• Title, Summary, Keyword: HDL-cholesterol

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The Relationship Between Serum Triglyceride/HDL Cholesterol, Total Cholesterol/HDL Cholesterol, LDL Cholesterol/HDL Cholesterol Ratios and Cardiovascular Disease Risk Factors in Korean Adults: Using the 2016 Korea National Health and Nutrition Examination Survey Data (한국 성인에서 혈청 중성지방/고밀도 콜레스테롤, 총 콜레스테롤/고밀도 콜레스테롤, 저밀도 콜레스테롤/고밀도 콜레스테롤 비와 심혈관 질환 위험요인들과의 관련성: 2016년도 국민건강영양조사 자료를 이용하여)

  • Yoo, Areum;Shin, Saeron
    • Journal of The Korean Society of Integrative Medicine
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    • v.7 no.3
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    • pp.127-139
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    • 2019
  • Purpose : The lipid profile is a major predictive index for cardiovascular disease, but there have only been a few studies conducted on the relationship between lipid ratio and cardiovascular disease risk factors in the Korean population. To address this research gap, we investigated the association between three lipid ratios and cardiovascular disease risk factors among Korean adults. Methods : This study used data from the seventh Korea National Health and Nutrition Examination Survey conducted in 2016. Lipid ratios included triglyceride (TG)/high density lipoprotein cholesterol (HDL), total cholesterol (TC)/HDL, and low density lipoprotein cholesterol (LDL)/HDL. Cardiovascular risk factors included in this research were: systolic blood pressure $(SBP){\geq}140$, diastolic blood pressure $(DBP){\geq}90$, fasting blood sugar $(FBS){\geq}126$, $HbA1c{\geq}6.5$, body mass index $(BMI){\geq}25$, waist circumference (WC) $men{\geq}90$, $women{\geq}85$, and metabolic syndrome (MetS). A complex samples logistic regression test was performed to analyze the association between lipid ratios and cardiovascular disease risk factors. Results : 1) TG/HDL ratio had statistically significant relationships with DBP, FBS, HbA1c, BMI, WC and MetS. 2) TC/HDL ratio was correlated to SBP, DBP, FBS, BMI, WC, and MetS. 3) LDL/HDL ratio had association with BMI, WC, and MetS. Conclusion : We identified significant association between lipid ratios and cardiovascular disease risk factors. The three lipid ratios were particularly strongly associated with BMI, WC, and MetS.

A Analysis on Serum Total Cholesterol, Atherogenic Index of Medical Check-up Subjects in One University Hospital by Age and Sex (종합 건강검진자에서의 성별.연령별 혈청 총콜레스테롤, 동맥경화지수의 상호연관성 분석)

  • Suk, Sung-Ja;Yoo, Wang-Keun
    • Journal of Society of Preventive Korean Medicine
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    • v.10 no.1
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    • pp.67-74
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    • 2006
  • Objectives: This study was carried out to establish the normal values of Serum Total Cholesterol, HDL-cholesterol by age and sex for healthy adult and the frequency of dyslipidemia as a risk factor of coronary atherosclerosis. Methods: Total cholesterol, and HDL-cholesterol measured among 14,485 in general growing people (8,712 males and 5,773 females) aged 20 to 69 years and analyzed to use the auto-analyzer Hitach 7600 in enzyme method. Result: 1. The levels of total cholesterol, HDL-cholesterol and atherogenic index were slightly positively correlated with age in both sexes. The mean values of serum lipid profiles were $190{\pm}32.9mg/dl$ in men and $181{\pm}32.8mg/dl$ in women for cholesterol, $50.1{\pm}11.4mg/dl$ in men and $54.5{\pm}12.0mg/dl$ in women for HDL-cholesterol, $3.9{\pm}1.0$ in men and $3.4{\pm}0.8$ in women for atherogenic index. 2. Mean values of total cholesterol and atherogenic index higher in men than in women at the age 20-40 years but significantly higher in women than in men at the age group 60 years.(p<0.001) 3. The frequency of hypercholesterolemia(${\geq}200mg/dl$) and low HDL-cholesterol(<35mg/dl) were increased with age in both sexs, significantly higher in women at the age group 60 years. The frequency of hypercholesterolemia(${\geq}200mg/dl$) and low HDL-cholesterol(<35mg/dl) in men and women was 37.5%, 25.3%, and 5.5%, 2.8%. Their requencies were higher in men than in women. Conclusion: Theses findings suggest that the mean concentrations of total cholesterol and HDL-cholesterol in men and women vary with age. The frequency of hypercholesterolemia(${\geq}200mg/dl$) in men and women was about 31.4% and increased with age.

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Lipoprotein Lipase Polymorphism rs10503669 is Associated with High-density Lipoprotein Cholesterol Levels in Korean Population

  • Sull, Jae Woong;Eom, Yong-Bin;Jee, Sun Ha
    • Biomedical Science Letters
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    • v.20 no.4
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    • pp.221-226
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    • 2014
  • High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated Lipoprotein lipase (LPL) as possibly being causal. Herein, the association between single nucleotide polymorphism (SNP) rs10503669 in the LPL gene and HDL cholesterol levels and triglyceride levels was tested in the Korean population. A total of 994 subjects from Seoul City were included in a replication study with LPL SNP rs10503669. SNP rs10503669 in the LPL gene was associated with mean HDL cholesterol levels (effect per allele 3.13 mg/dL, P<0.0001) and triglyceride levels (effect per allele -18.0 mg/dL, P=0.0026). Subjects with the CA/AA genotype had a 0.42-fold (range 0.23~0.77-fold) lower risk of having abnormal HDL cholesterol levels (<40 mg/dL) than subjects with the CC genotype. When analyzed by gender, the association of LPL was stronger in men than in women. This study clearly demonstrates that genetic variants in LPL influence HDL cholesterol levels and triglyceride levels in Korean adults.

Assessment of the Optimum LDL : HDL-cholesterol(LDL : HDL-C) Ratio for Predicting CHD (심혈관질환 예측을 위한 저밀도 대 고밀도 지단백 콜레스테롤 비(LDL : HDL-cholesterol ratio)의 적정기준에 관한 연구)

  • Yeoum, Soon-Gyo
    • Korean Journal of Adult Nursing
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    • v.20 no.6
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    • pp.917-931
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    • 2008
  • Purpose: This study was aimed to determine the optimum low-density lipoprotein : high-density lipoprotein-cholesterol (LDL : HDL-C) ratio for predicting coronary heart disease(CHD) in Korean people. Methods: It was analyzed this data of 5,431 adults who had undergone health examinations in a hospital in Gyeonggi-do between January 2006 and December 2007. The covariation of the coronary risk factors such as age, HbA1C, systolic blood pressure(SBP), and waist-to-stature ratio(WSR) were analyzed by using logistic regression analysis. Results: The LDL : HDL-C ratio in the male and female groups was mostly distributed between 1.5 and 4.0. The LDL : HDL-C ratio was the most significant cholesterol-related parameter influencing CHD (male: B = .306, p = .054, female : B = .940, p = .010), followed by LDL-C and total cholesterol. It was observed a sharp increase in the odds ratios for LDL : HDL-C ratios of 2.25 - 2.50(male) and 2.00 - 2.25(female). A significant difference was observed in both male(2.25 : $x^2$ = 2.494, p = .072) and female(2.00 : $x^2$ = 413.742, p = .000) groups. Conclusion: The risk level of CHD was set to 2.25 for males and 2.00 for females. Therefore, the optimum LDL : HDL-C ratio for Koreans should be far lower than that for the people in western countries.

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Effects of CPs (Combined Preparations) of Radix Salvia Miltiorrhiza, Radix Notoginseng, and Borneolum on Hyperlipidemia (CPs(단삼, 삼칠, 빙편 복합제)가 고지혈증에 미치는 영향)

  • 이건목;이길숭
    • The Journal of Korean Medicine
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    • v.25 no.2
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    • pp.22-32
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    • 2004
  • Objectives: In order to determine the effect of CPs, experimental studies were performed in hyperlipidemia humans. The contents of serum total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine were measured. Methods: We made a comparative study of total cholesterol, TG (triglyceride), LDL cholesterol, HDL cholesterol, AST/ALT and BUN/creatinine during one month off and on for twenty patients with hyperlipidemia who visited Gunpo Oriental Medical Center of Wonkwang University from December 2002 to July 2003. Results: The following result were obtained: 1. The serum TG and total cholesterol of patients who took CPs for one month showed significant (p<0.01) decrease. 2. The serum HDL-cholesterol and LDL-cholesterol of patients who took CPs for one month showed significantly increase in HDL, and decrease in LDL (p<0.05). 3. The serum AST/ALT and BUN/creatinine of patients who took CPs for one month showed no significant effects. Conclusions: According to the results mentioned above, the effects of CPs on serum triglyceride and total cholesterol of hyperlipidemia patients were significantly confirmed for decreasing effects.

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Genome-wide Linkage Study for Plasma HDL Cholesterol Level in an Isolated Population of Mongolia

  • Park, Han-Soo;Kim, Jong-Il;Cho, Sung-Il;Sung, Joo-Hon;Kim, Hyung-Lae;Ju, Young-Seok;Bayasgalan, Gombojav;Lee, Mi-Kyeong;Seo, Jeong-Sun
    • Genomics & Informatics
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    • v.6 no.1
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    • pp.8-13
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    • 2008
  • High-density lipoprotein (HDL) whose primary role is to transport cholesterol from peripheral tissues to the liver, is associated with the incidence of coronary heart disease. We analyzed HDL cholesterol levels in a genetically isolated population of extended Mongolian families. A total of 1002 individuals (54.5% women) from 95 families were enrolled. After genotyping by use of 1000 microsatellite markers, we performed a genome-wide linkage search with variance component analysis. The estimated heritability of HDL cholesterol was 0.45, revealing that HDL cholesterol was under significant genetic influence. We found peak evidence of linkage (LOD score=1.88) for HDL cholesterol level on chromosome 6 (nearest marker D6S1660) and potential evidences for linkage on chromosomes 1, 12 and 19 with the LOD scores of 1.32, 1.44 and 1.14, respectively. These results should pave the way for the discovery of the relevant genes by fine mapping and association analysis.

Effects of Dietary Fat Level and P/S Ratio on HDL-cholesterol, Total Cholesterol and Triglyceride in Plasma and Selected Tissues of Rats (식이의 총지방량과 P/S Ratio가 Plasma HDL-Cholesterol과 혈장 및 조직내의 지질함량에 미치는 영향)

  • Park, Hyun-Suh
    • Journal of Nutrition and Health
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    • v.16 no.3
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    • pp.200-208
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    • 1983
  • The present studies were designed to compare the effects of both dietary fat levels and P / S ratio on lipid components in plasma and tissues. Changes in plasma HDL-cholesterol, cholesterol and TG, and also in tissue cholesterol and TG were determined in young rats fed diets providing total dietary fat as 10%, 25% or 45% of calories and P / S ratio as 0.2 or 4.0. Plasma cholesterol levels were getting higher as dietary fat levels increased at P / S 0.2. Plasma cholesterol was lower in rats fed dietary fat either 25% or 45 %, each with P / S 4.0. But at 10% no change in plasma cholesterol were observed by P / S 4.0 because of a possible insufficiency of the absolute amount of PUFA. HDL-cholesterol was rather less sensitive to the modification of dietary fat level, but was reduced in rats fed diets of P / S 4.0 at either 25% or 45% fat, even though HDL-cholesterol were increased in the group of 10% with P / S 0.2. Total cholesterol per g- liver were significantly increased as dietary fat levels increased. Liver cholesterol levels were higher in rats fed diets of P / S 4.0 at higher fat levels (25% or 45%) which possibly suggested that a reduction of plasma cholesterol by high PUFA diet was not at least from a decreased synthesis of cholesterol in liver. However, in muscle no significant differences were found by feeding high P / S ratio at each levels of fat. At 10% fat level, compared to 25% or 45%, cholesterol level was lower in g-liver but higher in g- muscle. Plasma TG was decreased as more dietary fat were supplied at P / S ratio, but no consistant response obtained at low P / S ratio. TG per g-liver were reduced by feeding P / S 4.0 diet at 10% or 45% fat level but no differences were found in muscle. P / S 4.0 diet was more efficient in lowering plasma cholesterol TG and HDL-cholesterolt levels only if fat level was more than 25% of the total calories And young rats were more resistant to dietary fat modification.

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The Relationships of Serum Mg, Ca, Ca/Mg Ratio with Serum Lipid Profiles in College Women Living Choong-Nam Area (일부 충남지역 여대생의 혈청 마그네슘(Mg), 칼슘(Ca), 칼슘/마그네슘(Ca/Mg)비율과 혈청지질과의 상관관계 연구)

  • 김애정
    • Journal of the East Asian Society of Dietary Life
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    • v.8 no.4
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    • pp.379-387
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    • 1998
  • Magnesium(Mg) plays an important role in lipid metabolism and Mg deficiency but Ca sufficiency Increases serum cholesterol and triglyceride. The relationships of serum Mg, Ca, Ca/Mg ratio with lipids was examined in 79 female college students in Choong-Nam area. Subjects were divided into underweight, normal and overweight groups according to their BMI. The average age, body weight, height and BMI were 21.9yr, 55.9kg, 158.5cm and 22.62kg/$m^2$ respectively. Height was not different between groups. Serum cholesterol and LDL-cholesterol concentrations were significantly lower in the underweight group than other groups. BMI had positive correlations with LDL-cholesterol, atherogenic index (AI) and LDL-cholesterol/HDL-cholesterol ratio(LPH), and negative correlations with HDL-cholesterol/total cholesterol ratio. Serum minerals (serum Mg, Ca, Ca/Mg ratio) and serum lipid concentrations were not significantly different between groups. However, there was a tendency of increasing serum Mg level with increasing serum HDL-cholestrol, HDL-cholesterol/total cholesterol ratio and decreasing serum LDL-cholesterol, LPH, total cholesterol/HDL-cholesterol ratio(TPH) and AI. And there was a tendency of increasing serum Ca level with increasing serum HDL-cholesterol/total cholesterol ratio and decreasing serum triglyceride, LDL-cholesterol, LPH, TPH and AI. And there was a tendency of increasing serum Ca /Mg ratio level with decreasing triglyceride, serum LDL-cholesterol and TPH. This study was limited within serum levels of minerals (serum Mg, Ca and Ca/Mg ratio), serum lipids concerned with CHD, therefore I hope there will be wider efforts to consider about the dietary levels of minerals for presentation of the connection between dietary Mg, Ca and serum lipids.

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Comparison of Lipid Profile Ratios in Patients with High-grade Brain Cancers according to the Presence of Recurrence during Cancer-related Therapy (항암치료 받는 악성 뇌종양 환자의 재발여부에 따른 지질프로필 비율의 비교)

  • Kim, Sanghee
    • Journal of Korean Biological Nursing Science
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    • v.19 no.2
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    • pp.107-112
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    • 2017
  • Purpose: The purpose of this study was to identify the lipid profile ratios as factors affecting disease progress in patients with high-grade primary brain cancers undergoing concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy. Methods: The levels of lipid profile ratios were evaluated by looking at the total cholesterol (TC) to high-density lipoprotein (HDL)-cholesterol (TC/HDL-c), low-density lipoprotein (LDL)-cholesterol to HDL-cholesterol (LDL-c/HDL-c), and triglycerides to HDL-cholesterol (TG/HDL-c). This descriptive research was conducted 7 months after the initiation of CCRT and adjuvant chemotherapy. Results: A total of 36 patients with newly diagnosed primary malignant brain cancer were included in the study. The levels of lipid profile ratios such as TC/HDL-c, LDL-c/HDL-c, TG/HDL-c were significantly different between the patients with and without disease progress at 7 months after initiation of CCRT and adjuvant chemotherapy. Conclusion: The lipid profile ratios were indicators affecting disease prognosis with tumor-related factors at 7 months after initiation of CCRT and adjuvant chemotherapy. Therefore, lipid profile ratios indicating hyperlipidemia in patients with high-grade brain cancers should be carefully monitored during and after cancer-related therapy.

A Korean Family with Cholesterol Ester Transfer Protein Deficiency

  • Youn, Seo-Young;Shin, Ik-Soon;Hong, Yong-Hee;Lee, Dong-Hwan
    • Journal of Genetic Medicine
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    • v.9 no.1
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    • pp.38-41
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    • 2012
  • A 32-year-old female patient and her sister show high levels of high density lipoprotein (HDL) cholesterol in regular health checkups, since female patient was 11 years old. The patient's serum total cholesterol was 285 mg/dL and HDL cholesterol was 113 mg/dL. Her sister's total cholesterol was 240 mg/dL and the HDL cholesterol measured to be 90 mg/dL. Lipoprotein pattern and cholesteryl ester transfer activity gene analysis were examined in these patients. We found c.1321+1G>A (IVS14+1G/A) hetero mutation in cholesteryl ester transfer protein (CETP) genes. Generally, CETP mediates transfer and exchange of triglycerides and cholesteryl ester between plasma lipoproteins. Also we investigated a key role of HDL-CE and Apo A-1 metabolism. Patients with low levels of CETP have increased serum HDL levels. We hereby report two Korean cases of CETP deficiency in a family. Brief literature review ensues with the cases.