• Title/Summary/Keyword: Interdisciplinary studies

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A Study on the Cooperation between the Humanities & Social Sciences and Natural Science & Technology (인문.사회과학과 과학기술부분 협력 방안에 관한 연구)

  • 이종수
    • Journal of Korea Technology Innovation Society
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    • v.3 no.3
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    • pp.125-140
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    • 2000
  • The paper studies on the cooperation between the humanities & social sciences and natural science & technology in 1990's. The article showed policy alternatives about the crisis of humanities & social sciences. That was science wars and we heard that was announced by Sokal affair. In this article, the author inquired into the Korean research policy's crisis and presented the policy alternatives about the crisis of humanities & social sciences and natural science & technology in various ways. In the concrete, the policy alternatives are cultural critique of technology and science and science & development of domain about interdisciplinary studies at the humanities & social science and natural science & technology. In conclusion, First, the author showed the appraisal and institutionalization of interdisciplinary studies. Second, the researcher proposed few policy alternatives and developmental area of interdisciplinary studies between the humanities & social sciences and natural science & technology.

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Cell-Based Assay Design for High-Content Screening of Drug Candidates

  • Nierode, Gregory;Kwon, Paul S.;Dordick, Jonathan S.;Kwon, Seok-Joon
    • Journal of Microbiology and Biotechnology
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    • v.26 no.2
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    • pp.213-225
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    • 2016
  • To reduce attrition in drug development, it is crucial to consider the development and implementation of translational phenotypic assays as well as decipher diverse molecular mechanisms of action for new molecular entities. High-throughput fluorescence and confocal microscopes with advanced analysis software have simplified the simultaneous identification and quantification of various cellular processes through what is now referred to as high-content screening (HCS). HCS permits automated identification of modifiers of accessible and biologically relevant targets and can thus be used to detect gene interactions or identify toxic pathways of drug candidates to improve drug discovery and development processes. In this review, we summarize several HCS-compatible, biochemical, and molecular biology-driven assays, including immunohistochemistry, RNAi, reporter gene assay, CRISPR-Cas9 system, and protein-protein interactions to assess a variety of cellular processes, including proliferation, morphological changes, protein expression, localization, post-translational modifications, and protein-protein interactions. These cell-based assay methods can be applied to not only 2D cell culture but also 3D cell culture systems in a high-throughput manner.

A Comparative Study on Deepfake Detection using Gray Channel Analysis (Gray 채널 분석을 사용한 딥페이크 탐지 성능 비교 연구)

  • Son, Seok Bin;Jo, Hee Hyeon;Kang, Hee Yoon;Lee, Byung Gul;Lee, Youn Kyu
    • Journal of Korea Multimedia Society
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    • v.24 no.9
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    • pp.1224-1241
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    • 2021
  • Recent development of deep learning techniques for image generation has led to straightforward generation of sophisticated deepfakes. However, as a result, privacy violations through deepfakes has also became increased. To solve this issue, a number of techniques for deepfake detection have been proposed, which are mainly focused on RGB channel-based analysis. Although existing studies have suggested the effectiveness of other color model-based analysis (i.e., Grayscale), their effectiveness has not been quantitatively validated yet. Thus, in this paper, we compare the effectiveness of Grayscale channel-based analysis with RGB channel-based analysis in deepfake detection. Based on the selected CNN-based models and deepfake datasets, we measured the performance of each color model-based analysis in terms of accuracy and time. The evaluation results confirmed that Grayscale channel-based analysis performs better than RGB-channel analysis in several cases.

Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity

  • Zhang, Siqi;Sun, Yuhua;Sui, Yi;Li, Yan;Luo, Zuyuan;Xu, Xiao;Zhou, Ping;Wei, Shicheng
    • Tissue Engineering and Regenerative Medicine
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    • v.15 no.6
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    • pp.751-760
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    • 2018
  • BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the low efficiency of this process is still an important issue that needs to be resolved. Many studies have aimed to improve efficiency, but developing accurate methods to determine efficacy is also critical. Studies using pluripotency to estimate efficacy are rare. Telomerase is highly associated with pluripotency. METHODS: We have described a quantitative method to measure telomerase activity, telomeric repeat elongation assay based on quartz crystal microbalance (QCM). To investigate whether this method could be used to determine the efficiency of in vitro osteogenic differentiation based on pluripotency, we measured the pluripotency pattern of cultures through stemness gene expression, proliferation ability and telomerase activity, measured by QCM. RESULTS: We showed that the pluripotency pattern determined by QCM was similar to the patterns of proliferation ability and gene expression, which showed a slight upregulation at the late stages, within the context of the general downregulation tendency during differentiation. Additionally, a comprehensive gene expression pattern covering nearly every stage of differentiation was identified. CONCLUSION: Therefore, this assay may be powerful tools for determining the efficiency of differentiation systems based on pluripotency. In this study, we not only introduce a new method for determining efficiency based on pluripotency, but also provide more information about the characteristics of osteogenic differentiation which help facilitate future development of more efficient protocols.

Landing Stability Simulation of a 1/6 Lunar Module with Aluminum Honeycomb Dampers

  • Pham, Van Lai;Zhao, Jun;Goo, Nam Seo;Lim, Jae Hyuk;Hwang, Do-Soon;Park, Jung Sun
    • International Journal of Aeronautical and Space Sciences
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    • v.14 no.4
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    • pp.356-368
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    • 2013
  • The Korea Aerospace Research Institute plans to launch a lunar module by 2025, and so is carrying out a preliminary study. Landing stability on the lunar surface is a key design factor of a lunar module. In this paper, a 1/6 scale model of a lunar module is investigated, for its landing stability on non-level surfaces. The lunar module has four tripod legs, with aluminum honeycomb shock absorbers in each leg strut. ADAMS$^{TM}$, the most widely used multi-body dynamics and motion analysis software, is used to simulate the module's lunar landing. Three types of dampers in the struts (rigid, viscous, and aluminum honeycomb dampers), and two types of lunar surfaces (rigid and elastic) are considered. The Sforce function is adopted, to model the aluminum honeycomb dampers. Details on the modeling and analysis of the landing stability of the 1/6 scale lunar module and the simulation results are provided in this paper.

Enhanced and applicable algorithm for Big-Data by Combining Sparse Auto-Encoder and Load-Balancing, ProGReGA-KF

  • Kim, Hyunah;Kim, Chayoung
    • International Journal of Advanced Culture Technology
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    • v.9 no.1
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    • pp.218-223
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    • 2021
  • Pervasive enhancement and required enforcement of the Internet of Things (IoTs) in a distributed massively multiplayer online architecture have effected in massive growth of Big-Data in terms of server over-load. There have been some previous works to overcome the overloading of server works. However, there are lack of considered methods, which is commonly applicable. Therefore, we propose a combing Sparse Auto-Encoder and Load-Balancing, which is ProGReGA for Big-Data of server loads. In the process of Sparse Auto-Encoder, when it comes to selection of the feature-pattern, the less relevant feature-pattern could be eliminated from Big-Data. In relation to Load-Balancing, the alleviated degradation of ProGReGA can take advantage of the less redundant feature-pattern. That means the most relevant of Big-Data representation can work. In the performance evaluation, we can find that the proposed method have become more approachable and stable.

Mass Spectrometry in the Determination of Glycosylation Site and N-Glycan Structures of Human Placental Alkaline Phosphatase

  • Solakyildirim, Kemal;Li, Lingyun;Linhardt, Robert J.
    • Mass Spectrometry Letters
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    • v.9 no.3
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    • pp.67-72
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    • 2018
  • Alkaline phosphatase (AP) is a membrane-bound glycoprotein that is widely distributed in the plasma membrane of cells of various organs and also found in many organisms from bacteria to humans. The complete amino acid sequence and three-dimensional structure of human placental alkaline phosphatase have been reported. Based on the literature data, AP consists of two presumptive glycosylation sites, at Asn-144 and Asn-271. However, it only contains a single occupied N-linked glycosylation site and no occupied O-linked glycosylation sites. Hydrophilic interaction chromatography (HILIC) has been primarily employed for the characterization of the glycan structures derived from glycoproteins. N-glycan structures from human placental alkaline phosphatase (PLAP) were investigated using HILIC-Orbitrap MS, and subsequent data processing and glycan assignment software. 16 structures including 10 sialylated N-glycans were identified from PLAP.

Tangible Game Console: Physical Entertainment Media Using I/O Coupling Units (텐저블 게임 콘솔: 입출력 일체화 개체를 이용한 물리적 엔터테인먼트 미디어에 대한 연구)

  • Han, Kyung-Hoon;Lee, Woo-Hun;Yun, Wan-Chul
    • 한국HCI학회:학술대회논문집
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    • 2006.02a
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    • pp.818-823
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    • 2006
  • 본 연구에서는 디지털 콘텐츠와 물리적 미디어가 유기적으로 결합할 수 있는 가능성을 모색하고자, 입출력 일체화 개체인 'I/O 셀(Cell)'과 그 집합체인 '텐저블 게임 콘솔(Tangible Game Console)'을 개발하였다. I/O 셀은 여러 종류의 센서와 액츄에이터가 하나의 물리적 노드 내에 통합되어 있는 개체로, 이 I/O 셀 다수를 집적하면 다양한 크기와 용도의 엔터테인먼트 미디어를 구성하는 것이 가능하다. 그 중 하나로 개발된 텐저블 게임 콘솔은 일종의 센서-액츄에이터 집합체로 셀들 사이의 연계를 통해 다양한 물리적 정보를 인식하고 표현할 수 있다. 텐저블 게임 콘솔은 기존 게임 콘텐츠의 주요한 표현 수단이었던 이미지와 텍스트 정보 대신에 물리적 정보를 통해 게임 콘텐츠를 구성하며, 조작대상과 조작수단이 일체화되어 있고, 또한 음악, 퍼즐, 액션 등 다양한 장르의 게임 콘텐츠가 적용 가능하다는 특징을 가지고 있다. 텐저블 게임 콘솔에서는 불, 바람, 물, 생명체 등의 물리적 현상을 형상/움직임/소리/빛 등을 통해 재현하며, 사용자는 이를 때리기/바람불기/흔들기/기울이기 등의 직접적인 조작을 통해 체험할 수 있다. 또한 물리적인 상호작용 과정이 일정한 게임 규칙을 가지고 구성되어 있어 지속성 있는 놀이 경험을 제공한다. 본 연구에서는 텐저블 게임 콘솔의 콘텐츠로 음악, 액션, 대전게임 등을 개발하였으며, 이 콘텐츠들의 놀이경험을 평가함으로써, 텐저블 게임 콘솔의 발전 가능성을 확인하였다.

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Performance Evaluation of a Bidirectional Piezoelectric Hybrid Actuator (양방향 압전-유압 하이브리드 구동장치의 성능 시험)

  • Jin, Xiaolong;Ha, Ngocsan;Goo, Namseo;Bae, Byungwoon;Kim, Taeheun;Ko, Hanseo;Lee, Changseop
    • Journal of the Korea Institute of Military Science and Technology
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    • v.18 no.3
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    • pp.213-219
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    • 2015
  • Piezoelectric-based hydraulic actuator is a hybrid device consisting of a hydraulic pump driven by piezoelectric stacks that is coupled to a conventional hydraulic cylinder via a set of fast-acting valves. Nowadays, such hybrid actuators are being researched and developed actively in many developed countries by requirement of high performance and compact flight system. In this research, a piezoelectric hybrid actuator has been designed and tested. To achieve bi-directional capabilities in the actuator, solenoid valves were used to control the direction of output fluid. The experimental testing of the actuator in uni-directional and bi-directional modes was performed to examine performance issues related to the solenoid valves. The results showed that the bi-directional performance was slightly lower than uni-directional performance due to air bubble developed in the valve system. A new design to solve the vacuum problem has been proposed to improve the performance of the hybrid actuator.

Thermal Strain Measurement of Austin Stainless Steel (SS304) during a Heating-cooling Process

  • Ha, Ngoc San;Le, Vinh Tung;Goo, Nam Seo;Kim, Jae Young
    • International Journal of Aeronautical and Space Sciences
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    • v.18 no.2
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    • pp.206-214
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    • 2017
  • In this study, measurement of thermophysical properties of materials at high temperatures was performed. This experiment employed a heater device to heat the material to a high temperature. The images of the specimen surface due to thermal load at various temperatures were recorded using charge-coupled device (CCD) cameras. Afterwards, the full-field thermal deformation of the specimen was determined using the digital image correlation (DIC) method. The capability and accuracy of the proposed technique are verified by two experiments: (1) thermal deformation and strain measurement of a stainless steel specimen that was heated to $590^{\circ}C$ and (2) thermal expansion and thermal contraction measurements of specimen in the process of heating and cooling. This research focused on two goals: first, obtaining the temperature dependence of the coefficient of thermal expansion, which can be used as data input for finite element simulation; and second, investigating the capability of the DIC method in measuring full-field thermal deformation and strain. The results of the measured coefficient of thermal expansion were close to the values available in the handbook. The measurement results were in good agreement with finite element method simulation results. The results reveal that DIC is an effective and accurate technique for measuring full-field high-temperature thermal strain in engineering fields such as aerospace engineering.