• Title, Summary, Keyword: Formulation changes

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Effect of a polyherbal formulation (Diarun plus) on the glycemic status modified by physiological means in non-diabetic mice and rats

  • G, Senthilvel;M, Jegadeesan;P, Thirugnanasambantham;E, Mayisvren;M, Balasubramanian;N, Narayanan;S, Viswanathan;Austin, Anoop
    • Oriental Pharmacy and Experimental Medicine
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    • v.7 no.2
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    • pp.128-132
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    • 2007
  • Diarun plus, a polyherbal formulation containing herbal ingredients of folkloric Antidiabetic effect, was investigated for its effect on glycemic status in rats and mice. In contrast to conventional chemical induced diabetic animal models, changes in glycemic states were induced by physiological maneuvers. Results revealed that in euglycemic animals Diarun plus elicited little change (-10 to +10%), which was insignificant. In food deprivation/swim exercise induced hypoglycemia, Diarun plus reduced the degree of hypoglycemia in both rats and mice (from 38% to 27% in rats and 45% to 32% in mice). Similarly, the marked hyperglycemia induced by dextrose (70% in rats and 95% in mice) was reduced markedly to 8% and 25% respectively. The findings of the present study suggests that the ingredients of Diarun plus have the unique property of maintaining near euglycemic state irrespective of the altered glycemic state, and that have no significant effect in euglycemic condition.

Optimization in Recipe of Sous Vide Packaged Seasoned Beef (Sous vide 포장된 소고기 장조림의 배합비 최적화)

  • Sung, Ho-Jung;Lyu, Eun-Soon;Lee, Dong-Sun
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.14 no.2
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    • pp.65-72
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    • 2008
  • Vinegar and/or sake are often added for preservation hurdle in Korean seasoned beef product, affecting sensory quality. Sous vide packaging formerly developed requires optimization of formulation recipe in these ingredients. Therefore this study looked into the effect of vinegar and sake on the sensory quality attributes by response surface methodology. The addition of vinegar lowered the product pH significantly but sake addition did increase it slightly. Water activity did not change with the addition of these. Ten day storage at $8^{\circ}C$ did not make any significant changes in salt content and water activity. The added vinegar and/or sake in the formulation degraded the hedonic sensory scores of the product. The storage of the product made the degradation effect less pronounced. For the stored product the effect of sake on taste, texture and flavor was greater than that of vinegar. The respective addition of vinegar and sake less 4.0 and 4.5% could maintain the required sensory quality and thus was suggested in this study as their affordable use level for preservation hurdle.

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Pigment Influence of High Density Polyethylene Electrical Strength (고밀도 폴리에틸렌의 전계 세기의 영향)

  • Choi, Yong-Sung;Wee, Sung-Dong;Hwang, Jong-Sun;Lee, Kyung-Sup
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • pp.50-53
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    • 2008
  • In this work, the $TiO_2$ pigment influence in HDPE dielectric strength was analyzed. Chemical and structural characterizations were made to identify changes during the processing and your influence in the electrical properties. Formulations containing 0, 0.5, 1, 2.5, 4 and 6 of titanium dioxide were processed by extrusion and injection molding with stabilization-antioxidants, ultraviolet stabilizers and plasticizers. The electrical strength tests were analyzed by the statistical distribution of Weibull, and the maximum likelihood method. The high concentrations present lower values to electrical strength. The $\beta$ parameter could be using to insulator particles dispersion. The $TiO_2$ concentration variation shows that these incorporations implicate strength values increase has a maximum (5,35MV/cm). High pigment concentration induces a little falls in property values. Observing the $\beta$ parameter, minimum experiment electric field (Ebmin) and electric strength value, found that the best electric perform formulation was the formulation with 2.5% $TiO_2$ weight.

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Memory-improving effect of formulation-MSS by activation of hippocampal MAPK/ERK signaling pathway in rats

  • Kim, Sang-Won;Ha, Na-Young;Kim, Kyung-In;Park, Jin-Kyu;Lee, Yong-Heun
    • BMB Reports
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    • v.41 no.3
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    • pp.242-247
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    • 2008
  • MSS, a comprising mixture of maesil (Prunus mume Sieb. et Zucc) concentrate, disodium succinate and Span80 (3.6 : 4.6 : 1 ratio) showed a significant improvement of memory when daily administered (460 mg/kg day, p.o.) into the normal rats for 3 weeks. During the spatial learning of 4 days in Morris water maze test, both working memory and short-term working memory index were significantly increased when compared to untreated controls. We investigated a molecular signal transduction mechanism of MSS on the behaviors of spatial learning and memory. MSS treatment increased hippocampal mRNA levels of NR2B and TrkB without changes of NR1, NR2A, ERK1, ERK2 and CREB. However, the protein levels of pERK/ERK and pCREB/CREB were all significantly increased to $1.5{\pm}0.17$ times. These results suggest that the improving effect of spatial memory for MSS is linked to MAPK/ERK signaling pathway that ends up in the phosphorylation of CREB through TrkB and/or NR2B of NMDA receptor.

A Survey of Actual Guides for Children to Take the Oriental Medicine in the Oriental Clinics & the Oriental Hospitals (한의원과 한방병원에서 행해지고 있는 소아에 대한 한약복약지도 현황 조사 연구)

  • Lee, Su Jeong;Lee, Seung Yeon;Yu, Sun Ae
    • The Journal of Pediatrics of Korean Medicine
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    • v.27 no.3
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    • pp.12-19
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    • 2013
  • Objectives Children's unique taste bud often gives them difficult time to take oriental medicines. To overcome, survey was conducted focusing on useful and practical tips on how to take them. Methods The survey was carried out by posting mail questionnaire. Target clinics for the survey were selected by the internet search engine, Google, Daum, and Naver, and typing in "oriental treatment + pediatrics", "pediatrics + oriental medicine", "pediatric oriental clinic". 24 clinics were searched, but they were further narrowed down to the specialized pediatric oriental clinics. Also, total of 38 inquiry leaflets were distributed to 14 University Oriental Hospitals. Results If children refuse to take the medicine, mixture with sweeteners can be prescribed for them. Among them, oligosaccharide is the most recommended followed by sugar and honey. To avoid rejection to medication, use of different formulation, such as distillation medicine, soft X-Section, granulated medicine, and character printing can be used. Conclusions The most effective method is to investigate the mixture first, and then the alternative formulations.

Development of FCHEV Virtual Platform using Motor Model Based on Mathematical Formulation (수학적 모터 모델 기반 연료전지 자동차 가상 플랫폼 개발)

  • Kim, Sung-Soo;Park, Sangcheol;Choi, Jangyoung
    • Transactions of the Korean Society of Automotive Engineers
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    • v.21 no.6
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    • pp.31-39
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    • 2013
  • A virtual chassis platform for Fuel Cell Hybrid Electric Vehicles(FCHEV) has been developed, and a virtual platform similar to the actual system has been composed. In addition, major components such as a motor, fuel cell and battery for the virtual platform have been constructed by using a mathematical formulation. The FCHEV virtual platform using a detailed model based on the mathematical formula is capable of simulating various conditions according to changes of the control logic and component modules to evaluate performance, considering the vehicle dynamic characteristics. Usability of the mathematical model has been verified by comparative simulations according to the motor current control variation. In addition, reliability of the developed virtual chassis platform has been verified by simulating its fuel consumption with the UDDS(Urban Dynamometer Driving Schedule) FTP-72 velocity profile.

Effects of prestressing force on natural frequency of prestressed concrete beams considering self-weight

  • Shin, Soobong;Lee, Hokyoung;Lee, Jong-Han
    • Structural Engineering and Mechanics
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    • v.74 no.4
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    • pp.495-502
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    • 2020
  • This study investigated the effects of prestressing force on the natural frequency of concrete beams considering changes in the self-weight of the beam. For this, a finite element formulation was derived to account for the increase in the stiffness of a beam-tendon system due to the axial force and deformation induced by prestressing of the tendon. The developed finite element formulation was validated with the data obtained in laboratory experiments. The experimental natural frequencies of the small prestressed concrete (PSC) beam specimens were consistent with those obtained using the proposed method. The first natural frequency increased almost linearly as the prestressing force increased. The proposed method was then applied to four actual PSC bridges typically employed in the field. Different from the laboratory specimens, the first natural frequencies of the actual PSC bridges barely changed or increased with increasing prestressing force. The results of an analytical parametric study showed that the increase in the natural frequency strongly depended on the magnitude of the prestressing force relative to the total weight of the structure. Thus, the variation in the natural frequencies of the actual PSC bridges with high total weight relative to the prestressing force was negligible due to the application of the prestressing force.

Inter-Annual and Intra-Annual Variabilities of NDVI, LAI and Ts Estimated by AVHRR in Korea

  • Ha, Kyung-Ja;Oh, Hyun-mi;Kim, Ki-Young
    • Korean Journal of Remote Sensing
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    • v.17 no.2
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    • pp.111-119
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    • 2001
  • This study analyzes time variability of the normalized difference vegetation index (NDVI), the leaf area index (LAI) and surface temperature (Ts) estimated from AVHRR data collected from across the Korean peninsula from 1981 to 1994. In the present study, LAI defined as vegetation density, as a function of NDVI applied for the vegetation types and Ts defined by the split-window formulation of Becker and Li (1990) with emissivity of a function of NDVI, are used. Results of the inter-annual, intra-annual and intra-seasonal variabilities in Korea show: (1) Inter-annual variability of NDVI is generally larger in the southem and eastern parts of the peninsula than in the western part. This large variability results from the significant mean variation. (2) Inter-annual variability of Ts is larger in the areas of smaller NDVI. This result shows that the NDVI play a small role in emissivity. (3) Inter-annual variability of LAI is larger in the regions of higher elevation and urban areas. Changes in LAI are unlikely to be associated with NDVI changes. (4) Changes in NDVI and Ts are likely dominant in July and are relatively small in spring and fall. (5) Urban effect would be obvious on the time-varying properties of NDVI and Ts in Seoul and the northern part of Taejon, where NDVI decreases and Ts increases with a significant magnitude.

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The Stabilization of 20.0% Ascorbic Acid in Aqueous Cosmetic Formulation (아스코빅애씨드 고함량 안정화 수계 조성물 제조 방법)

  • Park, Jeong Mi;Eun, So Hee;Ko, Eun Ah;Han, Sang Keun;Kang, Hak Hee;Hyun, Seung Min
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.44 no.2
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    • pp.125-131
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    • 2018
  • Ascorbic acid (Vitamin C) has been widely used in skin care formulations. Due to its remarkable effects on anti-oxidation, collagen biosynthesis and whitening, ascorbic acid is considered as an effectible anti-aging active ingredient. But, the instability problems of ascorbic acid in cosmetic formulation such as oxidation, browning and changes in smell is the difficult issue to be overcome for the application of high concentration of ascorbic acid. We tried to stabilize the ascorbic acid in non-aqueous liquid formulation that contains polyol solvent at first. The non-aqueous system was effectible to reduce oxidation. But, ascorbic acid was crystallized in the non-aqueous formulation at the low temperature below $5^{\circ}C$. We tried to develop way to stabilize the ascorbic acid in aqueous solutions to solve the crystallizing problem. In this study, we search the optimal ratio of antioxidant combination, such as zinc sulfate, glutathione and curcuma longa (turmeric) root extract. Formulations were stored at - $16^{\circ}C$, $5^{\circ}C$, $25^{\circ}C$, $40^{\circ}C$, $50^{\circ}C$ and cycle($5-40^{\circ}C$) (in incubator) for a period of eight weeks to investigate their stability. In the stability analysis, the test parameters consisted of color, scent, phase separation and sedimentation. Ascorbic acid stability was checked by HPLC analysis.

Development of a Sunscreen Formulation that Increases UV Blocking Ability by UV Light (자외선에 의해 자외선 차단 효율이 상승하는 선크림 제형 개발)

  • Choi, Minsung;Cho, Hyeongjin;Song, Kyunghee;Song, Seungjin;Kang, Nae-Gyu;Park, Sun-Gyoo
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.45 no.2
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    • pp.139-150
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    • 2019
  • This study is investigated sunscreen formulation that enhances UV absorption efficiency by UV light. Ethylhexyl methoxycinnamate (OMC) is one of the most common UV filters. Many studies have been conducted about photostability of OMC. It is well known that under the UV exposure, trans-OMC could turn to cis-OMC, or produce various photoproducts including its dimers. Those chemical structure changes were understood as the reason of a decrease in UV absorption efficiency upon UV exposure. However, it was found that OMC and isoamyl p-methoxycinnamate (IMC) could even enhance its UV absorption efficiency when it was exposed to UV light in an environment similar to actual use. In order to develop sunscreen formulation that enhances UV absorption efficiency by UV light, emollient with high polarity and compatibility should be avoided from the formular. Those emollient seemed to prevent OMC or IMC from producing photoproducts under UV light. Finally, a sunscreen formulation (UV sensing SPF boosting formular) enhancing UV absorption efficiency by UV was developed by the UV activated SPF boosting technology, and the effect of the sunscreen was evaluated. in vitro SPF of the sunscreen was increased from 50.69 to 72.33 when it was exposed to UV light and its in vivo SPF (53.7) was 56.10% higher than that of the control sunscreen (below 34.4).