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PR페이지 - 한국 HP, 인디고 위크 기자간담회 개최

  • Jo, Gap-Jun
    • 프린팅코리아
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    • v.13 no.11
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    • pp.95-95
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    • 2014
  • 한국HP는 지난 10월 13일부터 17일까지 HP 인디고 파주 데모센터에서 미디어 관계자, 고객사를 대상으로 HP 인디고 위크 행사를 개최했다. 또한 첫째 날인 13일에는 기자간담회를 통해 연포장 및 골판지 분야를 포함하는 패키징 시장에 대한 비즈니스 전략을 강화할 계획이라고 밝혔다.

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Renoprotective Effect of Hominis Placenta Aqua-acupuncture in Streptozotocin Induced Diabetic Rats (자하차약침(紫河車藥鍼)이 당뇨유발(糖尿誘發) 흰쥐의 신장보호기능(腎臟保護機能)에 미치는 영향(影響))

  • You, Jin-ho;Choi, Do-young;Kang, Sung-gil
    • Journal of Acupuncture Research
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    • v.19 no.4
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    • pp.152-166
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    • 2002
  • Objective : This study was undertaken to determine whether Hominis Placenta(HP) aqua-acupuncture exerts renoprotective effect on diabetic nephropathy induced by streptozotocin(STZ) in rats. Methods : In order to study the renoprotective effect of HP aqua-acupuncture, experimental animals were divided into 5 groups and treated for 2 weeks as follows: control group was injected subcutaneously by saline aqua-acupuncture into Sinsu(BL23) in STZ induced diabetic rats, 5% HP aqua-acupuncture group was injected subcutaneously by 5% HP aqua-acupuncture into Sinsu(BL23) in STZ induced diabetic rats, 10% HP aqua-acupuncture group was injected subcutaneously by 10% HP aqua-acupuncture into Sinsu(BL23) in STZ induced diabetic rats, normal group was injected subcutaneously by saline aqua-acupuncture into Sinsu(BL23) in normal rats, and Captopril group was administrated with captopril at a dose of 50mg/kg in STZ induced diabetic rats. Results : While HP aqua-acupuncture did not reduce any body weight, index of kidney hypertrophy, the plasma glucose concentration and BUN respectively, HP aqua-acupuncture showed lowering urinary albumin excretion rate and serum creatinine as compared with the control group. Gene and protein expressions of $TGF-{\beta}1$ and fibronectin in kidney, one of the extracellular matrix proteins were investigated. There were significant differences in expression levels in HP aqua-acupuncture group as compared with the control group, and $100{\mu}g/m{\ell}$ and $500{\mu}g/m{\ell}$ of HP depressed apoptosis, showing in a dose dependent manner. In the HE staining, HP aqua-acupuncture inhibited the injury of glomerulus and proximal convoluted tubule. Conclusions : HP aqua-acupuncture showed the renoprotective effect possibly through suppressions of $TGF-{\beta}1$ and fibronectin expressions in kidney.

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Study on the Satellite Thermal Control Hardware Composed of Two Parallel Channels Working for Heat Pipe and Phase Change Material (열관과 상변화물질을 일체형으로 병렬 배열한 위성용 열제어 부품 연구)

  • Kim, Taig-Young;Hyun, Bum-Seok;Lee, Jang-Joon;Rhee, Ju-Hun
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.38 no.11
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    • pp.1087-1093
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    • 2010
  • The satellite thermal control H/W composed of two parallel channels working for heat pipe (HP) and phase change material (PCM) is suggested for the high heat dissipating component which works intermittently with short duty. In a limited point of view, the HP-PCM device is a kind of off-the-shelf component that requires no dedicated configuration and thermal designs to PCM. Therefore, it can be used with less impact on the program cost and schedule different from most of the PCM applications. In present study the typical honeycomb structure radiator applying the HP-PCM device is designed and the detail thermal math model is developed for numerical analyses. The result comparison between without and with PCM shows that the HP-PCM device redistributes the peak heat around the whole mission period through the alternate melting and freezing of PCM, and, as a result, the maximum and minimum temperatures are effectively alleviated. The drawback of PCM application due to low thermal conductivity can be successfully resolved by means of parallel arrangement of HP channel.

Neuroprotection of Dopaminergic Neurons by Hominis Placenta Herbal Acupuncture in in vitro and in vivo Models of Parkinson's Disease Induced by MPP+/MPTP Toxicity

  • Jun, Hyung Joon;Nam, Sang Soo;Kim, Young Suk
    • Journal of Acupuncture Research
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    • v.32 no.1
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    • pp.23-36
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    • 2015
  • Objectives : This study was designed to investigate the neuroprotective effects of Hominis-Placenta (HP)on dopaminergic neurons. Methods : We examined the effect of invitro administration of HP against 1-methyl-4-phenylpyridinium( MPP+)-induced dopaminergic cell loss in primary mesencephalic culture and also used behavioral tests and performed analysis in the striatum and the substantia nigra of mouse brain, to confirm the effect of HP on dopaminergic neurons in an invivo 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mouse model. Animals were assigned to four groups: (1) Group 1(vehicle-treatedgroup), (2) Group 2(MPTPonlytreated group), (3) Group 3(MPTP+ saline-treated/$ST_{36}$ group), and (4) Group 4(MPTP+HP-treated/$ST_{36}$ group). HP at $20{\mu}L$ of 48 mg/kg dose was injected at $ST_{36}$ for 4 weeks at 2-day intervals. MPTP in saline was injected intraperitoneally each day for 5 days from the $8_{th}$ treatment of HP. We performed the pole test and rota-rod test on the first and seventh day after the last MPTP injection. To investigate the effect of HP on dopaminergic neurons, we performed analysis in the striatum and the substantia nigra of mouse brain after treatment with HP and/or MPTP. Results : Treatment with HP had no influence on cell proliferation and caused no cell toxicity in $PC_{12}$ and $HT_{22}$ cells. Our study showed that HP significantly prevented cell loss and protected neurites against MPP+ toxicity. Although the invivo treatment of HP herbal acupuncture at $ST_{36}$ showed a tendency to improve movement ability and protected dopaminergic cells and fibers in the substantia nigra and the striatum, it did not show significant changes compared with the MPTP treated group. Conclusions : These data suggest that HP could be a potential treatment strategy in neurodegenerative diseases such as Parkinson's disease.

Inflammatory Regulation by Haptoglobin in A549 Cells (A549 폐 상피세포에서 합토글로빈에 의한 염증반응 조절)

  • Kim Nam-Hoon;Lee Myung-Jae;Kim In-Sook
    • Journal of Life Science
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    • v.16 no.3
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    • pp.500-504
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    • 2006
  • Haptoglobin (Hp) is an acute phase protein, and its plasma level increases consistently in response to inflammation. To investigate the biological role of Hp in lung epithelial cells, the gene expressions of cyclooxygenase-2 (COX-2) and inflammatory cytokines were analyzed using human Hp gene-transfected A549 cells. Western blot analysis showed that COX-2 expression was markedly increased in Hp DNA-transfected cells (stable transfection and transient transfection) compared with that in vehicle DNA-transfected cells. When the Hp-expressing cells were treated with $1{\mu}g/ml$ of LPS or 100 U/ml of $IL-1{\beta}$ for 24 hr, the COX-2 expression was synergistically up-regulated. ACP-based PCR data demonstrated the Hp decreased SPARC expression, but increased IL-4 and S100AI expressions. These findings suggest that the Hp acts as a pro-inflammatory mediator in lung inflammation.

Helicobacter pylori infection and abdominal pain in children (Helicobacter pylori 감염과 소아 복통)

  • Seo, Jeong Kee
    • Clinical and Experimental Pediatrics
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    • v.49 no.2
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    • pp.136-143
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    • 2006
  • The relationship between H. pylori(Hp) infection and recurrent abdominal pain(RAP) in children is not clear. Current data in the literature regarding a causal relationship between Hp infection and childhood RAP are conflicting. However, meta-analysis and most of the recently published studies have not supported an association between Hp infection and an increased prevalence of abdominal pain. Most published studies have some problems and have been criticized on methodological grounds. Most of the existing studies have not been designed to include double-blind placebo controls. And, because of the low incidence of Hp infection in children, they have a problem of obtaining sufficient numbers of the Hp infected children. There is also a concern about the heterogeneity of testing methodology in the studies and diagnostic accuracy problems of the non-invasive tests such as low sensitivity of the serology tests and false positive results of the UBT in children. And conflicting results may be explained, in part, by the poor definition of RAP or dyspepsia for the study subjects. To date, no consensus exists for the treatment of Hp-infected children with RAP. Some authors suggest the clinical efficacy of Hp. But others suggest that eradication of Hp is not associated with improvement of RAP. The problem of the most treatment studies is that they had usually no control groups and the number of the subjects was small. In order to make reasonable decisions about treatment of Hp infection in children with RAP, long-term, randomized, double blind, well controlled studies in large numbers of children will be required.

Backbone 1H, 15N and 13C Resonance Assignment and Secondary Structure Prediction of HP0062 (O24902_HELPY) from Helicobacter pylori

  • Jang, Sun-Bok;Ma, Chao;Park, Sung-Jean;Kwon, Ae-Ran;Lee, Bong-Jin
    • Journal of the Korean Magnetic Resonance Society
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    • v.13 no.2
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    • pp.117-125
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    • 2009
  • HP0062 is an 86 residue hypothetical protein from Helicobacter pylori strain 26695. HP0062 was identified ESAT-6/WXG100 superfamily protein based on structure and sequence alignment and also contains leucine zipper domain sequence. Here, we report the sequence-specific backbone resonance assignment of HP0062. About 97.7% of all $^1H_N,\;^{15}N,\;^{13}C_{\alpha},\;^{13}C_{\beta}\;and\;^{13}C=O$ resonances were assigned unambiguously. We could predict the secondary structure of HP0062 by analyzing the deviation of the $^{13}C_{alpha}\;and\;^{13}C_{\beta}$ chemical shifts from their respective random coil values. Secondary structure prediction shows that HP0062 consist of two ${\alpha}$-helices. This study is a prerequisite for determining the solution structure of HP0062 and can be used for the study on interaction between HP0062 and DNA and other Helicobacter pylori proteins.

The Diagnostic Usefulness of Endoscopic Findings and Detection Rates of CLO and HpKit Test for Helicobacter pylori Infection in Children (소아의 Helicobacter pylori 감염에 있어서 위내시경 소견의 진단적 의의와 CLO 및 HpKit 검사의 검출률)

  • Lee, Seung Yeon;Yoo, Ji Hyung;Chung, Ki Sup
    • Clinical and Experimental Pediatrics
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    • v.45 no.4
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    • pp.482-488
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    • 2002
  • Purpose : We performed this study to evaluate the diagnostic usefulness of endoscopic finding of nodular gastritis, CLO and HpKit test for H. pylori infection in children. Methods : Gastroduodenal endoscopy and mucosal biopsy were performed on 212 children who visited our hospital between Jul. 1999 and May 2000 due to abdominal pain. We performed CLO and HpKit test for H. pylori with the time interval of 15, 30 minutes, 1, 2, 3, 24, 48, 72, 96, 120 and 144 hours. Histological examination of H. pylori was made by H-E or Alcian yellow stain with biopsy specimens. Sensitivity, specificity, positive predictive and negative predictive value of nodular gastritis, CLO and HpKit test were calculated from the analysis of above data. Results : Sensitivity and specificity of 3 hour-CLO test was 68.4% and 100% respectively. Sensitivity and specificity of 3 hour-HpKit test was 65.8% and 100% respectively. No significant difference in sensitivity and specificity was found between in 3 hour-CLO and HpKit test(P>0.05). Sensitivity of CLO test increased as time lapsed, but corresponding specificity did not decrease as time lapsed(sensitivity and specificity at 144 hours : 89.5% and 94.8% respectively). However, sensitivity of HpKit test increased as time lapsed, but specificity markedly decreased. Sensitivity and specificity of the nodular gastritis was 78.9% and 93.7% respectively. Conclusion : Both CLO and HpKit test have relatively low sensitivity and specificity for the detection of H. pylori in 3 hours of testing in children. The endoscopic finding of nodular gastritis is another good standard in the diagnosis of H. pylori infection in children.

Effects of Egg Size and Eggshell Conductance on Hatchability Traits of Meat and Layer Breeder Flocks

  • Shafey, Tarek M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.15 no.1
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    • pp.1-6
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    • 2002
  • Eggs obtained from 46 and 42 weeks old meat (Hybro) and layer (Leghorn) breeders flocks, respectively were used to examine the effects of genetic type of birds and egg size (small, medium and large) on variables of eggshell characteristics and hatchability traits. The variables measured were egg weight (EW), egg surface area (ESA) and eggshell characteristics (shell conductance (EC), per cent shell (PS), shell thickness (ST), shell volume (SV), shell density (SD) and hatchability traits (per cent hatchability (HP), early dead embryos (ED), late dead embryos (LD), pips with live embryos (PL) and pips with dead embryos (PD)). Genetic type of bird influenced all egg characteristics and HP of eggs. Eggs produced by the small Leghorn bird had lower EW, ESA, EC, ST, SV and HP than those produced by the heavy Hybro bird. The reduction of HP was associated with an increase in the percentage of ED and PL. Egg size influenced all variables measured except ST. Small size eggs had lower EW, ESA and EC and higher PS and SD than those of large eggs. Medium size eggs produced a higher HP when compared with that of large size eggs. The reduction of HP in large eggs was associated with higher percentage of ED, LD and PL. There were significant interactions between the genetic group of birds and egg size on LD and HP. Large egg size of Hybro birds had higher LD and lower HP than those of small size eggs produced by the same flock. However, There was no difference in HP and LD among the different egg sizes produced by Leghorn birds. It was concluded that genetic make up of birds and egg size influence eggshell characteristics and HP. The type of bird (heavy or small) influences the optimum egg size for successful hatching. Attention should be given to the size and eggshell characteristics of eggs of breeders' flocks for achieving maximum HP.