• Title/Summary/Keyword: Case-control study

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Assessment Model for Industrial Accidents Prevention Policy (산업재해 예방정책에 대한 평가모형)

  • Kim, Youngsun;Jo, Jinnam;Baik, Jaiwook
    • Journal of Applied Reliability
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    • v.17 no.1
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    • pp.38-49
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    • 2017
  • Purpose: The purpose of this study is to introduce the assessment model for industrial accidents prevention policy. Methods: 10 years of industrial accidents data are explored through EDA approach. Case control study is tried in order to assess the effectiveness of the measures taken by Korea Safety and Health Agency, Civilian, and 'Ministry of Employment and Labor'. Propensity score matching is used to match the characteristics of the two groups compared, and then case control study is again conducted. Next, logistic and Poisson regressions are used to assess the risk factors. Results: According to case control study involvement of 'Korea Safety and Health Agency' and 'Ministry of Employment and Labor' were not effective, but Civilian was. Propensity score matching leads to the same conclusion. Poisson regression reveals the impact of the risk factors on the industrial accidents. Industrial accidents occur more often as the number of employees grows. Mining, farming, fishing, 'transportation storage and telecommunication' and forestry have a higher level of industrial accidents but service industry has a lower level. It is odd that more involvement of Korea Safety and Health Agency, Civilian, and Ministry of Employment and Labor means more industrial accidents. Conclusion: 'Korea Safety and Health Agency', Civilian, and 'Ministry of Employment and Labor' seem to visit those industries with more industrial accidents.

Case-control Study of Risk Factors for Non-Hodgkin Lymphoma in Mumbai, India

  • Balasubramaniam, Ganesh;Saoba, Sushama;Sarade, Monika;Pinjare, Suvarna
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.2
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    • pp.775-780
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    • 2013
  • Background: In the year 2010, it is estimated that nearly 0.36 million new cases and 0.19 million deaths with Non-Hodgkin lymphoma occurred. In India, among males, NHL incidence rates vary across the country which has encouraged us to conduct a case-control study to study risk factors. Materials and Methods: The present unmatched hospital-based case-control study conducted at Tata Memorial Hospital included subjects registered between the years 1997-99. There were 390 'lymphoma cases' and 1,383 'normal controls. Results: Data on age, tobacco habits, occupational history, dietary factors, tea, coffee were collected by the social investigators. Univariate and multivariate methods were applied for obtaining the odds ratios for risk factors. Conclusions: In the study, cigarette smoking (OR=2.0) and bidi smoking (OR=2.8), were associated with excess risk of lymphoma. Among the dietary items, only consumption of mutton showed 7.3-fold significant excess risk for lymphoma. Consumption of milk showed a 6-fold excess risk (OR=1.5); while coffee showed a 50% reduction in risk for lymphoma. Among occupational exposure, exposure to use of pesticides showed 3-fold excess risk for lymphoma.

Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis

  • Park, Yeong Mi;Youn, Jiyoung;Cho, Chang Ho;Kim, Sung Hi;Lee, Jung Eun
    • Nutrition Research and Practice
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    • v.11 no.5
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    • pp.419-429
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    • 2017
  • BACKGROUND/OBJECTIVES: The relationship between folate and colorectal neoplasia remains controversial. We examined the association between serum folate concentrations and colorectal adenomas in a case-control study of Korean adults and conducted a meta-analysis. SUBJECTS/METHODS: Our case-control study included 113 pairs of case and control who underwent colonoscopy and provided blood samples. We used multivariable conditional logistic regression models to obtain the odds ratios and 95% confidence interval (CIs). For meta-analysis, we identified the relevant studies by searching the PubMed database up to February 2017, included our case-control study and combined the study-specific relative risks (RRs) using a random-effects model. RESULTS: In this case-control study, we included 58 men and 55 women with colorectal adenomas and sex and fasting status matched the controls. We did not find any significant association between the serum folate levels and colorectal adenomas in either men or women. For meta-analysis, a total of eleven studies were included in our analysis and classified into two groups; polyp clearance group (PC) for the studies that included participants who underwent endoscopies and had their polyps removed at baseline; and no polyp clearance group (NPC) for the studies that included participants whose histories of endoscopies were unknown or who underwent their first endoscopies. Four PC (1,311 cases and 1,672 non-cases) and eight NPC studies (3,501 cases and 11,347 non-cases) were included. The combined RRs (95% CIs) comparing the bottom with the top categories of circulating folate levels were 1.07 (0.97-1.18) for the NPC group but 1.45 (1.16-1.74) for the PC group. CONCLUSIONS: Low circulating folate levels were associated with new adenoma formation.

Risk Factors of Breast Cancer in Kyzylorda Oblast of Kazakhstan: a Case-Control Study

  • Toleutay, Ulpan;Reznik, Vitaly;Kalmatayeva, Zhanna;Smigelskas, Kastytis
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.10
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    • pp.5961-5964
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    • 2013
  • Background: Breast cancer in Kazakhstan and its Kyzylorda oblast is the most prevalent cancer in women and features increasing trends of incidence. The aim of study was to reveal risk factors for breast cancer among women of Kyzylorda oblast of Kazakhstan. Materials and Methods: A hospital-based case-control study was conducted at Kyzylorda oblast Oncology Center, including 114 cases of breast cancer and 196 controls. Binary logistic regression analysis was performed. Results: Social and behavioral risk factors for breast cancer were evaluated, among which unfavorable living conditions, chronic stress, unilateral breastfeeding, breastfeeding less than 3 months and over 2 years, abortions, and hereditary predisposition were found to be related with increased breast cancer risk. Breastfeeding for 6-24 months was found to be protective. Conclusions: The findings may have significant impact on activity planning aimed towards breast cancer reduction among women in Kazakhstan.

Lifestyle Factors Including Diet and Leukemia Development: a Case-Control Study from Mumbai, India

  • Balasubramaniam, Ganesh;Saoba, Sushama Laxman;Sarhade, Monika Nilesh;Kolekar, Suvarna Anand
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.10
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    • pp.5657-5661
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    • 2013
  • In India, among males, leukemia rates vary across the country. The present unmatched hospital-based case-control study conducted at Tata Memorial Hospital included subjects registered between the years 1997-99. There were 246 leukemia cases and 1,383 normal controls. Data on demographics, lifestyle, diet and occupation history were recorded. Cigarette (OR=2.1) and bidi smoking (OR=3.4) showed excess risk for leukemia. Odds ratios were 3.9 for fish-eaters, 0.40 for chilli eaters, 1.5 for milk drinkers and 0.60 for coffee drinkers, compared to non-drinkers/eaters. However, neither exposure to use of pesticides nor cotton dust showed any excess risk for leukemia.

Case-Control Study on Electrolytes as a Risk Factor of Stroke (뇌졸중 위험지표로서의 전해질 수치에 대한 환자;대조군 연구)

  • Kim, Min-Ji;Kang, Kyung-Won;Yu, Byeong-Chan;Choi, Sun-Mi;Kang, Ji-Sun;Moon, Seung-Hee;Lee, Jae-Hwi;Kim, Yoon-Sik;Seol, In-Chan
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.4
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    • pp.968-974
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    • 2008
  • This study was aimed to investigate the electrolytes and its relationship with acute stroke patients in each stroke type by case-control study. 217 patients with first-ever acute stroke within 2 weeks as the case group(Cases), 146 people without four major risk factors(hypertension, diabetes mellitus, hyperlipidema and ischemic heart disease) as the healthy control group(Normals), and 160 people as the general control group(Controls) were recruited at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital from july 2005 to march 2007 for this case-control study. We analyzed the odds ratio of electrolytes in binary logistic analysis and evaluated each stroke type and general characteristics such as age, sex etc. The level of sodium(Na+) and potassium(K+) were significantly lower in LAA, SVO type of ischemic stroke and hemorrhagic stroke. But the level of chloride(Cl-) had no significant relation with stroke occurance. In this study we demonstrated that low sodium(Na+) and potassium(K+) have an influence on stoke occurance than chloride(Cl-). And we think that the electrolytes must be considered in risk factors of ischemic stroke in Korean and more prospective studies are needed.

Urinary Bladder Cancer Risk Factors: A Lebanese Case-Control Study

  • Kobeissi, Loulou Hassan;Yassine, Ibrahim Adnan;Jabbour, Michel Elias;Moussa, Mohamad Ahmad;Dhaini, Hassan Rida
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.5
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    • pp.3205-3211
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    • 2013
  • Background: Bladder cancer is the second most incident malignancy among Lebanese men. The purpose of this study was to investigate potential risk factors associated with this observed high incidence. Methods: A case-control study (54 cases and 105 hospital-based controls) was conducted in two major hospitals in Beirut. Cases were randomly selected from patients diagnosed in the period of 2002-2008. Controls were conveniently selected from the same settings. Data were collected using interview questionnaire and blood analysis. Exposure data were collected using a structured face-to-face interview questionnaire. Blood samples were collected to determine N-acetyltransferase1 (NAT1) genotype by PCR-RFLP. Analyses revolved around univariate, bivariate and multivariate logistic regression, along with checks for effect modification. Results: The odds of having bladder cancer among smokers was 1.02 times significantly higher in cases vs. controls. The odds of exposure to occupational diesel or fuel combustion fumes were 4.1 times significantly higher in cases vs controls. The odds of prostate-related morbidity were 5.6 times significantly higher in cases vs controls. Cases and controls showed different clustering patterns of NAT1 alleles. No significant differences between cases and controls were found for consumption of alcohol, coffee, tea, or artificial sweeteners. Conclusions: This is the first case-control study investigating bladder cancer risk factors in the Lebanese context. Results confirmed established risk factors in the literature, particularly smoking and occupational exposure to diesel. The herein observed associations should be used to develop appropriate prevention policies and intervention strategies, in order to control this alarming disease in Lebanon.

A Study on the Impact Analysis of Security Flaws between Security Controls: An Empirical Analysis of K-ISMS using Case-Control Study

  • Kim, Hwankuk;Lee, Kyungho;Lim, Jongin
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.9
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    • pp.4588-4608
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    • 2017
  • The measurement of information security levels is a very important but difficult task. So far, various measurement methods have studied the development of new indices. Note, however, that researches have focused on the problem of attaining a certain level but largely neglecting research focused on the issue of how different types of possible flaws in security controls affect each other and which flaws are more critical because of these effects. Furthermore, applying the same weight across the board to these flaws has made it difficult to identify the relative importance. In this paper, the interrelationships among security flaws that occurred in the security controls of K-ISMS were analyzed, and the relative impact of each security control was measured. Additionally, a case-control study was applied using empirical data to eliminate subjective bias as a shortcoming of expert surveys and comparative studies. The security controls were divided into 2 groups depending on whether or not a security flaw occurs. The experimental results show the impact relationship and the severity among security flaws. We expect these results to be applied as good reference indices when making decisions on the removal of security flaws in an enterprise.

Colorectal Cancer and its Association with the Metabolic Syndrome: a Malaysian Multi-Centric Case-Control Study

  • Ulaganathan, V.;Kandiah, M.;Zalilah, M.S.;Faizal, J.A.;Fijeraid, H.;Normayah, K.;Gooi, B.H.;Othman, R.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3873-3877
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    • 2012
  • Objective: Colorectal cancer (CRC) and the metabolic syndrome (MetS) are both on the rise in Malaysia. A multi-centric case-control study was conducted from December 2009 to January 2011 to determine any relationship between the two. Methods: Patients with confirmed CRC based on colonoscopy findings and cancer free controls from five local hospitals were assessed for MetS according to the International Diabetes Federation (IDF) definition. Each index case was matched for age, gender and ethnicity with two controls (140: 280). Results: MetS among cases was highly prevalent (70.7%), especially among women (68.7%). MetS as an entity increased CRC risk by almost three fold independently (OR=2.61, 95%CI=1.53-4.47). In men MetS increased the risk of CRC by two fold (OR=2.01, 95%CI, 1.43-4.56), demonstrating an increasing trend in risk with the number of Mets components observed. Conclusion: This study provides evidence fora positive association between the metabolic syndrome and colorectal cancer. A prospective study on the Malaysian population is a high priority to confirm these findings.

Anthropometric and Reproductive Factors among Newly-Diagnosed Breast Cancer Patients and Healthy Women: A Case-Control Study

  • Zunura'in, Z;Almardhiyah, AR Ainaa;Gan, SH;Arifin, Wan N;Sirajudeen, KNS;Bhavaraju, VMK;Shahar, Suzana;Jan, JM Hamid
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.9
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    • pp.4439-4444
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    • 2016
  • The objective of this case-control study was to determine anthropometric and reproductive factors associated with the development of breast cancer among women. Fifty-six newly diagnosed breast cancer patients were recruited from the Oncology Clinic, Universiti Sains Malaysia (USM), and 56 healthy female hospital employees were recruited as controls. Socio-demographic and reproductive data were obtained using a standard questionnaire. Anthropometric factors (body weight, height, body fat percentage, visceral fat and waist and hip circumference) were assessed. A high waist circumference (adjusted OR= 1.04, [95% CI: 1.00, 1.09]) and being more than 30 years of age at first full-term pregnancy (adjusted OR=3.77, [95% CI: 1.10, 12.90]) were predictors of breast cancer development. The results of this study indicate that weight and reproductive health management should be emphasized for breast cancer prevention in Malaysia.