• Title, Summary, Keyword: Izmir, Turkey

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Adult Urological Soft Tissue Sarcomas: A Multicenter Study of the Anatolian Society of Medical Oncology (ASMO)

  • Unal, Olcun Umit;Oztop, Ilhan;Menekse, Serkan;Urakci, Zuhat;Bozkurt, Oktay;Ozcelik, Melike;Gunaydin, Yusuf;Yasar, Nurgul;Yazilitas, Dogan;Kodaz, Hilmi;Taskoylu, Burcu Yapar;Aksoy, Asude;Demirci, Umut;Araz, Murat;Tonyali, Onder;Sevinc, Alper;Yilmaz, Ahmet Ugur;Benekli, Mustafa
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.11
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    • pp.4777-4780
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    • 2015
  • Objective: To analyze clinicopathological characteristics, prognostic factors and survival rates of the patients with urological soft tissue sarcomas treated and followed up in Turkey. Materials and Methods: For overall survival analyses the Kaplan-Meier method was used. From medical records, nine prognostic factors on overall survival were analysed. Results: For the 53 patients (34 males, 19 females) whose charts were reviewed, the median age was 53 (range 22 to 83) years. Most frequently renal location (n=30; 56.6%) was evident and leiomyosarcoma (n=20, 37.7%) was the most frequently encountered histological type. Median survival time of all patients was 40.3 (95% CI, 14.2-66.3) months. In univariate analysis, male gender, advanced age (${\geq}50years$), metastatic stage, unresectability, grade 3, renal location were determined as worse prognostic factors. In multivariate analysis, metastatic stage, unresectability and grade 3 were determined as indicators of worse prognosis. Conclusions: Urological soft tissue sarcomas are rarely seen tumours in adults. The most important factors in survival are surgical resection, stage of the tumour at onset, grade and location of the tumour, gender and age of the patients.

Effectiveness of Online Education in Teaching Breast Self-Examination

  • Tuna, Arzu;Avdal, Elif Unsal;Yucel, Sebnem Cinar;Dal, Nursel Alp;Dicle, Aklime;Ozkan, Arife;Sezgin, Handan;Gumus, Aysun Babacan;Turgay, Ayse San;Degirmenci, Mustafa
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.7
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    • pp.3227-3231
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    • 2014
  • Background: This research evaluated the effectiveness of an online education model in teaching breast self-examination to university staff and students. Materials and Methods: 1,679 women participated in a breast self-examination online training program. Breast self-examination knowledge evaluation forms developed by Maurer (1997) were used in the research and were evaluated on a 100 point scale. Paired t-test and McNemar's Test statistics were employed. Results: The participants scored an average of 46.5 (14.0%) on knowledge on breast self-examination before training, but 77.4 (11.0%) one month after education and 76.7 (9.52%) after six months. There was a clear significant difference between these knowledge levels (p<0.05). Similarly, while the rate for systematic practice of breast self-examination among women was 30.8% before training it increased to 47.8% afterwards. Again the difference was significant (p<0.05). Conclusions: Online education is an effective method for teaching breast self-examination to women.

An investigation on plan geometries of RC buildings: with or without projections in plan

  • Inan, Tugba;Korkmaz, Koray;Cagatay, Ismail H.
    • Computers and Concrete
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    • v.9 no.6
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    • pp.439-455
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    • 2012
  • The interaction of plan geometry and structural configuration, a determinative factor in the earthquake behavior of buildings, has become a serious issue in the building industry in Turkey due to the poor seismic performance of R/C buildings during the latest earthquake. Consequently, designing new buildings without structural irregularities against earthquake loads is proving to be more significant. This study focuses on the effects of plan geometries on earthquake performances of buildings. In that respect, structural irregularities in the plan are investigated in detail based on the Turkish Earthquake Code (TEC 2007). The study is based on five main parametric models and a total of 40 sub-models that are grouped according to their plan geometries with excessive projections such as L-shaped, H-shaped, T-shaped and U-shaped models. In addition to these, a square model without any projections is also generated. All models are designed to have the same storey gross area but with different number of storeys. Changes in the earthquake behavior of buildings were evaluated according to the number of storeys, the projection ratios and the symmetry conditions of each model. The analysis of each structural irregularity resulted in many findings, which were then assessed. The study demonstrates that the square model delivers the best earthquake performance owing to its regular plan geometry.

Level of Knowledge and Behavior of Family Health Personnel Workers in Izmir about Early Diagnosis for Breast and Cervix Cancer

  • Yasli, Gokben;Turhan, Ebru;Eser, Sultan;Tozun, Mustafa;Oguz, Murat;Alpay, Fatma
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.6
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    • pp.2501-2505
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    • 2015
  • Purpose: The present study was carried out to measure knowledge level and behavior of family health personnel (FHP) in Izmir on early diagnosis of breast and cervical cancers. Materials and Methods: The study population of this cross-sectional study was not selected. A questionnaire was applied to all FHP to measure knowledge level and behavior about cancer. The participation rate was 88%. Breast examination, mammography analysis, Papanicolaou smear applications were determined as dependent variables, and knowledge level about breast and cervical cancer, age, professional time as FHP as independent variables. Data were evaluated using definitive statistics, chi-square and logistic regression tests in SPSS software package for Windows 15.0. Results: A total of 970 family health personnel participated in the research. The age range was 20-45 years (82.4%). Mean age was $37.9{\pm}7.4$. Response rate was 87.3%. Of the participants, 88.4% performed breast self-examination. Rate of performing mammography at least once was 24.1%. Rate of performing Pap-smear examination at least once was 61.0%. In logistic regression analyses, it was determined that people with knowledge on breast and cervical cancer were those performing breast self-examination, mammography and Pap-smear examinations (p<0.05. Conclusions: It is essential that the knowledge, behavior and manners of health providers on early diagnosis for cancer increases awareness in the general population and provides information on execution ofthe most effective methods for generating a healthy society.

Relationship between Epidermal Growth Factor Receptor Gene Mutations and Clinicopathological Features in Patients with Non-Small Cell Lung Cancer in Western Turkey

  • Unal, Olcun Umit;Oztop, Ilhan;Calibasi, Gizem;Baskin, Yasemin;Koca, Dogan;Demir, Necla;Akman, Tulay;Ellidokuz, Hulya;Yilmaz, Ahmet Ugur
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.6
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    • pp.3705-3709
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    • 2013
  • Background: To investigate epidermal growth factor receptor (EGFR) gene mutations in patients with non-small cell lung cancer (NSCLC) and to analyze any relationship with clinicopathological features and prognosis. Materials and Methods: EGFR gene exons 18-21 in 48 specimens of paraffin-embedded tumor tissue from NSCLC patients were amplified by PCR, followed by direct sequencing and analysis of links to clinicopathological features and prognosis. Results: EGFR mutations were detected in 18 of 48 (42.6%) patients with NSCLC. There were 9 cases of mutations in exon 20, 7 in exon 19 and 2 in exon 21. Mutations were more frequently observed in women (5/7 pts, 71.4%) than in men (13/41 pts, 31.7%) (p=0.086) and in non-smokers (5/5 pts, 100%) than smokers (13/43 pts, 30.2%). There was negative correlation of EGFR mutations with smoking status (p=0.005). EGFR mutations were more frequently observed with adenocarcinoma histology (13/32 pts, 40.6%) than in other types (5/16 pts, 31.3%) (p=0.527). The patients with EGFR mutations had better survival than those with wild-type EGFR (p=0.08). There was no association of EGFR mutations with metastatic spread. Conclusions: EGFR mutations in NSCLC were here demonstrated more frequently in females, non-smokers and adenocarcinoma histology in the western region of Turkey. Patients with EGFR mutations have a better prognosis.

Caregiver Burden and Perceived Social Support among Caregivers of Patients with Cancer

  • Kahriman, Fatma;Zaybak, Ayten
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3313-3317
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    • 2015
  • The purpose of this study is to describe the relationship between caregiver burden and perceived social support among caregivers of patients with cancer. The research was conducted in a university hospital in ${\dot{I}}zmir$, Turkey. Eighty patient relatives who provided care service to patients with cancer who were admitted at hematology and oncology clinics participated in the study. The findings indicated that the care burden score was mild level. The mean of the perceived social support score was $58.4{\pm}21.0$ supporting the conclusion that there is a weak and negative-direct relation between caregiver and perceived social support and that as the perceived social support increased, conversely, care burden decreased.

Family History Attributes and Risk Factors for Breast Cancer in Turkey

  • Gokdemir-Yazar, Ozden;Yaprak, Seval;Colak, Muhteber;Yildirim, Ediz;Guldal, Dilek
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2841-2846
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    • 2014
  • Background: When dealing with breast cancer, early detection is closely associated with determining and closely monitoring high risk groups. The aim of this study was to determine the preventable risk factors that are specific for our country, and to understand which risk factors were most predominant. Materials and Methods: The study was planned as a case-control design. Women diagnosed with breast cancer who visited the Surgery, Obstetrics and Gynaecology, and Radiation Oncology outpatient clinics of the Izmir Dokuz Eylul University (DEU) School of Medicine were accepted as the case group. Then a control group matched for age was established among females who visited the outpatient clinics on the same days. A questionnaire prepared by the researchers was implemented using a face-to-face interview technique. The Mann-Whitney U test was used in the comparisons of the group averages, and the Pearson chi-square test in the comparisons between groups. In order to determine the dominant risk factors, binary logistical regression test was implemented. Results: A total of 138 patients, 69 cases and 69 controls, were included in the study. A significant difference can be detected between the groups in terms of BMI, smoking, breast cancer prevalence among first degree family members, presence of breast cancer among distant family members, existence of other types of cancers among family members and the age of onset of menopause (p<0.05). Logistical regression analysis revealed that the presence of breast cancer among first degree relatives increased the risk of developing breast cancer 5.7 times. Conclusions: Although some results of this study are compatible with findings in the literature, some are not. In order to determine unique risk factors, there is a clear need for large-scale studies.

Social Perceptions of Breast Cancer by Women Still Undergoing or Having Completed Therapy: a Qualitative Study

  • Mermer, Gulengul;Nazli, Aylin;Ceber, Esin
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.2
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    • pp.503-510
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    • 2016
  • Background: Diagnosis and treatment of breast cancer is a crisis situation which effects women's lives physically, socially and spiritually. Investigating women's perceptions of this disease is crucially important for treatment decisions. We therefore determined social perceptions and interpretations of women diagnosed with breast cancer during therapy and in the post-treatment period. Materials and Methods: In the study, focus group and in-depth interviews were made with women still undergoing or having completed breast cancer treatment. Some 25 women were included in the research. Content analysis was used in the analysis of the qualitative data obtained after the focus group and in-depth interviews. Results: Some of the women demonstrated positive perceptions towards accepting the disease, whereas others had emotions such as rebellion and anger. The loss of a breast is important with different interpretations. Conclusions: Women's acceptance or rebellion against the disease varies within their social interpretations after the treatment, as at the stage of diagnosis/treatment. All stages of breast cancer negatively affect the social life of the affected individual as much as her body. Nurses assume crucial roles in coping with these negative effects. Thus, it is necessary to know, and sociologically interpret, what is indicated by the information on what the negative effects concerning the disease are and how they are interpreted.

Earthquake response of roller compacted concrete dams including galleries

  • Karabulut, Muhammet;Kartal, Murat Emre
    • Structural Engineering and Mechanics
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    • v.72 no.2
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    • pp.141-153
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    • 2019
  • The effect of galleries on the earthquake behavior of dams should be investigated to obtain more realistic results. Therefore, a roller compacted concrete (RCC) dam with and without galleries are examined under ground motion effects. For this purpose, Cine RCC dam constructed in Aydın, Turkey, is selected in applications. The optimal mesh around galleries is investigated to obtain the most realistic results. Two-dimensional finite element models of Cine RCC dam with and without galleries are prepared by using ANSYS software. Empty and full reservoir conditions were taken into account in the time-history analyses. Hydrodynamic effect of the reservoir water was taken into account considering two-dimensional fluid finite elements based on the Lagrangian approach. It is examined that how principle stresses and displacements change by height and during earthquake. The dam-foundation-reservoir interaction was taken into consideration with contact-target element pairs. The displacements and principle stress components obtained from the linear analyses are compared each other for various cases of reservoir water and galleries. According to numerical analyses, the effect of galleries is clear on the response of RCC dam. Besides, hydrodynamic water effect obviously increases the principle stress components and horizontal displacements of the dam.

Seismic analysis of Roller Compacted Concrete (RCC) dams considering effect of viscous boundary conditions

  • Karabulut, Muhammet;Kartal, Murat E.
    • Computers and Concrete
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    • v.25 no.3
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    • pp.255-266
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    • 2020
  • This study presents comparation of fixed and viscos boundary condition effects on three-dimensional earthquake response and performance of a RCC dam considering linear and non-linear response. For this purpose, Cine RCC dam constructed in Aydın, Turkey, is selected in applications. The Drucker-Prager material model is considered for concrete and foundation rock in the nonlinear time-history analyses. Besides, hydrodynamic effect was considered in linear and non-linear dynamic analyses for both conditions. The hydrodynamic pressure of the reservoir water is modeled with the fluid finite elements based on the Lagrangian approach. The contact-target element pairs were used to model the dam-foundation-reservoir interaction system. The interface between dam and foundation is modeled with welded contact for both fixed and viscos boundary conditions. The displacements and principle stress components obtained from the linear and non-linear analyses are compared each other for empty and full reservoir cases. Seismic performance analyses considering demand-capacity ratio criteria were also performed for each case. According to numerical analyses, the total displacements and besides seismic performance of the dam increase by the effect of the viscous boundary conditions. Besides, hydrodynamic pressure obviously decreases the performance of the dam.