• Title, Summary, Keyword: Catechin

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Catechin Dimer (Catechin 이합체)

  • Ahn, Byung-Zun
    • Korean Journal of Pharmacognosy
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    • v.10 no.2
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    • pp.41-53
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    • 1979
  • A 6', 8a-bonded catechin dimer was synthesized by action of phenoloxidase on 2mol (+)-catechins. The same dimer and other two dimers which are also 6', 8a-bonded were isolated from the fresh cortex of Quercus robur. The 4, 8a-bonded and the etherified 4, 8a-bonded dimers were isolated from it. It was discussed about the meaning of the enzymatically produced 6', 8a-bonded dimers in plant cell. The isolated dimers are as following: 1. 6', 8a-bonded dimers: (+)-catechin-(+)-catechin-6', 8a-dimer(IX), (+)-catechin-(+)-gallocatechin-6', 8a-dimar (XIII), (+)-gallocatechin-(+)-catechin-6', 8a-dimer(XIV). 2. 4, 8a-bonded dimers: (+)-catechin-(+)-catechin-4, 8a-dimer(X), (-)-epicatechin-(+)-catechin-4, 8a-dimer (XI), (+) -galloatechin-(+)-catechin-4, 8a-dimer (XII). 3. 4,8a-bonded dimers with ether linkage: etherified(+)-catechin-(+)-catechin-4, 8a-dimer (XV), etherifid (+)-catechin-(+)-gallocatechin-4, 8a-dimer (XVI), etherified (+)-gallocatechin-(+)-catechin-4, 6a-dimer (XVII).

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Stability of Ascorbic Acid in the Catechin Solution (Catechin용액 중에서 Ascorbic acid의 안정성)

  • Kim, Sang Oak
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.12 no.3
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    • pp.284-288
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    • 1983
  • This experiment was carried out to investigate the stability of ascorbic acid (AsA) in the mixed solution of AsA and catechin according to the content changes of AsA and catechin under boiling, and for the respective concentration and pH. The loss of AsA was most for 10 minutes of boiling and accelerated by the mixture of catechin, but the loss was less in the high mixture rate than in the low the loss of catechin most for 10 minutes of boiling, also as the concentration of AsA becomes higher but that of cathchin lower, and as that of AsA lower but that of catechin higher, the loss of catechin becomes less moreover in the case of the low content ratio of catechin, the stability of AsA was better in order of the pH 4, pH 5, pH 6, namely as the pH increased, but in the case of the high better in order of the pH 6, pH 5, pH 4, that is as in decreased.

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Catechin Glycoside from Ulmus davidiana

  • Son, Byeng-Wha;Park, Jong-Hee;Zee, Ok-Pyo
    • Archives of Pharmacal Research
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    • v.12 no.3
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    • pp.219-222
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    • 1989
  • Cartechin and catechin glycoside named uldavioside A were isolated from the Korean folk medicine Ulmus davidiana. Based on chemical and physicochemical evidences, their structure have been determined as (+) catechin (1) and (+)-catechin-5-0-$\betha$ D-apiofuranoside (2).

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Analysis on the Antioxidant Activity of Catechin Concentrations and Green Tea Extract Powder (녹차 분말과 카테킨의 농도에 따른 항산화력 비교 분석)

  • Choi Kyung-Min;Yun Young-Gab;Jiang Jing-Hua;Oh Sung-Su;Yang Hwan-Deok;Kim Hyoung-Jun;Park Jin-Young;Jeon Byung-Hun;Kim Suk-Il;Park Hyun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.19 no.6
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    • pp.1580-1584
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    • 2005
  • Antioxidative activities of catechin from green tea extracts were examined by the methods of 1,1-Diphenyl-2-picrylhydrazyl (DPPH) electron donating ability, hydroxy scavenging activity and the inhibitory effect on xanthine oxidase activity. The resulted demonstrated the fact that Catechin one (containing Green tea extracts plus catechin 51%) of green tea extracts product showed at 65.5% in electron donating activity on the DPPH. The electron donating ability on the DPPH of Catechin one was increased to 10% than purified catechin. Catechin one showed the activity at 64.5% in scavenging activity using hydroxy radical method. To the Catechin one provided to increase the hydroxy scavenging activity up to 3 fold. Inhibitory effects of the catechin one measured with xanthine oxidase method was 6.5%. Although the antioxidative activity of catechin (98% purified) was lower than that of Catechin one (containing Green tea extracts plus catechin 51%) in same catechin concentrations ($5{\mu}g$, respectively). Therefore, we may suggest that Catechin one can be used as a functional food additive possessing the potent antioxidative activity.

Protective Effect of Green Tea Extract, Catechin on UVB-Induced Skin Damage (녹차추출물 성분 catechin이 자외선에 의해 손상된 피부에 미치는 영향)

  • 이은희;이종권;홍진태;정경미;김용규;이선희;정수연;이용욱
    • Journal of Food Hygiene and Safety
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    • v.16 no.2
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    • pp.117-124
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    • 2001
  • The main constituent of green tea, catechins have been reported to have numberous biological anti-vites including antimutagenic, antibacterial, hypocholesterolemic, antioxidant and antitumor properties. In the present study, we examined the protective effect of catechin on UVB-induced skin damage. Catechin (3 mg/mouse) was topically treated to dorsal area of SHK-1 hairless mouse daily for 2 weeks. UVB (100 mJ/$\textrm{cm}^2$) was also treated soon after application of catechin alone or with catechin for 2 weeks. Catechin reduced UVB-induced infiltration of inflammatory cells, fibrosis of cells and collagen-fiber formation. In addition, catechin also prevented UVB-induced DNA fragmentation and apoptosis cell number, but not changed p53 level. Furthermore catechin inhibited UVB-induced cell proliferation. There results showed that catechin have preventive effect aganinst UVB-induced skin damages. and these effects could contribute to the antitumor promoters activity.

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Quantitative Analysis of (+)-Catechin and Diosgenin from Smilax china L. Rhizome (토복령에 함유되는 (+)-Catechin과 Diosgenin의 함량분석)

  • Yin, Jun;Yoon, Ki Hoon;Hwang, Yoon Jeong;Lee, Ji Yeon;Shin, Hwa Sup;Lee, Min Won
    • Korean Journal of Pharmacognosy
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    • v.46 no.3
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    • pp.189-194
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    • 2015
  • Validation and contents determination of (+)-catechin and diosgenin from Smilax china L. rhizome (SC) were confirmed using Ultra-Performance Liquid Chromatography (UPLC). (+)-Catechin was isolated from 60% prethanol SC extract and diosgenin was isolated by acid hydrolysis of saponin fraction from 60% prethanol extract of SC. Finally we have established the validation of the isolated compounds [(+)-catechin, diosgenin] and contents determinations of (+)-catechin and diosgenin by UPLC on 60% prethanol extract of SC [(+)-catechin: 0.06878%, diosgenin: 0.48169%], and on hot water extract of SC [(+)-catechin: 0.06584%, diosgenin: 0.42178%].

Effects of Green Tea Catechin on Changes of Calcium and Phosphorus Contents in Chronic Cadmium-Poisoned Rats (녹차 Catechin이 만성 카드뮴 중독 쥐의 칼슘, 인 함량 변화에 미치는 영향)

  • Choi, Jeong-Hwa;Rhee, Soon-Jae
    • Journal of Nutrition and Health
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    • v.34 no.8
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    • pp.881-886
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    • 2001
  • The purpose of this study was to Investigate the effects of green tea catechin on changes of mineral contents in chronic cadmium-poisoned rats. Sprague-Dawley male rats weighing 100 $\pm$ 10g were randomly assigned one of normal group and three cadmium poisoned groups. Cadmium groups were classified to catechin free diet(Cd-0C group), 0.25% catechin diet(Cd-0.25C group) and 0.5% catechin diet(Cd-0.5C group) according to the levels of catechin supplement. Animals were raised for 20 weeks. Cadmium was supplied in drinking water which contained 50ppm Cd$^{2+}$. Effects of catechin were analyzed on changes of mineral contents in chronic cadmium poisoned rats by determining the calcium accumulation in bones, blood, urine and faces and phosphorus In blood and urine. Cd-poisoning inducted the decrease of red blood cell(RBC), white blood cell(WBC), contents of blood hemoglobin and hematocrit, but the levels of those indices were increased by catechin supplementation. The contents of tibia and femur in Cd-0C group was significantly lower than in normal group, but those of catechin supplemetation group was similar to normal group. The calcium contents of urine and faces were higher in Cd-poisoned groups than in normal group, but they was lowered by catechin supplementation. The phosphorus contents of blood and urine in Cd-0C group was significantly lower than in normal group, but that of catechin supplementation group was similar to normal group. Catechin supplementation improved the calcium metabolism in chronic cadmium poisoned rats by increasing the contents of minerals such as calcium and phosphorus in blood and femur and by lowering the urinary and fecal calcium.m.

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Effects of Green Tea Catechin on Cadimium Accumulation in Chronic Cadmium Poisoned Rats (만성 카드뮴 중독 쥐에서 카드뮴 축적에 미치는 녹차 Catechin의 영향)

  • Choi, Jeong-Hwa;Rhee, Soon-Jae
    • Journal of Nutrition and Health
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    • v.34 no.4
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    • pp.384-392
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    • 2001
  • The purpose of this study was to investigate the effects of green tea catechin on the cadmium accumulation in body, cadmium excretion and detoxification functions in chronic cadmium poisoned rats. Sprague-Dawley male rats weighing 100$\pm$10g were randomly assigned to one normal group and three cadmium poisoned groups. Cadmium groups were classified to catechin free diet (Cd-0C group), 0.25% catechin diet(Cd-0.25C group) and 0.5% catechin diet(Cd-0.5C group) according to the levels of catechin supplement. Animals were maintained on 0, 0.25 and 0.5% catechin diets for 20 weeks and simultaneously administered 50ppm Cd(sup)2+ dissolved in the drinking water. Body weight, food intakes and food efficiency ratio in Cd-0C group was lower than the normal group. The accumulation of cadmium in rat liver, kidney, and blood was reduced by catechin supplementation. The excretion of cadmium in urine and feces was increased by catechin supplementation. The metallothionein(MT) contents in liver and kidney were increased in all cadmium groups compared with that of normal group. The ratios of cadmium absorption and retention ratios were significantly decreased in catechin supplementation groups. Accordingly, catechin supplementation resulted to an excretion of cadmium in urine and feces and a lowered accumulation of cadmium in liver and kidney by increasing methallothionein synthesis that led to the significant decrease in cadmium absorption and retention ratios.(Korean J Nutrition 34(4) : 384~392, 2001)

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Spectroscopic Studies on the Oxidation of Catechin in Aqueous Solution

  • Bark, Ki-Min;Yeom, Ji-Eun;Yang, Jeong-Im;Yang, Ik-Jun;Park, Chul-Ho;Park, Hyoung-Ryun
    • Bulletin of the Korean Chemical Society
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    • v.32 no.9
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    • pp.3443-3447
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    • 2011
  • The spectroscopic behavior of catechin (5,7,3',4'-tetrahydroxyflavan-3-ol), has been studied in the presence and the absence of air using UV-vis absorption spectrophotometry and fluorescence spectroscopy. The UV-vis absorption spectrum of catechin shows a very sharp and strong absorption maximum peak at 275 nm in deaerated water. New absorption maximum peaks appeared in aerated water, as well as in basic aqueous solution, caused by the oxidation of catechin. The absorbances in the UV-vis absorption spectrum of catechin decreased when the solution was left in the dark for a long time. The fluorescence emission spectrum of catechin after a long time period differs markedly from that in freshly prepared solution; the fluorescence maxia shifted as time passes after adding catechin to the solutions. When the deaerated basic catechin solutions were left in the dark for a long time, their fluorescence quantum yields were found to be nearly zero. This suggests that the oxidized catechin molecules were seen to have slowly undergone successive chemical reactions in basic buffer solution.

Differentiation Inducing Effect of (+)-Catechin in Human Leukemia HL60 Cells ((+)-Catechin에 의한 백혈병 세포 HL-60의 분화 유도효과)

  • 이수진;염윤기;안형수;안령미;이세윤
    • Toxicological Research
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    • v.15 no.1
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    • pp.19-25
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    • 1999
  • (+)-Catechin inhibited the growth and induced the differentiation of HL-60 human leukimia cells. The degree of a differentiation by (+)-catechin during the differentiation, the expression assay, To understand the molecular mechanism of (+)-catechin during the differentiation, the expression level of oncogenes was detected by Northern blot analysis. c-Myc mRNA level was reduced after treatment with (+)-Catechin (10-4), however, the expression of c-jun was increased with a concentration dependent manner in HL-60 cells. These results showed that the differentiation and antiproliferation of HL-60 cells against (+)-Catechin was related to the reduction of c-myc and the induction of c-jun expression.

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