• Title, Summary, Keyword: Cell-mediated Immune Response

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Effect of Aconitine and Heated Aconitine on the Immune Response in Mice (Aconitine 및 가열처리한 Aconitine이 Mouse의 면역반응에 미치는 영향)

  • 안영근;김정훈;정동환
    • Environmental health and toxicology
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    • v.3 no.1_2
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    • pp.33-42
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    • 1988
  • Dose-dependent, immune modulatory effects of aconitine and heated aconitine were studied in mice. Mice, administered aconitine and heated aconitine intraperitoneally every other day for 4 weeks, were sensitized and challenged with sheep red blood cells. Serum antibody titer, foot pad swelling and rosette forming cell number were measured to evaluate hurmoral and cell mediated immune responses. The results show that Humoral immune response was suppressed by aconitine 0.05 mg/kg and heated aconitine but increased by aconitine 0.10 mg/kg administration. Cell mediated immune response was suppressed in all groups. Especially heated aconitine administration significantly suppressed the cell mediated immune response. The number of peripheral circulating white blood cell was reduced by aconitine but was not affected by heated aconitine.

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A Design of An Active PID control using Immune Algorithm for Vibration Control of Building Structure (구조물 진동제어를 위한 Immune Algorithm을 이용한 Active PID 제어기 설계)

  • Lee, Young-Jin;Cho, Hyun-Cheol;Lee, Kwon-Soon
    • Proceedings of the KIEE Conference
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    • pp.72-74
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    • 2005
  • In this paper, we propose an adaptive PID controller using a cell-mediated immune response to improve a PID control performance. The proposed controller is based on the specific immune response of the biological immune system that is cell-mediated immunity. The immune system of organisms in the real body regulates the antibody and the T-cells to protect an attack from the foreign materials like virus, germ cells, and other antigens. It has similar characteristics that are the adaptation and robustness to overcome disturbances and to control the plant of engineering application. We first build a model of the T-cell regulated immune response mechanism and then designed an I-PID controller focusing on the T-cell regulated immune response of the biological immune system. We apply the proposed methodology to building structures to mitigate vibrations due to strong winds for evaluation of control performances. Through computer simulations, system responses are illustrated and additionally compared to traditional control approaches.

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Studies on the Effect of Captafol and Ethanol the Murine Immune System (Captafol 免疫毒性에 미치는 Ethanol의 영향)

  • 박귀례
    • Journal of Environmental Health Sciences
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    • v.14 no.1
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    • pp.115-122
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    • 1988
  • Captafol (1H-Isoindole-1.3(2H)-dione, 3a, 4, 7, 7a-tetrahydro-2-[1, 1, 2, 2-tetrahydroethyltkio]) is widely used as fungicide in agriculture. Immune modulatory effects of captafol and ethanol were studied in mice. Mice administered captafol intra peritoneally every other day for 5 times, and ethanol per os as captafol. Mice were sensitized and challenged with sheep red blood cells, serum antibody titer, foot pad swelling, and rosette forming cell number were mediated immune response. 1. The result show that humoral immune response and cell mediatea response were suppressed by captafol. 2. Especially effect of ethanol on the captafol immune response were significantly suppressed the humoral immune response and cell mediated immune response.

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A Study on Nonlinear PID Controller Design Using a Cell-Mediated Immune Response (세포성 면역 반응을 이용한 비선형 PID 제어기 설계에 관한 연구)

  • Park Jin-Hyun;Choi Young-Kiu
    • The Transactions of the Korean Institute of Electrical Engineers D
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    • v.52 no.5
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    • pp.259-267
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    • 2003
  • In this paper, we propose a nonlinear variable PID controller using a cell-mediated immune response. An immune feedback response is based on the functioning of biological T-cells. An immune feedback response and P-controller of conventional PID controllers resemble each other in role and mechanism. Therefore, we extend immune feedback mechanism to nonlinear PE controller. And in order to choose the optimal nonlinear PID controller games, we also propose the on-line tuning algorithm of nonlinear functions parameters in immune feedback mechanism. The trained parameters of nonlinear functions are adapted to the variations of the system parameters and any command velocity. And the adapted parameters obtained outputs of nonlinear functions with an optimal control performance. To verify performances of the proposed control systems, the speed control of nonlinear BC motor is performed. The simulation results show that the proposed control systems are effective in tracking a command velocity under system variations.

A Vibration Control of the Strcture using Immune Response Algorithm (면역반응 알고리즘을 이용한 구조물의 진동제어)

  • 이영진;이권순
    • Journal of Korean Port Research
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    • v.13 no.2
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    • pp.389-398
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    • 1999
  • In the biological immunity, the immune system of organisms regulates the antibody and T-cells to protect the attack from the foreign materials which are virus, germ cell, and other antigens, and supports their stable state. It has similar characteristics that has the adaptation and robustness to overcome disturbances and to control the plant of engineering application. In this paper, we build a model of the T-cell regulated immune response mechanism. We have also designed an immune response controller(IRC) focusing on the T-cell regulated immune response of the biological immune system that include both a help part to control the response and a suppress part to adjust system stabilization effect. We show some computer simulation to control the vibration of building structure system with strong wind forces excitation also demonstrate the efficiency of the proposed controller for applying a practical system even with existing nonlinear terms.

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A Study on Steering Performance Improvement of the AGV using Cell-Mediated Immune Algorithm (세포성 면역 알고리즘을 이용한 AGV의 조향 성능 향상에 관한 연구)

  • Lee, Y.J.;Sohn, J.H.;Lee, J.W.;Cho, H.C.;Lee, K.S.
    • Proceedings of the KIEE Conference
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    • pp.2572-2574
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    • 2000
  • In this paper, cell-mediated immune algorithm(CMIA) controller was proposed and applied for the autonomous guided vehicle(AGV) driving. It was based on specific immune response of the biological immune system which is the cell-mediated immunity. To verify the performance of the designed CMIA controller, some experiments were performed for the control of steering and speed of AGV. And then the displacement and speed tracking error of the AGV was mainly investigated. As results, the capability of realization and reliableness were proved by comparing the response characteristics of the classical controller with the proposed CMIA controller.

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An Experimental Study on the Effects of Row, Dried and Steamed Roots of Rehmanniae glutinosa on cell-mediated and Humoral Immune Response in Mice (생지황(生地黃) 건지황(乾地黃) 숙지황(熟地黃)이 세포성(細胞性) 면역반응(免疫反應) 및 체액성면역반응(體液性免疫反應)에 미치는 영향(影響))

  • Whang, Yong Myong
    • Journal of Sasang Constitutional Medicine
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    • v.1 no.1
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    • pp.139-151
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    • 1989
  • In order to investigate the effects of Raw, Dried and Steamed Roots of Rehmanniae Radix (R.R.: from Wonju province, Korea) on cell-mediated arid humoral immune response, the author performed this experimental study. Delayed type hypersensitivity (DTH) and rosette forming cells (RFC) for cell-mediated immune response, hemagglutinin (HA) titers, hemolysin (HL) titers were maeasured in ICR mice. The results were summarized as follows: 1) DTH was increased with the order of Steamed Roots of R.R., Raw Roots of R.R., Dried Roots of R.R.-treated group, as compared with the control group, with statistical significance. 2) RFC were increased with the order of Raw Roots of R.R., Steamed Roots of R.R., Dried Roots of R.R.-treated group, as compared with the control group, with statistical significance. 5) HA titers were increased with the order of Steamed Roots of R.R., Row Roots of R.R., Dried Roots of R.R.treated group, as compared with the control group, with statistical significance. 4) HL. titers were increased with the order of Raw Roots of R.R., Steamed Roots of R.R., Dried Roots of R.R.-treated group, as compared with the control group, with statistical significance. Through in the experimental study in ICR mice, these findings suggest that all of the treated group was increased in cell-mediated immune reaponse, Raw, Steamed Roots of R.R. were increased more as compared with the Dried Roots of R.R., and all of the treated group was increased in humoral immune response, Raw, Steamed Roots of R.R. were increased more as compared with the dried Roots of R.R.

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The Effects of High-dose Vitamin C Administration on the Cell-mediated Immune Response in Mice (다용량 비타민 C 투여가 생쥐 세포매개면역반응에 미치는 영향)

  • Noh, Kahwa;Kim, Heun-gon;Shin, Young-ah;Lim, Hyunja;Mun, Sung-kyu;Lee, Yongtaek;Lee, Wang Jae;Lee, Dongsup;Hwang, Young-il
    • IMMUNE NETWORK
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    • v.3 no.3
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    • pp.211-218
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    • 2003
  • Background: Vitamin C is an essential nutrient, taken as a daily supplement by many people. Recently, high-dose vitamin C is considered as a therapeutic regimen in some clinical situations. Until now, few studies have been done with the effects of high-dose vitamin C on the immune response. Methods: In this experiment, the effects of high-dose vitamin C on cell-mediated immune response in immunologically competent mice were evaluated. After intraperitoneal injection of 2.5, 5, or 10 mg/day of vitamin C for 10 days, delayed type hypersensitivity (DTH) was provoked against DNFB in the pinnae as a model for cell-mediated immune response. Severity of DTH reaction was evaluated as the thickness of pinnae, and the vitamin C levels were measured in the serum, liver, kidney, lung, pinnae, and splenocytes. Results: After challenge, the thickness increased at its peak on the $2^{nd}$ day in all groups. On the first day, the pinnae were thicker in the injected groups than in the control. On the contrary, the increment of the pinnae thickness was attenuated and the number of cells infiltrated in the site of DTH decreased proportionately to the amount of vitamin C administered from the second day on. With vitamin C exogenously given, the serum level peaked at 30 min after injection, and returned abruptly to its basal level without accumulation. However, it accumulated in the liver, kidney, and especially in the pinnae inflamed and splenopcytes, proportionately to the amount administered. Conclusion: Based on these results, it is suggested that, in one hand, exogenously administered high-dose vitamin C accumulated in the splenocytes and presumably changed the function of them resulting in the augmented cell-mediated immune response, as was revealed in the first day of DTH reaction. On the other hand, it seems likely that the vitamin C also showed anti-inflammatory effects.

Effects of Probiotic and Prebiotic on Average Daily Gain, Fecal Shedding of Escherichia Coli, and Immune System Status in Newborn Female Calves

  • Roodposhti, Pezhman Mohamadi;Dabiri, Najafgholi
    • Asian-Australasian Journal of Animal Sciences
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    • v.25 no.9
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    • pp.1255-1261
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    • 2012
  • Thirty two Holstein female calves (initial body weight = $40{\pm}3.0$ kg) were used to investigate the effects of probiotic and prebiotic on average daily gain (ADG), fecal E. coli count, white blood cell count, plasma IgG1 level and cell-mediated immune response to injection of phytohemagglutinin in suckling female calves. Calves were assigned randomly to one of the four treatments, including whole milk without additives (control), whole milk containing probiotic, whole milk containing prebiotic and whole milk containing probiotic and prebiotic (synbiotic). Average daily gain was greater in calves fed probiotic, prebiotic and synbiotic at weeks 6, 7 and 8 (p<0.05). E. coli count was significantly lower in calves fed probiotic, prebiotic and synbiotic on d 56 (p<0.05). There was no significant difference between treatments in blood samples and cell-mediated response. This study showed that addition of probiotic, prebiotic and combination of these additives to milk enhanced ADG and reduced fecal E. coli count in preruminant calves.

A Design of Adaptive Controller based on Immune System (면역시스템에 기반한 적응제어기 설계에 관한 연구)

  • Lee Kwon Soon;Lee Young Jin
    • Journal of Institute of Control, Robotics and Systems
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    • v.10 no.12
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    • pp.1137-1147
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    • 2004
  • In this paper, we proposed two types of adaptive control mechanism which is named HIA(Humoral Immune Algorithm) PID and CMIA(Cell-Mediated Immune Algorithm) controller based on biological immune system under engineering point of view. The HIA PID which has real time control scheme is focused on the humoral immunity and the latter which has the self-tuning mechanism is focused on the T-cell regulated immune response. To verify the performance of the proposed controller, some experiments for the control of AGV which is used for the port automation to carry container without human are performed. The experimental results for the control of steering and speed of an AGV system illustrate the effectiveness of the proposed control scheme. Moreover, in that results, proposed controllers have better performance than other conventional PID controller and intelligent control method which is the NN(neural network) PID controller.