• Title, Summary, Keyword: Hypercholesterolemia

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Influence of Crude Drugs on Serum Total Cholesterol Contents in Rabbits (수종생약(數種生藥)이 Rabbit의 혈청(血淸) Total Cholesterol 치(値)에 미치는 영향)

  • Ko, Geon-Il
    • Journal of Pharmaceutical Investigation
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    • v.13 no.4
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    • pp.196-201
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    • 1983
  • Banggi, Banggi Whanggi Tang and Gami Jodeung San have been used to prevent and treat arteriosclerosis in oriental medicine. In order to investigate preventive and therapeutic effects of its crude drugs, this research was studied in cholesterol induced hypercholesterolemia rabbits. The rusults were as follows. 1) By concurrent administeration of Banggi or Banggi Whanggi Tang with cholesterol, serum total cholesterol contents were increased more slowly than control group. But in the case of Gami Jodeung San, serum total cholesterol contents were increased as well as control group. 2) By administration of Banggi Whanggi Tang or Gami Jodeung San on induced hydercholesterol rabbits, serum total cholesterol contents were decreased faster than control group. According to this result, it is suggested that Banggi and Banggi Whanggi Tang have preventive and therapeutic effects on hypercholesterolemia rabbits and that Gami Jodeun San has not preventive effect but therapeutic effect.

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Hypocholesterolemic Effects of Soybean Lecithin in Cholesterol-Fed Rats

  • Moon Min-Sun;Kwun In-Sook;Kim Yangha
    • Nutritional Sciences
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    • v.8 no.4
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    • pp.237-241
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    • 2005
  • The present study was performed to elucidate the hypocholesterolemic action of lecithin on the diet-induced hypercholesterolemia in rats. Male Sprague-Dawley rats (n=24) were fed lecithin-free (control) diet or diets containing $2\%\;or\;5\%$ lecithin for 4 weeks. Hypercholesterolemia was induced by adding $1\%$ cholesterol and $0.5\%$ cholic acid to all diets. No difference was found in food intake and body weight gain among groups. The lecithin treated groups showed significant improvement in the plasma levels of total cholesterol and LDL-cholesterol (p<0.05) compared to the control group, while the plasma triacylglyceride was not significantly affected 1he atherogenic index and HDL-cholesterol level were decreased in the lecithin groups. The diets with $2\%\;or\;5\%$ lecithin significantly decreased the activity of cholestetyl ester transfer protein (CETP) by $14\%\;or\;17\%$, respectively. Also, lecithin diets increased the activity of lecithin: cholesterol acyltransferase (LCAT). These results suggest that lecithin accounts for the hypocholesterolemic effect due to the decreased CETP activity and increased LCAT activity.

Purification and Identification of Squalene Synthase Inhibitor Isolated from Fermented Soybean Paste

  • Choi, Sung-Won;Kim, Dong-Seob;Hur, Nam-Youn;Park, Cheon-Seok;Baik, Moo-Yeol
    • Food Science and Biotechnology
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    • v.14 no.1
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    • pp.89-93
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    • 2005
  • Squalene synthase (SQS) inhibitors were screened from various plants and food extracts. Effective SQS inhibitor was purified from fermented soybean paste using ethanol extraction, HP-20 column chromatography, ethyl acetate extraction, silica gel column chromatography, and crystallization. Through UV spectrometry, $^1H$ NMR, $^{13}C$ NMR, and mass spectrometry, SQS inhibitor was identified as daidzein with molecular mass of 254 and molecular formula of $C_{15}H_{10}O_4$. Daidzein showed $IC_{50}$ value of 50 nmol/L against SQS, confirming its potential as therapeutic agent for hypercholesterolemia.

Egg phospholipids exert an inhibitory effect on intestinal cholesterol absorption in mice

  • Lee, Yoojin;Han, Catherine Y.;Bae, Minkyung;Park, Young-Ki;Lee, Ji-Young
    • Nutrition Research and Practice
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    • v.13 no.4
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    • pp.295-301
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    • 2019
  • BACKGROUND/OBJECTIVES: Consumption of cholesterol-rich foods, such as eggs, has a minimal effect on circulating cholesterol levels in healthy humans. To gain insight, we investigated whether phospholipids rich in eggs (EPL) interfere with intestinal cholesterol absorption in vivo. MATERIALS/METHODS: To investigate the acute effect of EPL on intestinal cholesterol absorption, male C57BL/6J mice were orally administered with 6, 11, or 19 mg of EPL for three days. We also tested the effect of chronic EPL consumption on cholesterol metabolism in the small intestine and the liver in mice with diet-induced hypercholesterolemia. Male C57BL/6J mice were fed a high fat/high cholesterol (HF/HC; 35% fat, 0.25% cholesterol, w/w) diet for 4 weeks to induce hypercholesterolemia, and subsequently the mice were either fed 0, 0.4 or 0.8% (w/w) of EPL for 6 weeks. RESULTS: Intestinal cholesterol absorption was significantly decreased by the highest dose of acute EPL administration compared to control. Chronic EPL supplementation did not significantly alter intestinal cholesterol absorption nor plasma levels of total cholesterol and low-density lipoprotein cholesterol. In the small intestine and the liver, EPL supplementation minimally altered the expression of genes which regulate cellular cholesterol levels. CONCLUSION: Although chronic EPL consumption was not able to counteract hypercholesterolemia in HF/HC-fed mice, acute EPL administration decreased intestinal cholesterol absorption. This study provides in vivo evidence that acute administration of PLs in eggs prevent cholesterol absorption in the intestine, suggesting a mechanism for a minimal effect of egg consumption on circulating cholesterol levels.

Correlation of the Nutritional Status of Antioxidant Vitamins and Serum Lipids and MDA Levels in Postmenopausal Women (폐경기 여성의 항산화 비타민 영양 상태와 혈중 지질 및 MDA 농도와의 관계)

  • Kim Sang-Yeon;Jung Kyung-Ah
    • Journal of the East Asian Society of Dietary Life
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    • v.16 no.2
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    • pp.145-155
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    • 2006
  • This study investigated the correlation of the nutritional status of antioxidant vitamins and serum lipids and MDA levels in postmenopausal women. Data about general characteristics, dietary intakes and biochemical parameters, including serum lipids, MDA and antioxidant vitamins levels, were collected from 85 postmenopausal women. The subjects were classified into three groups according to their serum total cholesterol level: normocholesterolemia group (NC, < 200 mg/dL), moderate hypercholesterolemia group (MC, $200{\sim}239mg/dL$) and hypercholesterolemia group(HC, ${\geq}240mg/dL$). The results are as follows. 1) General characteristics and serum MDA levels were not significantly different among the three groups. 2) Daily nutrients intakes adjusted to energy intake were not significantly different among the three groups, and were compatible with dietary reference intakes (DRIs) for Koreans. 3) Dietary Vt. A, ${\beta}-carotene$, Vt. C and Vt. E intake were not significantly different among the groups, while Vt. E intake was positively related with serum TC (r=0.288, p<0.05) and triglyceride (r=0.341, p<0.001) levels. 4) Serum Vt. A level standardized by serum TC level was significantly low and serum Vt. E level was significantly high in the HC group. Serum Vt. E level was positively related with serum TC level (r=0.389, p<0.001). 5) Dietary Vt. E intake was negatively correlated to serum MDA level (r=-0.242 p<0.05). Serum Vt. C and Vt. E levels were also negatively correlated to serum MDA level (r=-0.312, p<0.001 and r=-0.299, p<0.05). When the correlation was analyzed only in the group with hypercholesterolemia, correlation coefficients between the antioxidant vitamin and serum MDA level were higher. We concluded that intakes of antioxidant vitamins can contribute to decreasing the risk of cardiovascular disease by decreasing the oxidative stress of body rather than by controlling serum lipid levels.

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Fenofibrate Reduces Age-related Hypercholesterolemia in Normal Rats on a Standard Diet

  • Han, Ying;Do, Mi-Hyang;Kim, Mi-Sun;Seo, Eun-Hui;Park, Mi-Kyoung;Kim, Duk Kyu;Lee, Hye-Jeong;Seo, Su-Yeong
    • The Korean Journal of Physiology and Pharmacology
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    • v.14 no.2
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    • pp.77-81
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    • 2010
  • Plasma cholesterol is increased in normal aging in both rodents and humans. This is associated with reduced elimination of cholesterol and decreased receptor-mediated clearance of plasma low-density lipoprotein (LDL) cholesterol. The aims of this study were: (1) to determine age-related changes in plasma lipid profiles, and (2) to determine the effect of fenofibrate, an activator of peroxisome proliferator activated receptor alpha (PPAR $\alpha$), on plasma lipid profiles in normal rats on a standard diet. Male Sprague-Dawley (SD) rats (n=15) were fed standard chow and water from 10 to 25 weeks of age. During that period, we measured daily food intake, body weight, fasting and random blood glucose levels, plasma total cholesterol (TC), triglycerides (TG), and free fatty acid (FFA) levels. At 20 weeks of age, all rats were randomly divided into two groups: a fenofibrate group (in which rats were gavaged with 300 mg/kg/day of fenofibrate) and a control group (gavaged with water). Fenofibrate treatment lasted 5 weeks. There were no significant changes in daily food intake, blood glucose, and plasma TG level with age. Body weight, plasma TC, and FFA levels were significantly increased with age. Fenofibrate significantly decreased plasma concentrations of TC and FFA, which had been increased with age. However, fenofibrate did not influence the plasma concentration of TG, which had not increased with age. These results suggest that fenofibrate might have a novel role in preventing age-related hypercholesterolemia in SD rats on a normal diet.

Effects of Portulaca oleracea Powder on the Lipid Levels of Rats Fed a Hypercholesterolemia Inducing Diet

  • Lee, Soo-Jung;Shin, Jung-Hye;Kang, Min-Jung;Kim, Mi-Ju;Kim, Sung-Hee;Sung, Nak-Ju
    • Preventive Nutrition and Food Science
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    • v.16 no.3
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    • pp.202-209
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    • 2011
  • This study was initiated to investigate the effects of lyophilized purslane (Portulaca oleracea) powder (5% and 10%) on lipid levels in rats fed a hypercholesterolemia-inducing diet (1% cholesterol). During the four week study, there were no significant differences in either weight change or the food efficiency ratio between the group fed the hypercholesterol diet alone (HC) and the groups fed the purslane powder (HCPO-I and HCPO-II, 5% and 10% purslane, respectively). In serum, the levels of total lipid, total cholesterol and LDL-C decreased significantly for the group fed the 10% purslane powder (HCPO-II) in comparison with the group fed the 5% purslane powder (HCPO-I). The atherogenic index (AI) was reduced by about 51% for the group fed the 10% purslane powder (1.47) in comparison with the HC group (3.03). The activities of GOT, GPT, ALP and LDH decreased significantly for the groups fed the purslane powder in comparison with the HC group. Regarding liver tissue, the levels of total lipid, total cholesterol and triglyceride decreased significantly for the purslane powder-fed rats compared to the HC group. The fecal lipid profiles increased significantly as the amount of purslane powder was increased. Compared to the HC group, the fecal total cholesterol and triglyceride levels were higher in the group fed the 10% purslane powder by about 2.8 times and 2.3 times, respectively. For the serum and liver tissue, the content of lipid peroxide decreased significantly in the groups fed purslane powder compared to the HC group. The data from this experiment show an increase in the lipid levels discharged in feces, suggesting that the supplementation of purslane powder to a hypercholesterolemia-inducing diet reduces lipid levels.