• Title, Summary, Keyword: Cheunggyeongsamul-tang

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Effects of Cheunggyeongsamul-tang Extract on Longitudinal Bone Growth in Adolescent Female Rats (청경사물탕(淸經四物湯) 추출물의 성장기 흰쥐 장골길이 성장에 대한 효과)

  • Lee, Jung-Hun;Lee, Se-Na;Son, Jae-Bong;Keum, So-Hyun;Leem, Kang-Hyun
    • The Korea Journal of Herbology
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    • v.24 no.4
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    • pp.149-157
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    • 2009
  • Objectives : This study was designed to investigate the effects of Cheunggyeongsamul-tang extract on the growth of longitudinal bone in adolescent female rats. Methods : Longitudinal bone growth was measured by fluorescent microscopy. To examine the effects on the growth plate metabolism, the total height of growth plate, the induction of local insulin-like growth factor-1 (IGF-1), IGF-1 receptor, bone morphogenetic protein-2 (BMP-2), BMPR-1A, indian hedgehog (IHH), and parathyroid hormone-related protein (PTH-rP) were measured. Results : Cheunggyeongsamul-tang extract enhanced longitudinal bone growth and total height of the growth plate. Also, it promoted the induction of local IGF-1, BMP-2, IHH and PTH-rP of the growth plate. Conclusions : This study shows that the Cheunggyeongsamul-tang extract effects longitudinal bone growth in adolescent rats and might be used for both stunted adolescents and inherent growth failure patients.

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