• Title, Summary, Keyword: PSA

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The Development of a Advanced Information Management System for PSA (확률론적 안전성 평가를 위한 정보 관리 시스템 개발)

  • Kim Seung-Hwan
    • Journal of the Korea Society of Computer and Information
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    • v.10 no.6
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    • pp.337-344
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    • 2005
  • In order to Perform a PSA. it requires a large number of data for various fields. Therefore, the effective management of the data is essential to perform and review a PSA and to maintain the quality of a PSA. Korea Atomic Energy Research Institute (KAERI) is developing a PSA information management system (AIMS: Advanced Information Management System for PSA) which enhances the accessibility to PSA information for all PSA related activities. The AIMS is a database system that stores all references and links to the information used for the PSA analysis. The AIMS consists of a database, information browsing modules and a PSA model manager. This Paper describes how we implemented such a database centered application in the view of two areas, database design and data (document) service.

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Development of Enzyme Immuno Assay for Analysis of Free Prostate Specific Antigen in Serum (혈청 유리형 전립선항원 (free PSA) 측정을 위한 효소면역측정법의 개발)

  • Kyung-Ok Lee;Kyung-In Kim;Kyu-Pum Lee
    • Biomedical Science Letters
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    • v.3 no.2
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    • pp.107-114
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    • 1997
  • Recent reports indicate that the clinical usefulness of prostate specific antigen (PSA), particulary in the differentiation of benign prostate hyperplasia from prostate cancer, can be improved by measuring the amount of free PSA in serum. Measuring free PSA is especially useful in attempts to improve diagnositc performance of PSA in the diagnostic gray zone of total PSA. The objective of this study was to develop free PSA assay kit using sandwich microplate enzyme immunoassay format. We chose a test format with polyclonal anti-PSA antibodies coated on the wells and monoclonal anti-free PSA antibodies for quantification to gain higher test sensitivity. We adpoted 10 uL of specimen and 2 hours of first incubation time with detecting antibody for free PSA EIA format using microplate. The within-day and between-day precision (%CV) in the high and low concentration ranges were below 4%. The correlation coefficient between in-house free PSA assay and commercial assay kit was r=0.9965 (slope=0.0984, y intercept=0.0173, N=27). No hook effect was found by 40 ng/mL and correlation coefficient (r) value of the fitted linear regression was over 0.995. The recovery tests were in the range of 98.9∼104.1% for free PSA. In conclusion, in-house free PSA enzyme immune assay is cost effective, simple and rapid and could be useful for the prognosis after theraphy as well as for the differential diagnosis between prostate cancer and benign prostate hyperplasia.

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Phenotypic Characteristics of Pseudomonas syringae pv. actinidiae Strains from Different Geographic Origins (지리적 기원이 다른 Pseudomonas syringae pv. actinidiae 균주들의 표현형적 특성)

  • Choi, Eun Jin;Lee, Young Sun;Kim, Gyoung Hee;Koh, Young Jin;Jung, Jae Sung
    • Korean Journal of Microbiology
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    • v.50 no.3
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    • pp.245-248
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    • 2014
  • Pseudomonas syringae pv. actinidiae is the causal agent of bacterial canker in kiwifruit (genus Actinidia). Multilocus sequence analysis of seven housekeeping and 11 type III effector genes differentiated the virulent P. syringae pv. actinidiae isolates worldwide into three groups designated as Psa1-Psa3. In this work, a total of 12 P. syringae pv. Actinidiae strains, including three Psa1, three Psa2, three Psa3 strains isolated from Korea and three Psa3 strains from Italy, were compared based on their phenotypic properties. Strains with different geographic origins had unique growth patterns as demonstrated by growth rate at several temperatures; all tested strains exhibited maximum growth at temperatures below $22^{\circ}C$, while the growth of Psa3 strains was completely inhibited above $30^{\circ}C$. Psa3 strains isolated from Korea had longer lag phases than the Psa3 strains from Italy. The Psa2 strains were different from Psa1 and Psa3 strains in the API 20NE test, in which the Psa2 strains could not utilize potassium gluconate, capric acid and trisodium citrate. Psa3 strains isolated from Korea could hydrolyze esculin. The API ZYM test showed that ${\beta}$-glucosidase activity was detected only from Psa3 strains. The strains belonging to the three Psa groups differed with regard to their susceptibility to ampicillin, novobiocin, and oleandomycin.

Review of measurement of prostate specific antigen: in the aspect of insurance medicine (전립선암 선별을 위한 PSA 측정의 보험의학적 의미)

  • Park, Kwang-Il
    • Journal of Korean Life Insurance Medical Association
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    • v.29 no.1
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    • pp.16-21
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    • 2010
  • The measurement of prostate specific antigen (PSA) in screening for prostate cancer is recently performed as a routine check-up in clinical medicine and insurance medicine. Several factors may affect serum PSA levels. As prostate size increases with increasing age, the PSA concentration also rises. Increasing body mass index (BMI) is associated with a lower mean PSA concentration. Inhibitors of 5-alpha-reductase such as finasteride and dutasteride produce a 50 percent or greater decrease in serum PSA during the first three months of therapy, which persists as long as the drug is continued. Men who are regularly taking non-steroidal antiinflammatory drugs (NSAIDs) or acetaminophen have lower PSA levels. Emerging concepts regarding PSA testing that may help refine the interpretation of an elevated concentration include: PSA density, PSA velocity, and Free versus complexed or bound PSA. With many insurance companies, PSA level has become part of a standard battery of blood tests, along with HIV, cholesterol, liver enzymes, and other predictors of premature death. But, there is no clear proof of benefit, so we have to monitor the value of PSA test as a prostate cancer screening test in insurance medicine.

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Pattern of Decrease of Prostate Specific Antigen after Radical Radiotherapy for the Prostate Cancer (전립선암 환자에서 방사선치료 루 전립선특이항원 농도 변화 양상)

  • Kim Bo-Kyoung;Park Suk Won;Ha Sung Whan
    • Radiation Oncology Journal
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    • v.17 no.2
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    • pp.136-140
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    • 1999
  • Purpose : Prostate specific antigen (PSA) is a useful tumor marker, which is widely used as a diagnostic index and predictor of both treatment and follow-up result in prostate cancer. A prospective analysis was carried out to obtain the period of PSA normalization and the half life of PSA and to analyze the factors influencing the period of PSA normalization. The PSA level was checked before and serially after radical radiotherapy. Materials and Method : Twen쇼 patients with clinically localized prostate cancer who underwent radical external beam radiotherapy were enrolled in this study. Accrual period was from April 1993 to May 1998. Median follow-up period was 20 months. Radiotherapy was given to whole pelvis followed by a boost to prostate. Dose range for the whole pelvis was from 45 Gy to 50 Gy and boost dose to prostate, from 14 Gy to 20 Gy. The post-irradiation PSA normal value was under 3.0 ng/ml. The physical examination and serum PSA level evaluation were performed at 3 month interval in the first one year, and then at every 4 to 6 months. Results : PSA value was normalized in nineteen patients (95%) within 12 months. The mean period of PSA normalization was 5.3 (${\pm}$2.7) months. The half life of PSA Of the nonfailing patients was 2.1 (${\pm}$0.9) month. The nadir PSA level Of the nonfailing Patients waS 0.8 (${\pm}$0.5) ng/ml. The period of PSA normalization had the positive correlation with pretreatment PSA level (R$^{2}$=0.468). The nadir PSA level had no definite positive correlation with the pretreatment PSA level (R$^{2}$=0.075). The half life of serum PSA level also had no definite correlation with pretreatment PSA level (R$^{2}$=0.029). Conclusion :The PSA level was mostly normalized within 8 months (85%). If it has not normalized within 12 months, we should consider the residual disease in prostate or distant metastasis. In 2 patients, the PSA level increased 6 months or 20 months before clinical disease was detected. So the serum PSA level can be used as early diagnostic indicator of treatment failure.

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Metabolisrrt of Dammarane Triterpene Glycosides of Korean Ginseng(I) (인삼 사포닌의 체내 대사에 관한 연구(I) 동위원소 표지 사포닌의 흡수, 체내 분포 및 배설에 관하여)

  • 한병훈;장일무
    • Journal of Ginseng Research
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    • v.2 no.1
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    • pp.17-33
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    • 1977
  • Panax Saponin A(PSA) , one of dammarane glycosides of Korean ginseng, was labeled with $^{3}H$ or $^{14}C$ by our Previously reported Procedures of organic synthesis. Tracer studies with $^{3}H$-PSA in wino yielded the following results: 1). Oral and intraperitoneal administration of $^{3}H$-PSA resulted in the rapid appearance and prolonged retention of $^{3}H$-PSA in all organs such as liver, brain, bone marrow and spleen of mice. 2). The amount pi cellular intake of $^{3}H$-PSA was shown to have a certain level of saturation ranging from 0.4mg to 0. 7mg Per 20gm body weight of mice. Administration of $^{3}H$-PSA within the dosage of the saturation point did net give urinary excretion of 3H-PSA. On the contrary, excessive administration of $^{3}H$-PSA resulted in rapid excretion of the substance in the urine of mice.

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Compact $H_2$ PSA process for Hydrogen station (수소 station을 위한 Compact형 $H_2$ PSA 공정 실험)

  • Lee, Jang-Jae;Woo, Eun-Ji;Kim, Myung-Jum;Lee, Chang-Ha
    • 한국신재생에너지학회:학술대회논문집
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    • pp.118-121
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    • 2007
  • 수소 스테이션의 수소분리정제를 위한 Compact 형 PSA를 연구하였다. 수소 스테이션의 공정과정 중에서 수소 분리를 위한 PSA 장치는 에너지효율면에서 장점을 가지고 있지만 부피가 커서 많은 부지를 차지하는 단점이 있다. 수소 PSA의 이러한 단점을 줄이기 위하여 하나의 흡착탑 안에 다른 흡착탑을 넣는 Dual bed 형태의 Compact형 수소 PSA공정을 연구하였다. Compact형 수소 PSA는 하나의 bed안에 다른 하나의 bed를 넣음으로써 시스템이 차지하는 부피를 줄이는 한편, inner bed와 outer bed사이의 열교환 효과가 나타나기 때문에 그 효율을 높일 수가 있다. Compact형 Dual bed는 활성탄으로 충진하였고 공급 기체로는 4성분 수소 혼합물 ($H_2/CO/CH_4/CO_2$, 69:2:3:26 vol.%)를 사용하였다. 흡착탑의 동특성을 알아보기 위하여 공급유량 7LPM, 흡착압력 9atm의 조건으로 파괴 실험을 수행하였다. 또한, Compact형 흡착탑의 열교환 효과가 PSA공정에 미치는 영향을 보고자 한 쪽 탑에서 흡착을 할 때, 다른 탑에서 탈착이 일어나는 실험을 하였다. 그리고 P/F ratio에 따라 Compact형 PSA 공정 실험을 하고 Compact형 흡착탑과 같은 부피의 일반 두 탑 PSA 공정을 시뮬레이션 값과 비교함으로써 Compact형 PSA의 성능을 알아 보았다. 그 결과 Dual bed PSA는 작은 부피를 차지하는 장점뿐만 아니라 열적 효과로 인하여 기존의 단일 흡착탑 PSA에 비하여 보다 높은 효율을 나타내면서 우수한 수소 분리 성능을 보여주었다.

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Human Kallikrein-2, Prostate Specific Antigen and Free-Prostate Specific Antigen in Combination to Discriminate Prostate Cancer from Benign Diseases in Syrian Patients

  • Bachour, Dala-Maria;Chahin, Emil;Al-Fahoum, Sahar
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.16
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    • pp.7085-7088
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    • 2015
  • Background: The high incidence of prostate cancer as the most common malignancy in males in many countries raises the question of developing reliable detection tests. The prostate specific antigen (PSA) test is the most widely used for screening for prostate cancer; however, its low specificity elevates the number of unnecessarily biopsies. Serum human kallikrein-2 (hK2) is considered as a promising marker, and especially its ratio to fPSA, for predicting the presence of malignancy to select the best choice referring to biopsy or surveillance. In this study, we investigated the role of hK2 and its combinations with other markers to discriminate prostate cancer from benign diseases in Syrian patients. Materials and Methods: In this prospective oriented cross-sectional cohort study, serum samples were collected from patients referred to many Hospitals in Damascus, Syria, between May 2011 and March 2012, and diagnosed with biopsy proven benign prostate hyperplasia (BPH) or prostate cancer (PCa). Serum was analyzed for hK2, PSA and fPSA, and the ratios of fPSA/PSA and hK2/fPSA were calculated. Results: We found that mean hK2/fPSA ratios were significantly higher (P=0.01) in prostate cancer patients than in the BPH or control groups. Also the ratio hk2/fPSA gave the largest area under the curve (AUC:0.96) which was significantly larger than for fPSA/PSA (AUC:0.41) indicative of higher specificity. Conclusions: Our results demonstrate that the ratio of hK2/fPSA might be superior to the use of fPSA/PSA alone. The hK2 could be shown to enhance the early detection of prostate cancer; especially the ratio hK2/fPSA improves specificity and hence may reduce the number of negative biopsies.

Spread of Bacterial Canker of Kiwifruit by Secondary Infection of Pseudomonas syringae pv. actinidiae Biovar 3 in Gyeongnam in 2016 (2016년 경남지역 Pseudomonas syringae pv. actinidiae Biovar 3의 2차감염에 의한 키위 궤양병의 확산)

  • Kim, Gyoung Hee;Choi, Eu Ddeum;Lee, Young Sun;Jung, Jae Sung;Koh, Young Jin
    • Research in Plant Disease
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    • v.22 no.4
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    • pp.276-283
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    • 2016
  • Bacterial canker caused by Pseudomonas syringae pv. actinidiae (Psa) occurred at 202 kiwifruit orchards for the survey period of 2013-2016, of which Psa biovar 2 (Psa2) and Psa biovar 3 (Psa3) were detected at 73 and 129 kiwifruit orchards, respectively. The number of kiwifruit orchards infected by Psa3 in 2016 increased nearly two times compared to 2015. Psa3 was detected from all the kiwifruit cultivars except some kiwiberry cultivars growing in Korea. Yellow-fleshed cultivars Hort16A and Jecy-gold and red-fleshed cultivar Hongyang were highly susceptible to Psa3. Our epidemiological and random amplification of polymorphic DNA analyses indicated that the first Psa3 incidence on Hongyang orchard in Sacheon, Gyoungnam might result from an introduction of Psa3-contaminated pollens from China for artificial pollination in 2014 and recent outbreaks of Psa3 in Sacheon and Goseong, Gyoungnam in 2016 might be due to rapid spread of bacterial canker by secondary infection of Psa3 from Hongyang orchard to neighboring Jecy-gold and Hayward orchards.

KAERI 에서의 PSA Workstation 개발

  • 한상훈;김태운;박창규
    • Proceedings of the Korean Nuclear Society Conference
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    • pp.610-615
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    • 1996
  • PSA 모델링 및 데이타 관리를 효과적으로 수행하고 PSA 정량화를 자동화할 수 있도록 PSA workstation 을 개발하고 있다. Windows용 고장수목 및 사건수목 편집기, 데이타 관리 모듈 개발등의 PSA모델링 및 관리 모듈이 개발되었고, 또한 최소단절집합 생성 방법 개선, 규칙기반 회복조치 분석 및 고장수목 순환논리 분석 방법 개발등을 통한 PSA 정량화 방법의 개선이 이루어졌다. PSA workstation은 PSA 응용 소프트웨어 개발의 기초로도 사용될 수 있다.

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