• Title, Summary, Keyword: Iodine-131

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Imaging of Tumor Proliferation Using Iodine-131-Iodomethyluridine (Iodine-131-Iodomethyluridine을 이용한 종양세포증식의 영상화에 관한 실험적 연구)

  • Min Kyung-Yoon;Kim, Chang-Guhn;Kim, Hyun-Jeong;Lim, Hyung-Guhn;Rho, Ji-Young;Juhng Seon-Kwan;Won Jong-Jin;Yang, David J.
    • The Korean Journal of Nuclear Medicine
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    • v.30 no.3
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    • pp.344-350
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    • 1996
  • Purpose : Noninvasive imaging of tumor cell proliferation could be helpful in the evaluation of tumor growth potential and could provide an early assessment of treatment response. Radiolabeled thymidine, uridine and adenosine have been used to evaluate tumor cell proliferation. These nucleoside analogs are incorporated into DNA during proliferation. Iodine-131-Iodomethyluridine, an analog of Iodine-131-Iododeoxyuridine, is also involved in DNA/RNA synthesis. The purpose of this study was to develop Iodine-131-Iodomethylurdine and image tumor proliferation using Iodine-131-Iodomethyluridine. Materials and Methods : Radiosynthesis of Iodine-131-5-Iodo-2'-O-methyluridine (Iodine-131-Iodomethyluridine) was prepared from 10 mg of 2'-O-methyluridine(Sigma chemical Co., St. Louis, Missouri) and 2.1 mCi(SP. 10Ci/mg) of Iodine-131-labeled sodium iodide in $100{\mu}l$ of water using iodogen reaction. Female Fischer 344 rats were inoculated in the thigh area with breast tumor cells(13765 NF, $10^5$ cells/rat S.C.). After 14 days, the Iodine-131-Iodomethyluridine $10{\mu}Ci$ was injected to three groups of rats(3/group). The percent of injected dose per gram of tissue weight was determined at 0.5-hours, 2-hours, 4-hours, and 24-hours respectively. Tumor bearing rats after receiving Iodine-131-Iodomethyluridine($50{\mu}Ci$ IV) were euthanized at 2 hours after injection. Autoradiography was done using freeze-dried $50{\mu}m$ coronal section. After injection of Iodine-131- Iodomethyluridine ($10{\mu}Ci$/rat, IV) in three breast tumor-bearing rats, planar scintigraphy was taken at 45 minutes, 90 minutes and 24 hours. Results : Iodine-131-Iodomethyluridine was conveniently synthesized using iodogen reaction. The biodistribution showed fast blood clearance and the tumor-to-tissue uptake ratios showed that optimal imaging time was at 2 hours postinjection. Autoradiogram and planar scintigram indicated that tumor could be well visualized. Conclusion : The findings suggest that Iodine-131-Iodomethyluridine, a new radio-iodinated nucleoside, has potential use for evaluation of active regions of tumor growth.

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Protein-Bound Iodine-131 and Metabolism of Iodine-131 in Korean Native Goats (재래산양(在來山羊)에 있어서 PBI131 Conversion Ratio 와 I131의 대사(代謝))

  • Kwun, J.K.;Sung, J.K.;Rhee, Y.S.;Lee, Y.B.
    • Korean Journal of Veterinary Research
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    • v.6 no.1
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    • pp.18-23
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    • 1966
  • The protein-bound iodine-131, the concentration of iodine-131 in blood, and the excretion rate of I-131 through urine and feces were observed in nine Korean native goats, 3 months age, following administration of $3{\mu}C$ of I-131 per kg of body weight. No signiant differences were found due to sex and castration. 1. The average protein-bound iodine-131 conversion ratio of goats was 16.7% in 24 hours. In castrated group, the lowest proteinbound iodine-131 conversion ratio was observed. 2. The average concentration of iodine-131 in bleed, increased very rapidly by 2 hours(4.75%) and rapidly decreased within 6 hours(0.73%). 3. The average excretion rate of I-131 through urine was highest in 24 hours(19.00%) and decreased rapidly within 48 hours(5.32%). 4. The average excretion ration rate of I-131 though feces was highest in 24 hours(2.55%), and decreased slowly.

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Study on Removal of Artificial Radionuclide (I-131) in Water (물속의 인공방사성핵종(I-131) 제거율 연구)

  • Jeong, Gwanjo;Lee, Kyungwoo;Kim, Bogsoon;Lee, Suwon;Lee, Jonggyu;Koo, Ami
    • Journal of Korean Society of Environmental Engineers
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    • v.36 no.11
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    • pp.747-752
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    • 2014
  • Iodine-131, an artificial radionuclide, mostly exists as iodide ion ($^{131}I^-$) and iodate ion ($^{131}IO_3{^-}$) in the water, and When a short time contacted, it could not be removed by poly aluminum chloride (PACl) and powdered activated carbon (PAC). Although the removal rate of iodine-131 was not related with turbidity of raw water, it showed linear relationship with contact time with PAC. With the mixture of PACl (24 mg/L or more) and PAC (40 mg/L or more), about 40% of iodine-131 could be removed. Iodine-131 could be removed little by sand filtration, but approximately 100% by granular activated carbon (GAC), both virgin-GAC and spent-GAC. Microfiltration process could remove little iodine-131 while reverse osmosis process could remove about 92% of iodine-131.

The Study of Iodine Metabolism IN VIVO Utilizing I-131 (방사선 동위원소 I-131을 이용한 요드의 IN VIVO 대사 연구)

  • Byun, Si-Myung
    • Applied Biological Chemistry
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    • v.19 no.2
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    • pp.70-74
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    • 1976
  • In order to study the mechanism of biosynthesis of thyroid hormones, radioactive iodine was injected into the rats and thyroid glands were removed. Iodine compounds hydrolyzed by pancreatin viokase were separated by paper chromatography and analyzed by radioautography. Radioautograms showed that the uptake of iodine starts immediately and forms diiodotyrosine through monoiodotyrosine. Evidence supported the possibility that diiodotyrosine is a precursor of thyrosine and triiodothyronine is a degradation product of thyroxine. The rat administered propylthiouracil showed inorganic iodine concentration activity, while the binding activity was prevented.

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Determination of Thyroid Secretion Rate in Rabbit (토끼의 갑상선 측정)

  • 이종진;윤세중
    • The Korean Journal of Zoology
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    • v.3 no.1
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    • pp.19-23
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    • 1960
  • A method for determination of thyroid secretion rate in rabbit by means of radioactive iodine presented. After injection of radioactive iodine, in vivo determination so f radioactivity in thyroid gland were made during a 19 day-experimental period. In the same period blood samples were drawn and analyzed for protein-bound iodine (PBI) and for protein-bound radioactive iodine(PBI181). A rate constant for secretion of thyroid hormone was calculated from the disappearance rate of radioactive iodine in thyroid gland. The secretion rate of radioactive hormone iodine was calculated by multiplying this rate constant by the amount of radioactive iodine present in thyroid gland. Assuming that the specific radioactiveness of the circulating thyroid hormone and of the hormone just secreted were identical , thyroid secretion rate was calculated by the equation. {{{{ { Secreted hormone-iodine , gamma /hr} over { Secreted hormone-I^131, % dose/hr }= { PBI, ${\gamma}$/ml.Serum} over { PBI^131 , % dose/ml . Serum } }} The method presented consisted of measurements for series of independent criteria on thyroid function, and the resulting thyroid secretion rate was calculated by combination of those.

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Evolution of iodine from $NaI-Na_2 O_2$ System

  • Lee, Sang-Hoon
    • Nuclear Engineering and Technology
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    • v.4 no.2
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    • pp.109-115
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    • 1972
  • The evolution of radioiodine 131I from a sodium peroxide system as a function of time, temperature, and carrier gas (nitrogen) flow rate was studied. Virtually no iodine was volatilized at 25$0^{\circ}C$ and a very small amount, of the order of 10$^{-3}$ % per flour, at 63$0^{\circ}C$. Substantially greater amounts of iodine were volatilized at 7$25^{\circ}C$ and 83$0^{\circ}C$. The data are consistent with the hypothesis that the mechanism of transfer is distillation of sodium iodide, and that elemental iodine is not produced in this system.

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Thyroid Activity and Body Gain in Native and Saanen Goats (재래종과 Saanen 종 염소의 갑상선 기능과 증체율의 비교)

  • Kwun, Jong Kuk
    • Korean Journal of Veterinary Research
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    • v.12 no.1
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    • pp.21-24
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    • 1972
  • In native and Saanen goats, the thyroidal iodine uptake rate and its correlation between thyroidal activity and body gain were studied. The results were as follows: 1. The thyroidal iodine-131 uptake rate in native and Saanen goats were 10.46% and 21.26%, respectively, and the difference was statistically significant (P<0.01). 2. The correlation coefficients between monthly body gain and thyroidal iodine-131 uptake rate were -0.32 and -0.46 in native and Saanen goats, respectively. The correlations were negative and not significant between the rates.

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Evaluation of Adsorption Characteristics of Radioactive Iodine (I-131) for Various Materials of Granular Activated Carbon (GAC) (입상활성탄 재질별 방사성 핵종(I-131) 흡착 특성 평가)

  • Park, Hong-Ki;Son, Hee-Jong;Yeom, Hoon-Sik;Kim, Young-Jin;Choi, Jin-Taek;Ryu, Dong-Choon
    • Journal of Environmental Science International
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    • v.24 no.9
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    • pp.1123-1129
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    • 2015
  • This research was performed by means of several different virgin granular activated carbons (GAC) made of each coal, coconut and wood, and the GACs were investigated for an adsorption performance of iodine-131 in a continuous adsorption column. Breakthrough behavior was investigated that the breakthrough points of the virgin two coals-, coconut- and wood-based GACs were observed as bed volume (BV) 7080, BV 5640, BV 5064 and BV 3192, respectively. The experimental results of adsorption capacity (X/M) for iodine-127 showed that two coal- based GACs were highest (208.6 and $139.1{\mu}g/g$), the coconut-based GAC was intermediate ($86.5{\mu}g/g$) and the wood-based GAC was lowest ($54.5{\mu}g/g$). The X/M of the coal-based GACs was 2~4 times higher than the X/M of the coconut-based and wood-based GACs.

Effect of Depression and Anxiety on Symptoms in Thyroid Cancer Patients Undergoing Radioactive Iodine($I^{131}$) Therapy (고용량 방사성요오드($I^{131}$)치료를 받는 갑상선암 환자의 우울, 불안이 증상에 미치는 영향)

  • Chun, Nami
    • Asian Oncology Nursing
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    • v.12 no.4
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    • pp.297-304
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    • 2012
  • Purpose: This study was to identify the symptom severity, interference and their psychological predictors in thyroid cancer patients hospitalized for radioactive iodine administration. Methods: One hundred seventy-seven thyroid cancer patients admitted to the isolation room for Iodine ($I^{131}$) therapy were recruited. Subjects were asked to complete the questionnaire on core symptoms, thyroid cancer symptoms, interference, depression and state anxiety in the evening after receiving radioactive iodine therapy. Data was analyzed using frequency, percentage, mean, Pearson's correlation, and multiple regression with SPSS vs. 19. Results: Lack of appetite, drowsiness, sleep disturbance, fatigue, and nausea were the 5 most core symptoms. More than 20% of patients experienced moderate to severe thyroid cancer symptoms including feeling cold, hoarseness, swallowing difficulty, and feeling hot. More than 30% of subjects experienced moderate to severe interferences in mood, general activity, and 22% in walking. Depression and state anxiety were identified as predictors of core symptoms, thyroid symptom severity and interference. Conclusion: Nursing interventions to reduce the symptom severity and interference need to be developed by considering thyroid cancer patients' depression and anxiety when hospitalized in the isolation room for radioactive iodine administration.

A Clinical Review of Radioactive Iodine-131 Therapy in Differentiated Thyroid Carcinoma (갑상선(甲狀線) 분화암(分化癌)의 방사성 요드-131 치료(治療)에 대한 임상적(臨庶的) 고찰(考察))

  • Park Yoon-Kyu;Lee Dae-Young;Chon Seong-Eun;Oh Sung-Soo;Chung Eul-Sam
    • Korean Journal of Head & Neck Oncology
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    • v.12 no.1
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    • pp.32-42
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    • 1996
  • This study was desinged to evaluate the effect of radioactive iodine-131 therapy in differentiated thyroid carcinoma treated at the Presbyterian Medical Center, Chonju during the 20-year period from 1975 to 1994. The authors reviewed 246 patients who received radioactive iodine-131. An analysis of the therapeutic response and survival rates of the 246 patients has been carried out. The male to female ratio was 1 : 3.6. The peak incidence was in the 4th and 6th decades. The histologic findings in the 246 patients were papillary adenocarcinoma in 200 cases, follicular adenocarcinoma in 29 cases, mixed type in 14 cases, and others in 3 cases. Combined treatment modalities of 246 patients consisted of sugery and radioiodine in 222 cases, surgery with radioiodine and external irradiation in 11 cases, and surgery with radioiodine, external irradiation and chemotherapy in 5 cases. 42 of the 246 cases showed recurrence and the commonest type of combined treatment for recurrent case was surgery followed by radioiodine-131. The highest accumulated total dosage of radioiodine-131 was 480mCi in that case femoral metastasis was noticed. The most common locoregional metastatic site was ipsilateral cervical node, and neighbouring muscle, vessel, trachea, recurrent layngeal nerve, in order of frequency. The determinate 10-year survival rate was 91.8% in the group receiving surgery followed by radioiodine-13l and 71.4% in patients receiving surgery, radioiodine-13l with XRT. The determinate 10-year survival rate was better for patients under 40 years of age who received radioiodine as compared to patients over 40 year of age(85.7% vs. 33.3%). The most usual primary therapeutic dosage in the group of cervical lesion was 90$\sim$120mCi after surgery.

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