• Title, Summary, Keyword: Diagnostic ratio

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Diagnostic value of eosinopenia and neutrophil to lymphocyte ratio on early onset neonatal sepsis

  • Wilar, Rocky
    • Clinical and Experimental Pediatrics
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    • v.62 no.6
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    • pp.217-223
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    • 2019
  • Purpose: To determine the diagnostic value of eosinopenia and the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of early onset neonatal sepsis (EONS). Methods: This cross-sectional study was conducted in the Neonatology Ward of R.D. Kandou General Hospital Manado between July and October 2017. Samples were obtained from all neonates meeting the inclusion criteria for EONS. Data were encoded using logistic regression analysis, the point-biserial correlation coefficient, chi-square test, and receiver operating characteristic curve analysis, with a P value <0.05 considered significant. Results: Of 120 neonates who met the inclusion criteria, 73 (60.8%) were males and 47 (39.2%) were females. Ninety (75%) were included in the sepsis group and 30 (25%) in the nonsepsis group. The mean eosinophil count in EONS and non-EONS groups was $169.8{\pm}197.1cells/mm^3$ and $405.7{\pm}288.9cells/mm^3$, respectively, with statistically significant difference (P<0.001). The diagnostic value of eosinopenia in the EONS group (cutoff point: $140cells/mm^3$) showed 60.0% sensitivity and 90.0% specificity. The mean NLR in EONS and non-EONS groups was $2.82{\pm}2.29$ and $0.82{\pm}0.32$, respectively, with statistically significant difference (P<0.001). The diagnostic value of NLR in the EONS group (cutoff point, 1.24) showed 83.3% sensitivity and 93.3% specificity. Conclusion: Eosinopenia has high specificity as a diagnostic marker for EONS and an increased NLR has high sensitivity and specificity as a diagnostic marker for EONS.

Diagnostic Significance of the Serum Thyroxine Binding Globulin(TBG) in Various Thyroid Diseases (각종 갑상선 질환에서 혈청 Thyroxine 결합글로부린 (TBG)의 진단적 의의)

  • Han, Bong-Heon;Lee, Houn-Young;Ko, Suk-Man;Yoon, Sang-Ryong;Ro, Heung-Kyu
    • The Korean Journal of Nuclear Medicine
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    • v.15 no.2
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    • pp.43-51
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    • 1981
  • In an attempt to evaluate the diagnostic significance of the serum thyroxine binding globulin (TBG) in various thyroid disease states, the authors measured serum $T_3$ uptake, $T_3$, total $T_4\;free\;T_4$, TSH and TBG by radioimmunoassay technique, and calculated the free $T_4$ index$(FT_4I)$ and $T_4/TBG$ ratio in 10 cases of normal subjects, 11 cases of hypothyroidism, 62 cases of euthyroidism and 37 cases of hyperthyroidism. The data were analysed in the aspects of diagnostic significance in each thyroid disease state, and the results were as follows; 1. In 10 cases of normal subjects, serum TBG was $17.4\sim26.8{\mu}g/ml$, $FT_4I$ was $5.1\sim9.7$, and $T_4/TBG$ ratio was $21.9\sim49.9(Mean{\pm}S.D.)$. 2. In 62 cases of euthyroidism with diffuse and nodular goiter, $FT_4I$ was $7.26{\pm}1.82,\;T_4/TBG$ ratio was $31.47{\pm}10.42$, and there were no significant difference from those of normal subjects (p>0.5). 3. In 11 cases of hypothyroidism, the $FT_4I$ was $3.13{\pm}2.15,\;T_4/TBG$ ratio was $11.3{\pm}5.31$, significantly lower than normal controls (p<0.01). 4. In 37 cases of hyperthyroidism, the $FT_4I$ was $30.0{\pm}12.0,\;T_4/TBG$ ratio was $121.4{\pm}62.2$, significantly higher than normal controls (p<0.01). 5. There were significant correlations between the $FT_4I$ and $T_4/TBG$ ratio, total $T_4\;and\;T_4/TBG$ ratio, in each thyroid function states. 6. The $FT_4I$ showed 100% of diagnostic value in hyperthyroidism, 89.2% in euthyroidism, and 80% in hypothyroidism group. The $T_4/TBG$ ratio showed 100% of diagnostic value in hyperthyroidism and hypothyroidism, and 80.6% in euthyroidism group. The above results suggest that $T_4/TBG$ ratio and $FT_4I$ showed same diagnostic value in hyperthyroidism group, but $T_4/TBG$ showed higher diagnostic significance than $FT_4I$ in hypothyroidism.

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Diagnosis Method for Power Transformer using Intelligent Algorithm based on ELM and Fuzzy Membership Function (ELM 기반의 지능형 알고리즘과 퍼지 소속함수를 이용한 유입변압기 고장진단 기법)

  • Lim, Jae-Yoon;Lee, Dae-Jong;Ji, Pyeong-Shik
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.66 no.4
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    • pp.194-199
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    • 2017
  • Power transformers are an important factor for power transmission and cause fatal losses if faults occur. Various diagnostic methods have been applied to predict the failure and to identify the cause of the failure. Typical diagnostic methods include the IEC diagnostic method, the Duval diagnostic method, the Rogers diagnostic method, and the Doernenburg diagnostic method using the ratio of the main gas. However, each diagnostic method has a disadvantage in that it can't diagnose the state of the power transformer unless the gas ratio is within the defined range. In order to solve these problems, we propose a diagnosis method using ELM based intelligent algorithm and fuzzy membership function. The final diagnosis is performed by multiplying the result of diagnosis in the four diagnostic methods (IEC, Duval, Rogers, and Doernenburg) by the fuzzy membership values. To show its effectiveness, the proposed fault diagnostic system has been intensively tested with the dissolved gases acquired from various power transformers.

Hepatocellular carcinomas: correlation of enhancement degree with pathologic grades triple contrast MR imaging

  • Kim, Joo-Hee;Kim, Myeong-Jin;Park, Young-Nyun;Kim, Kyung-Sik;Lee, Woo-Jung
    • Proceedings of the KSMRM Conference
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    • pp.108-108
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    • 2001
  • Purpose: To correlate the histological differentiation of hepatocellular carcinomas (HCCs) with finding on triple contrast-enhanced MR imaging using gadolinium-chelates, superparamganetic ire oxides (SPIO), and mangafodipir trisodium. Method: Ten patients with proven HCC underwent triple contrast-enhanced MRI befo surgical resection. Subjective ratings of the enhancement pattern and degree were compare with the histological grades determined on surgical specimen. Quantitative measurements signal-to-noise ratio (S/N) of the lesion and the lesion-to-liver contrast-to-noise ratio C/N on the enhanced MR images, and the degree of S/N and C/N changes between the unenhanced and enhanced images were also correlated with the histological grades.

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Intraarterial Scintigraphy in Recurrent Cervix Cancer - The Evaluation of Radionuclide Therapeutic Trials - (자궁경부재발암 환자의 국소동맥 주입식 동위원소 검사 -방사성 동위원소의 치료시도를 위한 평가-)

  • Kim, Eun-Young;Suh, Jin-Suck;Park, Chang-Yun;Lee, Jong-Tae;Yoo, Hyung-Sik
    • The Korean Journal of Nuclear Medicine
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    • v.24 no.2
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    • pp.293-298
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    • 1990
  • We performed 17 intraarterial scintigraphies in six patients with recurrent cervix cancer. With Seldinger method, the agent (four different radiopharmaceuticals) was perfused at the same speed of infusion of anticancer drugs (25 cc/hour) through internal iliac artery. There were four different radiopharmaceuticals; I-131-Lipiodol, Tc (Technetium)-99m-HSa (Human Serum Albumin), $^{99m}Tc-Sucralfate$ and $^{99m}Tc-MAA$ (Macroaggraegated Albumin). We evaluate the distribution pattern of radioactivity by the use of ratio of Tumor/Extratumor uptake (T/ET ratio). Our results reveals that $^{99m}Tc-MAA$ scan showed the highest T/ET ratio and the other were not ideal agents for intraarterial therapy of recurrent cervix cancer. In conclusion, an ideal radioisotope and tracer which can block capillary, for example MAA, should be re-evaluated or produced in order to treat the patient with recurrent cervix cancer.

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Medical Image Compression using Adaptive Subband Threshold

  • Vidhya, K
    • Journal of Electrical Engineering and Technology
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    • v.11 no.2
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    • pp.499-507
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    • 2016
  • Medical imaging techniques such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and Ultrasound (US) produce a large amount of digital medical images. Hence, compression of digital images becomes essential and is very much desired in medical applications to solve both storage and transmission problems. But at the same time, an efficient image compression scheme that reduces the size of medical images without sacrificing diagnostic information is required. This paper proposes a novel threshold-based medical image compression algorithm to reduce the size of the medical image without degradation in the diagnostic information. This algorithm discusses a novel type of thresholding to maximize Compression Ratio (CR) without sacrificing diagnostic information. The compression algorithm is designed to get image with high optimum compression efficiency and also with high fidelity, especially for Peak Signal to Noise Ratio (PSNR) greater than or equal to 36 dB. This value of PSNR is chosen because it has been suggested by previous researchers that medical images, if have PSNR from 30 dB to 50 dB, will retain diagnostic information. The compression algorithm utilizes one-level wavelet decomposition with threshold-based coefficient selection.

Limited Diagnostic Value of microRNAs for Detecting Colorectal Cancer: A Meta-analysis

  • Zhou, Xuan-Jun;Dong, Zhao-Gang;Yang, Yong-Mei;Du, Lu-Tao;Zhang, Xin;Wang, Chuan-Xin
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.8
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    • pp.4699-4704
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    • 2013
  • Background: MicroRNAs have been demonstrated to play important roles in the development and progression of colorectal cancer. Several studies utilizing microRNAs as diagnostic biomarkers for colorectal cancer (CRC) have been reported. The aim of this meta-analysis was to comprehensively and quantitatively summarize the diagnostic value of microRNAs for detecting colorectal cancer. Methods: We searched PubMed, Embase and Cochrane Library for published studies that used microRNAs as biomarkers for the diagnosis of colorectal cancer. Summary estimates for sensitivity, specificity and other measures of accuracy of microRNAs in the diagnosis of colorectal cancer were calculated using the bivariate random effects model. A summary receiver operating characteristic (SROC) curve was also generated to summarize the overall effectiveness of the test. Result: Thirteen studies from twelve published articles met the inclusion criteria and were included. The overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odd ratio of microRNAs for the diagnosis of colorectal cancer were 0.81 (95%CI: 0.79-0.84), 0.78 (95%CI: 0.75-0.82), 4.14 (95%CI: 2.90-5.92), 0.24 (95%CI: 0.19-0.30), and 19.2 (95%CI: 11.7-31.5), respectively. The area under the SROC curve was 0.89. Conclusions: The current evidence suggests that the microRNAs test might not be used alone as a screening tool for CRC. Combining microRNAs testing with other conventional tests such as FOBT may improve the diagnostic accuracy for detecting CRC.

Assessing the Diagnostic Value of Serum Dickkopf-related Protein 1 Levels in Cancer Detection: a Case-control Study and Meta-analysis

  • Jiang, Xiao-Ting;Ma, Ying-Yu;Guo, Kun;Xia, Ying-Jie;Wang, Hui-Ju;Li, Li;He, Xu-Jun;Huang, Dong-Sheng;Tao, Hou-Quan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.21
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    • pp.9077-9083
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    • 2014
  • Background: This study aimed to summarize the potential diagnostic value of serum DKK1 levels in cancer detection. Materials and Methods: Serum DKK1 was measured using enzyme-linked immunosorbent assay in a case-control study. Then we performed a meta-analysis and the pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic (sROC) curves were used to evaluate the overall test performance. Results: Serum DKK1 levels were found to be significantly upregulated in gastric cancer as compared to controls. ROC curve analysis revealed an AUC of 0.636, indicating the test has the potential to diagnose cancer with poor accuracy. The summary estimates of the pooled sensitivity, specificity and diagnostic odds ratio in meta-analysis were 0.55 with a 95% confidence interval (CI) (0.53-0.57), 0.86 (95%CI, 0.84-0.88) and 12.25 (95%CI, 5.31-28.28), respectively. The area under the sROC was 0.85. Subgroup analysis revealed that the diagnostic accuracy of serum DKK1 in lung cancer (sensitivity: 0.69 with 95%CI, 0.66-0.74; specificity: 0.95 with 95%CI, 0.92-0.97; diagnostic odds ratio: 44.93 with 95%CI, 26.19-77.08) was significantly higher than for any other cancer. Conclusions: Serum DKK1 might be useful as a noninvasive method for confirmation of cancer diagnosis, particularly in the case of lung cancer.