• Title/Summary/Keyword: Lipid Metabolism

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Pheophorbide A-methyl Ester, Acyl-CoA: Cholesterol Acyltransferase Inhibitor from Diospyros kaki

  • Rho, Mun-Chual;Chung, Mi-Yeon;Song, Hye-Young;Kwon, Oh-Eok;Lee, Seung-Woong;Baek, Jin-Ah;Jeune, Kyung-Hee;Kim, Koan-Hoi;Lee, Hyun-Sun;Kim, Young-Kook
    • Archives of Pharmacal Research
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    • v.26 no.9
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    • pp.716-718
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    • 2003
  • In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an $IC_{50}$ value of 1.85 $\mu$ g/mL.

Anti-atherosclerotic Effects of Ethanol Extract of Soy Leaves (Glycine max) Supplementation on Suppression of Atherogenic Lesion Formation in LDL Receptor-Deficient Mice (저밀도지단백질 수용체 결손 마우스에서 동맥병변 형성을 억제하는 콩잎 주정추출물의 항동맥경화 효과)

  • Han, Jong-Min;Han, Jang-Il;Baek, Seung-Hwa;Li, Hua;Park, Ji-Seon;Cho, Moon-Hee;Park, Ki-Hun;Lee, Woo-Song;Jeong, Tae-Sook
    • 한국약용작물학회:학술대회논문집
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    • 2008.11a
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    • pp.388-389
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    • 2008
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Investigation of Effective Korean Herbal Medicine for Psoriasis - Focusing on Lipid Metabolism - (건선에 효과적인 한약 처방 탐색 - 지질 대사를 중심으로)

  • Han, Chang-Yi;Kim, Jundong;Seo, Gwang-Yeel;Kim, Kyu-Seok;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.34 no.3
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    • pp.70-79
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    • 2021
  • Objectives : The purpose of this study is to investigate the possibility of using herbal medicine for the management of psoriasis focusing on lipid metabolism. Methods : We reviewed studies about pathophysiology, and medical treatment of psoriasis, the relationship between psoriasis and metabolic syndrome and lipid metabolism, and herbal medicine on Pubmed and Google scholar. Results : Psoriasis is a chronic multi-organ inflammatory disease not limited to skin, and steroids, immuno-suppressants, and biological agents are used. It is known that psoriasis and metabolic syndrome act as mutual risk factors, and lipid metabolism are involved in psoriasis. The effects of various single herbal preparations and complex herbal extract, decoction on improving lipid metabolism have been consistently reported, and there was an improvement of psoriatic skin lesions and improvement of blood lipid levels through herbal medicine. Conclusions : Herbal medicine research in psoriasis has focused on the anti-inflammatory effect and the suppression effect of certain immune mediators. However, considering that psoriasis is affected by lipid metabolism and side effects of Western medicines, the use of herbal medicines for the purpose of controlling lipid metabolism in psoriasis is useful in aspects of reducing side effects of concurrent Western medicine, improving the severity of psoriasis, and managing metabolic risk factors.

Effect of Kikkanol F Monoacetate and 5-Hydroxy-6,7,3',4'-tetramethoxyflavone Isolated from Chrysanthemum indicum L. on IL-6 Production (감국에서 분리한 Kikkanol F Monoacetate와 5-Hydroxy-6,7,3',4'-tetramethoxyflavone의 IL-6 생성억제활성)

  • Nam, Jung-Yeon;Lee, Hyun-Sun;Lee, Seung-Woong;Chung, Mi-Yeon;Choe, Jeong-Ho;Yoo, Eun-Sook;Kim, Young-Kook;Rho, Mun-Chual
    • Korean Journal of Pharmacognosy
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    • v.36 no.3 s.142
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    • pp.186-190
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    • 2005
  • Searching for inhibitors of lipopolysaccharide (LPS)-induced IL-6 (Interleukin-6) production from medicinal herbs, we isolated two active compounds though bioactivity-guided fractionation from the methanol extract of Chrysanthemum indicum L.. They were determined as kikkanol F monoacetate (1) and 5-hydroxy-6,7,3',4'-tetramethoxyflavone (2) by means of spectroscopy techniques such as NMR and MS. The compound 1 and 2 inhibited LPS-induced IL-6 production in the PAW264.7 cells with $IC_{50}$ value of $47\;{\mu}g/ml$ and $27\;{\mu}g/ml$, respectively.