• Title, Summary, Keyword: Calorie restriction

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Improvement of Type II Diabetes by Very-low-calorie Diet - A Case Report (초저열량 식이와 한방비만치료를 통한 당뇨 개선 1례 보고)

  • Kim, Kil-Soo;Kim, Ho-Jun
    • Journal of Korean Medicine for Obesity Research
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    • v.2 no.1
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    • pp.83-87
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    • 2002
  • Increasing body weight is closely associated with increasing risk for glucose intolerance and type II diabetes. Especially, abdominal distribution of weight and visceral obesity also seriously increase the morbidity and mortality. Dietary program including very-low-calorie diet(VLCD) is regarded as most effective in the control of obesity and diabetes, which mainly due to calorie restriction rather than weight loss itself. We are reporting a case of diabetes with obesity whose fast glucose was over 220 mg/dl and BMI was $25.1kg/m^2$(fat rate 32.8%, WHR 0.9). She was prescribed VLCD and oriental medical diet program. After 10 days of hospitalization, her glucose level dropped dramatically with 3kg loss of body weight She has further lost her weight until about 53kg, but the glucose level ceased to go down probably due to loosened calorie restriction.

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Effects of Protein Depletion and Protein Calorie Restriction on Metabolic and Enzymatic Activities in Adult Rats (열량제한(熱量制限) 및 무단백식이(無蛋白食餌)가 흰쥐의 체내대사(體內代謝)에 미치는 영향(影響))

  • Kim, Kyung-Ja;Kim, Sook-He
    • Journal of Nutrition and Health
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    • v.6 no.3
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    • pp.1-8
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    • 1973
  • Metabolic responses to the protein-free, high-carbohydrate diet and subsequent food restriction on the same diet at the level of 50% and 75% has been studied on the adult albino rats. The energy source was either corn starch or sugar. In experiment I, adult male rats weighing $509{\pm}8g$ were divided into two groups 10 rats each. Rats fed on the stock diet served as a control. Rats of restriction group received a protein free diet until they reduced their weight down to 400g and continue on a protein-calorie restriction diet until they reduced their weight down to 300g. In experiment II, 28 adult male rats and the same numbers of female rats weighing $329{\pm}5g$ and $223{\pm}4g$ respectively were divided into four groups, 7 males and females in each. Rats fed on a stock diet were sacrificed at the point when others started a protein free diet. These were served as the control. The protein free group received a protein free diet ad libitum for 4 weeks. The 50% restriction group and 75% restriction group were fed on a protein free diet coupled with food restriction at levels of 50% and 75% respectively for 3 weeks. In the result of this study: 1. The rate of body weight changes was similar between the males and the females. Feeding protein free diet ad lib. initiated a rapid weight lost of approximately 25% and protein free diet coupled with food restriction showed 37-43% reduction of their initial weight. 2. There was no significant differences in the value of the N concentration in liver, spleen, brain and muscle between controls and experimental groups. 3. Rats fed on protein free diet showed 1/10 value of the control in the nitrogen excretion in urine. However female showed less N excretion than male. 4. Observing blood picture, the effects of protein depletion and calorie restriction were not appeared any remarkable changes. 5. There was no sign of fatty liver which might result from protein depletion and calorie restriction. 6. Following semi-starvation, FAO and HMP-DH total enzyme activity was reduced, but activity per unit weight was relatively stable.

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Alternation of Adhesion Molecules during Aging and Modulation by Calorie Restriction

  • Zou , Yani;Yu, Byung-Pal;Yoon , Sick;Jung, Kyung-Jin;Chung, Hae-Young
    • Proceedings of the PSK Conference
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    • pp.329.1-329
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    • 2002
  • Expressions of adhesion molecules (AMs) are closely related to the formation of early atherosclerosis. an age-dependent process. However. previous research only provided limited and conflicted reports about alternated AMs expressions during aging and even much less is known about modulation of AMs by calorie restriction (CR), the only established anti-aging experimental paradigm. (omitted)

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Effect of High Fat Diet and Calorie-restricted Diet on Protein Kinase C Activity in Mouse Epidermal Cell (고지방식이와 열량제한식이가 백서상피세포의 Protein Kinase C 활성에 미치는 영향)

  • Choe, Myeon
    • Journal of Nutrition and Health
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    • v.24 no.3
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    • pp.149-156
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    • 1991
  • To determine the effect of dietary fat and calorie level on protein kinase C(PKC) activity in mouse epidermal cells, female BALB/C mice (4weeks of age) were placed on high (24.6% ), moderate(5%) fat or calorie-restricted diets for at least 4 weeks. Diets were formulated on a nutrient/kcal basis such that the mice consumed the same amounts of protein. vitamins, minerals and fiber per kcal. PKC was assayed by the procedure of Wise et at. An apparent increase of PKC activity was observed from the aminal fed high fat diet when compared with the aminal fed moderate fat diet. PKC activity was decreased 40% by calorie restriction. In summary levels of dietary fat may contribute to mechanism of tumor promotion by increasing PKC activity in the mouse skin model.

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The Effect of Protein and Carbohydrate on the Recovery Rate of Restricted Rats (탄수화물 및 단백질이 식이 제한을 받은 흰쥐의 회복에 미치는 영향)

  • 신동순
    • Journal of the Korean Home Economics Association
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    • v.19 no.2
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    • pp.175-182
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    • 1981
  • This study was designed to compare the effect of protein with that of calorie, both of which were supplemented by separate feeding, on the recovery rate and metabolic change of undernourished rats. During the two weeks of food restriction, the weight of body and some major internal organs was reduced, compared with normal growing rats, but the extent of reduction was various. After that, recovery food was supplemented for two weeks. The amount of body nitrogen retention and its -percentage were lower in unsupplemented and sugar supplemented groups. Among the supplemented groups, its amount was increased according as the protein intake was higher, while its percentage was decreased. Body and internal organs weight change showed a similar tendency. Interrelation between calorie intake and body fat retention (liver fat content and epididymal fat pad weight) was not found regularly. Consequently, the recovery rate from restriction was higher in protein supplemented group than calorie supplemented group. But no significant difference could be found between the groups.

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The Effect of Detraining on Lipoprotein and Body Composition after 8 Week Calorie Restriction and Different Level of Aerobic Exercise among Obese Middle-aged Women (비만중년여성에서 절식과 여러 수준의 유산소 트레이닝 후 운동중단이 지단백 및 신체조성에 미치는 영향)

  • Lee, Chang-Sik;Kim, Yong-Young
    • Journal of agricultural medicine and community health
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    • v.35 no.2
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    • pp.165-176
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    • 2010
  • Objectives: This study is to identify the effect of detraining on lipoprotein and body composition after 8 week calorie restriction and different level of aerobic exercise among obese middle-aged women. Methods: The 30 middle-aged women whose body fat were over 30% were randomly allocated into three groups of control, exercise group of 40% $VO_2$max level, and exercise group of 60% $VO_2$max level. All the participants were taught to record their calorie intake and restrict daily 500kcal intake. After eight-week exercise and daily 500kcal restriction, their body compositions and blood lipid levels were measured again. Results: The weight, BMI, body fat, total cholesterol, triglyceride, and LDL-cholesterol levels showed significant decreases after eight-week exercise and calorie restriction in the two exercise groups. However, detraining tended to increase them again after detraining of 4 weeks, and even more after 8 weeks. Conclusions: Detrainging after calorie restriction and exercise tended to increase levels of indices for body composition and lipoprotein among obese middle-aged women.

Effects of Calorie Restriction on Microsomal Mixed Function Oxidase System and Free Radical in Kidney of SAMP8 Mice

  • kim, Hyun-Jeong;Choi, Jin-Ho;Rhee, Soon-Jae
    • Nutritional Sciences
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    • v.7 no.4
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    • pp.189-195
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    • 2004
  • 1bis study investigated the antioxidative effect in kidney of senescence-accelerated prone SAMP8 mice with calorie restriction. 4-weeks-old SAMP8 female mice were divided into 4 groups according to the experimental feeding period: for 4, 8, 12 month, and at natural death. Each group was subdivided into 2 groups, with thirteen mice each one, as ad libitum group and as dietary restriction group (60% of ad libitum feeding amount). After feeding for a given period, the mice were sacrificed to get the following results: among the experimental groups, there wereno significant differences in xanthine oxidase (XOD) activity in their kidney tissues. The contents of cytochrome $P_{450}$ decreased in ad libitum group and dietary restriction group by age. The activity of NADPH-cytochrome $P_{450}$ reductase showed a trend similar to cytochrome $P_{450}$. Superoxide radical content increased with age. At the 4th, 8th and 12 months of the experimental period, the activity in the dietary restriction group was less than that of ad libitum group by as much as 17% 14% and 14% respectively. For hydrogen peroxide, the contents were increased in the ad libitum group with age, while no correlation between content and age was observed in the dietary restriction group. In the 8th and 12th months of the experimental period, the were in the dietary restriction group less than that of ad libitum group counterpart as much as 17% and 20o/c, respectively. For the cellular membrane stability of the kidney, no significant correlation with age was observed in either the dietary restriction group or the ad libitum group. However at the 12th month of the experiment, however, the stability in the dietary restriction group was 11 % higher than that in the ad libitum group. In conclusion, with these results obtained from the SAMP8 mouse model, we demonstrate that dietary restriction has the effects of anti-oxidation and anti-senescence in the kidney.

Effect of Wild Plant Extracts Based on Korea Traditional Prescription on Endurance Exercise Performance during Calorie Restriction Period (초저열량식이로 인한 체력 저하에서 산야초추출물의 지구력 증진 효과)

  • Kim, Joong-Hark;Kim, Hwa-Young;Chang, Hey-Eun;Chung, Ji-Sang;Hwang, Sung-Joo;Park, Mi-Hyoun;Hong, Seong-Gil
    • Korean Journal of Food Science and Technology
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    • v.38 no.1
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    • pp.147-151
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    • 2006
  • Effects of wild plant extract (Lak) based on Korea traditional prescription on maximal exercise performance and endurance were evaluated using calorie-restriction animal model. In acute forced swimming test with 10% body weight attached to tail, dietary Lak supplementation increased exercise performance endurance by increasing concentrations of ATP and insulin-like growth factor-1 (IGF-1) under calorie-restriction condition, and decrement of blood lactic acid concentration and increment of muscle ATP content were observed. These results suggest Lak is very effective for decreasing side-effects of obesity therapy using very low calorie diet.

Alteration of Cellular Adhesion Molecules during Aging and Their Modulation by Calorie Restriction

  • Zou, Yani;Kim, You-Jung;Kim, Ji-Young;Kang, Dae-Yoen;Kim, Nam-Deuk;Lee, Kyung-Hee;Chung, Hae-Young
    • Proceedings of the PSK Conference
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    • pp.221.2-222
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    • 2003
  • Expressions of cellular adhesion molecules (CAMs) are closely related to the formation of early atherosclerosis, an age-dependent vascular disorder. However. previous research provided only limited and conflicted reports on age-related alterations of CAMs' expressions and even much less is known the modulation of CAMs by calorie restriction (CR), In this study, expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), E-selectin, P-selectin and platelet/endothelial cell adhesion molecule-1 (PECAM-1) in aorta and kidney were investigated by western blot and immuno-histochemical stain utilizing ad libitum (AL) and CR rat. (omitted)

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