• Title, Summary, Keyword: EOC

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Application of Multiplex Nested Methylated Specific PCR in Early Diagnosis of Epithelial Ovarian Cancer

  • Wang, Bi;Yu, Lei;Yang, Guo-Zhen;Luo, Xin;Huang, Lin
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.3003-3007
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    • 2015
  • Objective: To explore the application of multiplex nested methylated specific polymerase chain reaction (PCR) in the early diagnosis of epithelial ovarian carcinoma (EOC). Materials and Methods: Serum and fresh tissue samples were collected from 114 EOC patients. RUNX3, TFPI2 and OPCML served as target genes. Methylation levels of tissues were assessed by multiplex nested methylated specific PCR, the results being compared with those for carcinoma antigen 125 (CA125). Results: The serum free deoxyribose nucleic acid (DNA) methylation spectrum of EOC patients was completely contained in the DNA spectrum of cancer tissues, providing an accurate reflection of tumor DNA methylation conditions. Serum levels of CA125 and free DNA methylation in the EOC group were evidently higher than those in benign lesion and control groups (p<0.05). Patients with early EOC had markedly lower serum CA125 than those with advanced EOC (p<0.05), but there was no significant difference in free DNA methylation (p>0.05). The sensitivity, specificity and positive predicative value (PPV) of multiplex nested methylated specific PCR were significantly higher for detection of all patients and those with early EOC than those for CA125 (p<0.05). In the detection of patients with advanced EOC, the PPV of CA125 detection was obviously lower than that of multiplex nested methylated specific PCR (p>0.05), but there was no significant difference in sensitivity (p>0.05). Conclusions: Serum free DNA methylation can be used as a biological marker for EOC and multiplex nested methylated specific PCR should be considered for early diagnosis since it can accurately determine tumor methylation conditions.

A Study on the Analysis of Geo-Accuracy with KOMPSAT-1 EOC Pass Imagery (KOMPSAT-1 EOC Pass 영상의 기하정확도 분석에 관한 연구)

  • 서두천;임효숙
    • Korean Journal of Remote Sensing
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    • v.19 no.6
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    • pp.447-456
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    • 2003
  • This study investigated the method for obtaining 3-dimensional terrain information on inaccessable areas by evaluating geometric accuracy of the EOC pass image and scene image acquired from the KOMPSAT-1 satellite. For this purpose, the following four experiments were conducted to evaluate the accuracy of the KOMPSAT-1 EOC satellite data. 1) Calculation of ground coordinates by using ancillary data and image coordinates on Level 1R that were processed by the pre-processing system of KOMPSAT-1. 2) Calculation of 3-dimensional ground coordinates from the ground coordinates of stereo images calculated by using ancillary data, based on space intersections. 3) Execution of bundle adjustment by using GCP (Ground Control Point) extracted in a part of the stereo pass image (KOMPSAT-1 EOC, 1 scene size); and then, evaluation of the ground coordinates from the calculated exterior orientation. 4) Evaluation of accuracy by applying the exterior orientation calculated from 3) To the whole pass image.

Towards the development of an accurate DEM generation system from KOMPSAT-1 Electro-Optical Camera Data (다목적 실용위성 1호기 EOC카메라 영상으로부터 DEM 추출을 위한 시스템개발에 관한 고찰)

  • Taejung Kim;Heung Kyu Lee
    • Korean Journal of Remote Sensing
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    • v.14 no.3
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    • pp.232-249
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    • 1998
  • The first Korean remote sensing satellite, Korea Multi-Purpose Satellite (KOMPSAT-1), is going to be launched in 1999. This will carry a 7m resolution Electro-Optical Camera (EOC) for earth observation. The primary mission of the KOMPSAT-1 is to acquire stereo imagery over the Korean peninsular for the generation of 1:25,000 scale cartographic maps. For this mission, research is being carried out to assess the possibilities of automated or semi-automated mapping of EOC data and to develop, if necessary, such enabling tools. This paper discusses the issue of automated digital elevation model (DEM) generation from EOC data and identifies some important aspects in developing a DEM generation system from EOC data. This paper also presents the current status of the development work for such a system. The development work will be described in three pares of sensor modelling, stereo matching and DEM interpolation. The performance of the system is shown with a SPOT stereo pair. A DEM generated from commercial software is also presented for comparison. The proposed system seems to generate promising results.

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Possible Epithelial Ovarian Cancer Association with HPV18 or HPV33 Infection

  • Zhang, Pei-Pei;Zhou, Lei;Cao, Jia-Shi;Li, Yi-Ping;Zeng, Zhi;Sun, Ni;Shen, Li;Zhu, Hao-Yue;Ruan, Yang;Zha, Wen-Ting;Wang, Xin-Yu;Zhang, Ke-Qiang;Zhang, Ran
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.6
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    • pp.2959-2964
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    • 2016
  • The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data. The prevalence of HPV18 and HPV33 in EOC group and benign group was higher than in the normal group. HPV18 and HPV33 may play a role in the development of both EOC and ovarian benign tumor and may participate in the development of EOC with traditional risk factors, family history and abortion, possibly exerting synergistic effects.

Comparison of DEM Accuracy and Quality over Urban Area from SPOT, EOC and IKONOS Stereo Pairs (SPOT, EOC, IKONOS 스테레오 영상으로부터 생성된 도심지역 DEM의 정확도 및 성능 비교분석)

  • 임용조;김태정
    • Korean Journal of Remote Sensing
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    • v.18 no.4
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    • pp.221-231
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    • 2002
  • In this study we applied a DEM generation algorithm developed in-house to satellite images at various resolution and discussed the results. We tested SPOT images at l0m resolution, EOC images at 6.6m and IKONOS images at 1m resolution. These images include the same urban area in Daejeon city. For camera model, we used Gupta & Hartley's(1997) DLT model for all three image sets. We carried out accuracy assessment using USGS DTED for SPOT and EOC and 23 check points for IKONOS. The assessment showed that SPOT DEM had about 38m RMS error, EOC DEM 12m RMS error and IKONOS DEM 6.5m RMS error. In terms of image resolution, SPOT and EOC DEM error corresponds to 2∼4 pixels where as IKONOS DEM error 6∼7pixels. IKONOS DEM contains more errors in pixels. However, in IKONOS DEM, individual buildings, apartments and major roads are identifiable. All three DEMs contained errors due to height discontinuity, occlusion and shadow. These experiments show that our algorithm can generate urban DEM from 1m resolution and that, however, we need to improve the algorithm to minimize effects of occlusion and building shadows on DEMs.

Application of EOC Images to Developed the GIUH (지형학적순간단위유랑도 분석을 위한 EOC 스테레오 영상 활용)

  • Choi, Hyun;Kang, In-Joon;Hong, Sun-Heun
    • Korean Journal of Remote Sensing
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    • v.20 no.2
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    • pp.91-102
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    • 2004
  • This paper reflects the estimation of using the EOC(Electro-optical Camera) images supporting GIUH(geomorphological instantaneous unit hydrograph) approach. We have analyzed GIUH in its density and frequency distribution by creating a DEM(digital elevation model) for the sub basin produced from the EOC images and examined topographical and hydrological application possibility of the EOC images. In this process, we have topographical basin characteristic analysis that use the remote sensing technique analyzing the DEM creation process of the EOC stereo images by studying the basic topographical hydrology analysis about abstraction technique since it is flirty complex and is more time-consuming than other method. we executed statistical analysis of a basin size and river length using the frequency function after divided lattice spacing applied have to the sub river basin from the image data and the digital map into 10m intervals ranging from 10m to 100m. After comparing and examining the peak and time to peak of the GIUH, we proceeded with a comparative analysis by lattice concerning the topographical divergence rate, area ratio, length ratio. Accumulating the peak and time to peak of the GIUH is altered to non-linear form in accordance to lattice dimension as well as basin factor. It was proved that the lattice dimension is one of the important factors about the peak and time to peak of the GIUH.

Characteristics of the Electro-Optical Camera(EOC) (다목적실용위성탑재 전자광학카메라(EOC)의 성능 특성)

  • Seunghoon Lee;Hyung-Sik Shim;Hong-Yul Paik
    • Korean Journal of Remote Sensing
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    • v.14 no.3
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    • pp.213-222
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    • 1998
  • Electro-Optical Camera(EOC) is the main payload of the KOrea Multi-Purpose SATellite(KOMPSAT) with the mission of cartography to build up a digital map of Korean territory including a Digital Terrain Elevation Map(DTEM). This instalment which comprises EOC Sensor Assembly and EOC Electronics Assembly produces the panchromatic images of 6.6 m GSD with a swath wider than 17 km by push-broom scanning and spacecraft body pointing in a visible range of wavelength, 510~730 nm. The high resolution panchromatic image is to be collected for 2 minutes during 98 minutes of orbit cycle covering about 800 km along ground track, over the mission lifetime of 3 years with the functions of programmable gain/offset and on-board image data storage. The image of 8 bit digitization, which is collected by a full reflective type F8.3 triplet without obscuration, is to be transmitted to Ground Station at a rate less than 25 Mbps. EOC was elaborated to have the performance which meets or surpasses its requirements of design phase. The spectral response, the modulation transfer function, and the uniformity of all the 2592 pixel of CCD of EOC are illustrated as they were measured for the convenience of end-user. The spectral response was measured with respect to each gain setup of EOC and this is expected to give the capability of generating more accurate panchromatic image to the users of EOC data. The modulation transfer function of EOC was measured as greater than 16 % at Nyquist frequency over the entire field of view, which exceeds its requirement of larger than 10 %. The uniformity that shows the relative response of each pixel of CCD was measured at every pixel of the Focal Plane Array of EOC and is illustrated for the data processing.

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Prognostic Significance of Preoperative Anemia, Leukocytosis and Thrombocytosis in Chinese Women with Epithelial Ovarian Cancer

  • Chen, Ying;Zhang, Lei;Liu, Wen-Xin;Liu, Xiang-Yu
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.3
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    • pp.933-939
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    • 2015
  • Malignant tumors are often accompanied by increased risk of hematological abnormalities. However, few studies have reported any prognostic impact of preoperative thrombocytosis, leukocytosis and anemia in epithelia ovarian cancer (EOC). This study aimed to investigate preoperative hematological parameters for anemia, leukocytosis and thombocytosis in relation to established prognostic factors and survival in EOC cases. A total of 816 Chinese women treated for EOC were retrospectively included in the study focusing on the relationship between preoperative hemoglobin, leukocyte and platelet counts, and a panel of clinicopathologic characteristics and outcome. Preoperative anemia was present in 13.4%, leukocytosis in 16.7% and thrombocytosis in 22.8%. Additionally, EOC patients with low differentiation grade, advanced stage, lymph node (LN) metastasis, residual disease ${\geq}1cm$, ascites volume >1,000ml, serum cancer antigen 125 (CA125) >675U/ml, and disease recurrence had the higher prevalence of preoperative anemia, leukocytosis and thrombocytosis (all p<0.05). Moreover, EOC patients with older age or postmenopausal EOC patients had the higher prevalence of thrombocytosis (28.7% vs 17.3% or 26.0% vs 17.7%). Furthermore, in a Cox proportional hazard model, thrombocytosis was an independent factor for progression-free survival (PFS) and overall survival (OS) (p<0.001). Conclusively, preoperative anemia, leukocytosis or thrombocytosis in EOC patients is closely associated with more malignant disease phenotype and poorer prognosis. Significantly, thrombocytosis may independently predict the disease-specific survival for EOC patients.

Comparative Study of KOMPSAT-1 EOC Images and SSM/I NASA Team Sea Ice Concentration of the Arctic (북극의 KOMPSAT-1 EOC 영상과 SSM/I NASA Team 해빙 면적비의 비교 연구)

  • Han, Hyang-Sun;Lee, Hoon-Yol
    • Korean Journal of Remote Sensing
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    • v.23 no.6
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    • pp.507-520
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    • 2007
  • Satellite passive microwave(PM) sensors have been observing polar sea ice concentration(SIC), ice temperature, and snow depth since 1970s. Among them SIC is playing an important role in the various studies as it is considered the first factor for the monitoring of global climate and environment changes. Verification and correction of PM SIC is essential for this purpose. In this study, we calculated SIC from KOMPSAT-1 EOC images obtained from Arctic sea ice edges from July to August 2005 and compared with SSM/I SIC calculated from NASA Team(NT) algorithm. When we have no consideration of sea ice types, EOC and SSM/I NT SIC showed low correlation coefficient of 0.574. This is because there are differences in spatial resolution and observing time between two sensors, and the temporal and spatial variation of sea ice was high in summer Arctic ice edge. For the verification of SSM/I NT SIC according to sea ice types, we divided sea ice into land-fast ice, pack ice, and drift ice from EOC images, and compared them with SSM/I NT SIC corresponding to each ice type. The concentration of land-fast ice between EOC and SSM/I SIC were calculated very similarly to each other with the mean difference of 0.38%. This is because the temporal and spatial variation of land-fast ice is small, and the snow condition on the ice surface is relatively dry. In case of pack ice, there were lots of ice ridge and new ice that are known to be underestimated by NT algorithm. SSM/I NT SIC were lower than EOC SIC by 19.63% in average. In drift ice, SSM/I NT SIC showed 20.17% higher than EOC SIC in average. The sea ice with high concentration could be included inside the wide IFOV of SSM/I because the drift ice was located near the edge of pack ice. It is also suggested that SSM/I NT SIC overestimated the drift ice covered by wet snow.

The Cover Classification using Landsat TM and KOMPSAT-1 EOC Remotely Sensed Imagery -Yongdamdam Watershed- (Landsat TM KOMPSAT-1 EOC 영상을 이용한 용담댐 유역의 토지피복분류(수공))

  • 권형중;장철희;김성준
    • Proceedings of the Korean Society of Agricultural Engineers Conference
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    • pp.419-424
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    • 2000
  • The land cover classification by using remotely sensed image becomes necessary and useful for hydrologic and water quality related applications. The purpose of this study is to obtain land classification map by using remotely sensed data : Landsat TM and KOMPSAT-1 EOC. The classification was conducted by maximum likelihood method with training set and Tasseled Cap Transform. The best result was obtain from the Landsat TM merged by KOMPSAT EOC, that is, similar with statistical data. This is caused by setting more precise training set with the enhanced spatial resolution by using KOMPSAT EOC(6.6m${\times}$6.6m).

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