• Title, Summary, Keyword: Creatinine

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Urinary Creatinine Concentration in the Korean Population in KNHANES IV, 2009 (한국인의 요중 크레아티닌 농도에 관한 연구 -국민건강영양조사 4기 자료 이용-)

  • Jung, Kyung-Sick;Kim, Nam-Soo;Lee, Byung-Kook
    • Journal of Environmental Health Sciences
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    • v.38 no.1
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    • pp.31-41
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    • 2012
  • Objectives: Biomonitoring is used to assess human environmental exposures. Urinary biomonitoring data are typically adjusted to a constant creatinine concentration to correct for variable dilutions among spot samples. Our objective was to investigate urinary creatinine concentrations by region, gender, age and lifestyle. Methods: We studied urinary creatinine concentrations in 6,286 Koreans aged 20 years old and older who participated the fourth Korea National Health and Nutrition Survey (KNHANES IV) in 2009. Urinary creatinine concentration analysis used the Jaffe method. Results: The average urinary creatinine concentration of 6,286 Koreans was 158.99 mg/dl. The urinary creatinine concentration was significantly higher among men (184.97 mg/dl) than women (130.02 mg/dl). In both men and women, urinary creatinine concentrations were significantly different according to age group (p < 0.01). Whereas the urinary creatinine concentration of men significantly differed with smoking in adjusted comparison analysis, that of women significantly differed by education level. Ninety-two percent of urinary creatinine concentration was included within WHO guidelines effective range(30 mg/dl ${\leq}$ urinary creatinine concentration ${\leq}$ 300 mg/dl). In multiple regression analysis, creatinine was influenced by gender, age and body mass index (BMI). Conclusions: The urinary creatinine value obtained from representative samples of adult Koreans aged 20 year and older in KNHANES IV 2009 could be used as a reference value for other nationally studied surveys, such as abandoned metal mine surveys and surveys for industrial complexes.

The Clinical Usefulness of Cystatin C in Evaluating Renal Function in Children with Various Renal Diseases (다양한 신질환을 가진 소아에서 Cystatin C 검사의 임상적 유용성)

  • Kim, Khi-Joo;Kim, Joung-A;Shin, Jae-Il;Hwang, You-Sik;Cheung, Il-Chun;Lim, Jong-Baeck;Lee, Jae-Seung
    • Childhood Kidney Diseases
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    • v.11 no.2
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    • pp.161-167
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    • 2007
  • Purpose : GFR(glomerular filtration rate) is a fundamental parameter in detecting renal impairment and predicts the progression of renal disease. Because serum creatinine has several disadvantages, serum cystatin C has been recently proposed as a new endogenous marker for GFR. We compared serum cystatin C with creatinine and creatinine clearance to investigate the clinical usefulness of cystatin C. Methods : We retrospectively analyzed 46 patients(60 case numbers) who had various renal diseases and classified them into 3 groups according to creatinine clearance(Group 1 : CrCl <40 mL/min/$1.73m^2$, Group 2 : CrCl 40-60 mL/min/$1.73m^2$, Group 3 CrCl >60 mL/min/$1.73m^2$). We measured serum creatinine, cystatin C and creatinine clearance and also analyzed the correlations among them. Results : Serum cystatin C and creatinine showed a similar correlation to creatinine clearance (r=0.685, r=0.640, respectively) and showed similar diagnostic accuracy in detecting decreased GFR(AUC, cystatin C 0.829 vs. creatinine 0.826, P=0.848). Serum cystatin C showed a greater sensitivity for detecting a decreased GFR than creatinine in Group 2 and 3(Group 1 : 100% vs. 100%, Group 2 : 70% vs. 35%, Group 3 : 46% vs. 15%). Conclusions : Serum cystatin C could be a useful endogenous marker for GFR and would be superior to serum creatinine in early detection of renal impairment in pediatric patients with renal diseases.

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Comparison of various methods of glomerular filtration rate measurements in children (소아 환아에서 다양한 사구체 여과율 측정법의 비교)

  • Lee, Na Mi;Lim, In Seok
    • Korean Journal of Pediatrics
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    • v.52 no.9
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    • pp.999-1004
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    • 2009
  • Purpose : Glomerular filtration rate (GFR) is a fundamental parameter in assessing renal function and predicting the progression of chronic renal disease. Because the use of serum creatinine has several disadvantages, many studies have investigated the use of cystatin C for estimating GFR. We compared creatinine clearance and GFR with formulas using serum creatinine and cystatin C. Methods : We retrospectively analyzed 211 patients with various renal diseases and classified them into two groups according to creatinine clearance (Group 1: CrCl >$90mL/min/1.73m^2$, Group 2: CrCl <$90mL/min/1.73m^2$). We measured serum creatinine, cystatin C, and creatinine clearance. We calculated GFR using the Schwartz, Counahan, Filler and Lepage, Bokencamp et al, and Grubb et al formulas. Results : GFR determined by the Schwartz formula had the highest correlation to creatinine clearance (r=0.415, P=0.00). GFR determined by various formulas using cystatin C had lower correlation to creatinine clearance (r=0.187, r=0.187, r=0.291). The Schwartz and Counahan formulas showed greater diagnostic accuracy in detecting decreased GFR than cystatin C in group 2 (areas under the curve: Schwartz, 0.596; Counahan, 0.572; Filler, 0.512; Bokencamp, 0.508; and Grubb, 0.514). Conclusion : GFR determined by the Schwartz and Counahan formulas using serum creatinine showed higher correlation coefficient than that determined by formulas using cystatin C. The formulas using cystatin C were not superior to those using serum creatinine in detecting decreased GFR. Cystatin C measurement was not satisfactory for assessing GFR in patients whose renal function was not severely decreased.

The Amount of Creatinine contained in Meats and the Processed Foods of Meats (육류 및 육가공식품 중의 총 Creatinine 함량)

  • 김정숙
    • The Korean Journal of Food And Nutrition
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    • v.12 no.1
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    • pp.91-94
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    • 1999
  • The amount of creatinine contained in the beef imported beef pork and chicken marketing four beef pork, and chicken, marketing four beef stocks seven ramyon soups and three hams and sausages were studied by spectrophotometry with alka-line picrate. Content of creatinine in beef was 252mg/100g of sample and it is higher than that of impor-ted beef. The amount of creatinine increases as follows; chicken

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Urine Specific Gravity as a Useful Tool for Screening Proteinuria in Children (소아 단백뇨 검사에 있어서 요비중의 유용성)

  • Kim, Jong-Hwa;Yoo, Kee-Hwan;Hong, Young-Sook;Lee, Joo-Won;Kim, Soon-Kyum
    • Childhood Kidney Diseases
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    • v.4 no.1
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    • pp.1-5
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    • 2000
  • Purpose: The plcr of spot urine has been uised to predict the timed urine protein excretion. Although this method reduces errors caused by variations in urine volume, it is relatively thconvenient and expensive. Recently, a more rapid and less expensive screening method with specific gravity(SG) has been reported, and we have examined whether estimated-creatinine(Cr-est) with urine 5G could be used in place of urine creatinine to predict 24-hour collected urine protein excretion in children. Methods: We had retrospectively analyzed protein, creatinine and urine SG in randomized spot urine samples of 147 patients from March 1998 till June 1998 in Korea university Guro hospital and compared the urinary protein creatinine ratio(P/Cr) with the protein estimated-creatinine ratio(P/Cr-est). We compared the correlation of urinary creatinine vs-urine 5G with the timed urine pretein excretion. Results: 1) urine SG accurately estimated urine creatinine concentration (r=0.407, P<0.001, Cr=SG x 4485.82-4482.87). 2) P/Cr correlated with urine protein excretion measured in a 24-hour urine collection (r=0.771, P<0.001, 24-hour collected urine protein : 0.338 x (P/Cr) 4+667.885). 3) P/Cr-est correlated with a 24-hour collected urine protein (r=0.723, P<0.001, 24-hour collected urine protein =0.354 x (P/Cr-est)+726.044), Conclusions: These results suggest that P/Cr-est with urine SG could be useful method for screening proteinuria in children.

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Concentration of Serum and Urine Creatinine in Children and Adolescents

  • Kwon, Se-Young;Na, Young-Ak
    • Korean Journal of Clinical Laboratory Science
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    • v.46 no.4
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    • pp.117-123
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    • 2014
  • Creatinine is a general marker as a screening test for renal disease. This study was conducted to provide basic data about pediatric concentration for serum and urine creatinine. The data from the 2011 Korean National Health and Nutrition Examination Survey was used. Analysis was done on 488 Children and Adolescents (boys 278, girls 210) aged 10 to 19, the Jaffe reaction method was used to gather the data. The highest serum creatinine levels were found in boys aged 19 to 20 years, the mean being 0.97 mg/dL (min 0.81 mg/dL, max 1.14 mg/dL). The levels showed increase over those in the 10 year old group. The highest urine creatinine levels were found aged 19 to 20 years, and the mean was 222.68 mg/dL (min 133 mg/dL, max 324 mg/dL). In the case of girls, the highest serum creatinine levels were found with those aged between 18 and 19, the mean being 0.71 mg/dL (min 0.49 mg/dL, max 0.84 mg/dL). The levels showed increase over the 11 to 18 year old group. The highest urine creatinine levels were found aged 14 to 15 years, and the mean was 218.44 mg/dL (min 131 mg/dL, max 321 mg/dL). The mean difference in serum creatinine in all age groups was statistically significant except for those aged 10 to 14, that of urine creatinine in all age groups was not significant statistically except for those aged 12 to 13, 17 to 18. Therefore, it is suggested that reference values for children and adolescents should be divided into different groups according to gender, further studies are needed using complementing data of the pediatrics.

EFFECT OF LEVEL OF FEED INTAKE ON THE EXCRETION OF PURINE DERIVATIVES AND PURINE DERIVATIVES TO CREATININE RATIO IN THE URINE OF SHEEP

  • Han, Y.K.;Shin, H.T.;Landis, J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.5 no.3
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    • pp.465-468
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    • 1992
  • Urinary purine derivatives and creatinine excretion was measured in a total of 4 white Alpine sheep. They were given diets 718 to 1060 g/kg dry matter (DM) of roughage. The crude protein content of this diets was on average $93.87{\pm}5.57g$ in kg DM. Purine derivatives-N excretion increased linearly with incremental DM intake and was significantly correlated (n = 16) with amounts of digestible organic matter (DOM) intake: allantoin-N (mg) = 1.205 (${\pm}0.070$) $\times$ DOM (g) - 136.709 (${\pm}37.399$), r = 0.9770, RSD = 22.97; uricacid-N (mg) = 0.131 (${\pm}0.041$) $\times$ DOM (g) + 11.380 (${\pm}21.881$), r = 0.6306, RSD = 13.44; Hypoxanthine-N (mg) = 0.049 (${\pm}0.014$) $\times$ DOM (g) - 28.640 (${\pm}7.708$), r = 0.6544, RSD = 4.73; total purine derivatives-N (mg) = 1.385 (${\pm}0.083$) $\times$ DOM (g) - 90.261 (${\pm}44.552$), r = 0.9706, RSD = 27.47. Microbial protein synthesis per kg DOM was estimated of 113 g. The urinary creatinine-N excretion was on average 9.10 mg/kg live weight (LW) with a standard error of 0.12 mg creatinine-N per kg LW. The excretion of creatinine excreton was not related to feed intake. Daily creatinine excretion (mg/d) was calculated from individual LW measurements and the average creatinine excretion (mg/kg LW). It was possible to predict the daily urinary purine derivatives excretion (r = 0.9720 for allantoin, r = 0.9886 for total purine derivatives) from the ratio of purine derivatives (mg/100 ml) and creatinine (mg/100 ml) in the urine and the daily creatinine excretion.

A Study on Evaluating Solute Excretion in the Normal Neonate (정상 신생아에서 용질배설 측정 의의에 관한 연구)

  • Choi Jeong Hoon;Kim Mi Kyung;Yoo Kee Hwan;Hong Young Sook;Lee Joo Won;Kim Soon Kyum
    • Childhood Kidney Diseases
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    • v.4 no.1
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    • pp.6-10
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    • 2000
  • Purpose: To evaluate whether the urinary creatinine concentration is a reliable reference value to standardize urinary solute excretion in a spot urine sample during the first week of life. Methods: Spontaneously voided urine specimens were obtained in 49 healthy full term neonates, and in 33 healthy older children with the median ages of $5.7{\pm}4.3$ years, two urine samples were available with an interval of 2 to 3 days. Urine creatinine concentration was determined by the Jaffe test(CoBAS, Integra, Roche, Swiss). Uurine osmolality was determined by the freezing point depression test(Multi-osmette, Precision, USA). Results: Mean urinary creatinine and osmolality values of the first urine samples were not significantly different with the second urine samples in each group. Mean urinary creatinine and osmolality values in neonates were significantly different from the older children of the each urine sample(P<0.01). In neonates, the mean of the urinary oreatinine/osmolality ratios was higher than that of the older children(P<0.01). The urinary creatinine and the creatinine/osmolality values of the first urine samples were closely correlated with those of the second samples in both two groups(P<0.001). Conclusion: The urinary creatinine concentration during the first day of life is relatively stable, even when corrected for urinary osmolality The urinary creatinine and the urinary creatinine/osmolality ratio, therefore, can be used to standardize the urinary excretion of solutes in the neonate.

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Trend of the Changes in the Level of Blood Lead, Urinary Arsenic and Urinary Cadmium of children in Ulsan ; 3-year Follow-up Study (울산지역 어린이들의 혈중 연, 요중 비소 및 카드뮴 농도 변화추이 - 3년 추적조사)

  • Yoo, Cheol-In;Lee, Ji-Ho;Lee, Hun;Kim, Yang-Ho;Lee, Choong-Ryeol
    • Journal of Preventive Medicine and Public Health
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    • v.34 no.2
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    • pp.166-174
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    • 2001
  • Objectives : To obtain basic data on blood lead level and urinary level of arsenic and cadmium of children living near a petrochemical estate and a suburban area in Ulsan, Korea and to observe the trend of the changes. In the level of these metals in these children. Methods : The study subjects comprised 626 children living near a petrochemical estate and 299 children living in a suburban area of Ulsan. We analyzed the level of lead, arsenic and cadmium using atomic absorption spectrometer. Results : The mean levels of blood lead in children living near the petrochemical estate were $5.25{\mu}g/dl,\;5.24{\mu}g/dl,\;and\;7.24{\mu}g/dl$, and in the years 1997, 1999, and 2000, respectively, whereas those of children living in the suburban area were $3.81{\mu}g/dl,\;4.75{\mu}g/dl,\;and\;7.19{\mu}g/dl$ respectively. The mean levels of urinary arsenic in children living near the petrochemical estate were $4.57{\mu}g/g$ creatinine, $4.78{\mu}g/g$ creatinine, and $6.02{\mu}g/g$ creatinine in the year 1997, 1999, and 2000 respectively, whereas those of children living in suburban area were $2.35{\mu}g/g$ creatinine, $4.75{\mu}g/g$ creatinine, and $7.07{\mu}g/g$ creatinine, respectively. The mean levels of urinary cadmium in children living near the petrochemical estate were $1.15{\mu}g/g$ creatinine, $1.05{\mu}g/g$ creatinine, and $1.71{\mu}g/g$ creatinine in the year 1997, 1999, and 2000, respectively, whereas those of the children living in the suburban area were $0.74{\mu}g/g$ creatinine, $1.29{\mu}g/g$ creatinine, and $1.48{\mu}g/g$ creatinine, respectively. There were increasing trends in the level of blood lead, urinary arsenic and cadmium of children in Ulsan, and the differences in the level of these metals were disappearing between the children living in other areas year by year. Conclusions : These results suggest that the amount of exposure to lead, arsenic, and cadmium is increasing from year to year, and there is a need for periodic biological and atmospheric monitoring of these metals in Ulsan.

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Correlation Analysis of Serum Hormones and Components in Hanwoo during Slaughtering Process (한우 도축시 혈청 호르몬과 혈액 성분의 상관 관계 분석)

  • Jeon, G.J.;Kim, M.J.;Cho, K.H.;Ryu, J.W.;Kim, I.C.;Choi, G.K.;Jung, H.Y.;Lee, H.K.
    • Journal of Embryo Transfer
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    • v.21 no.4
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    • pp.287-297
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    • 2006
  • Concentration of hormones and blood components at the last fatting stage was changed before slaughter in Hanwoo steers and bulls. Two months before slaughter and shipment, concentration of cortisol and creatinine was increased, but that of calcium was decreased. Concentration of insulin growth factor-1 (IGF-1) was decreased after shipment, and inorganic phosphorus (IP) was decreased at slaughter. It is unclear that changes of concentration in between 2 months before slaughter and shipment were either caused by aging or stresses (abstinence, environmental change, blood drawing, and shipment). Changes of blood concentration between shipment and slaughter may be accounted for overall responses from abstinence, shipment, and unfamiliar environment. A positive correlation between 2 months before slaughter and before shipment was detected for IGF-1, total protein (TP), albumin, creatinine, high density lipoprotein cholesterol (HDLC), and globulin in steers, and creatinine and globulin in bulls. A positive correlation between 2 month before slaughter and slaughter was detected for IGF-1, blood urea nitrogen (BUN), IP and HDLC in steers, and creatinine in bulls. A positive correlation between before shipment and slaughter was detected for testosterone, IGF-1, creatinine, triglyceride, HDLC and globulin in steers, and TP, creatinine, HDLC and globulin in bulls.