• Title, Summary, Keyword: Disease mapping

Search Result 124, Processing Time 0.047 seconds

HGLM and EB Estimation Methods for Disease Mapping (HGLM과 EB 추정법을 이용한 질병지도의 작성)

  • 김영원;조나경
    • The Korean Journal of Applied Statistics
    • /
    • v.17 no.3
    • /
    • pp.431-443
    • /
    • 2004
  • For the purpose of disease mapping, we consider the four small area estimation techniques to estimate the mortality rate of small areas; direct, Empirical estimation with total moment estimator and local moment estimator, Estimation based on hierarchial generalized linear model. The estimators are compared by empirical study based on lung cancer mortality data from 2000 Annual Reports on the Cause of Death Statistics in Gyeongsang-Do and Jeonla-Do published by Korean National Statistical Office. Also he stability and efficiency of these estimators are investigated in terms of mean square deviation as well as variation of estimates.

Diagnosing Parkinson's Disease Using Movement Signal Mapping by Neural Network and Classifier Modulation

  • Nikandish, Hajar;Kheirkhah, Esmaeil
    • ETRI Journal
    • /
    • v.39 no.6
    • /
    • pp.851-858
    • /
    • 2017
  • Parkinson's disease is a growing and chronic movement disorder, and its diagnosis is difficult especially at the initial stages. In this paper, movement characteristics extracted by a computer using multilayer back propagation neural network mapping are converted to the symptoms of this disease. Then, modulation of three classifiers of C4.5, k-nearest neighbors, and support vector machine with majority voting are applied to support experts in diagnosing the disease. The purpose of this study is to choose appropriate characteristics and increase the accuracy of the diagnosis. Experiments were performed to demonstrate the improvement of Parkinson's disease diagnosis using this method.

The Effectiveness of Mapping Biopsy in Patients with Extramammary Paget's Disease

  • Kim, Byung Jun;Park, Shin Ki;Chang, Hak
    • Archives of Plastic Surgery
    • /
    • v.41 no.6
    • /
    • pp.753-758
    • /
    • 2014
  • Background Extramammary Paget's disease (EMPD) is an intraepithelial carcinoma usually occurring on the skin or mucosa of the perineum. Clinically, it resembles eczema or dermatitis, and misdiagnosis and treatment delays are common. The treatment of choice for EMPD is a wide excision with adequate margins. Wide excision with intraoperative frozen biopsy and Mohs micrographic surgery are common methods; however, these are associated with a high recurrence rate and long operation time, respectively. Methods Between January 2010 and June 2013, 21 patients diagnosed with EMPD underwent mapping biopsy. Biopsy specimens were collected from at least 10 areas, 2 cm from the tumor margin. When the specimens were positive for malignancy, additional mapping biopsy was performed around the biopsy site of the positive result, and continued until no cancer cells were found. Based on the results, excision margins and reconstruction plans were established preoperatively. Results The patients (18 male, 3 female) had a mean age of 66.5 years (range, 50-82 years). Almost all cases involved in the perineal area, except one case of axillary involvement. Permanent biopsy revealed one case (4.8%) of positive cancer cells on the resection margin, in which additional mapping biopsy and re-operation was performed. At the latest follow-up (mean, 27.4 months; range, 12-53 months), recurrence had not occurred. Conclusions Preoperative mapping biopsy enables accurate resection margins and a preoperative reconstructing plan. Additionally, it reduces the operation time and risk of recurrence. Accordingly, it represents an effective alternative to Mohs micrographic surgery and wide excision with intraoperative frozen biopsy.

Current Status of Comparative Mapping in Livestock

  • Lee, J.H.;Moran, C.;Park, C.S.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.16 no.10
    • /
    • pp.1411-1420
    • /
    • 2003
  • Comparative maps, representing chromosomal locations of homologous genes in different species, are useful sources of information for identifying candidate disease genes and genes determining complex traits. They facilitate gene mapping and linkage prediction in other species, and provide information on genome organization and evolution. Here, the current gene mapping and comparative mapping status of the major livestock species are presented. Two techniques were widely used in comparative mapping: FISH (Fluorescence In Situ Hybridization) and PCR-based mapping using somatic cell hybrid (SCH) or radiation hybrid (RH) panels. New techniques, using, for example, ESTs (Expressed Sequence Tags) or CASTS (Comparatively Anchored Sequence Tagged Sites), also have been developed as useful tools for analyzing comparative genome organization in livestock species, further enabling accurate transfer of valuable information from one species to another.

Fine mapping of qBK1, a major QTL for bakanae disease resistance in rice

  • Ham, Jeong-Gwan;Cho, Soo-Min;Kim, Tae Heon;Lee, Jong-Hee;Shin, Dongjin;Cho, Jun-Hyun;Lee, Ji-Yoon;Yoon, Young-Nam;Song, You-Chun;Oh, Myeong-Kyu;Park, Dong-Soo
    • Proceedings of the Korean Society of Crop Science Conference
    • /
    • /
    • pp.92-92
    • /
    • 2017
  • Bakanae disease is one of the most serious and oldest problems of rice production, which was first described in 1828 in Japan. This disease has also been identified in Asia, Africa, North America, and Italy. Germinating rice seeds in seed boxes for mechanical transplantation has caused many problems associated with diseases, including bakanae disease. Bakanae disease has become a serious problem in the breeding of hybrid rice, which involves the increased use of raising plants in seed beds. The indica rice variety Shingwang was selected as resistant donor to bakanae disease. One hundred sixty nine NILs, YR28297 ($BC_6F_4$) generated by five backcrosses of Shingwang with the genetic background of susceptible japonica variety, Ilpum were used for QTL analysis. Rice bakanae disease pathogen, CF283, was mainly used in this study and inoculation and evaluation of bakanae disease was performed with the method of the large-scale screening method developed by Kim et al. (2014). SSR markers evenly distributed in the entire rice chromosomes were selected from the Gramene database (http://www.gramene.org), and the polymorphic markers were used for frame mapping of a $BC_5F_5$ resistant line. Here, we developed 168 near-isogenic rice lines (NILs, $BC_6F_4$) to locate a QTL for resistance against bakanae disease. The lines were derived from a cross between Shingwang, a highly resistant variety (indica), and Ilpum, a highly susceptible variety (japonica). The 24 markers representing the Shingwang allele in a bakanae disease-resistant NIL, YR24982-9-1 (parental line of the $BC_6F_4$ NILs), were located on chromosome 1, 2, 7, 8, 10, 11, and 12. Single marker analysis using an SSR marker, RM9, showed that a major QTL was located on chromosome 1. The QTL explained 65 % of the total phenotype variation in $BC_6F_4$ NILs. The major QTL designated qBK1 was mapped in 91 kb region between InDel15 and InDel21. The identification of qBK1 and the closely linked SSR marker, InDel18, could be useful for improving rice bakanae disease resistance in marker-assisted breeding.

  • PDF

Bayesian Analysis and Mapping of Elderly Korean Suicide Rates (베이지안 모형을 활용한 국내 노인 자살률 질병지도)

  • Lee, Jayoun;Kim, Dal Ho
    • The Korean Journal of Applied Statistics
    • /
    • v.28 no.2
    • /
    • pp.325-334
    • /
    • 2015
  • Elderly suicide rates tend to be high in Korea. Suicide by the elderly is no longer a personal problem; consequently, further research on risk and regional factors is necessary. Disease mapping in epidemiology estimates spatial patterns for disease risk over a geographical region. In this study, we use a simultaneous conditional autoregressive model for spatial correlations between neighboring areas to estimate standard mortality ratios and mapping. The method is illustrated with cause of death data from 2006 and 2010 to analyze regional patterns of elderly suicide in Korea. By considering spatial correlations, the Bayesian spatial models, mean educational attainment and percentage of the elderly who live alone was the significant regional characteristic for elderly suicide. Gibbs sampling and grid method are used for computation.

Using Intervention Mapping to Develop a Community-based Disease Self-management Support Program for Patients with Osteoarthritis (Intervention Mapping을 적용한 지역사회기반의 골관절염 자기관리지지 프로그램 개발)

  • Ahn, Yang Heui
    • Journal of muscle and joint health
    • /
    • v.22 no.3
    • /
    • pp.245-257
    • /
    • 2015
  • Purpose: The purpose of this study was to apply intervention mapping (IM) to develop a community-based disease self-management support program for patients with osteoarthritis. Methods: IM was applied as follows: i) a needs assessment has been carried out by a literature review, survey and interview with osteoarthritis patients; ii) on the basis of the needs assessment, identification of expected outcomes and change objectives for the target population; iii) selection of theory-based methods and practical applications to influence self-management and the determinants of behavior; iv) design of the intervention by developing activities and materials such as osteoarthritis self-management guide and smart patient pocket book. The activities were integrated into an existing healthcare activities; v) implementation and evaluation plan has been developed. Results: The program is aimed at improving health status through activating patients by a patient-centered and tailored intervention for patients with osteoarthritis; consists of 8 sessions with coaching and cognitive emotional psychological skills; includes smart patient, communication, osteoarthritis, medication adherence, pain control, depressive mood control, physical activity and healthy diet. Conclusion: The IM is a systematic and feasible method for developing the program. The next step is to evaluate the impact of the intervention on activation, and health status.