• Title/Summary/Keyword: Fine needle aspiration cytology

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Fine Needle Aspiration Cytology of Papillary-Cystic Variant of Acinic Cell Carcinoma of Salivary Gland - A Case Report - (타액선 유두상-낭성 선방세포암종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Lee, Ah-Won;Yoo, Jin-Young;Kim, Byung-Kee;Kang, Seok-Jin
    • The Korean Journal of Cytopathology
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    • v.12 no.1
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    • pp.45-48
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    • 2001
  • Acinic cell carcinoma(ACC) is the third common malignancy in major salivary gland. Fine needle aspiration cytology is a useful tool for the diagnosis of salivary gland lesions. However, some low grade malignancies, such as ACC and mucoepidermoid carcinoma show relatively high false negative rate, mainly due to deceptively benign cytomorphologic appearance. We experienced a papillary-cystic variant of ACC, having different cytopathologic features compared with those of classic ACC. Our case showed monolayered sheets and papillary clusters without any acinic structures or naked nuclei of the tumor cells. Foamy proteinaceous material was seen in the background. The tumor cells had a large amount of granular cytoplasm and eccentric nuclei. Many vacuolated or clear cells were also noted.

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Fine Needle Aspiration Cytology of Metastatic Melanoma in the Breast - A Case Report - (유방에 전이한 악성 흑색종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Oh, Young-Lyun;Ko, Young-Hyeh
    • The Korean Journal of Cytopathology
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    • v.9 no.1
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    • pp.111-115
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    • 1998
  • Although the characteristic cytologic features of melanoma have been well described the diagnosis of metastatic melanoma by fine needle aspiration cytology (FNAC) may be difficult in the case of amelanotic melanoma and in the absence of awareness of clinical history. Furthermore, when the breast is the site of initial presentation, it could simulate a primary breast carcinoma leading to misdiagnosis. The recognition of metastatic malignant melanoma in FNAC material is essential to avoid an unnecessary mastectomy and to ensure appropriate chemotherapy. We experienced a case of metastatic melanoma of breast which presented as solitary breast mass in a 56-year-old woman. She had a history of surgical excision of right foot for melanoma one year ago. The cytologic smears were composed of noncohesive epithelioid cells with round or eccentric nuclei, bi-or multi-nucleation, prominent nucleoli, fine chromatin, and intranuclear inclusions. The cytoplasm of tumor cells had scanty melanin pigment but were diffusely positive for S-100 protein.

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Fine Needle Aspiration Cytology of Clear Cell Sarcoma - A Case Report - (투명세포육종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Lim, Sung-Chul;Chung, You-Kyung;Kim, Dong-Chool;Lee, Yoon-Kyung;Shin, Eun-Taik
    • The Korean Journal of Cytopathology
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    • v.9 no.2
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    • pp.233-239
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    • 1998
  • Clear ceil sarcoma(CCS) is an uncommon soft tissue sarcoma that occurs in tendons and aponeuroses, usually of the lower extremities and is believed to be of neural crest origin that have a capability to produce melanin. These tumors commonly metastasize and have a very poor prognosis. The fine needle aspiration cytologic finding of CCS is not well documented. We recently experienced a case of CCS. The patient was a 54-year-old male with painful swelling of the right inguinal area. Fine needle aspiration cytology revealed polygonal or fusiform tumor cells with clear or granular cytoplasm and vesicular nuclei containing one or two nucleoli. Immunohistochemical staining for S-100 protein and HMB-45 revealed strong positivity and variable developing stages of premelanosomes were observed by electron microscopy in the excised specimen.

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Fine Needle Aspiration Cytology of Myositis Ossificans - A Case Report - (골화성 근염의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Kim, Dong-Won;Lee, Dong-Wha
    • The Korean Journal of Cytopathology
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    • v.9 no.1
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    • pp.123-127
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    • 1998
  • The aspiration cytologic finding of myositis ossificans is not well documented but similar to that seen in nodular fasciitis except less cellularity. Myositis ossificans is a reactive condition that is sometimes mistaken microscopically for extraosseous osteosarcoma. Cytologically, myositis ossificans may be distinguished from extraosseous osteosarcoma by the presence of uniform benign stromal cells composed of mature fibroblasts and osteoclastic giant cells. However, the differential diagnosis may be difficult in the early stage of this reactive and proliferative process. We recently experienced a case of myositis ossificans. The patient was a 67-year -old woman with painful swelling of the left index finger for one month. Simple x-ray finding showed a soft tissue mass with calcific center at middle phalanx of the left hand. Fine needle aspiration cytology revealed a few individual or clusters of spindle cells in dense eosinophilic stroma with osteoclastic giant cells. The spindle cells were uniform smooth-bordered, and oval nuclei with single small inconspicuous nucleoli, and elongated cytoplasm. The scattered individual cells had eccentric nuclei with one or two nucleoli and abundant, basophilic cytoplasm.

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Fine Needle Aspiration Cytology of Lipoblastoma - A Report of Two Cases - (지방모세포종의 세침흡인 세포학적 소견 - 2예 보고 -)

  • Oh, So-Yeong;Chung, Myoung-Ja;Moon, Woo-Sung;Kang, Myoung-Jae;Lee, Dong-Geun
    • The Korean Journal of Cytopathology
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    • v.9 no.2
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    • pp.241-244
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    • 1998
  • Lipoblastoma is a rare benign neoplasm occurring exclusively in children below the age of three years. It affects chiefly the upper and lower extremities, and less commonly head and neck area, trunk, mediastinum, mesentery, and retroperitoneum. We present two cases of lipoblastoma occurring in the mediastinum of a 21-month-old boy and in the back of a 15-month-old boy. The characteristic features of Fine needle aspiration cytology smears were the presence of immature fat cells in the form of spindle-shaped cells, stellate cells and vacuolated lipoblasts along with lipocytes against a myxomatous background. Two tumors were histologically confirmed to be lipoblastomas. Lipoblastoma can be cytologically diagnosed by considering the cytologic findings and the age of the patient.

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Fine Needle Aspiration Cytology of Pulmonary Hamartoma (폐과오종의 세침흡인 세포학적 소견)

  • Lee, Tae-Jin;Lee, Jin-Sook;Gong, Gyung-Yub;Khang, Shin-Kwang;Ro, Jae-Y.
    • The Korean Journal of Cytopathology
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    • v.11 no.1
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    • pp.19-24
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    • 2000
  • Pulmonary hamartomas are uncommon benign tumors, usually discovered radiologically as a solitary coin lesion in asymptomatic individual. The approach to the patient with a peripheral lung nodule has changed with the increasing acceptance of fine needle aspiration cytology(FNAC) as a rapid, safe, inexpensive, and highly accurate diagnostic tool. However, a few reports describing the FNAC findings of pulmonary hamarioma have appeared in the cytologic literature and the experience of FNAC is limited. We reviewed all 9 cases of pulmonary hamartoma with histologic confirmation after FNAC seen at Asan Medical Center since 1995 to evaluate cytologic findings and to determine the value of FNAC in identifying that lesion. Originally, seven of nine patients were diagnosed as pulmonary hamartoma, while two patients were diagnosed as inflammatory lesion and adenocarcinoma of each. On review, eight of nine patients were considered as diagnostic of pulmonary hamartoma. The diagnostic findings in FNAC of pulmonary hamartoma were the presence of fibrillary myxoid tissue with spindle cells as well as hyaline cartilage.

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Fine Needle Aspiration Cytology of the Sclerosing Hemangioma of the Lung - A Report of Five Cases - (폐의 경화성 혈관종의 세침흡인 세포학적 소견 - 5예 보고 -)

  • Kim, Ji-Young;Lee, Yong-Hee;Lee, Kwang-Gil
    • The Korean Journal of Cytopathology
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    • v.9 no.2
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    • pp.193-199
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    • 1998
  • Sclerosing hemangioma is a rare, benign neoplasm of the lung, usually presented as a solitary pulmonary nodule in an otherwise asymptomatic middle-aged woman. Cytologically it shows papillary, sheet, and cyst-like arrangements representing three main histologic patterns of papillary, solid, and angiomatous ones, respectively. Herein, we report the fine needle aspiration cytology of 5 cases of sclerosing hemangioma of the lung. The most characteristic finding is cyst-like spaces Intimately related to the papillary or solid cell nests. The tumor cells are relatively monotonous round to oval, small to medium in size. They have small amount of eosinophilic cytoplasm. The nuclei are uniform, round and have small but conspicuous nucleoli. The tumor cells in one of the presenting cases are large with abundant cytoplasm and show moderate nuclear pleomorphism. The nuclear chromatin, however, is fine and even without exception, even in the case showing nuclear pleomorphism. Major differential diagnoses based on the cytologic findings are well-differentiated papillary adenocarcinoma, bronchioloalveolar carcinoma, and carcinoid tumor.

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Fine Needle Aspiration Cytology of Pulmonary Lesions in Wegener's Granulomatosis - A Case Report - (Wegener's Granulomatosis 폐병변의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Seo, Eun-Joo;Kwon, Hi-Jeong;Min, Ki-Ouk
    • The Korean Journal of Cytopathology
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    • v.9 no.1
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    • pp.85-88
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    • 1998
  • We described the findings of fine needle aspiration cytology of the lung from a patient with Wegener's granulomatosis. Early diagnosis and prompt treatment of the patients with Wegener's granulomatosis is essential for a better prognosis. However, the variety of clinical presentations and nonspecific radiologic infiltrates of Wegener's granulomatosis frequently make the diagnosis difficult. Although an open lung biopsy is required for a firm diagnosis, fine needle aspiration cytology & biopsy preparation can also provide an adequate tissue sample, when the findings of fine needle aspiration are considered with clinical manifestations and ANCA value in the serum. The cytologic smears showed scattered necrotic tissue fragments entrapping many neutrophils and occasional epithelioid cells. Multinucleated giant cells were infrequently observed. Ziehl-Neelsen stain for acid fast bacilli was negative. All the cytologic features recapitulated the histopathologic findings of purulent and necrotizing granulomatous inflammation seen in Wegener's granulomatosis.

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Fine Needle Aspiration Cytology of Salivary Duct Carcinoma with Calcification in Submandibular Gland - A Case Report - (악하선의 석회화를 동반한 타액선 관암종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Yun, Ki-Jung;Han, Weon-Cheol;Jo, Hyang-Jeong;Lee, Kwang-Man
    • The Korean Journal of Cytopathology
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    • v.12 no.1
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    • pp.49-52
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    • 2001
  • Salivary duct carcinoma is an uncommon aggressive malignant epithelial neoplasm with similarity to intraductal carcinoma of the breast. This neoplasm occurs most often in the parotid gland of middle-aged and older males. About 7% of reported tumors occured in the submandibular gland. The report of salivary duct carcinoma with calcification is rare. We report a case of salivary duct carcinoma with calcification in the submandibular gland. The patient was a 73-year-old male with a mass of the right submandibular gland for 1 year. On the fine needle aspiration cytology, the aspirate showed scant cellularity, small clusters of tumor cells, and scattered small calcifications. Nuclei of the tumor cells showed mild pleomorphism and round to oval in shape, and cytoplasm was abundant and finely granular. Nucleoli were indistinct and necrosis was not noted. There were no cribriform or papillary arrangements of tumor cells. Cytologlc findings of salivary duct carcinoma are variable depending on histologic findings, and calcifications could be an additional cytologic findings.

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Fine Needle Aspiration Cytology of Mucinous Cystic Carcinoma of the Pancreas - A Case Report - (췌장의 점액 낭샘암종의 세침흡인 세포소견 -1예 보고-)

  • Lee,, Kyung-Ji;Lee, Kyo-Young;Kang, Chang-Suk;Shim, Sang-In;Lee, Ah-Won
    • The Korean Journal of Cytopathology
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    • v.16 no.2
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    • pp.88-92
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    • 2005
  • Mucious cystic neoplasm of pancreas is a cystic neoplasm composed of columnar, mucin-producing epithelium and is supported by ovarian-type stroma. The key to the cytologic evaluation of pancreatic cystic lesions is to recognize the cytologic components as being diagnostic of a mucin-producing cystic neoplasm, as all of these neoplasms need to be resected. We report the use of fine needle aspiration cytology in the diagnosis of an invasive mucinous cystic carcinoma confirmed by partial pancreatectomy. The cytologic specimen showed a abundant mucin background and sheets or papillae of neoplastic cells. There are mucin-containing columnar cells that show a variable degree of cytologic atypia.