• Title, Summary, Keyword: Medical Accelerator Maze

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COMPUTATIONAL DETERMINATION OF NEUTRON DOSE EQUIVALENT LEVEL AT THE MAZE ENTRANCE OF A MEDICAL ACCELERATOR FACILITY

  • Kim, Hong-Suk;Lee, Jai-Ki
    • Journal of Radiation Protection and Research
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    • v.32 no.1
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    • pp.15-20
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    • 2007
  • An empirical formula fur the neutron dose equivalent at the maze entrance of medical accelerator treatment rooms was derived on the basis of a Monte Carlo simulation. The simulated neutron dose equivalents around the Varian medical accelerator by the MCNPX code were employed. Two cases of target rotational planes were considered: parallel and perpendicular to maze walls. Most of the maximum neutron dose equivalents at the doorway were found when the target rotational planes were parallel to maze walls and the beams were directed to the inner maze entrances. The neutron dose equivalents at the outer maze entrances were calculated for about 698 medical accelerator facilities which were generated from the geometry configurations of running treatment rooms, based on such gantry rotation that produces the maximum neutron dose at the doorway. The results calculated with the empirical formula in this study were compared with those calculated by the Kersey method for 7 operating facilities. It was found that the maximum disagreement between the calculation of this study and that of the Kersey method was a factor of 8.54 with the value calculated by the Kersey method exceeding that of this study. It was concluded that the kersey method estimated the neutron dose equivalent at the doorway computed by MCNPX more conservatively than this study technique.

Ameliorative Effect of Schisandra chinensis and Ribes fasciculatum Extracts on Hydrogen Peroxide-Induced Neuronal Cell Death in Neuroblastic PC12 Cells and the Scopolamine-Induced Cognitive Impairment in a Rat Model (오미자칠해목 추출물의 과산화수소로 유발된 PC12뇌세포 사멸과 스코폴라민으로 유발된 렛드 동물모델에 대한 개선 효과)

  • Park, Eun-kuk;Han, Kyung-Hoon;Heo, Jae-Hyeok;Kim, Nam-Ki;Bae, Mun-Hyoung;Seo, Young-Ha;Yong, Yoon-joong;Jeong, Seon-Yong;Choi, Chun-Whan
    • The Korean Journal of Food And Nutrition
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    • v.33 no.3
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    • pp.347-355
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    • 2020
  • Cognitive impairment is considered to be key research topics in the field of neurodegenerative diseases and in understanding of learning and memory. In the present study, we investigated neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts in hydrogen peroxide-induced neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley® (SD) rat in vivo. Apoptotic cell death in neuroblastic PC12 cell line was induced by hydrogen peroxide for 1 hour at 100 μM. However, mixture of SC and RF treatment prevented peroxide induced PC12 cell death with no neurotoxic effects. For in vivo experiment, the effect of SC and RF extracts on scopolamine-induced cognitive impairment in SD rat was evaluated by spontaneous alternation behavior in Y-Maze test. After 30 min scopolamine injection, the scopolamine-induced rats presented significantly decreased % spontaneous alteration and acetylcholine level, compared to non-induced group. However, treatment of SC+RF extracts rescued the reduced % spontaneous alteration with acetylcholine concentration from hippocampus in scopolamine-induced rats. These results suggested that mixture of SC and RF extract may be a potential natural therapeutic agent for the prevention of cognitive impairment.