• Title, Summary, Keyword: Mouth neoplasms

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A Case of Simultaneous Squamous Cell Carcinomas in Mouth Floor and Esophagus (식도암이 동시에 발견된 구강저부의 편평세포암 환자 1예)

  • Kim, Tae Min;Song, In Sik;Joo, Jae Woo;Kim, Min-Su;Oh, Kyoung Ho;Lee, Ju-Han;Kwon, Soon Young
    • Korean Journal of Head & Neck Oncology
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    • v.32 no.2
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    • pp.73-77
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    • 2016
  • Simultaneous second primary tumors are not uncommon in patients with oral cavity squamous cell carcinoma. Many studies have previously shown that oral cavity squamous cell carcinoma patients with simultaneous second primary tumor generally have a poor prognosis. Additionally, the choice of the optimal therapeutic modality for oral cavity squamous cell carcinoma patients who present with simultaneous second primary tumor remains problematic. We reported a case of simultaneous squamous cell carcinomas in mouth floor and esophagus, that multidisciplinary team performed resection and reconstruction simultaneously.

Mutations in the tyrosine kinase domain of the EGFR gene are rare in the Korean Oral Squamous Cell Carcinoma

  • Lee, Eun-Ju
    • Journal of the Korea Society of Computer and Information
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    • v.21 no.9
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    • pp.101-106
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    • 2016
  • The epidermal growth factor receptor(EGFR) protein kinase signaling is an important pathway in cancer development and recently reported that EGFR and its kinase domain molecules are mutated in various of cancers including head and neck cancer. Functional deregulation of EGFR due to mutations in coding exons and copy number amplification is the most common event in cancers, especially among receptor tyrosine kinases(TK). We have analyzed Korean oral squamous cell carcinomas (OSCC) cell lines for mutations in EGFRTK. Exons encoding the hot-spot regions in the TK domain of EGFR (exons 17 to 23) were amplified by using polymerase chain reaction(PCR) and sequenced directly. EGFR expression was also analyzed in 8 OSCC cell lines using western blotting. Data analysis of the EGFR exons 17 to 23 coding sequences did not show any mutations in the 8 OSCC cell lines that were analyzed. The absence of mutations indicate that protein overexpression might be responsible for activation rather than mutation.

Clear cell odontogenic carcinoma mimicking a cystic lesion: a case of misdiagnosis

  • Kim, Minkyu;Cho, Eunae;Kim, Jae-Young;Kim, Hyun Sil;Nam, Woong
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.40 no.4
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    • pp.199-203
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    • 2014
  • Clear cell odontogenic carcinoma (CCOC) is a rare jaw tumor that was classified as a malignant tumor of odontogenic origin in 2005 by the World Health Organization because of its aggressive and destructive growth capacity and metastasis to the lungs and lymph nodes. We report a case of a 66-year-old female who had swelling, incision and drainage history and a well-defined unicystic radiolucent lesion that was comparable to a cystic lesion. At first, the patient received decompression, and the lesion size decreased. Three months after decompression, cyst enucleation was performed. The pathologic result indicated that the lesion was CCOC. In this report we emphasize that patients with painful cystic lesions in addition to jaw enlargement and loosening teeth should be considered for the possibility of malignancy.

Deep benign fibrous histiocytoma in the oral cavity: a case report

  • Jo, Eun;Cho, Eunae Sandra;Kim, Hyun Sil;Nam, Woong
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.41 no.5
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    • pp.270-272
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    • 2015
  • Benign fibrous histiocytoma (FH) is a benign tumor composed of fibroblasts and histiocytes in varying proportions. This tumor is usually found in adult extremities but rarely occurs in deep soft tissues of the oral cavity. As it is difficult to diagnose with physical and radiologic exams, deep benign FH can only be diagnosed by histopathology. We report a case of a 36-year-old female patient who came to our department with painless swelling in the right buccal mucosa. This case report reviews the clinical, radiological, and histological aspects of this tumor.

Unusual malignant neoplasms occurring around dental implants: A report of 2 cases

  • Oh, Song Hee;Kang, Ju Hee;Seo, Yu-Kyeong;Lee, Sae Rom;Choi, Yong-Suk;Hwang, Eui-Hwan
    • Imaging Science in Dentistry
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    • v.48 no.1
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    • pp.59-65
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    • 2018
  • Osseointegrated implants are now commonplace in contemporary dentistry. However, a number of complications can occur around dental implants, including peri-implantitis, maxillary sinusitis, osteomyelitis, and neoplasms. There have been several reports of a malignant neoplasm occurring adjacent to a dental implant. In this report, we describe 2 such cases. One case was that of a 75-year-old man with no previous history of malignant disease who developed a solitary plasmacytoma around a dental implant in the left posterior mandible, and the other was that of a 43-year-old man who was diagnosed with squamous cell carcinoma adjacent to a dental implant in the right posterior mandible. Our experiences with these 2 cases suggest the possibility of a relationship between implant treatment and an inflammatory cofactor that might increase the risk of development of a malignant neoplasm.

A SOLITARY NEUROFIBROMA OF THE FLOOR OF MOUTH (구강저에 발생한 단독형 신경섬유종)

  • Kim, Yong-Kack;Chung, Boong-Hee;Yu, Hyeon-Seok;Kwak, Jae-Keun;Kim, Kyu-Yeong
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.12 no.3
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    • pp.81-86
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    • 1990
  • Benign neural sheath neoplasms are not common in the maxillofacial region. These lesions can occur as solitary tumors, or they can affect many sites in the form of multiple neurofibromatosis. A solitary neurofibroma is seldom undergo sarcomatous transformation, since solitary neurofibroma is relatively radioresistant and its recurrence rate seems to be low, the treatment of choice is surgical excision. This case showed a solitary neurofibroma in the left side of the floor of mouth which occurred in a 33 - year -old female. The tumor was excised. And there is no evidence of disease. She is satisfied in function and esthetic aspect.

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Ancient Schwannoma Misdiagnosed as a Hemangioma in the Ventral Tongue

  • Lee, Sun Jae;Kim, Yongsoo;Leem, Dae Ho;Baek, Jin A;Shin, Hyo Keun;Ko, Seung O
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.35 no.6
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    • pp.402-407
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    • 2013
  • Schwannomas originate from the Schwann cells in the neural sheath of the peripheral nerves. Ancient schwannoma is one of five variants, and its characteristics include histopathological degeneration and diffuse hypocellular areas. Histopathological features show degenerative changes and atypical nuclei can easily be confused with malignant neoplasms. These cellular atypisms are caused solely by degenerative changes. Ancient schwannomas have been reported 17 cases of in the oral cavity and five cases in the ventral tongue, including the floor of the mouth. We report a new case of an ancient schwannoma, misdiagnosed as a hemangioma with a 10-year evolution, located in the ventral tongue of a 29-year-old female.

Adenoid cystic carcinoma presenting as an ulcer on the floor of the mouth: a rare case report

  • Khan, Saba;Agwani, Khalid;Bhargava, Puneet;Kumar, Sreeja P.
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.40 no.5
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    • pp.253-257
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    • 2014
  • Adenoid cystic carcinoma is a rare epithelial tumour, and comprises about 1% of all malignant tumours of the oral and maxillofacial region. It is a malignant tumour which may develop in the trachea, bronchus, lungs or mammary glands, in addition to the head and neck region. Occurrences in the head and neck are mostly detected in the major salivary gland, oral cavity, pharynx and paranasal sinus where it presents as a slow growing firm nodular swelling. The aim of the article is to highlight the unique presentation of adenoid cystic carcinoma as a solitary ulcer on the floor of the mouth.

Lipoma with Extraoral Swelling in the Labial Vestibule: Report of a Case

  • Cho, Ju-Yeon;Nam, Ki-Young
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.34 no.4
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    • pp.267-270
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    • 2012
  • Lipoma is the most common benign neoplasm of the body with rare occurrence in the oral cavity. It represents 1~4% of benign neoplasms of the mouth, which affect the buccal mucosa, floor of the mouth, tongue and lips. We report a case of lipoma in the labial vestibule with extraoral swelling, which could easily be misdiagnosed as an odontogenic abscess. Excisional biopsy in this case revealed well-circumscribed masses, surrounded by a thin fibrous capsule and composed of sheets of mature adipocytes, arranged in a "chicken wire" configuration. After a computed tomography scan, excisoinal biopsy was done, and there were no recurrence after 5-month follow-up period.

Effect of STAT3 on Lysophosphatidic Acid-Induced Oral Cancer Cell Invasion

  • Song, Zi Hae;Cho, Kyung Hwa;Kim, Jin Young;Lee, Hoi Young
    • Journal of dental hygiene science
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    • v.19 no.2
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    • pp.141-146
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    • 2019
  • Background: Oral cancer has a high incidence worldwide and has been closely associated with smoking, alcohol, and infection by the human papillomavirus. Metastasis is highly important for oral cancer survival. Lysophosphatidic acid (LPA) is a bioactive lipid mediator that promotes various cellular processes, including cell survival, proliferation, metastasis, and invasion. Signal transducer and activator of transcription (STATs) are transcription factors that mediate gene expression. Among the seven types of STATs in mammals, STAT3 is involved in invasion and metastasis of numerous tumors. However, little is known about the role of STAT3 in oral tumor invasion. In the present study, we hypothesized that STAT3 mediates LPA-induced oral cancer invasion. Methods: Immunoblotting was performed to analyze LPA-induced STAT3 activation. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was performed to assess the survival rates of YD-10B cells. STAT3 levels in LPA-treated oral tumor cells were evaluated by performing in vitro invasion assay. Results: To the best of our knowledge, this is the first study to demonstrate that LPA enhances STAT3 phosphorylation in oral cancer. In addition, treatment with WP1066, a selective inhibitor of STAT3, at a concentration that does not cause severe reduction in cell viability, significantly attenuated LPA-induced YD-10B cancer cell invasion. Conclusion: The results suggested that LPA induces oral tumor cells with greater invasive potential via STAT3 activation. Our findings provided important insights into the mechanisms underlying mouth neoplasms.