• Title/Summary/Keyword: Fine needle aspiration cytology

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Nuclear Morphometry of Fibroadenoma and Carcinoma of Breast - Comparison between fine needle aspiration cytology and biopsy - (유방 섬유선종과 유방암종의 화상 계측에 관한 연구 - 세침 홉인 세포 검사와 조직 검사간의 비교를 중심으로 -)

  • Sohn, Jin-Hee;Choi, Young-Hee;Park, Young-Eui
    • The Korean Journal of Cytopathology
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    • v.9 no.2
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    • pp.161-168
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    • 1998
  • Primary breast lesions diagnosed by fine needle aspiration cytology, confirmed by histologic examination were analyzed by morphometry to evaluate the difference between benign and malignant lesions, and the methods obtaining the sample. four size factors and 5 form factors were evaluated in 22 fibroadenomas and 20 carcinomas by image analyzer(Zeiss Ibas 2000) using the H-E stained slides. Nuclear size was significantly larger in the carcinoma cells than fibroadenoma cells both in the cytology and biopsy specimens, but the form factors were not significantly different. Both fibroadencma and carcinoma cells were significantly larger in cytologic smear than histologic section. The cells in the cytology were more regular and round than those in histology, but not statistically significant. Fibroadenomas having cellular proliferation and atypism exhibited larger size and more irregular nuclei than non-proliferative fibroadenoma, but not statistically significant. Therefore nuclear morphometric analysis can be a helpful method to diagnose the questionable breast lesions and is a method appropriate for use as a quality control procedure in the fine needle aspiration cytology.

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Fine Needle Aspiration Cytology of Inflammatory Myofibroblastic Tumor in Mesentery - A Case Report - (장간막에서 발생한 염증성 근섬유모세포종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Son, Hyun-Jin;Kim, Joo-Heon;Moon, Woo-Sung;Choi, Ho-Yeul;Kang, Myoung-Jae
    • The Korean Journal of Cytopathology
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    • v.11 no.1
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    • pp.35-39
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    • 2000
  • Since inflammatory myofibroblastic turner was initially recognized in the lung, this tumor has been described in other extrapulmonary sites. In spite of relatively uniform histologic findings in various organs, a rarity in extrapulmonary sites and highly vascular characteristics frequently lead to a misdiagnosis in preoperative radiology and fine needle aspiration cytology. We present a case of inflammatory myofibroblastic tumor occurring in the mesentery of a 4-month-old girl. Fine needle aspiration cytology smear disclosed characteristic spindle cells intermixed with prominent mature plasma cells and lymphocytes. According to the immunohistochemical staining, we recognized that the intervening spindle cells are myofibroblasts which have reactivity for the both actin and vimentin.

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Fine Needle Aspiration Cytologic Diagnosis of Thymoma Presenting as a Thyroid Nodule - A Report of Two Cases - (갑상선 종괴로 촉지된 흉선종의 세침흡인 세포학적 진단 - 2예 보고 -)

  • Kim, Dong-Ja;Park, Ji-Young;Kum, Yoon-Seup;Park, Tae-In;Sohn, Yoon-Kyung
    • The Korean Journal of Cytopathology
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    • v.11 no.1
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    • pp.41-45
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    • 2000
  • Thymoma is the most common anterior mediastinal tumor in adults. Rarely, it is presented as the anterior neck mass, commonly located in the anterolateral aspect of the neck or adjacent to the thyroid. We experienced two cases of fine needle aspiration cytology of thymoma, mimicking thyroid mass. The first case was an ectopoic cervical thymoma in a 31-year-old female. The fine needle aspiration cytology was misinterpreted as reactive hyperplasia of lymph node. But the histologic diagnosis was thymoma, predominantly lymphocytic type. The second case was an invasive thymoma in a 66-year-old female, who complained a large anterior neck mass. The fine needle aspiration cytology revealed biphasic population of some clusters of epithelial cells and scattered lymphocytes. The cytologic diagnosis was thymoma and was confirmed as invasive thymoma after the biopsy. Therefore, when the cytologic feature of anterior neck mass shows the both lymphocyte and epithelial component, the differential diagnosis should Include the possibility of thymoma.

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Fine Needle Aspiration Cytologic Findings of Thyroid Lymphoma -Report of Two Cases- (갑상선 림프종의 세침흡인 세포학적 소견 -2 예 보고-)

  • Lee, Hye-Kyung;Lee, Jong-Min;Kang, Chang-Suk
    • The Korean Journal of Cytopathology
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    • v.13 no.1
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    • pp.33-37
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    • 2002
  • We report two different types of thyroid lymphoma associated with Hashimoto's thyroiditis. Both showed autoantibodies and were compatible with Hashimoto's thyroiditis according to their clinical backgrounds. A 76-year-old female noted a painless, rapidly growing mass in her neck which was diagnosed as diffuse non-Hodgkin's lymphoma, large cell type, after the fine needle aspiration cytology of the thyroid. She underwent chemo-radiotherapy and is free of the disease 10 months after diagnosis. The other patient, a 73-year-old female with a diffuse golfer, was diagnosed on fine needle aspiration cytology as having Hashimoto's thyroiditis. Three years later she developed a hard nodular growth in the both lobes of the thyroid. This was subjected to fine needle aspiration cytology and needle biopsy and was diagnosed as a MALT lymphoma. She refused any treatment and died 12 months after the diagnosis.

Fine Needle Aspiration Cytology of Proliferative Fasciitis (증식성 근막염의 세침흡인 세포학적 소견)

  • Choi, Yoon-Jung;Yi, Sang-Yeop;Yang, Woo-Ick;Jung, Soon-Hee;Lee, Kwang-Gil
    • The Korean Journal of Cytopathology
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    • v.4 no.1
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    • pp.52-56
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    • 1993
  • Proliferative fasciitis is a benign pseudosarcomatous mesenchymal lesion occurring in the subcutis. The lesion occurs clinically as a tumorous mass that develops within a rather short time in elderly patients. We recently experiecened a case of fine needle aspiration cytology of proliferative fasciitis in the left anterior chest wall of a 72 year-old male patient. The smear revealed two types of cells. One was the large and mostly oval cell with one or two nuclei lying at the periphery of the cell body and abundant basophilic cytoplasm like the ganglion cell. The nuclei were round to oval, had vesicular chromatin and contained prominent nucleoli. The other was the spindle shaped fibroblast with an oval nucleus. The differential diagnosis includes a true tumor such as ganglioneuroma, rhabdomyosarcoma, and liposarcoma and therefore fine needle aspiration cytology is very much indicated in order to exclude these possibilities.

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Fine Needle Aspiration Cytologic Findings of Fibromatosis Colli - A Report of Three Cases - (경부섬유종증의 세침흡인 세포소견 - 3예 보고 -)

  • Park, In-Suh;Kim, Lucia;Choi, Suk-Jin;Han, Jee-Young;Chu, Young-Chae;Choi, Sun-Geun;Kim, Joon-Mee
    • The Korean Journal of Cytopathology
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    • v.16 no.1
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    • pp.61-65
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    • 2005
  • Fibromatosis colli is a benign fibrous tissue proliferation of sternocleidomastoid muscle, which is usually observed during the first month of life, often associated with congenital torticollis. It should be differentiated from other neck masses in infants because the usual initial treatment of fibromatosis celli is conservative management and invasive therapy should be avoided. Fine needle aspiration cytology provides an excellent minimally invasive diagnostic way for evaluation of infantile neck masses. We describe three cases of fibromatosis colli diagnosed by fine needle aspiration cytology. All of them were younger than one month and presented as a neck mass. Clinical impressions were malignant tumors in two cases and fibromatosis colli in one case. Fine needle aspiration cytology revealed benign and mature fibroblasts and atrophic striated muscle fibers. The cytologic diagnosis was fibromatosis colli or benign fibous lesion.

Fine Needle Aspiration Cytology of the Intraductal Papillary Mucinous Tumor of the Pancreas -A Case Report- (췌관내 유두모양점액종양의 세침흡인 세포학적 소견 -1예 보고-)

  • Do, In-Gu;Park, Jae-Hoon;Kim, Youn-Wha;Lee, Ju-Hie;Yang, Moon-Ho;Hong, Sung-Wha;Park, Yong-Koo
    • The Korean Journal of Cytopathology
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    • v.14 no.2
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    • pp.91-95
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    • 2003
  • Intraductal papillary mucinous tumor of the pancreas is characterized by intraductal papillary proliferation of mucin-producing epithelial cells with or without excessive mucin secretion. According to the degree of epithelial dysplasia, intraductal papillary mucinous tumor is classified into adenoma, borderline tumor, and carcinoma. We recently experienced a case of fine needle aspiration cytology of the intraductal papillary mucinous adenoma in a 69-year-old male. The fine needle aspiration cytology yielded flat sheets of columnar, mucin containing epithelial cells in the background of dense mucin containing degenerated cellular material and histiocytes.

Fine Needle Aspiration Cytology of Primary Pulmonary Amyloidosis - A Case Report - (원발성 폐 아밀로이드증의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Cho, Hyun-I;Oh, Young-Ha;Jeong, Seong-Hwan;Ha, Seung-Yeon
    • The Korean Journal of Cytopathology
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    • v.11 no.2
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    • pp.99-102
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    • 2000
  • Pulmonary amyloid deposition generally occurs with concurrent primary systemic amyloidosis. Localized forms of pulmonary amyloidosis are rare and appear most frequently as an incidental finding on chest radiographs. We present a case of nodular pulmonary amyloid tumor suggested by fine needle aspiration cytology(FNAC) and confirmed by histology examination with the polarizing light microscopy. A 41-year-old woman presented with ill-defined nodules. In the middle and lower lobes of both lungs. FNAC of the nodules revealed waxy, acellular amorphous fragments. Thoracotomy for diagnosis may be avoided by FNAC diagnosis of this unusual lesion.

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Fine Needle Aspiration Cytology of Osteoclastic Giant Cell Tumor of the Pancreas (췌장의 파골성 거대세포종양의 세침흡인세포학적 소견)

  • Sung, Sun-Hee;Han, Woon-Sup
    • The Korean Journal of Cytopathology
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    • v.9 no.1
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    • pp.89-94
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    • 1998
  • A case of fine needle aspiration cytology of an osteoclastic giant cell tumor of pancreas, which is an uncommon variant of ductal adenocarcinoma, is described. Aspirated tumor cells were characterized by three populations: (1) bland osteoclast like giant cells with multiple small, round nuclei with distinct nucleoli, and abundant cytoplasm, (2) Individually scattered or loosely clustered medium sized mononuclear tumor cells, having fine chromatin, smooth nuclear membrane, often prominent nucleoli, and high N/C ratio, (3) bland or atypical spindle shaped cells. Osteoid like lacy material was also seen on cell block section. The immunohistochemical studies using paraffin embedded cell block section showed positivities for vimentin and lysozyme in both giant and mononuclear turner cells. However, they were negative for cytokeratin, epithelial membrane antigen, S-100 protein, carcinoembryonic antigen, and p53.

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Fine Needle Aspiration Cytology of Ganglioneuroma - A Case Report - (신경절신경종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Kim, Hee-Kyung;Jin, So-Young;Lee, Dong-Wha
    • The Korean Journal of Cytopathology
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    • v.14 no.1
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    • pp.12-16
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    • 2003
  • Ganglioneuroma is a well-differentiated, benign tumor of the sympathetic nervous system. These tumors belong to a family of neoplasm that exhibit a wide range of differentiation, with neuroblastoma at one end and ganglioneuroma at the other. Because it share morphologic features with other both benign and malignant neural tumors, accurate preoperative diagnosis is often difficult. Nonetheless, it is critical for proper management. Fine needle aspiration cytology (FNAC) in the diagnosis of the ganglioneuroma has been a little documented. We describe a case of mediastinal ganglioneuroma in a 33-month-old girl. The diagnosis was suggested on FNAC and was confirmed by histopathologic examination later.