• Title, Summary, Keyword: Lymphadenopathy

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Profile of Lymphadenopathy in Kashmir Valley: a Cytological Study

  • Qadri, Sumyra Khurshid;Hamdani, Nissar Hussain;Shah, Parveen;Lone, Mohammad Iqbal;Baba, Khalil Mohammad
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3621-3625
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    • 2012
  • Lymphadenopathy is one of the commonest and significant manifestations of local as well as systemic ailments, especially malignancies. Fine needle aspiration cytology (FNAC) helps in diagnosing the disease itself, in general, but more importantly ruling out malignancy, in particular. Hence it saves much of the cost and use of resources incurred with excision biopsy of such lymph nodes. This prompted us to study the cytologic patterns of lymphadenopathy in our setting and the diagnostic utility of FNAC in the evaluation of lymphadenopathy. In this retrospective observational study, 1,579 patients (953 males and 626 females) with lymphadenopathy who were subjected to FNAC over a period of three years (January 2009 to December 2011) were studied. The cervical region was involved in most of the cases (76%) followed by the axillary region (17.5%). Metastatic malignancy (38.2%) was the commonest cause of lymphadenopathy followed by reactive lymphoid hyperplasia (36.9%), tuberculosis (9.1%) and lymphomas (8.6%). Squamous cell carcinoma (32.2%) followed by adenocarcinoma (21.9%) were the most frequent metastatic tumors. FNAC is a useful diagnostic tool in the management of patients presenting with lymphadenopathy and should be considered before more invasive and costly procedures are performed, particularly in developing countries.

Extensive silicone lymphadenopathy after breast implant insertion mimicking malignant lymphadenopathy

  • Lee, Youngseok;Song, Sung Eun;Yoon, Eul-Sik;Bae, Jeoung Won;Jung, Seung Pil
    • Annals of Surgical Treatment and Research
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    • v.93 no.6
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    • pp.331-335
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    • 2017
  • Silicone implants are widely used in aesthetic and reconstructive breast surgery. Silicone lymphadenopathy is a well-known rare complication of implant insertion. Silicone leakage from a rupture or silicone bleeding can accumulate in lymph nodes. Foreign body reactions in the affected lymph nodes may be misdiagnosed as metastasis or malignant lymphadenopathy upon initial presentation if silicone lymphadenopathy is not considered in the initial diagnosis. We report a case of siliconoma with extensive involvement of multiple lymph nodes mimicking malignant features to emphasize that clinicians should carefully evaluate each patient's medical history and disease status during differential diagnosis.

Comparison between Kawasaki disease with lymph-node-first presentation and Kawasaki disease without cervical lymphadenopathy

  • Kim, Jung Ok;Kim, Yeo Hyang;Hyun, Myung Chul
    • Korean Journal of Pediatrics
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    • v.59 no.2
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    • pp.54-58
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    • 2016
  • Purpose: We evaluated the characteristics of patients with Kawasaki disease (KD) who presented with only fever and cervical lymphadenopathy on admission, and compared them with the characteristics of those who presented with typical features but no cervical lymphadenopathy. Methods: We enrolled 98 patients diagnosed with KD. Thirteen patients had only fever and cervical lymphadenopathy on the day of admission (group 1), 31 had typical features with cervical lymphadenopathy (group 2), and 54 had typical features without cervical lymphadenopathy (group 3). Results: The mean age ($4.3{\pm}2.1$ years) and duration of fever ($7.5{\pm}3.6$ days) before the first intravenous immunoglobulin (IVIG) administration were highest in group 1 (P=0.001). Moreover, this group showed higher white blood cell and neutrophil counts, and lower lymphocyte counts after the first IVIG administration as compared to the other groups (P =0.001, P =0.001, and P =0.003, respectively). Group 1 also had a longer duration of hospitalization and higher frequency of second-line treatment as compared to groups 2 and 3 (group 1 vs. group 2, P =0.000 and P =0.024; group 1 vs. group 3, P =0.000 and P =0.007). A coronary artery z score of >2.5 was frequently observed in group 1 than in group 3 (P = 0.008). Conclusion: KD should be suspected in children who are unresponsive to antibiotics and have prolonged fever and cervical lymphadenopathy, which indicates that KD is associated with the likelihood of requiring second-line treatment and risk of developing coronary artery dilatation.

Lymphadenopathy (림프절 종대)

  • Chung, Nack-Gyun
    • Korean Journal of Pediatrics
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    • v.51 no.8
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    • pp.797-803
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    • 2008
  • Lymphadenopathy is a common problem in children and adolescents. A wide variety of diseases and conditions may present as lymphadenopathy and an understanding of these conditions is essential to determine the most appropriate diagnostic work-up for each patient. A detailed history and physical examination with careful attention to the anatomical regions drained by the involved lymph node or mass often leads to the appropriate diagnosis. A majority of these children will prove to have a benign disorder; however, it is important for the pediatrician to have an appreciation for the malignant diseases or serious systemic illnesses that may initially present with lymphadenopathy, to ensure the timely diagnosis of a serious disease.

Metastatic Lymphadenopathy in Kashmir Valley: A Clinicopathological Study

  • Qadri, Sumyra Khurshid;Hamdani, Nissar Hussain;Shah, Parveen;Baba, Khalil Mohammad
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.1
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    • pp.419-422
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    • 2014
  • Background: Lymphadenopathy is a common presentation in both benign and malignant diseases which need to be diagnosed without delay. Fine needle aspiration cytology (FNAC) helps us diagnose a disease and follow its course, including the response to therapy. Aim: This study aimed to analyze the clinicopathological features of metastatic lymphadenopathy and the diagnostic utility of FNAC in our setting. Materials and Methods: This two-year prospective study included all the patients with metastatic lymphadenopathy, diagnosed with FNAC. Results: A total of 412 cases (male:female ratio, 1.3:1; age range, 3 to 90 years) were studied. Supraclavicular lymph nodes were involved most commonly (50.5%). The commonest metastatic tumor was squamous cell carcinoma in general (30.1%) and in males (37.6%), and infiltrating ductal carcinoma (25.3%) in females. Lung, with 64 (15.5%) cases followed by esophagus, 60 (14.6%) cases; breast, 49 (11.9%) cases; skin, 32 (7.8%) cases; and stomach, 25 (6.1%) cases were the most common primary sites of malignancy. In 69 patients, excision biopsy was performed. Histopathological findings correlated well with that of cytology in all these cases. Conclusions: FNAC is an important tool in the diagnostic work up of metastatic lymphadenopathy, which in the hands of an experienced and skilful cytopathologist can avoid the need for excision biopsy.

Differential Diagnosis of Fine Needle Aspiration Cytology of Benign Lymphadenopathy (양성 림프절 증식의 세침흡인 세포검사의 감별진단)

  • Han, Eun-Mee;Song, Dong-Eun;Eom, Dae-Un;Choi, Hye-Jeong;Cha, Hee-Jeong;Huh, Joor-Yung
    • The Korean Journal of Cytopathology
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    • v.17 no.2
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    • pp.99-107
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    • 2006
  • In the investigation of superficial lymphadenopathy of unknown cause, fine needle aspiration (FNA) cytology plays an invaluable role. It enables the differentiation of benign lymphadenopathy from lymphoid and non-lymphoid malignancies, obviating the need for open biopsy, and allowing the triage of patients. Cytopathologists should be familiar with the typical FNA patterns of benign lymphadenopathy, and recognize and differentiate among categories. In a minority of cases of benign lymphadenopathy, FNA can render a specific diagnosis. Benign lymphadenopathies are generally categorized into reactive lymphoid hyperplasia (RLH), inflammatory or infectious processes, and benign lymphoproliferative disorders. RLH characteristically presents with a heterogeneous and polymorphous smear composed of normal cellular constituents of lymph nodes, in contrast with the homogeneous or monomorphic smear of most lymphomas. The caveat is that various malignant disorders may also present with polymorphous populations. It is also important to recognize thatbenign lymphoid smears may sometimes contain atypical cells that raise the suspicion of malignancy. Clinical information should always be the integral part of the diagnostic criteria in FNA of lymphadenopathy. If there is any doubt about the benign nature of the smear, it is prudent to suggest biopsy and ancillary studies.

Fine Needle Aspiration Cytopathology of Pediatric Lympha denopathy among Sudanese Children

  • Ahmed, Hussain Gadelkarim;Elmubasher, Maysa Badawi;Salih, Rashid Awad Abdallah;Elhussein, Gamal Eldin Mohamed Osman;Ashankyty, Ibraheem Mohmmed Alamin
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.7
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    • pp.4359-4363
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    • 2013
  • Background: Pediatric lymphadenopathy is a challenging medical situation for the child patient, the parents, and the physician. Although the bulk of masses will be benign the fear of malignancy is omnipresent. Therefore, the objective of this study was to identify the common cytopathological patterns of lymphadenopathy among Sudanese children. Methods: One hundred pediatric patients presenting with peripheral lymphadenopathy were included in the study, their ages ranging from 2 to 14 years, with a mean age of 7 years. Demographic characteristics, clinical manifestations and FNA materials were prospectively obtained. Results: FNA was performed in 100 cases (100%). There were no technical complications. All cases confirmed adequacy of specimen. Overall, FNA demonstrated 90 (90%) benign lesions and 10 (10%) malignant diagnosis. The benign lesions were reactive lymphoid hyperplasia (n=64), followed by benign granulomatous disease (n=26). Of the 10 cases diagnosed with malignancy, 7 (7%) were cases of non-Hodgkin`s lymphoma and the remaining 3 (3%) were Hodgkin's lymphomas. Conclusion: Pediatric lymphadenopathy is common in Sudan. CLA is the common frequent site. Lymphoma represents a major challenge in this setting.

A Case Report of Alopecia Treated by Gagamsunbangpaedok-tang (Jiājiǎnxiānfángbàidú-tāng) - Focused on Multi-patched Alopecia Areata with Lymphadenopathy (가감선방패독탕(加減仙防敗毒湯) 투약을 통한 탈모증 치험 1례 - 임파선염을 동반한 다발성 원형탈모증 치료를 중심으로)

  • Cho, Ah-Ra;Hong, Seung-Ug
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.1
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    • pp.130-139
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    • 2014
  • Objectives : This is a clinical report on a 27-year-old patient with Multi-patched Alopecia Areata(AA) assumed to be occurred by chronic lymphadenopathy, and treated by oriental medicine treatment. Methods : The patient was treated by herb medication and acupuncture. The improvement of the patient was judged by magnifying glass, camera and VAS scale. Results & Conclusions : The AA patches were shown the regrowth of hair. And the pain from lymphadenopathy was disappeared. Oriental medicine treatment including Gagamsunbangpaedok-tang $(Ji\bar{a}ji\check{a}nxi\bar{a}nf\acute{a}ngb\grave{a}id\acute{u}-t\bar{a}ng)$ was effective to regrow hair on AA patches and reduce the symptom of lymphadenopathy as well.

Toxocariasis Mimicking Lymphoma and Presenting as Multiple Lymphadenopathy: A Case Report (전신 림프절 비대로 발현되어 림프종으로 오인된 톡소카라증: 증례 보고)

  • Choi, Yoonmi;Park, Cheol Min;Kim, Jeong Woo;Park, Yang Shin;Lee, Jongmee;Choi, Jae Woong;Kim, Kyeong Ah;Lee, Chang Hee
    • Journal of the Korean Society of Radiology
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    • v.79 no.5
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    • pp.286-289
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    • 2018
  • Toxocariasis, a parasitic infection, causes hyper eosinophilia resulting in radiological presentation of eosinophilic infiltrations in the involved organs. In the abdomen, toxocariasis has been reported to manifest as infiltrations in the liver or in the gastrointestinal tract, but it is known to be uncommon to manifest as multiple lymphadenopathy. There have been two case reports of toxocariasis presenting as generalized lymphadenopathy in the chest, neck and inguinal regions. To the best of our knowledge, generalized conglomerated lymphadenopathy occurring mostly in the abdomen from toxocariasis has not been published in the English literature. Herein, we report a rare case of toxocariasis presenting as multiple conglomerated lymphadenopathy mimicking lymphoma on CT.

AIDS-Related Non-Hodgkin Lymphoma: Imaging Feature Analysis of 27 Cases and Correlation with Pathologic Findings

  • Yang, Jun;Wang, Peng;Lv, Zhi-Bin;Wei, Lian-Gui;Xu, Yun-Liang;Zhou, An;Xu, Dong-Hai;Ma, Da-Qing
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.18
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    • pp.7769-7773
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    • 2014
  • Background: Some tumor types are related to HIV, including non-Hodgkin lymphoma (NHL). The morbidity and mortality of NHL has remained high, even after highly active antiretroviral therapy (HAART) was introduced. We collected cases of AIDS with NHL, and evaluated the imaging features and strategies for diagnosis. Materials and Methods: There were 27 patients with AIDS and tumors confirmed by pathology. There were 9 patients with Burkitt lymphoma, 16 with diffuse large B cell lymphomas (DLBCLs), and 2 with primary central nervous system (PCNS) lymphomas. All of the patients underwent a series of imaging studies. Three radiologists analyzed the images, and any disagreement was discussed until consensus was reached. Results: The radiologic manifestations of AIDS with NHL were mainly masses and lymphadenopathy, 3 patients having one mass and 12 two or more masses. 7 patients had lymphadenopathy in one site and 3patients had lymphadenopathy in two or more sites. Coarse mucosal folds, thickening of the gastrointestinal wall, and lumen narrowing were typical manifestations of NHL within the gastrointestinal tract. There were 4 patients with masses and 5 with lymphadenopathy inthe 9 with Burkitt lymphoma, and 11 patients with masses 5 with lymphadenopathy in the 16 with DLBCLs. Conclusion: NHL is a malignancy that usually occurs in patients with AIDS. Imaging is an important method by which to evaluate lesions, masses, and lymphadenopathy. Fine needle aspiration biopsy and stereotaxis biopsy are useful methods by which to diagnose NHL.