• Title/Summary/Keyword: Cosmetics

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Antioxidant and Antimelanogenic Effects of Stevia rebaudiana Flower Extract

  • So, Gyeongseop;Lee, Sung Ryul;Kim, Sung Hyeok;Ha, Chang Woo;Park, Yuna;Jang, Sohee;Bak, Jong Phil;Koo, Hyun Jung;Sohn, Eun-Hwa
    • Korean Journal of Plant Resources
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    • v.32 no.3
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    • pp.220-227
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    • 2019
  • Stevia rebaudiana (Asteraceae), a perennial plant, has been used as a low-calorie sweetener and is being developed as a therapeutic agent for diabetes, hypertension, myocardial diseases, and microbial infections. Despite the common use of its leaves and stem, the bioavailability of the components present in S. rebaudiana flowers, when used as ingredients of cosmetics, has not been well investigated. Herein, we investigated the antioxidative and antimelanogenic effects of an aqueous extract of S. rebaudiana flowers (Stevia-F). Total flavonoid and phenolic content in Stevia-F were determined to be $8.64{\pm}0.23mg$ of quercetin equivalents/100 g and $631.5{\pm}2.01mg$ of gallic acid equivalents/100 g, respectively. The $IC_{50}$ values of Stevia-F for reducing power, and 2,2-diphenyl-1-picryl-hydrazyl-hydrate radical, hydrogen peroxide, and nitric oxide scavenging activities were 5541.96, 131.39, 466.34, and $10.44{\mu}g/mL$, respectively. Stevia-F showed inhibitory effects on the tyrosinase ($IC_{50}=134.74{\mu}g/mL$) and ${\alpha}$-glucosidase ($IC_{50}=114.81{\mu}g/mL$) activities. No significant cytotoxicity of Stevia-F was observed in B16F10 cells, treated with up to $100{\mu}g/mL$ of the extract for 24 and 48 h (p > 0.05). Stevia-F ($1-100{\mu}g/mL$) suppressed ${\alpha}$-melanocyte stimulating hormone-induced melanin production in B16F10 cells (p < 0.05) and also inhibited the cellular tyrosinase activity (p < 0.05). Overall, our results show that Stevia-F possesses potential for inhibiting tyrosinase and ${\alpha}$-glucosidase activities and has significant antioxidant capacity. The antimelanogenic potential of Stevia-F should extend the usage of S. rebaudiana flowers in the development of skin-whitening products.

Kojic Acid Derivatives, Have Tyrosinase Inhibitory Activity to Suppress the Production of Melanin in the Biosynthetic Pathway (생체 내 경로에서 멜라닌 생성을 억제하는 타이로신 억제제로서의 코직산 유도체)

  • Park, Jung Youl;Lee, Ha Neul;Hu, Meng Yang;Park, Jeong Ho
    • Journal of Life Science
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    • v.29 no.7
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    • pp.755-761
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    • 2019
  • Kojic acid (KA) is produced by Aspergillus oryzae-sort of like mushrooms, which is commonly called as koji in Japan. KA is used as a chelation agent and a preservative preventing oxidative browning of fruits. KA also shows antibacterial and antifungal properties. Because KA stops the production of melanin by inhibiting tyrosinase in the biosynthetic pathway from tyrosine to melanin in skin, it has been applied as a skin lightening ingredient in cosmetics. Since some animal studies have shown that high amounts of KA had side effects such as in liver, kidney, reproductive, cardiovascular, gastrointestinal, respiratory, brain, and nervous system, more efficient KA derivatives are needed to be developed in order to safely apply as a skin lightening ingredient. A series of KA derivatives via conjugated with triazole by click reaction were synthesized and their in vitro tyrosinase inhibitory activities were evaluated. Most of all KA derivatives have shown in moderate tyrosinase inhibitory activities. In case of KA-hybrid compound, 1~3 have shown tyrosinase inhibitory activities about 50~10,000 times more effective tyrosinase inhibitor compared to KA itself. Specifically, the $IC_{50}$ value of KA-hybrid compound, 2 was $0.0044{\pm}0.74{\mu}M$ against tyrosinase. It is about 10,000 times more effective tyrosinase inhibitor compared to KA itself ($IC_{50}=45.2{\pm}4.6{\mu}M$).

Tuning the rheological properties of colloidal microgel controlled with degree of cross-links (가교도가 제어된 콜로이드 마이크로겔의 유변학적 물성 분석)

  • Han, Sa Ra;Shin, Sung Gyu;Oh, Seung Joo;Cho, Sung Woo;Jung, Naseul;Kang, Bu Kyeung;Jeong, Jae Hyun
    • Journal of the Korean Applied Science and Technology
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    • v.36 no.2
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    • pp.645-655
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    • 2019
  • In this study, colloidal microgel with viscoelasticity were prepared by using dispersion containing physical crosslinking agents and microgels with various strengths depending on the degree of cross-links.As the chemical crosslinking agent PEGDA400 content increased, hydrogels have various physical properties the swelling ratio decreased from $2.0{\times}10^4%$ to $6.0{\times}10^3%$ and increased viscosity by about 60%. The colloidal microgel was prepared with micro hydrogel grinded to $100{\mu}m$ size and the rheological behavior was confirmed with physical cross linking agent. A colloidal microgel having various viscosities was prepared by controlling starch and alginate based on micro-hydrogel containing 0.75% (w/v) of PEGDA400. In conclusion, these results would be highly useful for applying as a product that can give various physical properties to the colloidal suspensions, cosmetics, paint, and food industry.

Enzymatic synthesis of benzyl alcohol galactoside using Escherichia coli β-galactosidase (대장균 β-galactosidase를 이용한 benzyl alcohol galactoside의 합성 연구)

  • Jung, Kyung-Hwan
    • Journal of the Korean Applied Science and Technology
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    • v.36 no.2
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    • pp.572-580
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    • 2019
  • Recently, it has been reported that benzyl alcohol (BzOH) as an additive in cosmetics, food, and medicine lead to toxicity and allergy problem. Then, to circumvent this hurdle, we carried out the synthesis of benzyl alcohol galactoside (BzO-gal). Previously, it was confirmed that BzO-gal was synthesized by transgalactosylation reaction using Escherichia coli (E. coli) ${\beta}$-galactosidase (${\beta}-gal$). Meanwhile, in this study, two peaks of BzO-gal as sodium adduct ion (m/z=293.1004) and protonated ion (m/z=271.1180) were detected in the reaction mixture by liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS). In addition, the amount of ${\beta}-gal$ and BzOH concentration, temperature, pH, and lactose concentration, respectively, were optimized (${\beta}-gal$, 0.75 U/mL; BzOH, 185 mM; temperature, $40^{\circ}C$, pH, 7.5; lactose, 350 g/l). Under these optimal conditions, 185 mM BzOH was converted into about 131 mM BzO-gal, in which the conversion yield was about 72%. In the future, BzO-gal will be applicable as a substitute for BzOH as a less toxic preservative for the cosmetic, pharmaceutical, and food industries, and we are planning to investigate the characteristics of BzO-gal as a preservative.

Antioxidant and anti-inflammatory activities of different extraction solvents of Cryptoporus volvatus (한입버섯의 추출 용매별 항산화 및 항염증 활성)

  • An, Gi-Hong;Han, Jae-Gu;Cho, Jae-Han
    • Journal of Mushroom
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    • v.17 no.3
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    • pp.136-143
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    • 2019
  • In this study, we analyze the antioxidant and anti-inflammatory activities of various extracts of Cryptoporus volvatus. Three extracts were prepared using hot-water, 70% ethanol, and 70% methanol. Compared to the hot-water and 70% methanol extracts, the 70% C. volvatus ethanol extracts showed significantly higher DPPH radical scavenging activities (76.1%), nitrite scavenging activities (29.5%), and total polyphenol content (9.17 mg GAE/g). The DPPH radical and nitrite scavenging activities of C. volvatus both correlated significantly with the total polyphenol content. The Pearson's correlation coefficient of DPPH radical and nitrite scavenging activities with total polyphenol content were r = 0.744 (p<0.05) and r = 0.921 (p<0.01), respectively. To test their anti-inflammatory effects, nitric oxide production and cell viability were measured by performing nitric oxide (NO) and MTT assays on lipopolysaccharide-treated RAW 264.7 cells. The NO production levels of the 70% ethanol extract-treated cells were slightly lower than those of the others. In our MTT assay, the hot-water extracts showed higher cell viabilities (81.4%) than those of 70% ethanol and 70% methanol extracts. The ${\beta}$-glucan content of C. volvatus was 37.8%. From the results of this study, it is suggested that C. volvatus, an easily accessible wild mushroom, has potential to be used in the development of medicines, cosmetics, and functional health foods.

Development of Sustainable Anti-aging Products Using Aquaponics Technology (아쿠아포닉스 기술을 이용한 친환경 항노화 제품 개발)

  • Kim, You Ah;Jeon, Tae Byeong;Jang, Wookju;Park, Byoung Jun;Kang, Hakhee
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.45 no.3
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    • pp.307-317
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    • 2019
  • To develop sustainable new natural anti-aging ingredients from Korean native plants, we investigated the cultivation potential of Nymphoides indica using the eco-friendly aquaponics system, and tested the anti-aging effects from N. indica extracts. N. indica could be grown in aquaponics system using floating leaved deep water culture method, and propagated through rhizome propagation. It was confirmed that the nitrate ($80{\mu}g/mL$), potassium ($63.5{\mu}g/mL$) and water temperature ($25^{\circ}C$) greatly affected the cultivation of the N. indica. In addition, synergistic effects were found when two major components (3,7-di-O-methylquercetin-4'-O-${\beta}$-glucoside & sweroside) were present at more than about $5{\mu}g/mL$. The extract had a significant effect on the recovery of skin cells damaged by environmental pollutant such as $benzo[{\alpha}]pyrene$, ammonium nitrate, formaldehyde. It also suppressed $PGE_2$, $TNF-{\alpha}$ and COX-2, and inhibited the production of MMP-1. Taken together, the results suggested that the standardized extracts of N. indica cultivated in the aquaponics has considerable potential as a new cosmetics ingredient with an anti-aging effect.

Antimelanogenic Effect of Isomaltol Glycoside from Red Ginseng Extract (홍삼추출물에 함유된 이소말톨 글리토시드의 멜라닌 생성저해 효과)

  • Lee, Sang Myung
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.45 no.3
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    • pp.255-263
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    • 2019
  • Isomaltol glycoside is a hydrophilic furanic glycoside in which the amino acids and sugars of ginseng are thermally denatured during red ginseng production. Various skin whitening tests were conducted on isomaltol glycoside containing a lot of red ginseng extract in order to investigate the skin whitening effect as a cosmetic raw material. We have tested melanin content assay in B16-F10 cells, zebrafish embryo pigmentation assay, mushroom tyrosinase inhibitory activity, western blot analysis to determine skin whitening activity of isomaltol glycosides. In the zebrafish melanin content assay, isomaltol glycoside decreased total melanin content by about 20% and zebrafish tyrosinase activity by about 10% after treatment with 50 and $100{\mu}g/mL$ compared to the untreated control group. Isomaltol glycoside also showed a concentration-dependent decrease in melanin content in B16-F10 melanoma. Furthermore, it increased the expression of MITF phosphorylation factors p-AKT and p-ERK in B16-F10 melanoma and decreased the concentration of MITF. It also inhibited tyrosinase, TRP-1 and TRP-2 expression. The content of isomaltol glycoside was about 3% in the ginseng extract and about 1% in the ginseng root. Thus, isomaltol glycoside is considered as one of the main components that exhibit the whitening activity of ginseng when considered quantitatively as whitening activity.

Study on the Tensile Strength of Virgin Hair by High-Density Oxidative Dye Application (버진 헤어(Virgin hair)의 고명도(高明渡) 산화염모제 시술에 따른 모발 인장강도 연구)

  • Lim, Sun-Nye;Park, Jang-Soon
    • Journal of Digital Convergence
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    • v.17 no.8
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    • pp.447-452
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    • 2019
  • Modern people are investing a lot of time and economically in their appearance as a means of expressing their aesthetic desires. They have a lot of hair dyes that make up most of their appearance, but their hair damage is serious. Especially, they use hair dyes which are very popular among the hair cosmetics that make up most of their appearance, but their hair damage is serious. The purpose of this study is to investigate the hair tensile strength of hair with oxidative hair dye to induce styling while minimizing hair damage. The results showed that the Max. load, Max. stress, Max. elongation, break load, break stress, break elongation, maximum modulus and tangential modulus according to evaluation interval were significantly different between control and 8N-10N experimental groups. The maximum modulus and tangential modulus for the strain interval did not show tendency to increase or decrease constantly, although there was a difference between the control and experimental group. Therefore this study was conducted to investigate the correlation between hair loss and hair damage through the treatment of high grade oxidative hair dye, which is widely used in ield of industry. We want to provide application data.

Anti-obesity and Anti-diabetic Effects of the Fermented Ethanol Extracts from White Jelly Fungus (Tremella fuciformis Berk) with Lactobacillus rhamnosus BHN-LAB 76 (Lactobacillus rhamnosus BHN-LAB 76로 발효한 흰목이버섯 (Tremella fuciformis Berk) 추출물의 항비만 및 항당뇨 효과)

  • Yoon, Yeo-Cho;Kim, Byung-Hyuk;Kim, Jung-Gyu;Lee, Jun-Hyeong;Park, YeEun;Park, Hye-Suk;Hwang, Hak-Soo;Kwon, Gi-Seok;Lee, Jung-Bok
    • Microbiology and Biotechnology Letters
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    • v.47 no.3
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    • pp.323-331
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    • 2019
  • White jelly fungus (Tremella fuciformis Berk; TF) has been used as a traditional medicine in Asia; it is known to prevent hypertension, aging, cancer, and arteriosclerosis. This study aimed to investigate the anti-diabetic effects of fermented Tremella fuciformis Berk (FTF) ethanol extracts fermented with L. rhamnosus BHN-LAB 76. We show that FTF increases the ${\alpha}$-glucosidase inhibitory activity and suppress the adipogenesis of 3T3-L1 adipocytes. These inhibitory effects of FTF are accompanied by the regulation of the phosphorylation of AMPK, JNK, and Akt. These data demonstrate that FTF not only inhibits adipogenesis by affecting the adipogenic signaling, but also increases the anti-diabetic effects by regulating the insulin signaling pathway. Therefore, we suggest that the FTF can be used for developing functional food and cosmetics materials.

Analysis of the affiliated department and the name trend of the department of beauty department of a university located in the central region (중부권역 소재 대학 뷰티학과의 소속 계열과 학과 명칭 동향에 관한 분석)

  • Oh, Jeong-Sun;lee, Sook-ja;Park, Jang-Soon
    • Journal of the Korea Convergence Society
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    • v.13 no.5
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    • pp.327-332
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    • 2022
  • In the age of population cliff, an aggressive entrance exam strategy for the development of excellent human resources for beauty is very important for the survival of beauty departments and universities. Therefore, for the purpose of in-depth trend analysis of department names and affiliated departments that reflect department characteristics as well as external department promotion tools, we investigated and analyzed department affiliated departments and department titles in 2020 targeting the Beauty Department of Central University. As a result of the study, the departments belonging to each of the four regions had the most beauty arts department (28.57%) and health department (50.00%). In Daejeon, beauty design (37.5%) was the most, and in Chungcheong, beauty care, beauty cosmetics, and medical beauty care (11.11%) were the most. Through this study, it will be possible to analyze the overall characterization trend of the Department of Beauty, and it will be used as an important basic data to suggest the future direction of the department when the departments are merged or separated in the future. In addition, I believe that it will provide a foothold for follow-up research on the curriculum for each department or the change of department name by year.