• Title, Summary, Keyword: FACT-G

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Effect of Taichichuan Training on Quality of Life in Cancer Patients (태극권 수련이 암환자의 삶의 질에 미치는 영향)

  • Jeong, Tae-Young;Jeong, Sung-Ro;Yoo, Hwa-Seung
    • Journal of Korean Traditional Oncology
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    • v.13 no.1
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    • pp.33-42
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    • 2008
  • Objective: To investigate a clinical effect of Taichichuan training focussing on improvement of quality of life in cancer patients. Methods: The subject of study consisted of 10 cancer patients at the East-West Cancer Center of Dunsan Oriental hospital. The survey method of this study is Functional Assessment of Cancer Therapy-General (FACT-G) korean version. Patients performed Taichichuan twice a week and filled out FACT-G questionnaire before and after training. Results: Although total FACT-G score decreased 0.7 point after training, emotional well-being score increased 1.0 point after training. Male improved FACT-G score better than female. Over 50 age improved FACT-G score better than under 50 age. Over stage Ⅲ improved FACT-G score better than Under Stage II. Patients who were treated integrative treatment improved FACT-G score better than patients who were only treated conventional treatment. But all results were not significant statistically. Conclusions: Emotional well-being tends to improve after training, but this study cannot proved Taichichuan training improve quality of life in cancer patients. Well designed advanced study will be needed to prove its benefits.

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A Study on Quality of Life of Advanced Hepatobiliary and Pancreatic Cancer patients Administered with Traditional Korean Cancer Treatment (간, 담도, 췌장의 진행암으로 한방병원에 내원한 환자의 삶의 질(FACT-G)에 대한 분석)

  • Choi, Chul-Min;Koh, Byung-Hee;Kim, Se-Hyun;Choi, Won-Cheol;Lee, Soo-Kyung
    • The Journal of Korean Medicine
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    • v.29 no.4
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    • pp.30-38
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    • 2008
  • Objectives: The main goals of cancer treatment are improvement of quality of life and survival prolongation. There is a limitation to prolonging the survival time in hepatobiliary and pancreatic cancer. The purpose of this study was to evaluate the quality of life of hepatobiliary and pancreatic cancer patients who visited for traditional Korean cancer treatment. Methods: We evaluated the quality of life of 23 hepatobiliary and pancreatic cancer patients who visited for oriental medicine treatment at East-West Neo Medical Center from June to October of 2007. FACT-G (Functional Assessment Cancer Therapy-General), used in this study, is a scale for evaluation of QOL confirmed validity and reliability, popularly used in many countries to evaluate QOL of cancer patients. Results: The average age of enrolled patients was 57. There were 10 hepatocellular carcinoma patients, 7 pancreatic cancer patients, 6 biliary tract cancer patients. Twenty one patients were in stage IV and 20 patients had distant metastases. By Sasang constitution, Taeumin were 7, Soyangin were 8, and Soeumuin were 8. The baselines of FACT-G score in the first visit were from 34.33 to 85, and the mean score was 67.3. The mean score of FACT-G in hepatocellular carcinoma patients was 67.5, that of pancreatic cancer patients was 62.5, and that of biliary tract cancer patients was 71. Conclusions: This study is valuable as an initial QOL study of hepatobiliary and pancreatic cancer patients who visited an oriental medical clinic. We believe that consistent studies will be necessary to demonstrate oriental treatment-related quality of life with hepatobiliary and pancreatic cancer.

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Quality of Life in Gestational Trophoblastic Neoplasia Patients after Treatment in Thailand

  • Leenharattanarak, Pattaramon;Lertkhachonsuk, Ruangsak
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.24
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    • pp.10871-10874
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    • 2015
  • Background: Gestational trophoblastic neoplasia (GTN) is a malignant disease which occurs in women of reproductive age. Treatment of GTN has an excellent outcome and further pregnancies can be expected. However, data concerning quality of life in these cancer survivor patients are limited. This study aimed to assess quality of life in women who were diagnosed with GTN and remission after treatment, and to determine factors that may affect quality of life status. Materials and Methods: This cross sectional study was conducted from July 2013 to May 2014 in the Gestational Trophoblastic Disease Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Patients who were diagnosed GTN and complete remission were recruited. Data collection was accomplished by interview with two sets of questionnaires, one general covering demographic data and the other focusing on quality of life, the fourth version of Functional Assessment of Cancer Therapy (FACT-G). Descriptive statistics were used to determine general data and quality of life scores. Students t-test and one way ANOVA were used to compare between categorical and continuous data. Results: Forty four patients were enrolled in this study. The overall mean quality of life score (FACT-G) was 98.2. The overall FACT-G score was not significantly correlated with age, education level, stage of disease, treatment modalities, and time interval from remission to enrollment. However, patients who needed further fertility showed significant lower FACT-G scores in the emotional well-being domain (p=0.02). Conclusions: Overall quality of life scores in post-treatment gestational trophoblastic neoplasia patients are in the mild impairment range. Patients who desire fertility suffer lower quality of life in the emotional well-being domain.

The expression of human Spt16 is associated with cell proliferation (인간 Spt16 단백질 발현과 세포 증식 사이의 연관성에 관한 연구)

  • Gwak, Jung-Sug;Cho, Mun-Ju;Ryu, Min-Jung;Oh, Sang-Taek
    • Journal of Life Science
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    • v.17 no.3
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    • pp.381-385
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    • 2007
  • Facilitates chromatin transcription (FACT) is a chromatin-specific elongation factor required for transcription of chromatin templates in vivo and in vitro. FACT consists of human homologue of the Saccharomyces cerevisiae Spt16/Cdc68 protein (hSpt16) and the high mobility group-1-like protein structure-specific recognition protein-1 (SSRP-1). Here we show that the protein level of hSpt16 is massively down-regulated in quiescent T98C cells using both immunofluorescence and western blot analysis. In contrast, we observe high level of the hspt16 expression in the proliferative T98G cells. Interestingly, the expression of SSRP-1 is not altered in both quiescent and proliferative states. Taken together, our findings implicate that the expression of hSpt16 is associated with the proliferative state and can be used as a proliferation marker.

THE KÜNNETH ISOMORPHISM IN BOUNDED COHOMOLOGY PRESERVING THE NORMS

  • Park, HeeSook
    • Bulletin of the Korean Mathematical Society
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    • v.57 no.4
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    • pp.873-890
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    • 2020
  • In this paper, for discrete groups G and K, we show that the cohomology of the complex of projective tensor product B*(G)⨶B*(K) is isomorphic to the bounded cohomology Ĥ*(G × K) of G × K, which is the cohomology of B*(G × K) as topological vector spaces, where B*(G) is a complex of bounded cochains of G with real coefficients ℝ. In fact, we construct an isomorphism between these two cohomology groups that carries the canonical seminorm in Ĥ*(G × K) to the seminorm in the cohomology of B*(G)⨶B*(K).

YANG-MILLS CONNECTIONS ON A COMPACT CONNECTED SEMISIMPLE LIE GROUP

  • Park, Joon-Sik
    • East Asian mathematical journal
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    • v.26 no.1
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    • pp.75-79
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    • 2010
  • Let G be a compact connected semisimple Lie group, g the Lie algebra of G, g the canonical metric (the biinvariant Riemannian metric which is induced from the Killing form of g), and $\nabla$ be the Levi-Civita connection for the metric g. Then, we get the fact that the Levi-Civita connection $\nabla$ in the tangent bundle TG over (G, g) is a Yang-Mills connection.

Study of the electrical propety for $Ge_{1-x}$$Sn_x$/$Ge_{1-y}$$Sn_y$((001) with a direct gap (직접천이 띠간격을 갖는 $Ge_{1-x}$$Sn_x$/$Ge_{1-y}$$Sn_y$(001)의 전기적 특성 연구)

  • 박일수;전상국
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.13 no.12
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    • pp.989-995
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    • 2000
  • G $e_{1-x}$ S $n_{x}$G $e_{1-y}$S $n_{y}$ is a very promising material for the high-speed device due to the fact that electron and hole mobilities for the strained G $e_{1-x}$ S $n_{x}$G $e_{1-y}$S $n_{y}$ are greatly enhanced. Because G $e_{1-x}$ S $n_{x}$G $e_{1-y}$S $n_{y}$ has a direct band gap for the proper combination of x and y, it can be applied to the optoelectronic device. Therefore, the study of the electrical property for G $e_{1-x}$ S $n_{x}$G $e_{1-y}$S $n_{y}$(001) with a direct energy gap is needed. G $e_{1-x}$ S $n_{x}$ layer can not be grown thickly due to the large difference of lattice constants. This fact prefers the structure of the device where electrons and holes move in the plane direction. The transverse mobilities of electron and hole for G $e_{0.8}$S $n_{0.2}$Ge(001) are 2~3 times larger than those for Ge/Ge/ sub0.8/S $n_{0.2}$(001). Therefore, G $e_{0.8}$S $n_{0.2}$Ge(001) is expected to be better than Ge/G $e_{0.8}$S $n_{0.2}$(001) for the development of the high-speed device.h-speed device.device.h-speed device. device.

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Toxicological Aspects of Carboxylesterases -A Sensitive Biomarker of Organophosphate Toxicity-

  • Satoh, Tetsuo;Suzuki, Satoshi;Hosokawa, Masakiyo
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.108-113
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    • 1998
  • Egasyn is accessory protein of ${\beta}$-glucuronidase(${\beta}$-G) in the liver microsomes. Liver microsomal ${\beta}$-G is stabilized within the luminal site of the microsomal vesicles by complexation with egasyn which is one of carboxylesterase isozymes. We investigated the effects of organophosphorus compounds(OPs) such as insecticides on the dissociation of egasyn-${\beta}$-glucuronidase(EG) complex. The EG complex was easily dissociated by administration of OPs, i.e., Fenitrothion, EPN, Phenthionate, and bis-p-nitrophenyl phosphate(BNPP), and resulting ${\beta}$-G dissociated was released into blood, leading to the rapid and transient increase of plasma ${\beta}$-G level with a concomitant decrease of liver microsomal ${\beta}$-G level. In a case of phenthionate treatment, less increase in plasma ${\beta}$-G level was observed, as compared with those of other OPs. This may be explained by a fact that phenthionate was easily hydrolyzed by carboxylesterase. Similarly, carbamate insecticides such as Carbaryl caused rapid increase of plasma ${\beta}$-G level. In contrast, no significant increase of plasma ${\beta}$-G level was observed when pyrethroid insecticides were administered to rats. This is due to a fact that pyrethroids such as Phenthrin and Allethrin were easily hydrolyzed by A-esterase as well as carboxylesterase. On the other hand, addition of OPs to the incubation mixture containing liver microsomes caused the release of ${\beta}$-G from microsomes to the medium. From these in vivo and in vitro data, it is concluded that increase of the plasma ${\beta}$-G level after OPs administration is much more sensitive biomarker than cholinesterase inhibition to acute intoxication of OPs and carbamates.

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HARMONIC TRANSFORMATIONS OF THE HYPERBOLIC PLANE

  • Park, Joon-Sik
    • Journal of the Chungcheong Mathematical Society
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    • v.22 no.4
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    • pp.771-776
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    • 2009
  • Let (H, g) denote the upper half plane in $R^2$ with the Riemannian metric g := ($(dx)^2$ + $(dy)^2$)$/y^2$. First of all we get a necessary and sufficient condition for a diffeomorphism $\phi$ of (H, g) to be a harmonic map. And, we obtain the fact that if a diffeomorphism $\phi$ of (H, g) is a harmonic function, then the following facts are equivalent: (1) $\phi$ is a harmonic map; (2) $\phi$ is an affine transformation; (3) $\phi$ is an isometry (motion).

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Effects of Herba Taraxaci Herbal-Acupuncture on Adjuvant Arthritis in Rats (포공영(蒲公英) 약침(藥鍼)이 Rat의 Adjuvant 관절염(關節炎)에 미치는 영향(影響))

  • Ha, Ji-Yong
    • Journal of Pharmacopuncture
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    • v.2 no.1
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    • pp.135-152
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    • 1999
  • To investigate effects of Taraxaci herbal-acupuncture on Adjuvant Arthritis in rats, the edema rate, the number of WBC, the quantity of total protein, albumin and globulin in the blood serum and histological test of the muscular tissue were measured in the arthritis part. 1. After elicitating arthritis of Sprague Dawely(SD) rats by injection of Freund's complets adjuvant for 2 weeks, saline was injected for the Exp. I group and Taraxaci herbal-acupuncture was injected for the Exp. II group during 30days. Selected point was $ST_{35}$ in both the groups. And then the volume of the paw were checked. The volume of paw was $0.84{\pm}0.14mm$ in the Exp. I group and $0.38{\pm}0.17mm$ in the Exp. II group, the swelling of the paw was restricted significantly in the Exp. II group(p<0.05) 2. The number of WBC was $10.34{\pm}0.14(10^3/ml)$ in the normal group and $37.47{\pm}5.46(10^3/ml)$ in the Exp. I group. It was $20.39{\pm}4.23(10^3/ml)$ in the Exp. II group. This fact showed that the group Exp. II was more effective than the Exp. I group in the treatment of arthritis(p<0.05) 3. The content of the total protein in the blood serum was $6.14{\pm}0.43g/dl$ in the normal group, $7.95{\pm}0.94g/dl$ in the Exp. I group, and $6.38{\pm}1.75g/dl$ in the Exp. II group. This fact showed that the group Exp. II was more effective than the Exp. I group in the treatment of arthritis(p<0.05) 4. The contents of albumin in the blood serum was $2.94{\pm}0.13g/dl$ in the normal group, $2.01{\pm}0.48g/dl$ in the Exp. I group. and $2.71{\pm}0.34g/dl$ in the Exp. II group. This fact showed that the group Exp. II was more effective than the Exp. I group in the treatment of arthritis(p<0.05) 5. The contents of globulin in the blood serum was $3.19{\pm}0.48g/dl$ in the normal group, $4.70{\pm}1.26g/dl$ in the Exp. I group. and $3.67{\pm}0.56g/dl$ in the Exp. II group. There was no significance in the serum globulin between Exp. II group and Exp. I group from the stastical analysis 6. In histological finding, because of severe inflammatory reaction, remarkably irregular tissue and large amount of inflammatory cells were found in the Exp. I group. But the Exp. II group showed small amount of inflammatory cells, the refrained inflammatory state and even recovering state. From these results, it is showed Taraxaci herbal-acupuncture refrain inflammatory reaction and muscular tissue necrosis in SD rats paw were induced by Freund's complete adjuvant