• Title, Summary, Keyword: Hypertriglyceridemia

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Association between dairy product intake and hypertriglyceridemia in Korean adults

  • Park, Seon-Joo;Park, Junghyun;Song, Hong Ji;Lee, Chang-Ho;Lee, Hae-Jeung
    • Nutrition Research and Practice
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    • v.14 no.2
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    • pp.152-159
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    • 2020
  • BACKGROUND/OBJECTIVES: Hypertriglyceridemia may be a more important predictor of cardiovascular disease in Asian population consuming carbohydrate-rich foods than in Western populations. Dairy products are known to play a beneficial role in obesity, dyslipidemia, and metabolic syndrome, but the results vary depending on gender and obesity. In this study, we investigated the associations between dairy product intake and hypertriglyceridemia in Korean adults. SUBJECTS/METHODS: The participants were selected from the Korea National Health and Nutrition Examination Survey 2007-2012 (KNHANES IV and V). A total of 22,836 participants aged 19-64 years were included in the analysis. A food frequency questionnaire used to determine the frequency of consumption of products (milk and yogurt). Multivariable logistic regression was used to assess the associations between dairy product intake and hypertriglyceridemia. RESULTS: A significantly decreased risk of hypertriglyceridemia was detected in the highest dairy product intake frequency group (≥ 1 time/day) (odd ratio [OR] = 0.79; 95% confidence interval [CI] 0.64-0.97, P for trend = 0.022) compared to that for the lowest dairy product intake frequency group. Among obese participants, the group with the highest intakes of milk (in men, OR = 0.64; 95% CI: 0.46-0.91, P for trend = 0.036) and yogurt (in women; OR = 0.53; 95% CI: 0.29-0.94, P for trend = 0.019) showed inverse associations with hypertriglyceridemia. No associations were detected in normal weight participants. CONCLUSION: The association between dairy product intake and hypertriglyceridemia differed by gender and obesity status. Further prospective studies are needed to confirm these associations.

Progress of Short-term Herbal Medicine Administration for Hypertriglyceridemia: a Case Report (고중성지방혈증에 대한 단기 한약 투약 경과 : 증례보고)

  • Kim, Bo-min;Jo, Hee-geun
    • The Journal of Internal Korean Medicine
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    • v.40 no.3
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    • pp.517-524
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    • 2019
  • Objectives: This study reported the progress of herbal medicine administration for hypertriglyceridemia. Methods: Patients diagnosed with hypertriglyceridemia were treated with Taiyintiaowei decoction three times a day. After the triglyceride level dropped, we prescribed Wujisan decoction three times a day to maintain the normal range of triglycerides. Results: The patients' blood triglyceride level decreased from 432 mg/dL to 113 mg/dL. The triglyceride level remained steady in the normal range. Adverse events were not observed. Conclusions: Herbal medicines may be effective in controlling hypertriglyceridemia. Further studies on related topics are needed.

Hypertriglyceridemia in Obese Children and Adolescents

  • Jung, Mo Kyung;Yoo, Eun-Gyong
    • Journal of Obesity & Metabolic Syndrome
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    • v.27 no.3
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    • pp.143-149
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    • 2018
  • The increasing prevalence of obesity in children and adolescents is a serious public health concern. Hypertriglyceridemia is common in obese children and adolescents, and elevated triglyceride (TG) level is a known biomarker of cardiometabolic risk. Results from genetic studies suggest that TG and TG-rich lipoproteins and, more specifically, remnant cholesterol are in the causal pathway of cardiovascular disease. However, simultaneous measurement of all remnants has not yet been established, and plasma TG level can be used as a useful marker of remnant cholesterol. Adipose tissue dysfunction, including impaired adipocyte TG storage and release of fatty acids, mediates the development of obesity-related complications. The prevalence of hypertriglyceridemia increases in overweight or obese children and is associated with other cardiometabolic risk factors. Recently, the TG/high-density lipoprotein cholesterol (HDL-C) ratio was recognized as a marker of structural vascular changes and insulin resistance in obese youth. Recent guidelines recommend universal lipid screening with nonfasting non-HDL-C measurement in children at 9-11 years of age; however, fasting lipid profiles should be measured in obese children and overweight adolescents and in those with high non-HDL-C in universal screening. The primary approach to lower TG in children includes dietary and lifestyle modifications; however, children with severe hypertriglyceridemia should also be referred to a pediatric lipid specialist.

The Effect of High Fat Diet on the Vasoendothelial Cell in Healthy Adults

  • Choi Sun-Young;Kim Jai-Young
    • Biomedical Science Letters
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    • v.11 no.1
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    • pp.79-84
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    • 2005
  • This study was performed to determine whether postprandial hypertriglyceridemia can affect the endothelial function. Endothelial function was assessed by flow-mediated endothelium-dependent brachial artery vasodilation (FMD) which was defined as percentile changes of diameter. Thirty one patients were enrolled in this study. The serum lipid profiles and FMD were measured at fasting, and after low fat and high fat meals. The serum triglycerides at 2 hours after a high fat meal were significantly increased compared to those measured at 2 hours after a low-fat meal and at fasting state (P<0.05). The FMD was transiently decreased (P<0.0001) from $11.4{\pm}3.2\%$ at fasting state to $6.5{\pm}2.5\%$ after a high-fat meal. The FMD was inversely related with postprandial hypertriglyceridemia (P<0.05). In conclusion, this study may suggest that postprandial hypertriglyceridemia causes endothelial dysfunction.

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An Update on Hypertriglyceridemia-Induced Acute Pancreatitis (고중성지방혈증 급성췌장염의 최신 지견)

  • Kim, Hong Ja
    • The Korean Journal of Medicine
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    • v.93 no.6
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    • pp.518-524
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    • 2018
  • Hypertriglyceridemia a major cause of acute pancreatitis, accounting for up to 10% of all cases. The pathophysiological mechanism of hypertriglyceridemia-induced acute pancreatitis (HTGP) is presumed to involve the hydrolysis of triglycerides by pancreatic lipase resulting in an excess of free fatty acids and elevated chylomicrons, which are thought to increase plasma viscosity and induce ischemia and inflammation in pancreatic tissue. Although the clinical course of HTGP is similar to other forms of acute pancreatitis, the clinical severity and associated complications are significantly higher in patients with HTGP. Therefore, an accurate diagnosis is essential for treatment and prevention of disease recurrence. At present, there are no approved guidelines for the management of HTGP. Different treatment modalities such as apheresis/plasmapheresis, insulin, heparin, fibric acids, and omega-3 fatty acids have been successfully implemented to reduce serum triglycerides. Following acute phase management, lifestyle modifications including dietary adjustments and drug therapy are important for the long-term management of HTGP and the prevention of relapse. Additional studies are required to produce generalized and efficient treatment guidelines for HTGP.

Korean Medical Treatment Focusing on Cheongsim-tanggamibang for Hypertriglyceridemia Patient : A Case report (고중성지방혈증 환자에 대한 청심탕가미방 중심의 한방치료 : 증례보고)

  • Oh, Ji-Won;Lee, Jun-Hee
    • Journal of Sasang Constitutional Medicine
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    • v.32 no.3
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    • pp.55-63
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    • 2020
  • Introduction The purpose of this study was to investigate the effect of Cheongsim-tanggamibang on hypertriglyceridemia in a 37-year-old Taeeum- type male patient. Case presentation A 37-year-old male patient complained of hyperhidrosis and hot sensation was diagnosed with hypertriglyceridemia by blood test and 'Liver-Heat Lung-Dry (Ganyeol-paeJo) severe pattern' of Korean Medicine. Cheongsim-tanggamibang was executed twice everyday during 2 months from July, 23rd to September, 21st of 2019. The effectiveness of Cheongsim-tanggamibang was assessed with blood test. Conclusions After the Korean traditional medicine treatment with Cheongsim-tanggamibang prescription, blood triglyceride and total cholesterol levels decreased, and chief complaining symptoms with hot sensation also improved.

Relationship between food and nutrient intake and the risk of hypertriglyceridemia in Vietnamese women residing in Bavi: the Korean Genome and Epidemiology Study (KoGES) (베트남 Bavi 지역 여성의 식품 및 영양섭취상태와 고중성지방혈증 위험도의 관계: 한국인유전체역학조사사업)

  • Kim, Jeong Ki;Kim, Ji Myung;Kim, Hyesook;Chung, Hye Won;Chang, Namsoo
    • Journal of Nutrition and Health
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    • v.46 no.1
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    • pp.15-25
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    • 2013
  • The purpose of this study is to investigate the proportion and associated risk factors of hypertriglyceridemia in rural Vietnamese women. Research data were collected as part of the Korean Genome and Epidemiology Study (KoGES). A cross-sectional study of 957 Vietnamese women in their 20 to 30s was conducted in rural areas of Bavi, Vietnam. Subjects were classified as hypertriglyceridemic (serum TG ${\geq}$ 150 mg/dL). Demographic, socio-economic details, anthro-pometric measurements, and blood profiles were recorded. The proportion of hypertriglyceridemic subjects was 22.0%, and the mean age of hypertriglyceridemics subjects was older than that of normo-triglyceridemic subjects (p < 0.05). In hypertriglyceridemic subjects, height, HDL-cholesterol, and LDL-cholesterol were significantly lower, compared to subjects with normo-triglyceridemia, while weight, body mass index, waist hip ratio, body fat %, blood pressure, fasting blood sugar, total cholesterol, and atherogenic index were higher, compared to those with normo-triglyceridemia. Intake of cereal and cereal products, total plant food, and cereal/potato fiber in subjects with hypertriglyceridemia was significantly higher, compared to normo-triglyceridemic subjects. Hypertriglyceridemic subjects had a significantly lower intake of animal calcium and retinol than normo-triglyceridemic subjects. Significant positive relationships were observed between the prevalence of hypertriglyceridemia and consumption of total plant food [OR (95% CI) for the highest tertile, compared to the lowest: 1.764 (1.131-2.750); p for trend = 0.008] and crude fiber [OR (95% CI) for the highest tertile compared to the lowest: 1.651 (1.092-2.497); p for trend = 0.027]. In addition, a significant inverse relationship was observed between the prevalence of hypertriglyceridemia and cholesterol intake [OR (95% CI) for the highest tertile, compared to the lowest: 0.601 (0.400-0.901); p for trend = 0.012]. These findings may provide basic data for use by policymakers and dieticians in future development of nutrition and health programs to encourage healthier eating habits, and to prevent hypertriglyceridemia advancing cardiovascular disease in rural Vietnamese women.

Canola Oil Influence on Azoxymethane-induced Colon Carcinogenesis, Hypertriglyceridemia and Hyperglycemia in Kunming Mice

  • He, Xiao-Qiong;Cichello, Simon Angelo;Duan, Jia-Li;Zhou, Jin
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2477-2483
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    • 2014
  • Azoxymethane (AOM) is a potent genotoxic carcinogen which specifically induces colon cancer. Hyperlipidemia and diabetes have several influences on colon cancer development, with genetic and environmental exposure aspects. Here, we investigated plasma lipid and glucose concentrations in Kunming mice randomized into four groups; control (no AOM or oil exposure), AOM control, AOM + pork oil, and AOM + canola oil. Aberrant crypt foci (ACF), plasma cholesterol, plasma triglyceride, plasma glucose and organ weight were examined 32 weeks after AOM injection. Results revealed that AOM exposure significantly increased ACF number, plasma triglyceride and glucose level. Further, male mice displayed a much higher plasma triglyceride level than female mice in the AOM control group. Dietary fat significantly inhibited AOM-induced hypertriglyceridemia, and canola oil had stronger inhibitory effect than pork oil. AOM-induced hyperglycemia had no sex-difference and was not significantly modified by dietary fat. However, AOM itself not change plasma cholesterol level. AOM significantly increased liver and spleen weight in male mice, but decreased kidney weight in female mice. On the other hand, mice testis weight decreased when fed canola oil. AOM could induce colorectal carcinogenesis, hypertriglyceridemia and hyperglycemia in Kunming mice at the same time, with subsequent studies required to investigate their genome association.

Effects of Coriandrum Sativum L. on Lipid Metabolism in Rats with Hypertriglyceridemic Diet

  • Hwang, Geum-Hee;Heo, Young-Ran;Lee, Heung-Jae;Park, Ok-Ja;Kang, Seong-Koo;Kim, Yong-Doo
    • Nutritional Sciences
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    • v.4 no.1
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    • pp.13-19
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    • 2001
  • This study was designed to investigate the effects of Coriandrum Sativum L. on lipid metabolism in rats with hypertriglyceridemia. Also, we compared the effects of the leaf, seed and root of Coriandrum Sativum L. on lipid metabolism in rats with hypertriglyceridemia. Hypertriglyceridemia was induced in 32 male Sprague-Dawley rats weighting 108$\pm$13 g through the feeding of high-fat diets containing 20% fat and 5% cellulose for ten days. The rats were divided into four groups as follows : control (C), leaf (L), seed (S) and root (R) groups. For the five-week experimental period, the C group was fed the above diet an the L, S and R groups were fed Coriandrum Sativum L. diets containing 5% dry leaf, seed and root of Coriandrum Sativum L., respectively. Intake of diet and weight gain were significantly lower in the C group than in the L, S and R groups. But there was no significant difference among the L, S and R groups. Because of weight differences among the groups, all obtained data was adjusted to weight. The level of plasma total cholesterol was not significantly different among the four groups. But after adjusting to weight differences, the level of plasma triglyceride was significantly higher in the C groups than in the L and S groups. These results suggest that dietary Coriandrum Sativum L. may increase appetite and have an inhibitory effect on the lipid metabolism of rats with hypertriglyceridemia. Also, those effects may be partly different (leaf, root and seed) from those of Coriandrum Sativum L.

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Relation between Metabolic Syndrome and Obesity Pattern Identification Questionnaire in Middle-aged Health Check-up Examinees (중년 건강검진 수진자에서 대사증후군과 한방비만변증의 관련성)

  • Yoo, Jeong-Eun;Cho, Young-Hye;Gu, Hyun-Gyung;Kim, Bo-Young;Yun, Young-Ju
    • The Journal of Korean Medicine
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    • v.35 no.1
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    • pp.124-134
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    • 2014
  • Objectives: Metabolic syndrome is considered a coronary heart disease risk factor and its prevalence rate is increasing in Korea. Because obesity is relevant to metabolic syndrome, we investigated the relationship between metabolic syndrome and the Obesity Pattern Identification Questionnaire in middle-aged health check-up examinees. Methods: This was a cross-sectional study with 125 patients who visited a health promotion center of university hospital from October 2012 to January 2013. We analyzed the association of Obesity Pattern Identification Questionnaire and the diagnostic criteria of metabolic syndrome. Results: Pi deficiency (脾虛), phlegm (痰飮), liver stasis (肝鬱) and food accumulation (食積) pattern showed significantly highs score in the group with hypertriglyceridemia. Also, females demonstrated significantly high scores of liver stasis (肝鬱) and food accumulation (食積) in the group with hypertriglyceridemia. The questions of Pattern Identification that showed especially significant high score in the group of hypertriglyceridemia are as follows: 'Easily get annoyed', 'Usually worried', 'Frequently overeating or bingeing', and 'Having more after getting full'. There are positive correlations between triglyceride and the score of Pi deficiency (脾虛), phlegm (痰飮) and food accumulation (食積) pattern. Conclusions: Obesity Pattern Identification Questionnaire can be used for the management of hypertriglyceridemia in an effort to prevent metabolic syndrome.