• Title, Summary, Keyword: PET

Search Result 4,030, Processing Time 0.054 seconds

Quantitative Comparisons in $^{18}F$-FDG PET Images: PET/MR VS PET/CT ($^{18}F$-FDG PET 영상의 정량적 비교: PET/MR VS PET/CT)

  • Lee, Moo Seok;Im, Young Hyun;Kim, Jae Hwan;Choe, Gyu O
    • The Korean Journal of Nuclear Medicine Technology
    • /
    • v.16 no.2
    • /
    • pp.68-80
    • /
    • 2012
  • Purpose : More recently, combined PET/MR scanners have been developed in which the MR data can be used for both anatometabolic image formation and attenuation correction of the PET data. For quantitative PET information, correction of tissue photon attenuation is mandatory. The attenuation map is obtained from the CT scan in the PET/CT. In the case of PET/MR, the attenuation map can be calculated from the MR image. The purpose of this study was to assess the quantitative differences between MR-based and CT-based attenuation corrected PET images. Materials and Methods : Using the uniform cylinder phantom of distilled water which has 199.8 MBq of $^{18}F$-FDG put into the phantom, we studied the effect of MR-based and CT-based attenuation corrected PET images, of the PET-CT using time of flight (TOF) and non-TOF iterative reconstruction. The images were acquired from 60 minutes at 15-minute intervals. Region of interests were drawn over 70% from the center of the image, and the Scanners' analysis software tools calculated both maximum and mean SUV. These data were analyzed by one way-anova test and Bland-Altman analysis. MR images are segmented into three classes(not including bone), and each class is assigned to each region based on the expected average attenuation of each region. For clinical diagnostic purpose, PET/MR and PET/CT images were acquired in 23 patients (Ingenuity TF PET/MR, Gemini TF64). PET/CT scans were performed approximately 33.8 minutes after the beginnig of the PET/MR scans. Region of interests were drawn over 9 regions of interest(lung, liver, spleen, bone), and the Scanners' analysis software tools calculated both maximum and mean SUV. The SUVs from 9 regions of interest in MR-based PET images and in CT-based PET images were compared. These data were analyzed by paired t test and Bland-Altman analysis. Results : In phantom study, MR-based attenuation corrected PET images generally showed slightly lower -0.36~-0.15 SUVs than CT-based attenuation corrected PET images (p<0.05). In clinical study, MR-based attenuation corrected PET images generally showed slightly lower SUVs than CT-based attenuation corrected PET images (excepting left middle lung and transverse Lumbar) (p<0.05). And percent differences were -8.01.79% lower for the PET/MR images than for the PET/CT images. (excepting lung) Based on the Bland-Altman method, the agreement between the two methods was considered good. Conclusion : PET/MR confirms generally lower SUVs than PET/CT. But, there were no difference in the clinical interpretations made by the quantitative comparisons with both type of attenuation map.

  • PDF

Clinical Application of F-18 FDG PET (PET/CT) in Colo-rectal and Anal Cancer (대장-직장 및 항문암에서 F-18 FDG PET (PET/CT)의 임상 이용)

  • Kim, Byung-Il
    • Nuclear Medicine and Molecular Imaging
    • /
    • v.42 no.sup1
    • /
    • pp.52-59
    • /
    • 2008
  • In the management of colo-retal and anal cancer, accurate staging, treatment evaluation, early detection of recurrence are main clinical problems. F-18 FDG PET (PET/CT) has been reported as useful in the management of colo-rectal and anal cancer because that PET has high diagnostic performance comparing to conventional studies. In case of liver metastases, for confirmation of no extrahepatic metastases, in case of high risk of metastasis, for avoiding unnecessary operation, PET (PET/CT) is expected more useful. In anal cancer, PET is expected useful in lymph node staging. For the early prediction of chemotherapy or radiation therapy effect PET has been reported as useful, also. In early detection of recurrence by PET, cost-benefit advantages has been suggested, also. PET/CT is expected to have higher diagnostic performance than PET alone.

Gamma Camera Based FDG PET in Oncology

  • Park, Chan-Hui
    • 대한핵의학회:학술대회논문집
    • /
    • /
    • pp.45-53
    • /
    • 2002
  • Positron Emission Tomography(PET) was introduced as a research tool in the 1970s and it took about 20 years before PET became an useful clinical imaging modality. In the USA, insurance coverage for PET procedures in the 1990s was the turning point, I believe, for this progress. Initially PET was used in neurology but recently more than 80% of PET procedures are in oncological applications. I firmly believe, in the 21st century, one can not manage cancer patients properly without PET and PET is very important medical imaging modality in basic and clinical sciences. PET is grouped into 2 categories : conventional(c) and gamma camera $based_{(CB)}$ PET. $_{CB}PET$ is more readily available utilizing dual-head gamma cameras and commercially available FDG to many medical centers at low cost to patients. In fact there are more $_{CB}PET$ in operation than cPET in the USA. $_{CB}PET$ is inferior to cPET in its performance but clinical studies in oncology is feasible without expensive infrastructures such as staffing, rooms and equipments. At Ajou university Hospital, CBPET was installed in late 1997 for the first time in Korea as well as in Asia and the system has been used successfully and effectively in oncological applications. Ours was the fourth PET operation in Korea and I believe this may have been instrumental for other institutions got interested in clinical PET. The fellowing is a brief description of our clinical experience of FDG CBPET in oncology.

  • PDF

Electrical Properties and Temperature Effects of PET Films with Interface Layers

  • Dong-Shick kim;Lee, Kwan-Woo;Park, Dae-Hee;Lee, Jong-Bok;Seun Hwangbo
    • Transactions on Electrical and Electronic Materials
    • /
    • v.1 no.4
    • /
    • pp.25-29
    • /
    • 2000
  • In this paper, PET(Ployethylene Terephthalate) films with semiconducting and interface layers were investigated, The electrical properties, such as volume resistivity, tan$\delta$(dissipation factor) and breakdown strength at various temperatures were measured. Thermal analysis of PET and semiconducting films were measured and compared by differential scanning calorimeter(DSC) of each film. It is found that the volume resistivity of films(dependence on semiconducting interface layers)and electrical properties of PET films are changed ,Breakdown strength and dissipation factor of PET films with semiconducting layer (PET/S/PET) are decreased more greatly than PET and PET/PET films, due to the increase of charge density of charges at two contacted interfaces between PET and semiconductor, The dissipation factor of each films in increased with temperature,. For PET/S/PET film, is depended on temperature more than PET of PET/PET. However, the breakdown strength is increased up to 85$\^{C}$ and then decreased over 100$\^{C}$The electrical properties of PET films with semiconducting/interface layer are worse than without it It is due to a result of temperature dependency, which deeply affects thermal resistance property of PET film more than semiconducting/interface layers.

  • PDF

Bond and Flexural Properties of Fiber Reinforced Concrete with Recycled Poly Ethylene Terephthalate Waste (재생 폐 PET섬유보강 콘크리트의 부착 및 휨 특성)

  • Won, Jong-Pil;Park, Chan-Gi;Choi, Min-Jung
    • Journal of The Korean Society of Civil Engineers
    • /
    • v.28 no.3A
    • /
    • pp.401-406
    • /
    • 2008
  • This study can be used to produce structurally efficient recycled PET fiber from used waste PET bottles and evaluated the bond performance of the three type of recycled PET fiber and cement matrix. Also, the flexural tests were performed on concrete reinforced using the three type of recycled PET fibers. The test results showed that the recycled PET fiber was significantly increased bond strength. The flexural test results are demonstrated that recycled PET fibers improved the flexural toughness of concrete. Based on the bond and flexural test results, the bond and flexural performance of embossed type recycled PET fibers were significantly better than those of the other shape fibers.

  • PDF

Detection of Cancer with PET and PET/CT in Asymptomatic Volunteers (무증상 성인에서 PET과 PET/CT를 이용한 암 진단)

  • Chung, Ji-In;Cho, Han-Byoul;Shim, Jae-Yong;Choi, Joon-Young;Lee, Kyung-Han;Kim, Byung-Tae;Choi, Yoon-Ho
    • Nuclear Medicine and Molecular Imaging
    • /
    • v.43 no.6
    • /
    • pp.526-534
    • /
    • 2009
  • Purpose: We retrospectively investigated the diagnostic performance of $^{18}F$-fluorodeoxyglucose positron emission tomography (PET) and PET/CT for cancer detection in asymptomatic health-check examinees. Materials and Methods: This study consisted of 5091 PET or PET/CT conducted as part of annual health examination at one hospital from March 1998 to February 2008. To find the incidence of cancers, medical records of the subjects were thoroughly reviewed for a follow-up period of one year. The patterns of formal readings of PET and PET/CT were analyzed to assess the sensitivity and specificity for cancer detection. The histopathology and stage of the cancers were evaluated in relation to the results of PET. Results: Eighty-six cancers (1.7%) were diagnosed within one year after PET or PET/CT. When PET and PET/CT results were combined, the sensitivity was 48.8% and specificity was 81.1% for cancer detection. PET only had a sensitivity of 46.2% and a specificity of 81.4%, and PET/CT only had a sensitivity of 75.0% and a specificity of 78.5% respectively. There were no significant differences in cancer site, stage and histopathology between PET positive and PET negative cancers. In 19.3% of formal readings of PET and PET/CT, further evaluation to exclude malignancy or significant disease was recommended. Head and neck area and upper gastrointestinal tract were commonly recommended sites for further evaluation. Conclusions: PET and PET/CT showed moderate performance for detecting cancers in asymptomatic adults in this study. More experience and further investigation are needed to overcome limitations of PET and PET/CT for cancer screening.

Comparison of SUV for PET/MRI and PET/CT (인체 각 부위의 PET/MRI와 PET/CT의 SUV 변화)

  • Kim, Jae Il;Jeon, Jae Hwan;Kim, In Soo;Lee, Hong Jae;Kim, Jin Eui
    • The Korean Journal of Nuclear Medicine Technology
    • /
    • v.17 no.2
    • /
    • pp.10-14
    • /
    • 2013
  • Purpose: Due to developed simultaneous PET/MRI, it has become possible to obtain more anatomical image information better than conventional PET/CT. By the way, in the PET/CT, the linear absorption coefficient is measured by X-ray directly. However in case of PET/MRI, the value is not measured from MRI images directly, but is calculated by dividing as 4 segmentation ${\mu}-map$. Therefore, in this paper, we will evaluate the SUV's difference of attenuation correction PET images from PET/MRI and PET/CT. Materials and Methods: Biograph mCT40 (Siemens, Germany), Biograph mMR were used as a PET/CT, PET/MRI scanner. For a phantom study, we used a solid type $^{68}Ge$ source, and a liquid type $^{18}F$ uniformity phantom. By using VIBE-DIXON sequence of PET/MRI, human anatomical structure was divided into air-lung-fat-soft tissue for attenuation correction coefficient. In case of PET/CT, the hounsfield unit of CT was used. By setting the ROI at five places of each PET phantom images that is corrected attenuation, the maximum SUV was measured, evaluated %diff about PET/CT vs. PET/MRI. In clinical study, the 18 patients who underwent simultaneous PET/CT and PET/MRI was selected and set the ROI at background, lung, liver, brain, muscle, fat, bone from the each attenuation correction PET images, and then evaluated, compared by measuring the maximum SUV. Results: For solid $^{68}Ge$ source, SUV from PET/MRI is measured lower 88.55% compared to PET/CT. In case of liquid $^{18}F$ uniform phantom, SUV of PET/MRI as compared to PET/CT is measured low 70.17%. If the clinical study, the background SUV of PET/MRI is same with PET/CT's and the one of lung was higher 2.51%. However, it is measured lower about 32.50, 40.35, 23.92, 13.92, 5.00% at liver, brain, muscle, fat, femoral head. Conclusion: In the case of a CT image, because there is a linear relationship between 511 keV ${\gamma}-ray$ and linear absorption coefficient of X-ray, it is possible to correct directly the attenuation of 511 keV ${\gamma}-ray$ by creating a ${\mu}$map from the CT image. However, in the case of the MRI, because the MRI signal has no relationship at all with linear absorption coefficient of ${\gamma}-ray$, the anatomical structure of the human body is divided into four segmentations to correct the attenuation of ${\gamma}-rays$. Even a number of protons in a bone is too low to make MRI signal and to localize segmentation of ${\mu}-map$. Therefore, to develope a proper sequence for measuring more accurate attenuation coefficient is indeed necessary in the future PET/MRI.

  • PDF

Dielectric Properties and Breakdown Strength in Insulation/Semiconductive/Insulation (절연/반도전/절연층에 있어서 유전특성과 절연파괴 현상)

  • 강대용;오광영;김용주;박대회
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
    • /
    • /
    • pp.163-166
    • /
    • 1998
  • In this paper, breakdown strength and dielectric characteristics were experimented in the structures of insulation/insulation/insulation and insulation/semiconductor/insulation by using of insulation material of polyethylene terephthalate film. The breakdown strength and the permitivity of each specimen were measured as a function of temperature and frequency respectively. The breakdown strength of PET/PET/PET did not changed greatly but that of PET/SEMl/PEr increased as a function of temperature. As the frequency inclosed, the permitivity of PET/PET/PET and PET/SEMI/PET decreased. The tan $\delta$ of PET/PET/PET showed lower than that of PET/SEMl/PET in low frequency but higher in high frequency .

  • PDF

A Study on the Electrical Conduction and the Space Charge Distribution of the PET/SEMI/PET Film (절연/반도전/절연필름에 있어서 전기전도도와 공간전하분포)

  • Kang, D.Y.;Lee, C.H.;Park, D.H.;Han, S.O.;Suh, K.S.
    • Proceedings of the KIEE Conference
    • /
    • /
    • pp.1367-1369
    • /
    • 1997
  • 본 논문에서는 PET/PET 필름과 인터페이스를 갖는 PET/SEMI/PET필름에서의 전기 전도도와 공간전하분포를 고찰하였다. 반도전층을 가지고 있는 PET/SEMI/PET 필름의 전도전류는 PET/PET에 비하여 높았으며 특히 전압 인가후 순간적인 전류가 급격하게 소멸하였다. 또한 PET/SEMI/PET 필름의 공간전하 분포는 PET/PET 필름에 비해 높은 전하 형성을 보였다.

  • PDF

Clinical Application of F-18 FDG PET(PET/CT) in Malignancy of Unknown Origin (원발부위미상암에서 F-18 FDG PET (PET/CT)의 임상 이용)

  • Kim, Byung-Il
    • Nuclear Medicine and Molecular Imaging
    • /
    • v.42 no.sup1
    • /
    • pp.162-165
    • /
    • 2008
  • Diagnosis of primary origin site in the management of malignancy of unknown origin (MUO) is the most important issue. According to the histopathologic subtype of primary lesion, specialized treatment can be given and survival gain is expected. F-18 FOG PET (PET/CT) has been estimated as useful in detection of primary lesion with high sensitivity and moderate specificity. F-18 FDG PET (PET/CT) study before conventional studies is also recommended because it has high diagnostic performance compared to conventional studies. Although there has few data, F-18 FDG PET (PET/CT) is expected to be useful in diagnosis of recurrence, restaging, evaluation of treatment effect, considering that PET (PET/CT) has been reported as useful in other malignancies.