• Title, Summary, Keyword: Chemoprevention

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POTENT INHIBITION OF HUMAN CYTOCHROME P450 1 ENZYMES BY DIMETHOXYPHENYL VINYL THIOPHENE.

  • Lee, Sangk wang;Kim, Sanghee;Kim, Mie young;Chun, Young-Jin
    • Proceedings of the Korean Society of Toxicology Conference
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    • pp.92-92
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    • 2002
  • Recently we have reported that various hydroxystilbenes show strong inhibition of human P450 1 activity. A series of synthetic trans-stilbene derivatives were prepared and their inhibitory potentials were evaluated with the bacterial membrane of recombinant human P450 1A1, 1A2 or 1B1 coexpressed with human P450/NADPH-450 reductase to find new candidates for cancer chemoprevention.(omitted)

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CHEMOPREVENTIVE FOOD PHYTOCEHMICALS: SCREENING, ACTION MECHANISMS, AND METABOLISM

  • Murakami, Akira;Koshimizu, Koichi;Ohigashi, Hajime
    • Proceedings of the Korean Society of Toxicology Conference
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    • pp.33-34
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    • 2001
  • Cancer chemoprevention Chemoprevention with strategies using food phytochemicals is currently regarded ascompose one of the noticeable most visible and promising scientific fields for cancer control. A large body of data from both epidemiologic and rodent studies has demonstrated that the ingestion of various vegetables and fruits is occasionally beneficial for cancer risk reduction of cancer risks in humans.(omitted)

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EFFECT OF SELENIUM COMPOUNDS ON CHEMOPREVENTION AND TUMOR INVASION

  • Chung, An-Sik;Uhee Jung;Yoon, Sang-Oh
    • Proceedings of the Korean Society of Toxicology Conference
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    • pp.11-12
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    • 2001
  • Selenium is known to have both chemopreventive and therapeutic benefits of cancer. Recent studies have implicated that apoptosis is one of the most plausible mechanism of chemopreventive effects of selenium compounds and tumor invasion is a new factor involved in chemotherapy. In the present study, we demonstrate that Se-methylselenocysteine(MSC), one of the most effective selenium compound sat chemoprevention, induces apoptosis in HL-60 cells and that ROS plays a crucial role in MSC-induced apoptosis.(omitted)

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Current Mechanistic Approaches to the Chemoprevention of Cancer

  • Steele, Vernon E.
    • BMB Reports
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    • v.36 no.1
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    • pp.78-81
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    • 2003
  • The prevention of cancer is one of the most important public health and medical practices of the $21^{st}$ century. We have made much progress in this new emerging field, but so much remains to be accomplished before widespread use and practice become common place. Cancer chemoprevention encompasses the concepts of inhibition, reversal, and retardation of the cancer process. This process, called carcinogenesis, requires 20-40 years to reach the endpoint called invasive cancer. It typically follows multiple, diverse and complex pathways in a stochastic process of clonal evolution. These pathways appear amenable to inhibition, reversal or retardation at various points. We must therefore identify key pathways in the evolution of the cancer cell that can be exploited to prevent this carcinogenesis process. Basic research is identifying many genetic lesions and epigenetic processes associated with the progression of precancer to invasive disease. Many of these early precancerous lesions favor cell division over quiescence and protect cells against apoptosis when signals are present. Many oncogenes are active during early development and are reactivated in adulthood by aberrant gene promoting errors. Normal regulatory genes are mutated, making them insensitive to normal regulatory signals. Tumor suppressor genes are deleted or mutated rendering them inactive. Thus there is a wide range of defects in cellular machinery which can lead to evolution of the cancer phenotype. Mistakes may not have to appear in a certain order for cells to progress along the cancer pathway. To conquer this diverse disease, we must attack multiple key pathways at once for a predetermined period of time. Thus, agent combination prevention strategies are essential to decrease cancer morbidity. Furthermore, each cancer type may require custom combination of prevention strategies to be successful.

A Novel Synthetic Compound, YH-1118, Inhibited LPS-Induced Inflammatory Response by Suppressing IκB Kinase/NF-κB Pathway in Raw 264.7 Cells

  • Yun, Chang Hyun;Jang, Eun Jung;Kwon, Soon Cheon;Lee, Mee-Young;Lee, Sangku;Oh, Sei-Ryang;Lee, Hyeong-Kyu;Ahn, Kyung-Seop;Lee, Ho-Jae
    • Journal of Microbiology and Biotechnology
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    • v.25 no.7
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    • pp.1047-1055
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    • 2015
  • For the search of a potent first-in-class compound to inactivate macrophages responsible for inflammatory responses, in the present study, we investigated the anti-nflammatory effects of YH-1118, a novel synthetic compound, in a lipopolysaccharide (LPS)-stimulated mouse macrophage cell line, Raw 264.7. YH-1118 inhibited LPS-induced nitric oxide (NO) production and inducible NO synthase (iNOS) expression at both the protein and mRNA levels. The suppression of LPS-induced iNOS expression by YH-1118 was mediated via nuclear factor kappa B (NF-κB), but not activator protein-1 (AP-1) transcription factor. This was supported by the finding that YH-1118 attenuated the phosphorylation of inhibitor of κBα (IκBα) and nuclear translocation and DNA binding activity of NF-κB. Through the mechanisms that YH-1118 inhibited the activation of IκB kinases (IKKs), upstream activators of NF-κB, or p38 MAPK, YH-1118 significantly suppressed LPS-induced production of pro-inflammatory cytokines, tumor necrosis factor-α, interleukin-1β (IL-1β), and IL-6 (p < 0.05). In conclusion, our results suggest that YH-1118 inhibits LPS-induced inflammatory responses by blocking IKK and NF-κB activation in macrophages, and may be a therapeutic candidate for the treatment of various inflammatory diseases.

Moringa oleifera Lam: Targeting Chemoprevention

  • Karim, Nurul Ashikin Abd;Ibrahim, Muhammad Din;Kntayya, Saie Brindha;Rukayadi, Yaya;Hamid, Hazrulizawati Abd;Razis, Ahmad Faizal Abdull
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.8
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    • pp.3675-3686
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    • 2016
  • Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as ''murungai'' or ''kelor''. Glucomoringin, a glucosinolate with from M. oleifera is a major secondary metabolite compound. The seeds and leaves of the plant are reported to have the highest amount of glucosinolates. M. oleifera is well known for its many uses health and benefits. It is claimed to have nutritional, medicinal and chemopreventive potentials. Chemopreventive effects of M. oleifera are expected due to the existence of glucosinolate which it is reported to have the ability to induce apoptosis in anticancer studies. Furthermore, chemopreventive value of M. oleifera has been demonstrated in studies utilizing its leaf extract to inhibit the growth of human cancer cell lines. This review highlights the advantages of M. oleifera targeting chemoprevention where glucosinolates could help to slow the process of carcinogenesis through several molecular targets. It is also includes inhibition of carcinogen activation and induction of carcinogen detoxification, anti-inflammatory, anti-tumor cell proliferation, induction of apoptosis and inhibition of tumor angiogenesis. Finally, for synergistic effects of M. oleifera with other drugs and safety, essential for chemoprevention, it is important that it safe to be consumed by human body and works well. Although there is promising evidence about M. oleifera in chemoprevention, extensive research need to be done due to the expected rise of cancer in coming years and to gain more information about the mechanisms involved in M. oleifera influence, which could be a good source to inhibit several major mechanisms involved in cancer development.

Quinone Reductase Inducer from Radish Leaf Cultivated in the Soil Containing Sulfur (유황시비처리가 열무의 Quinone Reductase 유도물질 생성에 미치는 영향)

  • 김경아;노치웅;최경락;황해준;최혜선
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.6
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    • pp.946-950
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    • 2004
  • Young radishes which were grown in the soil containing sulfur increased quinine reductase (QR) activity in Hepa 1clc cells and isothiocyanate-like compound analyzed by HPLC. QR inducing activity was maximum in young radishes grown with 1,818 g/㎥ sulfur and was decreased when the soil was neutralized with lime mortar in order to improve a recovery. These results have suggested that consumption of young radishes, especially grown in the presence of sulfur, would prevent from cancer incidence through inducing detoxification enzymes and could have therapeutic effects for chemoprevention.

Effect of Ethanol Extract from Salvia miltiorrhiza on Chemoprevention and Metastasis of Breast Cancer (단삼 에탄올추출물이 유방암 예방 및 전이에 미치는 영향)

  • Shon, Yun-Hee;Cho, Hyun-Jung;Kim, Mee-Kyung;Jung, Eun-Jung;Nam, Kyung-Soo
    • Korean Journal of Pharmacognosy
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    • v.38 no.1
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    • pp.62-66
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    • 2007
  • Ethanol extract from Salvia miltiorrhiza (SME) was tested for breast cancer chemoprevention and metastasis by measuring the activites of cytochrome P45O 1A1, aromatase, ornithine decarboxylase (ODC), and matrix metalloproteinase (MMP)-9. SME significantly inhibited cytochrome P45O 1A1-mediated ethoxyresorufin O-deethylase (EROD) activity in a dose-dependent manner in a concentration range of 100${\sim}$l,200 ${\mu}g/ml$ (p<0.01). Microsomal aromatase (estrogen synthase) activity was suppressed 54.9%${\sim}$77.5% by the SME at concentration of 600${\sim}$l,200 ${\mu}g/ml$. ODC activity induced by 12-O-tet-radecanoylphorbol-13-acetate (TPA) was significantly reduced by the SME 900 and 1,200 ${\mu}g/ml$ (p<0.05) in MCF-7 breast cancer cells. In addition, SME (900 and 1,200 ${\mu}g/ml$) markedly inhibited MMP-9 activity, a key role in cancer metastasis. Therefore, SME is worth further investigation with respect to breast cancer chemoprevention or therapy.