-50 superfine column chromatography. Cell bodies of neurons containing immunoreactive GRP were scattered in pancreatic connective tissues and their nerve fibers innervated pancreatic acini and large ducts as determined by immunohistochemistry. The present results suggest that three distinct forms of GRP exist in intrapancreatic GRPergic neurons, which exert a stimulatory role in pancreatic exocrine secretion in rats.

  • PDF

Proteomic analysis of porcine pancreas development

  • Choi, Jong-Soon;Cho, Young-Keun;Yoon, Sung-Ho;Kwon, Sang-Oh;Koo, Deog-Bon;Yu, Kweon
    • BMB Reports
    • /
    • v.42 no.10
    • /
    • pp.661-666
    • /
    • 2009
  • Porcine pancreas development is not well studied at the molecular level despite being a therapeutic resource for diabetic patients. In this study, we investigated expression of lineage markers and performed proteomic analysis. Expression of the early lineage markers Pdx1 and Ptf1a was developmentally conserved between mice and pigs, whereas expression of the islet differentiation marker Pax4 was delayed in porcine compared with murine pancreas development. Proteomic analysis found that expression levels of chymotrypsinogen were down-regulated during porcine pancreas development while those of digestive enzymes like lipases, elastase and serine protease were up-regulated. In addition, specific isoforms of protein folding assistants such as protein disulfide isomerase and prefoldin were expressed at specific stages during the maturation of digestive enzymes. Taken together, these results show that development of the porcine pancreas is regulated by a concerted interplay of pancreas lineage marker proteins and other specified proteins, resulting in a functional endocrine and exocrine organ.