• Title, Summary, Keyword: Contrast medium

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Consideration of Adverse Reaction to MDCT Contrast Media (MDCT에 사용되는 조영제의 부작용에 대한 고찰)

  • Yang, Won-Seok;Shin, Seong-Gyu
    • Journal of radiological science and technology
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    • v.35 no.1
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    • pp.51-57
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    • 2012
  • In this experiment, we investigated 82 patients who suffered adverse reactions due to contrast medium. We selected the subjects out of 21,178 people who had an intravenous injection of contrast medium to undergo MDCT examination at one university hospital in Busan in 2007. As a result, the largest groups of the patients were as follows. 52.4% of the patients were male when classify by gender; 28.0% of the patients were 50's by age; 45% of the patients got when it was spring(April and March); 75.6% of the patients had a side effects when the speed of injection is 2.5mL/sec; 58.5% of the patients were suffered when the volume of injected contrast medium is over 130mL. Urticaria was the main symptom of side effect as 26.8%. And the main treatment for the effect was alleviating the symptoms before making patients to return home. Thus, practical preventive measures are needed as follows : use the OCS system to observe warning signs at risky patients, secure warming spaces for patients to cope with season changing, prepare enough emergency kits for the patients in danger, and establish CPR call systems, explain the risk of contrast medium and get agree about using contrast medium.

The Frontiers of Product Liability for Adverse Reactions to the Contrast Medium (조영제부작용에 대한 제조물책임의 한계)

  • Lim, Chang-Seon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.9 no.5
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    • pp.1386-1391
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    • 2008
  • The Korean Product Liability Act established the principle that a manufacturer has a duty to take care of a person who is not the customer who bought the product for him. In this instance, there is a duty to the patient for whom the product was purchased by the hospital from the pharmaceutical company. Therefore, the pharmaceutical company has the product liability for adverse reactions to the contrast medium. But the possibility for the patient to successfully sue the pharmaceutical company is quite low, because the patient needs to prove that a "defect" in the unsafe product was the cause of his injuries. And the physician or the radiological technologist can not reduce his liability risks based on the Product Liability Act. On the contrary, The has the product liability because diluting contrast medium belongs to the product category.

Maximum TE Setting Range for Quantitatively Evaluating T2 Relaxation Time : Phantom Study (T2 이완시간의 정량적 평가에 있어서 Maximum TE의 설정 범위에 대한 연구 : 팬텀연구)

  • Park, Jin Seo;Kim, Seong-Ho
    • Journal of radiological science and technology
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    • v.41 no.1
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    • pp.25-31
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    • 2018
  • This study aimed to evaluate the range of maximum TE that could measure T2 relaxation time accurately by setting diverse maximum TE with using contrast medium phantoms. Contrast medium phantoms ranging from low to high concentrations were made by using Gadoteridol. The relaxation time and relaxation rate were compared and evaluated by conducting T2 mapping by using reference data based on various TEs and data obtained from different maximum TEs. It was found that accurate T2 relaxation time could be expressed only when the maximum TE over a certain range was used in the section with long T2 relaxation time, such as the low concentration section of saline or gadolinium contrast medium. Therefore, the maximum TE shall be longer than the T2 relation time for accurately maturing the T2 relaxation of a certain tissue or a substance.

Influence of Intravenous Contrast Medium on Dose Calculation Using CT in Treatment Planning for Oesophageal Cancer

  • Li, Hong-Sheng;Chen, Jin-Hu;Zhang, Wei;Shang, Dong-Ping;Li, Bao-Sheng;Sun, Tao;Lin, Xiu-Tong;Yin, Yong
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.1609-1614
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    • 2013
  • Objective: To evaluate the effect of intravenous contrast on dose calculation in radiation treatment planning for oesophageal cancer. Methods: A total of 22 intravein-contrasted patients with oesophageal cancer were included. The Hounsfield unit (HU) value of the enhanced blood stream in thoracic great vessels and heart was overridden with 45 HU to simulate the non-contrast CT image, and 145 HU, 245 HU, 345 HU, and 445 HU to model the different contrast-enhanced scenarios. 1000 HU and -1000 HU were used to evaluate two non-physiologic extreme scenarios. Variation in dose distribution of the different scenarios was calculated to quantify the effect of contrast enhancement. Results: In the contrast-enhanced scenarios, the mean variation in dose for planning target volume (PTV) was less than 1.0%, and those for the total lung and spinal cord were less than 0.5%. When the HU value of the blood stream exceeded 245 the average variation exceeded 1.0% for the heart V40. In the non-physiologic extreme scenarios, the dose variation of PTV was less than 1.0%, while the dose calculations of the organs at risk were greater than 2.0%. Conclusions: The use of contrast agent does not significantly influence dose calculation of PTV, lung and spinal cord. However, it does have influence on dose accuracy for heart.

Preparation of Gold Coated Liposomes for CT Contrast Medium (CT 조영을 위한 금 코팅 리포솜의 제조)

  • Wee, Tae In;Jeon, Ye Won;Cho, Young Jae;Cho, Sung Keun;Ha, Jeung;Lee, Jeong Won;Cho, Sun Hang;Han, Hee Dong;Shin, Byung Cheol
    • Journal of the Korean Chemical Society
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    • v.57 no.5
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    • pp.634-639
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    • 2013
  • The use of medical imaging has been increased for diagnosis of cancer or vessel disease. Among the medical imaging, computed tomography (CT) is one of the popular methods, however, which should need administration of contrast medium. Therefore, we developed gold coated liposomes (GCL) as a contrast medium. To coat gold on the liposomal surface, positive charged liposomes was prepared and then negative $Au^-$ can coat on the liposomal surface by electronic interaction. The size of GCL was $154.8{\pm}9.2$ nm and surface charge was $27{\pm}3.2$ mV, respectively. The morphology of GCL was confirmed by electron microscopy (SEM) and transmission electron microscopy (TEM). The coating efficiency of gold was 18%. Chemical procedure for gold coating on liposomal surface was not toxic for cell cytotoxicity by MTT assay. Finally, we demonstrated attractive CT image for GCL. Taken together, the GCL would be useful for various vessel related disease as a contrast medium.

Physicochemical Analysis according to Temperature Changes of Iopamidol and Ioversol Formulation Contrast Agents (Iopamidol과 Ioversol 제제 조영제의 온도변화에 따른 물리화학적 분석)

  • Han, Beom-Hee
    • Journal of radiological science and technology
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    • v.43 no.4
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    • pp.273-280
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    • 2020
  • In this study, the P contrast agent of Iopamidol, which is a nonionic iodide contrast agent most commonly used as a vascular contrast agent in medical institutions, and the O contrast agent of Ioversol, were studied. The physicochemical changes according to the temperature change were compared and analyzed using the Bruker Avance 500MHz Nuclear Magnetic Resonance Spectrometer owned by the Korea Basic Science Institute (KBSI). There was no physical or chemical change in the O contrast medium of Ioversol formulation in temperature change. However, in the P contrast agent of Iopamidol, a doublet peak began to appear in the 1.1 ppm region of the sample at 60℃, and the doublet peak was clearly observed in the sample at 80℃. As a result of this study, 1H-NMR analysis revealed that the P contrast agent of the Iopamidol formulation was dissociated from chemical bonds as it rose to a high temperature of 60℃ or higher, resulting in the formation of foreign substances. It was evaluated that the O contrast agent of Ioversol formulation had physico-chemical stability than the P contrast agent of Iopamidol formulation. As shown in this study, it is necessary to analyze the physical and chemical changes of contrast agents according to various environmental factors.

A Study of Standarzied Uptake Value Change on the Type of Mateiral (물질의 종류에 따른 표준섭취계수의 변화에 관한 연구)

  • Kim, Ki-Jin;Kim, Chong-Yeal;Bae, Seok-Hwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.8
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    • pp.3572-3578
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    • 2011
  • In Positron Emission Tomography Computed Tomography, Standardized Uptake Value(SUV)is most generally used to discern tumors. However, SUV may be influenced other factors. In this study, experiment was conducted distrotion in image and change in SUV according to substance with GEMINI TF PET/CT of Philips.. SUV for materials resulted in 1.8 for stainless, 1.4 for stent, 2.4 for iodine contrast medium, 2.6 for Barium Sulfate, 1.6 for Gypsum, and 1.4 for paraffin respectively. The distortion of image was remarkable for the iodine contrast medium and Barium Sulfate. For the barium sulfate, the higher the density, the larger the distrotion of the images. As a result of test, it appeared that the metallic substance whose atomic number is low and contrast medium whose concentration is low didn't affect the distortion in image and the change in SUV. However, it tis necessary to minimize distortion in image and change in SUV, by removing the metallic substance and checking if there are contrast mdeium or before examination.

Study on Shielding using CT Contrast Medium (CT 조영제를 이용한 차폐체에 대한 연구)

  • Gang, Heon-Hyo;Kim, Dong-Hyun
    • Journal of the Korean Society of Radiology
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    • v.12 no.5
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    • pp.693-698
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    • 2018
  • Currently, shields for shielding medical radiation during medical examinations in the medical environment are lead robe and lead glass. Lead, the main component of this shielding, has limitations in lead poisoning and light weight, and high price. Iodine, which is used as contrast medium instead of lead shield, is expected to be effective as a shield because it has radiation absorbing properties. The purpose of this study was to evaluate the effectiveness of shielding by using acrylic plate filled with CT contrast agent for clinical use instead of conventional lead glass. As a result, it was found that the acrylic plate filled with the CT contrast agent showed a shielding effect of 7 times or more when the scattering ray dose was not shielded. Therefore, CT contrast agent composed of iodine is expected to be used as a shield instead of conventional lead glass.