• Title, Summary, Keyword: Lipid metabolism

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Pheophorbide A-methyl Ester, Acyl-CoA: Cholesterol Acyltransferase Inhibitor from Diospyros kaki

  • Rho, Mun-Chual;Chung, Mi-Yeon;Song, Hye-Young;Kwon, Oh-Eok;Lee, Seung-Woong;Baek, Jin-Ah;Jeune, Kyung-Hee;Kim, Koan-Hoi;Lee, Hyun-Sun;Kim, Young-Kook
    • Archives of Pharmacal Research
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    • v.26 no.9
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    • pp.716-718
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    • 2003
  • In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an $IC_{50}$ value of 1.85 $\mu$ g/mL.

Anti-atherosclerotic Effects of Ethanol Extract of Soy Leaves (Glycine max) Supplementation on Suppression of Atherogenic Lesion Formation in LDL Receptor-Deficient Mice (저밀도지단백질 수용체 결손 마우스에서 동맥병변 형성을 억제하는 콩잎 주정추출물의 항동맥경화 효과)

  • Han, Jong-Min;Han, Jang-Il;Baek, Seung-Hwa;Li, Hua;Park, Ji-Seon;Cho, Moon-Hee;Park, Ki-Hun;Lee, Woo-Song;Jeong, Tae-Sook
    • 한국약용작물학회:학술대회논문집
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    • pp.388-389
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    • 2008
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Effects of Chitosan Treated with Enzymatic Methods on Glucose and Lipid Metabolism in Rats (키토산의 효소분해물질이 흰쥐의 당 및 지방대사에 미치는 영향)

  • 이종미;조우균;박혜진
    • Journal of Nutrition and Health
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    • v.31 no.7
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    • pp.1112-1120
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    • 1998
  • This study was conducted to investigate the effets of chitosan and beef tallow at different level on glucose and lipid metabolism in rats. Dietary fot level was 20% and 40%, and chitosan was given at levels of 0%, 3%, and 5%(wt/wt) of diet. Chitosan supplement tended to decrease the serum total lipids, total cholesterol, and triglycerides. HDL cholesterol and HDL cholesterol : total cholesterol ratio tended to increase with 5% chitosan supplementation. LDL cholesterol and VLDL triglyceride tended to decrease with chitosan supplementation. Lipid concentration of liver and epididymal fat pad(EEP) tended to decrease with medium dietary fat and chitosan treatment. fecal excretion of total lipid and triglyceride exhibited a tendency to increase with high fat levels and chitosan. Length of small intestine and gastrointestinal transit time were not affected by dietary fit levels or chitosan supplements. Therefore, it could be suggested that chitosan supplement had beneficial effects on lipid metabolism. (Korean J Nutrition 31(7) : 1112-1120, 1998)

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Effects of Magnesium Supplement Levels and Periods on Lipid Metabolism and Enzyme Activities in Rats (저단백식이와 마그네슘 결핍식이 섭취시 마그네슘 보충이 흰쥐의 지질대사 및 효소 활성에 미치는 영향)

  • 정복미
    • Journal of Nutrition and Health
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    • v.26 no.8
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    • pp.933-941
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    • 1993
  • The present study was carried out to investigate the effects of magnesium supplement levels and periods on lipid metabolism in male Sprague-Dawley rats given low protein and magnesium deficient diets. The effect of magnesium supplement levels and periods on lipid metabolism in rats given a low protein and magnesium deficient diet for 2 weeks were investigated. Serum total lipid and triglyceride contents were significantly lower in magnesium supplement group compared with magnesium deficient group. Serum HDL-cholesterol/total cholesterol ratio was significantly increased as magnesium supplement level was increased. Liver total lipid, triglyceride, total cholesterol and phospholipid contents were significantly lower in magnesium supplement group than those in magnesium deficient group. Serum ALP, GOT and GPT activities were significantly decreased in magnesium supplement group compared with magnesium deficient group. In summary, the effect of magnesium supplement on lipid metabolism and enzyme activities were significant and we can see that magnesium supplement level propered to be requirement level(400 mg/kg diet)in the other cases except serum lipid contents.

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