• Title, Summary, Keyword: Fat Metabolism

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Effects of Porphyran and Insoluble Dietary Fiber Isolated from Laver, Porphyra yezoensis, on Lipid Metabolism in Rats Fed High Fat Diet (김에서 분리한 포피란과 불용성 식이섬유가 고지방식이 섭취 흰쥐의 지질대사에 미치는 영향)

  • Lee, Jung-Sun;Lee, Myung-Heon;Koo, Jae-Geun
    • The Korean Journal of Food And Nutrition
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    • v.23 no.4
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    • pp.562-569
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    • 2010
  • This study was conducted to investigate the hypocholesterolemic effects of porphyran and insoluble dietary fiber isolated from laver in rats fed high fat diet containing 1% cholesterol, 0.25% sodium cholate and 12% lard. Rats were fed, ad libitum, diets containing 5% diet fiber as cellulose(normal control or high fat control), porphyran or insoluble dietary fiber for 4 weeks. Among the groups fed high fat diet, liver weight was significantly lower in high fat porphyran group than high fat control. Plasma GOT, GPT, total cholesterol, cholesteryl ester, LDL-cholesterol and liver total cholesterol concentration were significantly lower in high fat porphyran group than high fat control. The feeding of porphyran significantly increased fecal cholesterol and bile acid excretion. The feeding of insoluble dietary fiber had no significant effect on either plasma or liver cholesterol levels, although fecal cholesterol level in the insoluble dietary fiber group was significantly higher than that in the high fat control. The results indicate that porphyran isolated from the laver may exert their hypocholesterolemic effect by increasing excretion of fecal bile acid and cholesterol.

Effect of Enzyme-Treated Radish Leaves on Lipid Metabolism in Rats Fed a High-Fat Diet

  • Kim, Yu-Na;Ku, Kyung-Hyung;Kang, Sin-Kwon;Choi, Jeong-Hwa
    • Preventive Nutrition and Food Science
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    • v.16 no.1
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    • pp.1-7
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    • 2011
  • The purpose of this study was to investigate the effect of enzyme-treated radish (Raphanus sativus L.) leaves on lipid metabolism in rats fed a high fat diet. Rats were divided into four experimental groups which were composed of a high fat diet group (HF group), a high fat diet with 10% radish leaf powder-supplemented group (MA group), a high fat diet with 5% enzyme-treated radish leaf powder-supplemented group (MB group) and a high fat diet with 10% enzyme-treated radish leaf powder-supplemented group (MC group). Total dietary fiber content of enzyme-treated radish leaves were greater than untreated radish leaves. Body weight gain and food efficiency ratio (FER) of the HF group increased compared to the MA, MB and MC groups. The serum total cholesterol, LDL-cholesterol and atherogenic index contents in the radish leaf powder-supplemented groups were lower than that of the HF group, while those values for the MB and MC groups were significantly lower than that of the HF group. The serum HDL-cholesterol contents of the MB and MC groups increased compared to the HF group. The hepatic triglyceride contents of the MA, MB and MC groups decreased compared to the HF group. In fact, the hepatic triglyceride contents of the MB and MC groups were significantly lower than the MA group. The hepatic total cholesterol contents of the MB and MC groups significantly decreased compared to those of the HF group. The fecal total cholesterol contents of the MA, MB and MC groups significantly increased compared to those of the HF group. These results indicate that supplementation with enzyme-treated radish leaves increase the useful fiber contents. Furthermore, it may have a pronounced impact on lipid metabolism of serum and liver in rats fed a high fat diet.

The effect of fucoxanthin rich power on the lipid metabolism in rats with a high fat diet

  • Ha, Ae Wha;Kim, Woo Kyoung
    • Nutrition Research and Practice
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    • v.7 no.4
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    • pp.287-293
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    • 2013
  • This study determined the effects of fucoxanthin on gene expressions related to lipid metabolism in rats with a high-fat diet. Rats were fed with normal fat diet (NF, 7% fat) group, high fat diet group (HF, 20% fat), and high fat with 0.2% fucoxanthin diet group (HF+Fxn) for 4 weeks. Body weight changes and lipid profiles in plasma, liver, and feces were determined. The mRNA expressions of transcriptional factors such as sterol regulatory element binding protein (SREBP)-1c, Carnitine palmitoyltransferase-1 (CPT1), Cholesterol $7{\alpha}$-hydroxylase1 (CYP7A1) as well as mRNA expression of several lipogenic enzymes were determined. Fucoxanthin supplements significantly increased plasma high density lipoprotein (HDL) concentration (P < 0.05). The hepatic total lipids, total cholesterols, and triglycerides were significantly decreased while the fecal excretions of total lipids, cholesterol, and triglycerides were significantly increased in HF+Fxn group (P < 0.05). The mRNA expression of hepatic Acetyl-CoA carboxylase (ACC), Fatty acid synthase (FAS), and Glucose-6-phosphate dehydrogenase (G6PDH) as well as SREBP-1C were significantly lower in HF+Fxn group compared to the HF group (P < 0.05). The hepatic mRNA expression of Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) and Acyl-CoA cholesterol acyltransferase (ACAT) were significantly low while lecithin-cholesterol acyltransferase (LCAT) was significantly high in the HF+Fxn group (P < 0.05). There was significant increase in mRNA expression of CPT1 and CYP7A1 in the HF+Fxn group, compared to the HF group (P < 0.05). In conclusion, consumption of fucoxanthin is thought to be effective in improving lipid and cholesterol metabolism in rats with a high fat diet.

The effects of black garlic (Allium satvium) extracts on lipid metabolism in rats fed a high fat diet

  • Ha, Ae Wha;Ying, Tian;Kim, Woo Kyoung
    • Nutrition Research and Practice
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    • v.9 no.1
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    • pp.30-36
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    • 2015
  • BACKGROUD/OBEJECTIVES: The mechanism of how black garlic effects lipid metabolism remains unsolved. Therefore, the objectives of this study were to determine the effects of black garlic on lipid profiles and the expression of related genes in rats fed a high fat diet. MATERIALS/METHODS: Thirty-two male Sqrague-Dawley rats aged 4 weeks were randomly divided into four groups (n=8) and fed the following diets for 5 weeks: normal food diet, (NF); a high-fat diet (HF); and a high-fat diet + 0.5% or 1.5% black garlic extract (HFBG0.5 or HFBG1.5). Body weights and blood biochemical parameters, including lipid profiles, and expressions of genes related to lipid metabolism were determined. RESULTS: Significant differences were observed in the final weights between the HFBG1.5 and HF groups. All blood biochemical parameters measured in the HFBG1.5 group showed significantly lower values than those in the HF group. Significant improvements of the plasama lipid profiles as well as fecal excretions of total lipids and triglyceride (TG) were also observed in the HFBG1.5 group, when compared to the HF diet group. There were significant differences in the levels of mRNA of sterol regulatory element binding protein-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and glucose-6-phosphate dehydrogenase (G6PDH) in the HFBG1.5 group compared to the HF group. In addition, the hepatic expression of (HMG-CoA) reductase and Acyl-CoA cholesterol acyltransferase (ACAT) mRNA was also significantly lower than the HF group. CONCLUSIONS: Consumption of black garlic extract lowers SREBP-1C mRNA expression, which causes downregulation of lipid and cholestrol metahbolism. As a result, the blood levels of total lipids, TG, and cholesterol were decreased.

Effects of Cladosiphon okamuranus on Lipid Metabolism in High-fat-diet Rats (고지방식이 흰쥐에서 큰실말의 지질대사에 미치는 효과)

  • Bae, Gui-Jeong;Ha, Bae-Jin
    • Journal of Life Science
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    • v.26 no.6
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    • pp.657-662
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    • 2016
  • Cladosiphon okamuranus is edible brown algae cultured commercially and extensively on the Okinawa coast in Japan. We examined the effects of Cladosiphon okamuranus on the lipid metabolism in high-fat-diet rats. Seven-week-old female SD rats were divided into five groups and fed high-fat diets for 42 days. In addition, Cladosiphon okamuranus was administered orally for 42 days at 95 mg/kg of the body weight of the rats. The effects of lipid metabolism were evaluated by the total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), glutamic pyruvate transaminase (GPT), glutamic oxalacetic transaminase (GOT) levels in sera. The levels of TC, TG, LDL, GPT, and GOT were reduced in the Cladosiphon okamuranus treated group compared with the high-fat diet group. However, the levels of HDL in the Cladosiphon okamuranus treated groups were higher than in the high-fat diet groups. These results demonstrated that Cladosiphon okamuranus had positive effects on lipid metabolism, suggesting Cladosiphon okamuranus could be used as an ingredient in useful, functional products.

Commarison of Body Fat Metabolism in Middle-aged Women Depending Upon Swimming Practice (운동(수영)여부에 따른 중년여성의 체지방 대사비교)

  • 차연수
    • Journal of Nutrition and Health
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    • v.28 no.5
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    • pp.397-405
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    • 1995
  • The present study examined the effects of swimming on some plasma parameters of lipid metabolism in the middle-aged women. The control group(C) was the women who lived without any intentional physical exercise, and the first experimental group(S I) and the second experimental group(S II) had gone swimming everyday at least one hour for 3-6 months, and more than one year, respectively. The results obtained were summarized as follows: 1) Energy and nutrient intakes of the three groups were not different, but the body fat(%) of two experimental groups(S I, S II) was significantly lower than that of control. 2) Total cholesterol and HDL-cholesterol in plasma were not significantly changed by swimming and swimming period. However, total lipids and LDL-cholesterol were significantly lower in the two experimental groups than in control. 3) The level of plasma triglycerides of SI was not different from the control, but SII showed significantly lower triglycerides. 4) Acid-soluble acylcarnitine and $\beta$-hydroxybutyrate concentration in plasma were significantly greater in SII than in control. There results suggest that regular swimming in a longer period might help to protect the risk of obesity and cardiovascular disease by modulating lipid metabolism.

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Effects of Polydextrose and Hydrolysed Guar Gum on Lipid Metabolism of Normal Rats with Different Levles of Dietary Fat (Polydextrose와 Hydrolysed Guar Gum이 지방량을 달리한 식이를 섭취한 정상백서의 지질대사에 미치는 영향)

  • Choe, Myeon;Kim, Jong-Dai;Ju, Jin-Soon
    • Journal of Nutrition and Health
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    • v.25 no.3
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    • pp.211-220
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    • 1992
  • Both hydrolysed guar gum and polydextrose have been used as a major fiber source in preparations of unctional drink products and other food products. In this study we determined the effects of these fibers on lipid metabolism of normal rats with two different dietary fat levels by using cellulose as the control. Serum total lipid triglyceride total cholesterol and HDL-colesterol were determined with proper enzymatic methods. Feed intake weight gain and feed efficiency ratio were also calcula-ted. Polydextrose-fed group showed lower serum triglyceride level than hydrolysed guar gum-fed group regardless of fat level used in this study without changing total lipid level in the serum. We also observed that polydextrose-fed group showed low serum cholesterol level nummerically high serum HDL-cholestrol level and more excretion of fecal neutral sterols when compare with those values of hydrolysed guar gum-fed group. The results indicate that polydextrose might have more beneficial roles in lipid metabolism when compare with hydrolysed guar gum.

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Flightless-I Controls Fat Storage in Drosophila

  • Park, Jung-Eun;Lee, Eun Ji;Kim, Jung Kwan;Song, Youngsup;Choi, Jang Hyun;Kang, Min-Ji
    • Molecules and Cells
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    • v.41 no.6
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    • pp.603-611
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    • 2018
  • Triglyceride homeostasis is a key process of normal development and is essential for the maintenance of energy metabolism. Dysregulation of this process leads to metabolic disorders such as obesity and hyperlipidemia. Here, we report a novel function of the Drosophila flightless-I (fliI) gene in lipid metabolism. Drosophila fliI mutants were resistant to starvation and showed increased levels of triglycerides in the fat body and intestine, whereas fliI overexpression decreased triglyceride levels. These flies suffered from metabolic stress indicated by increased levels of trehalose in hemolymph and enhanced phosphorylation of eukaryotic initiation factor 2 alpha ($eIF2{\alpha}$). Moreover, upregulation of triglycerides via a knockdown of fliI was reversed by a knockdown of desat1 in the fat body of flies. These results indicate that fliI suppresses the expression of desat1, thereby inhibiting the development of obesity; fliI may, thus, serve as a novel therapeutic target in obesity and metabolic diseases.

Sexually Dimorphic Control of Obesity and Skeletal Muscle Lipid Metabolism by Fenofibrate

  • Lim, Hyesook;Lee, Hyunghee;Yoon, Michung
    • Biomedical Science Letters
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    • v.19 no.1
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    • pp.17-24
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    • 2013
  • Animals show a sexual dimorphism in metabolic responses. We investigated to verify whether the peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) agonist fenofibrate regulates obesity and skeletal muscle lipid metabolism with sexual dimorphism and to determine the changes in skeletal muscle expression of $PPAR{\alpha}$ target genes. After both sexes of C57BL/6J mice received a high fat diet with or without fenofibrate for 7 weeks, we examined the effects of fenofibrate on not only body weight, adipose tissue mass, and skeletal muscle lipid accumulation, but also the mRNA expression of $PPAR{\alpha}$-related genes in skeletal muscle. Male mice given a fenofibrate-supplemented high fat diet showed decreased body weight gain and adipose tissue mass compared with mice fed a high fat diet alone, whereas fenofibrate did not reduce them in high fat diet-fed female mice. Lipid accumulation in skeletal muscle was inhibited by fenofibrate in male mice, but not in female mice. Gene expression analysis revealed that fenofibrate increased the mRNA levels of $PPAR{\alpha}$ target enzymes only in male mice. Therefore, our results suggest that sex-dependence differences in obesity and intramuscular lipid levels under fenofibrate treatment could be due in part to the differences in skeletal muscle $PPAR{\alpha}$ activation between male and female mice.