• Title, Summary, Keyword: Methylcellulose

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Effect of Methylcellulose on the Nylon Microcapsules Containing Acetaminophen

  • Park, Soon-Chull;Lee, Min-Hwa
    • Journal of Pharmaceutical Investigation
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    • v.13 no.3
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    • pp.89-99
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    • 1983
  • Nylon microcapsules containing acetaminophen could be obtained by interfacial polymerization between sebacoyl chloride and 1, 6-hexamethylenediamine. Methylcellulose affected the micromeritic properties and dissolution characteristics of microcapsules. The particle size distribution was affected by the stirring speed and viscosity grade of methylcellulose. The surface observed by the scanning electron microscopy was affected by the methylcellulose. Nylon microcapsules produced in above method containing acetaminophen exhibited the retarded dissolution in comparison with uncoated acetaminophen. Release of acetaminophen from microcapsules decreased with decreasing pH of medium and with increasing the viscosity grade of methylcellulose and stirring speed.

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Effect of Fungal Elicitor, Pluronic F-68 and Methylcellulose on Suspension Culture of Mentha piperita Cells (박하세포의 현탁배양에 대한 FungalElicitor, Pluronic F-68과 Methylcellulose의 영향)

  • 오재현;강윤모
    • KSBB Journal
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    • v.8 no.3
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    • pp.295-299
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    • 1993
  • The effect of fungal elicitor, Pluronic F-68 and methylcellulose on suspension culture of M piperita cells was investigated in shake flasks. About a two-fold increase in oil production was observed in response to the treatment of the fungal elicitor prepared from Rhodotorula rubra. Low concentration of Pluronic F-68 or methylcellulose enhanced Peppermint cell growth at 100 rpm of agitation.

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Modified Upper Gastrointestinal Study Using Methylcellulose After Administration of Barium Suspension : Comparison with Conventional Series (바륨 현탁액과 메틸셀룰로스(Methylcellulose)를 사용한 변형 상부위장관조영술 :전통적 바륨조영술과의 비교)

  • 이기창;최민철;서민호;정주현;윤정희
    • Journal of Veterinary Clinics
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    • v.17 no.2
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    • pp.411-415
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    • 2000
  • For comparison with conventional barium-gastrointestinal study, modified method using barium and methylcellulose was performed in 16 normal dogs (4-8 kg) divided into two groups. The group 1 received 8ml/kg of 40% w/v barium suspension only, and group 2 had taken 15 ml/kg of 0.6% w/v methylcellulose after administration 4 ml/kg of 40% w/v barium suspension by feeding tube. The barium suspension was prepared mixing full strength-barium suspension with water and methylcellulose solution was produced by blending methylcellulose sterilized water Sequential radiographs, lateral and ventrodorsal projections were obtained at 5 minute, 20 minute,40 minute. 60 minute and every 30 minutes thereafter, until the contrast is seen in the large intestine Inage qual- ity was rated by three veterinary radiologists as " poor" " fair ". "good", or "excellent" We analyzed the relationship between image quality,, transit time. Between two techniques, the modified method with 4ml of 40% w/v barium suspension and 15 ml of 0.6% w/v methylcellulose showed much better image quality ["excellent" result in 7 of the 8 subjects (88%)] and shorter transit time (107 minutes) toe the cecum. In addition, the best image quality was obtained at 20 and 40 minutes after admin-istration of contrast agent. It call be concluded the modified gastrointestinal study using methylcel-lulose after administration of barium suspension was a simple technique and easily improved the image quality and diagnostic accuracy of gstrointestinal disorders in small animal.racy of gstrointestinal disorders in small animal.

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Application of Edible Films to Food System Packaging (식품 포장재에 대한 가식성 필름의 응용성에 관한 연구)

  • Chun, Dong-Ho;Park, Jang-Woo
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.5 no.1
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    • pp.6-12
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    • 1999
  • This study was conducted to investigate the application of edible films to Raymyun soup packaging. The sorption isotherm curve and BET monolayer moisture content of Raymyun soup were estimated as a basic experiment. Also, the mechanical properties, water vapor permeability, and solubility of the films were investigated. Methylcellulose, sodium caseinate, and K-carrageenan films were used as edible films and glycerol and polyethylene glycol(MW 400) were used as plasticizers. In case tensile strength, methylcellulose films was 68.56 MPa and sodium caseinate film was 7.11 MPa. The elongations of sodium caseinate, methylcellulose, and K-carrageenan film were 115.41%, 23.79% and 0.60%, respectively. The water vapor permeabilties values of methylcellulose, sodium caseinate, and K-carrageenan film between 50% and 70% RH were $0.25-0.38ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa,\;0.62-0.84ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa\;and\;0.31-0.55ng{\cdot}m/m^2{\cdot}sec{\cdot}Pa$, respectively. For the solubility of films, sodium caseinate film showed the highest solubility and methylcellulose film showed the lowest solubility.

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Preparation of Buccal Patch Composed of Carbopol, Poloxamer and Hydroxypropyl Methylcellulose

  • Chun, Myung-Kwan;Kwak, Byoung-Tae;Choi, Hoo-Kyun
    • Archives of Pharmacal Research
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    • v.26 no.11
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    • pp.973-978
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    • 2003
  • A polymeric film composed of Carbopol, Poloxamer and hydroxypropyl methylcellulose was prepared to develop a buccal patch and the effects of composition of the film on adhesion time, swelling ratio, and dissolution of the film were studied. The effects of plasticizers or penetration enhancers on the release of triamcinolone acetonide (TAA) were also studied. The hydrogen bonding between Carbopol and Poloxamer played important role in reducing swelling ratio and dissolution rate of polymer film and increasing adhesion time. The swelling ratio of the composite film was significantly reduced and the adhesion time was increased when compared with Carbopol film. As the ratio of Poloxamer to hydroxypropyl methylcellulose increased from 0/66 to 33/33, the release rate of TAA decreased. However, no further significant decrease of release rate was observed beyond the ratio of 33/33. The release rate of TAA in the polymeric film containing polyethylene glycol 400, a plasticizer, showed the highest release rate followed by triethyl citrate, and castor oil. The release rate of TAA from the polymeric film containing permeation enhancers was slower than that from the control without enhancers. Therefore, these observations indicated that a preparation of a buccal patch is feasible with the polymeric film composed of Cabopol, Poloxamer and hydropropyl methylcellulose.

On the Development of Functional New Derivatives from Cellulose - Manufacturing of Reactive Cellulose Derivatives from Chlorinated Cellulose - (셀룰로오스로부터 기능성 신소재 개발에 관한 연구 - 염소화셀룰로오스로부터 반응성셀룰로오스의 제조 -)

  • Cho, Nam-Seok
    • Journal of the Korean Wood Science and Technology
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    • v.22 no.4
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    • pp.51-60
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    • 1994
  • Chlorodeoxycellulose derivatives have recently assumed importance since the halogen atoms can be changed with other functional groups to afford new derivatives of cellulose. Also, chlorinated cellulose has been employed as an intermediate in the preparation of various functional cellulose derivatives. In this study chlorodeoxycellulose was prepared by reaction of methylcellulose with mathanesulfonylchloride in N,N-dimethylformamide. Subsequently, conversion of the above chlorinated cellulose to unsaturated celluloseen was carried out by potassium tertiary butoxide in dimethyl sulfoxide. An anhydrocellulose as an intermediate for the reactive functional derivatives was made by simple alkali treatment. Preparation condition of allylated methylcellulose by using allylchloride and its thermal behavior were also described.

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Encapsulation of Bacillus polyfermenticus SCD with Alginate-Methylcellulose and Evaluation of Survival in Artificial Conditions of Large Intestine

  • Kim Cheon-Jei;Jun Song-Ae;Lee Na-Kyoung;Kim Kee-Tae;Lee Si-Kyung;Kim Chang-Han;Paik Hyun-Dong
    • Journal of Microbiology and Biotechnology
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    • v.16 no.3
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    • pp.443-449
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    • 2006
  • Bacillus polyfermenticus SCD was studied for its increasing stability by encapsulation, using 2, 3, and 4% sodium alginate. In these cases, 3% alginate resulted in the maximum survival of B. polyfermenticus SCD in artificial gastric juice for 3 h. Effects of several biopolymers on the encapsulated B. polyfermenticus SCD by 3% sodium alginate were investigated. Encapsulation with 0.5% methylcellulose showed the highest survival rate for 3 h in artificial gastric juice. Therefore, the optimized encapsulation material was 3% alginate with 0.5% methylcellulose. Furthermore, the survival of encapsulated B. polyfermenticus SCD was shown to be 122%, when 1% bile salt was added. Freeze-dried encapsulation resulted in lower survival than with non-dried encapsulation. Therefore, encapsulation was the most effective when 3% sodium alginate was used with 0.5% methylcellulose, but without freeze-drying.

A Study on Applying the Biopolymer (hydroxyethyl methylcellulose) to Prepare Quick Bread Rice Muffins (퀵 브레드 쌀 머핀 제조용 첨가물로써의 바이오폴리머(Hydroxyethyl Methylcellulose, HEMC) 활용성 검정)

  • Kim, Joo-Hee;Kang, Mi-Young
    • Korean journal of food and cookery science
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    • v.28 no.4
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    • pp.423-429
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    • 2012
  • We examined the quality characteristics and conducted a sensory evaluation of muffins made with rice flour and the biopolymer hydroxyethyl methylcellulose (HEMC) to identify a new health functional food additive. First, overrun and foam stability of HEMC-HV (high viscosity) was better than HEMC-LV (low viscosity) to prepare muffins. Also the quality of rice muffins(volume, specific cake volume, and baking loss) was analyzed. There was no significant difference in the sensory evaluation of rice flour muffins containing foam mixture(egg white:HEMC-HV, 3:1, v/v) and muffin made from flour. The results showed that HEMC-HV was suitable for quick bread muffin-making using 100% rice flour.

Preservation of Ultrastructure of Ultrathin Frozen Sections for Immunoelectron Microscopic Observation (면역전자현미경적 관찰을 위한 동결초박절편의 미세구조 보존)

  • Kim, Yun-Sang;Chae, Hee-Sun;Kim, Kyung-Yong;Lee, Won-Bok
    • Applied Microscopy
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    • v.28 no.4
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    • pp.465-475
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    • 1998
  • The cryoprotection, section retrieval and embedding methods were studied for the preservation of ultrastructure of ultracryomicrosections in immunoelectron microscopy. The results obtained were as follows. 1. The cryoprotection of ultrastructure with a mixture containing 1.7 M sucrose and 15% polyvinylpyrrolidone was better than that with 2.3 M sucrose. The stretching caused by surface tension and the electron lucent holes decreased more in the cryosections infused with 2.3 M sucrose than in those with the mixture. 2. The difference between section retrieval solutions in cases of cryoprotection with 2.3 M sucrose was that the destructive .effects such as electron lucent holes and stretching between myofribrils were less in a mixture containing 1% methylcellulose and 2.3 M sucrose than in 2.3 M sucrose. The difference was obscure in the mixture containing 1.7 M sucrose and 15% PVP, but the destructive effects were slightly less in a mixture containing 1% mthylcellulose and 2.3 M sucrose than in 2.3 M sucrose or 1% methylcellulose. 3. The embedding of cryosection on drying with 2% PVA or 2% methylcellulose exhibited some protective effect during observation with transmission electron microscope, but made the ultrastructure more obscure. 4. Mitochondrial membrane and cristae and myofilaments were well delinated in sections infused with 2.3 M sucrose and retrieved with 1% methylcellulose and 2.3 M sucrose. In summary, it is suggested that the cryoprotection with 2.3 M sucrose and section retrieval with a mixture containing 1% methylcellulose and 2.3 M sucrose are good for the ultrastructure of cryosections.

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