• Title, Summary, Keyword: Metabolic Profile

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Metabolic Risk Profile and Cancer in Korean Men and Women

  • Ko, Seulki;Yoon, Seok-Jun;Kim, Dongwoo;Kim, A-Rim;Kim, Eun-Jung;Seo, Hye-Young
    • Journal of Preventive Medicine and Public Health
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    • v.49 no.3
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    • pp.143-152
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    • 2016
  • Objectives: Metabolic syndrome is a cluster of risk factors for type 2 diabetes mellitus and cardiovascular disease. Associations between metabolic syndrome and several types of cancer have recently been documented. Methods: We analyzed the sample cohort data from the Korean National Health Insurance Service from 2002, with a follow-up period extending to 2013. The cohort data included 99 565 individuals who participated in the health examination program and whose data were therefore present in the cohort database. The metabolic risk profile of each participant was assessed based on obesity, high serum glucose and total cholesterol levels, and high blood pressure. The occurrence of cancer was identified using Korean National Health Insurance claims data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusting for age group, smoking status, alcohol intake, and regular exercise. Results: A total of 5937 cases of cancer occurred during a mean follow-up period of 10.4 years. In men with a high-risk metabolic profile, the risk of colon cancer was elevated (HR, 1.40; 95% CI, 1.14 to 1.71). In women, a high-risk metabolic profile was associated with a significantly increased risk of gallbladder and biliary tract cancer (HR, 2.05; 95% CI, 1.24 to 3.42). Non-significantly increased risks were observed in men for pharynx, larynx, rectum, and kidney cancer, and in women for colon, liver, breast, and ovarian cancer. Conclusions: The findings of this study support the previously suggested association between metabolic syndrome and the risk of several cancers. A high-risk metabolic profile may be an important risk factor for colon cancer in Korean men and gallbladder and biliary tract cancer in Korean women.

Effects of oral health knowledge, attitude, and behavior on oral health impact profile of metabolic syndrome patients (대사증후군 환자의 구강보건지식, 태도, 행위가 구강건강영향지수에 미치는 영향)

  • Lim, Mi-Hee
    • Journal of Korean society of Dental Hygiene
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    • v.18 no.6
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    • pp.1079-1090
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    • 2018
  • Objectives: This study aims to provide fundamental data on seeking more effective programs for metabolic syndrome patients' oral health by researching their knowledge, attitude and behaviors on oral health and considering the effects each factor has on the oral health impact profile. Methods: The research was conducted on 155 patients with metabolic syndrome who visited the metabolic syndrome center of S district between July $19^{th}$, 2016 and August 27th, 2016. Results: When the subjects had experiences of oral treatment within the past year, which indicated lower quality of life in relation to oral health. Oral health knowledge had a positive correlation with oral health attitude (0.241) and oral health behaviors (0.362), had a negative correlation with oral health impact profile (-0.283). Oral health attitude showed a positive correlation with oral health behaviors (0.476) (p<0.001). Conclusions: By conducting a oral health promotion business among metabolic syndrome patients including a oral care and treatment program which aim to enhance the oral knowledge, attitude and behaviors and comprehensively manage the oral health education program, it is expected that their quality of life related to oral health could be further improved.

Manifestation of metabolic Aberration in Rat urine Following Hypothalamic Lesions

  • Anbar, Michel;Kim, Kyoung-Rae
    • Archives of Pharmacal Research
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    • v.7 no.2
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    • pp.101-107
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    • 1984
  • The concentrations of metabolites of low molecular weights (90 to 310 amu) present in rat urine were determined by field ionization mass spectrometry. Three groups of rats were examined; intact controls, sham-operated rats and rats with selective lesions in their hypothalamus. The latter lesions are shown to induce characteristic aberrations in the metabolic profile, demonstrable five weeks after treatment, which are distinct from those induced by a sham operation.

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Comparison of Echocardiogram and Clinical Profile between Metabolically Healthy Obese (MHO) and Non Metabolically Healthy Obese (Non-MHO) Subjects

  • Hong, Seung-Bok;Shin, Kyung-A;Choi, Wan-Soo
    • Biomedical Science Letters
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    • v.18 no.3
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    • pp.260-267
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    • 2012
  • Obesity is associated with cardiovascular risk factors, such as dyslipidemia, hypertension and diabetes. However the presence of the obesity related deranged metabolic profiles varies widely among obese individuals. These individuals, known as 'metabolically healthy obese phenotype (MHO)', despite having excessive body fatness, display favorable metabolic profiles characterized by insulin sensitivity, no hypertension, as well as less dyslipidemia, less inflammation. The purpose of this study was to compare cardiac characterization and clinical profile of MHO and Non-MHO (nonmetabolically healthy obese) subjects in men. We measured treadmill exercise capacity (METs) and maximum blood pressure (BP) in 210 subjects through a medical checkup at J General Hospital. Metabolic syndrome was defined according to the modified Adult Treatment Panel III definition criteria. Both MHO and Non-MHO subjects showed statistically significant changes in the left ventricular mass index (P<.001, P<.01, respectively), A-velocity (P<.01, P<.001, respectively), E/A ratio (P<.01, P<.001, respectively), E'-velocity (P<.001, P<.001, respectively), HOMA-IR (P<.01, P<.001, respectively) and maximum systolic BP (P<.01, respectively) compared with the MH-NO (metabolically healthy non obese) subjects. In conclusion, MHO participants were at increased risk of cardiovascular disease and partly metabolic disorder.

Metabolic Differentiation of Saccharomyces cerevisiae by Ketoconazole Treatment

  • Keum, Young Soo;Kim, Jeong-Han
    • Journal of Applied Biological Chemistry
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    • v.56 no.2
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    • pp.109-112
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    • 2013
  • Azole fungicides are one of the most wide-spread antifungal compounds in agriculture and pharmaceutical applications. Their major mode of action is the inhibition of ergosterol biosynthesis, giving depletion of ergosterol, precursors and abnormal steroids. However, metabolic consequences of such inhibition, other than steroidal metabolitesare not well established. Comprehensive metabolic profiles of Saccharomyces cerevisiae has been presented in this study. Wild type yeast was treated either with glucose as control or azole fungicide (ketoconazole). Both polar metabolites and lipids were analyzed with gas chromatography-mass spectrometry. Approximately over 180 metabolites were characterized, among which 18 of them were accumulated or depleted by fungicide treatment. Steroid profile gives the most prominent differences, including the accumulation of lanosterol and the depletion of zymosterol and ergosterol. However, the polar metabolite profile was also highly different in pesticide treatment. The concentration of proline and its precursors, glutamate and ornithine were markedly reduced by ketoconazole. Lysine and glycine level was also decreased while the concentrations of serine and homoserine were increased. The overall metabolic profile indicates that azole fungicide treatment induces the depletion of many polar metabolites, which are important in stress response.

Accurate Metabolic Flux Analysis through Data Reconciliation of Isotope Balance-Based Data

  • Kim Tae-Yong;Lee Sang-Yup
    • Journal of Microbiology and Biotechnology
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    • v.16 no.7
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    • pp.1139-1143
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    • 2006
  • Various techniques and strategies have been developed for the identification of intracellular metabolic conditions, and among them, isotope balance-based flux analysis with gas chromatography/mass spectrometry (GC/ MS) has recently become popular. Even though isotope balance-based flux analysis allows a more accurate estimation of intracellular fluxes, its application has been restricted to relatively small metabolic systems because of the limited number of measurable metabolites. In this paper, a strategy for incorporating isotope balance-based flux data obtained for a small network into metabolic flux analysis was examined as a feasible alternative allowing more accurate quantification of intracellular flux distribution in a large metabolic system. To impose GC/MS based data into a large metabolic network and obtain optimum flux distribution profile, data reconciliation procedure was applied. As a result, metabolic flux values of 308 intracellular reactions could be estimated from 29 GC/ MS based fluxes with higher accuracy.

Reference intervals for blood metabolic profiles of Holstein cows in Korea (국내 젖소의 혈액 대사인자 프로파일 분석)

  • Jung, Suk-Han;Jung, Young-Hun;Choe, Changyong;Do, Yoon Jung;Cho, Ara;Oh, Sang-Ik;Kim, Eunju;Ha, Seungmin;Jeong, Ha Yeon;Yoo, Jae Gyu;Kim, Suhee
    • Korean Journal of Veterinary Service
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    • v.42 no.2
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    • pp.121-126
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    • 2019
  • Metabolic profile test is used to evaluate nutritional imbalance and metabolic disease in dairy cows. The reference intervals of metabolic parameters may change according to nation, region, decades, and maintenance system. Despite the need to be periodically updated for the reference intervals of metabolic parameters, it has rarely been investigated in Korea. Therefore, this aim of study was to provide the reference intervals of metabolic parameters using dairy cows surveyed in Korea during recent years. A metabolic profile test was conducted for 2,976 clinically healthy dairy cows in Korea. Blood samples were collected for the analysis of serum metabolites. This study provided reference intervals of thirteen metabolic parameters (${\beta}$-hydroxybutyrate [${\beta}-HB$], non-esterified fatty acids [NEFA], glucose, total cholesterol [T-COL], total protein, albumin, globulin, blood urea nitrogen [BUN], aspartate aminotransferase [AST], gamma-glutamyl transferase [GGT], calcium, phosphorus, and magnesium). BUN and AST values of the current study were higher than those of previous studies. In the present study, the other metabolic parameters showed low or similar value compared to previous results. Moreover, ${\beta}-HB$, NEFA, T-COL, ALB, BUN, AST, and GGT values were affected by lactation period. This study provided information on the reference intervals of metabolites in healthy dairy cows in Korea. The reference intervals from the present study would be useful in managing and diagnosing disease of dairy cows. However, careful attention should be given in interpreting disease condition for metabolites affected by lactation.

The effects of Mozart's music on metabolic response upon stress

  • Lee, Sujin;Yoo, Ga Eul;Chong, Hyun Ju;Choi, Seung Hong;Park, Sunghyouk
    • Journal of the Korean Magnetic Resonance Society
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    • v.24 no.1
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    • pp.23-29
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    • 2020
  • Mozart's music has been suggested to affect spatio-temporal reasoning of listeners, which has been called "Mozart effect". However, the effects of Mazart's music on human metabolism have not been known. We dissected Mozart's music into its compositional elements and studied their effects on metabolism of experimental animals. Mozart music significantly reduced cortisol level induced by stress. NMR metabolomic study revealed different urine metabolic profile according to the listening to Mozart's music. In addition, each element of music exhibited different metabolic profile. Functional MRI study also showed enhanced brain activity upon listening to Mozart's music. Taken together, Mozart's music seems to be related with brain activity, stress hormone and whole body metabolism.

Proteome Analysis of Recombinant CHO Cells Under Hyperosmotic Stress

  • Lee, Mun-Su;Kim, Gyeong-Uk;Kim, Yeong-Hwan;Lee, Gyun-Min
    • 한국생물공학회:학술대회논문집
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    • pp.311-314
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    • 2003
  • Under hyperosmotic stress, rCHO cells display decreased specific growth rate $({\mu})$ and increased specific antibody productivity $(q_{Ab})$. The effects of hyperosmotic stress on batch culture cellular dynamics are not well understood. To this end, we conducted a proteome profile of rCHO cells, using 2D-gel, MALDI-TOF-MS and MS/MS. As a result, the proteome profile of rCHO cells could be established using 41 identified proteins. Based on this proteome profile of rCHO cells, we have found at least 8 differently expressed spots at hyperosmotic osmolality (450 mOsm/kg). Among these spots, two metabolic enzymes were found to be up-regulated (pyruvate kinase and GAPDH), while down-regulated protein was identified as tubulin. It shows that hyperosmotic stress can alter metabolic state, by up-regulated activities of two glycolysis enzymes, which could lead to activate the generation of metabolic energy. Tubulin expression was down-regulated, suggesting a reduction of cell division. Finally, the increased conversion energy could leads to improve overall productivity.

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