• Title, Summary, Keyword: Homer3

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Growth and Differentiation Effects of Homer3 on a Leukemia Cell Line

  • Li, Zheng;Qiu, Hui-Ying;Jiao, Yang;Cen, Jian-Nong;Fu, Chun-Mei;Hu, Shao-Yan;Zhu, Ming-Qing;Wu, De-Pei;Qi, Xiao-Fei
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.4
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    • pp.2525-2528
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    • 2013
  • The Homer protein family, also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3). Homer3 can regulate transcription and play a very important role in the differentiation and development for some tissues (e.g. muscle and nervous systems). The current studies showed that Homer3 abnormal expression changes in acute myeloid leukemia (AML). Forced expression of Homer3 in transfected K562 cells inhibited proliferation, influenced the cell cycle profile, affected apoptosis induced by $As_2O_3$ through inhibition of Bcl2 expression, and also promoted cell differentiation induced by 12-O-tetra decanoylphorbol-acetate (TPA). These results showed that Homer3 is a novel gene which plays a certain role in the occurrence and development of AML.

Homer2 regulates amylase secretion via physiological calcium oscillations in mouse parotid gland acinar cells

  • Kang, Namju;Kang, Jung Yun;Shin, Dong Min;Yang, Yu-Mi
    • International Journal of Oral Biology
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    • v.45 no.2
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    • pp.58-63
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    • 2020
  • The salivary glands secrete saliva, which plays a role in the maintenance of a healthy oral environment. Under physiological conditions, saliva secretion within the acinar cells of the gland is regulated by stimulation of specific calcium (Ca2+) signaling mechanisms such as increases in the intracellular Ca2+ concentration ([Ca2+]i) via storeoperated Ca2+ entry, which involves components such as Orai1, transient receptor potential (TRP) canonical 1, stromal interaction molecules, and inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs). Homer proteins are scaffold proteins that bind to G protein-coupled receptors, IP3Rs, ryanodine receptors, and TRP channels. However, their exact role in Ca2+ signaling in the salivary glands remains unknown. In the present study, we investigated the role of Homer2 in Ca2+ signaling and saliva secretion in parotid gland acinar cells under physiological conditions. Deletion of Homer2 (Homer2-/-) markedly decreased the amplitude of [Ca2+]i oscillations via the stimulation of carbachol, which is physiologically concentrated in parotid acinar cells, whereas the frequency of [Ca2+]i oscillations showed no difference between wild-type and Homer2-/- mice. Homer2-/- mice also showed a significant decrease in amylase release by carbachol in the parotid gland in a dose-dependent manner. These results suggest that Homer2 plays a critical role in maintaining [Ca2+]i concentration and secretion of saliva in mouse parotid gland acinar cells.

Optimization of Residential Photovoltaic-Fuel Cell Hybrid System Using HOMER(R) (HOMER를 이용한 가정용 태양광-연료전지 하이브리드시스템의 운전 최적화)

  • Park, Se-Joon;Li, Ying;Choi, Young-Sung;Lee, Kyung-Sup
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.59 no.1
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    • pp.129-133
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    • 2010
  • A hybrid system which is combined several complementary new and renewable power sources, such as photovoltaic, fuel-cell, and wind generator, etc., has been presented in various approaches. For instance, a photovoltaic cannot always generate stable output power with ever-changing weather condition, so it might be co-generated with a wind generator, diesel generator, and some other sources. In this paper, a residential PV-FC hybrid system is suggested as a distribution power source, and its operation is optimized by HOMER$^{(R)}$. As a result, it is the most economic that 5[kW] PV, 1[kW] FC, 4 batteries, 2[kW] electrolyzer, 0.5[kg] $H_2$ tank, 3[kW] converter are applied to the hybrid system.

Capacity Optimizing method of Distributed Generators in Stand-Alone Microgrid Considering Grid Link-Characteristics

  • Han, Soo-Kyeong;Choi, Hyeong-Jin;Cho, Soo-Hwan
    • Journal of Electrical Engineering and Technology
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    • v.13 no.4
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    • pp.1483-1493
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    • 2018
  • Recently, more power facilities are needed to cope with the increasing electric demand. However, the additional construction of generators, transmission and distribution installations is not easy because of environmental problems and citizen's complaints. Under this circumstance, a microgrid system with distributed renewable resources emerges as an alternative of the traditional power systems. Moreover, the configuration of power system changes with more DC loads and more DC installations. This paper is written to introduce an idea of a genetic algorithm-based solution to determine the optimal capacity of the distributed generators depending on the types of system configuration: AC-link, DC-link and Hybrid-link types. In this paper, photovoltaic, wind turbine, energy storage system and diesel generator are considered as distributed generators and the feasibility of the proposed algorithm is verified by comparing the calculated capacity of each distributed resource with HOMER simulation results for 3 types of system configuration.

Conjugated Copolymers by Horner-Emmons Polycondensation and Electroluminescence Characteristics

  • Park, Lee-Soon;Jeong, Seung-Won;Kim, Sang-Dae;Seo, Hyeon-Jin
    • Journal of Information Display
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    • v.2 no.2
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    • pp.45-51
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    • 2001
  • Four types of conjugated polymers, poly(MEHPV-PV), poly(MEHPV-BPV), poly(MEHPV-AV) and poly(PZV-AV) were synthesized by Homer-Emmons reaction using potassium tert-butoxide. The Homer-Emmons reaction gave electroluminescent(EL) copolymers in good yield. Of the EL copolymers synthesized, poly(PZV-AV) containing phenothiazinylene vinylene and anthrylene vinylene as repeat unit exhibited red color in the light emitting diode(LED) which was very close to the NTSC standard red. Besides, double layer LED made with $Alq_3$ electron transport layer exhibited both enhanced emission intensity and efficiency compared to the single layer LED.

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System Thinking on Diabetes Prevention and Management (당뇨병 예방 및 관리의 시스템 사고)

  • Noh, Young-Min;Lee, Ji-Uhn;Park, Jun-Hee;Choi, Nam-Hee;Homer, Jack B.;Yun, Eun-Kyoung
    • Korean System Dynamics Review
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    • v.17 no.1
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    • pp.25-40
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    • 2016
  • This research aims to identify important variables and their effects on diabetes prevention or progression from prediabetes to diabetic complication using system thinking. Based on the existing studies, we have constructed a causal loop diagram explaining dynamics of diabetes and have found 7 important reinforcing loops and 3 balancing loops in the causal loop diagram. The CLD displays an effect of increasing prediabetes early detection and awareness on diabetes prevention. The findings indicate that the projects in Korea for reducing incidence of diabetes and potential risk of complication have focused on variables which are related only on diabetes even though prediabetes has been a critical point on diabetes prevention and management. Thus, it also concludes that the effect of projects focusing only on diabetes have faced limitation to manage diabetes accordingly.

Peripheral Vestibular Syndrome in a Cat with Foreign Body Otitis Media/Interna

  • Gu, Su-Hyun;Jung, Dong-In;Kang, Byeong-Teck;Kim, Ju-Won;Yoo, Jong-Hyun;Park, Chul;Park, Hee-Myung
    • Journal of Veterinary Clinics
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    • v.25 no.3
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    • pp.192-194
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    • 2008
  • A 15-month-old, intact male, domestic short hair cat was presented with ataxia, protrusion of the right third eyelid, and anorexia. Clinical signs were firstly noted after ear cleaning at home. Symptoms of the Homer's syndrome were evident. However, postural and proprioceptive reaction deficits were not detected on neurologic examination. Otoscopic examination revealed foreign body in right ear canal. A diagnosis of peripheral vestibular syndrome was made based on results of physical examination including neurologic and otic examination, blood work, and magnetic resonance imaging (MRI). Based on these examinations, the present patient was definitely diagnosed as otitis medial interna induced by foreign body. The vestibular signs were resolved 10 days after removal of cotton tips in right ear canal. This case report indicates that home-care cotton swab can iatrogenically induce otitis media/interna in cats.

The Oxidation of Hydrazobenzene by Oxygen Catalysed by Co (3MeOsalen) in Methanol

  • Homer Roger B.;Cannon Roderick D.;Kim Stephen S.B.
    • Bulletin of the Korean Chemical Society
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    • v.6 no.2
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    • pp.115-118
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    • 1985
  • The oxidation of hydrazobenzene by oxygen in methanol solution is catalysed by Co(3MeOsalen) which is a synthetic oxygen carrier. The products are trans-azobenzene and water. The rate of the reaction has been studied spectrophotometrically and the rate law established. A mechanism involving a ternary complex of catalyst, hydrazobenzene and oxygen has been proposed.

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Horner's Syndrome: A Rare Complication of Tube Thoracostomy - A case report - (폐쇄식 흉강삽관술 후 발생한 호너 증후군 - 치험 1예 -)

  • Choi, Jae-Woong;Kim, Joo-Hyun;Yoo, Byung-Su;Kang, Chang-Hyun;Kim, Young-Tae
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.43 no.6
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    • pp.816-819
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    • 2010
  • We report one case of Horner's syndrome, a rare complication of closed thoracostomy. A 17 year-old girl with a second attack of left side primary spontaneous pneumothorax visited an emergency room. After closed tube thoracostomy, she was admitted to a general ward for elective video-assisted thoracosopic bullectomy, which was delayed due to incidental right side acute otitis media. On the third day of admission, she presented with pain and discomfort in the left eye. Further examination revealed left side ptosis and miosis and led to a diagnosis of Homer's syndrome. The chest tube was pulled back 2 to 3 cm for repositioning. After two days she underwent video-assisted thoracoscopic bullectomy and mechanical pleurodesis and was discharged at postoperative day 7. Symptoms and signs of Homer's syndrome gradually resolved, and she had fully recovered at the 2 month postoperative outpatient follow-up.

An Economic Feasibility Study of Wind-Diesel Hybrid Power Systems for an Island in the Yellow Sea (서해 도서지역의 풍력-디젤 하이브리드 발전에 대한 경제성 분석)

  • Lee, Tak-Kee;Nam, Yong-Yun;Kim, Jae-Dong;Han, Jeong-Woo
    • Journal of Navigation and Port Research
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    • v.35 no.5
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    • pp.381-385
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    • 2011
  • In this paper, an economic feasibility study of wind-diesel hybrid power systems for an island in the Yellow Sea, where the maximum power generation is about 500kW, was performed. For the study, annual electric load variation and wind resource data of the island were collected and analyzed. HOMER program - a typical hybrid optimization model for electric renewables including wind resource, developed by the National Renewable Energy Laboratory - was used. Wind speed and diesel price were picked out as variables for the sensitivity analysis in order to find the economic accountability for the wind-diesel hybrid power system. As the result, even though it is not feasible economically under the present condition, if mean wind speed is over 3 m/sec. or diesel price goes up to 2.4 $ per liter, the wind-diesel hybrid power system for the island becomes a prospective candidate.