• Title, Summary, Keyword: C57BL/6 mouse

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Effect of Morus alba extract for hair growth promotion in C57BL/6 mouse (C57BL/6 mouse에서 뽕나무 추출물의 모발성장효과)

  • Jung, Juyoung;Park, Jaeyoung;Cheong, Hyeonsook
    • Journal of the Chosun Natural Science
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    • v.1 no.1
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    • pp.19-23
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    • 2008
  • Morus alba has been well known for its tonic effect or preventing of hypertension, aging, or diabetes mellitus in Asian countries. To evaluate the its effect on hair growth promotion, we performed the hair regrowth experiment with leaf, branch, root and fruit extract of Morus alba on animal model of C57BL/6 mouse. The hair regrowth effect was remarkable in the mouse treated branch and root extract (with what %), however, little effect on hair regrowth appeared on the mouse treated with leaf extract. Morus alba extract displayed antibacterial effects on Bacillus subtilis, Staphylococcus aureus, Pseudomonas and Candida albicans. These results indicated that branch and root extract of Morus alba could be applicable for hair regrowth or prevention of hair loss in human.

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Antialopecic Effect of Piperidinopyrimidine Derivative (피페리디노피리미딘계 유도체의 모발성장에 대한 효과)

  • Shin, Joon-Su;Kim, Kyoung-Soon;Kang, Kyoung-Hwan;Moon, Seong-Joon;Lee, Woo-Young;Kim, Bak-Kwang
    • YAKHAK HOEJI
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    • v.40 no.3
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    • pp.340-342
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    • 1996
  • To investigate the antialopecic effect of N-4-salicylomide-2-amino-6-piperidinopyrimidine 3-oxide(SALMI) and its salt on the hair of black mouse (C57BL/6), this study was carrie d out. When salmi and its salt in ethanol solution were administered to the black mouse (C57BL/6) by route of skin, both of them promoted the growth of hair.

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Formation of Metastases in C57 BL/6 Mouse Lung (LL/2 Cells접종에 의한 C57 BL/6 Mouse 폐에서의 전이과정)

  • Kim, Ji-Hyun;Lee, Ji-Young;Kim, Woo-Kap;Hwang, Woo-Ik
    • Applied Microscopy
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    • v.29 no.2
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    • pp.137-147
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    • 1999
  • Comparative differences between the fine structure of cultured LL/2 cell in vitro and tumor cells in vivo which were induced in the lung by inoculation of LL/2 cells to C57 BL/6 mouse via tail vein during 21 days are not observed except for cell configuration which was changed spindle shape into oval shape. At first tumor cells appeared at lymphatic nodules and around capillary in the lung. Tumor cells divided actively by mitosis, so they became tumor nodules. The pulmonary aveoli around tumor nodules were observed somewhat flattened in shape but the cells in the aveoli appeared to be in normal condition. Furthermore the normal lung cells were observed in the tumor nodules and some apoptotic tumor cells appeared in the large tumor nodules. A lot of neutropiles were observed in the aveoli and tumor nodules of C57 BL/6 mouse lung after inoculation 22 days and 31days.

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COX-inhibitors down-regulate TCDD-induced cyp1a1 activity in C57BL/6 mouse and Hepa- 1 cells.

  • Bang-Sylie;Cho, Min-Jung;Sheen, Yhun-Yhong
    • Proceedings of the PSK Conference
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    • pp.292.1-292
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    • 2002
  • In order to understand the mechanism of action of TCDD. we have examined the effect of COX-inhibitors on cypla1 activity. We observed the effect of COX-inhibitor on EROD activity in C57BL/6 mouse in vovo. And we also evaluated the effect of COX-inhibitors on cypla1 mRNA. mouse cyplal promoter activity and EROD activity in Hepa cell. When Aspirin were pretreated with 3MC in vivo, the EROD activity that was stimulated by 3MC was inhibited. (omitted)

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COX-INHIBITORS DOWN-REGULATE Cyplal ACTIVITY IN C57BL/6 MOUSE AND Hepa I CELLS.

  • Syrie Bang;Kim, Ja-Young;Sheen, Yhun-Yhong
    • Proceedings of the Korean Society of Toxicology Conference
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    • pp.90-90
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    • 2002
  • In order to understand the mechanism of action of TCDD, we have examine the effect of COX-inhibitors on Cyp1a1 activity. We observed the effect of COX-inhibitor on EROD activity in C57BL/6 mouse in vovo. And we also evaluated the effect of COX-inhibitors on mouse cyp1a1 promoter activity in Hepa cell.(omitted)

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COX-INHIBITORS DOWN-REGULATE TCDD-INDUCED cyp1a1 ACTIVITY IN C57BL/6 MOUSE AND Hepa- I CELLS

  • Syrie Bang;Cho, Min-Jung;Sheen, Yhun-Yhong
    • Proceedings of the Korean Society of Toxicology Conference
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    • pp.152-152
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    • 2002
  • In order to understand the mechanism of action of TCDD, we have examined the effect of COX-inhibitors on cyplal activity. We observed the effect of COX-inhibitor on EROD activity in C57BL/6 mouse in vivo. And we also evaluated the effect of COX-inhibitors on cyplal mRNA, mouse cyp1a1 promoter activity and EROD activity in Hepa cell.(omitted)

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Animal Skin Pigmentation Model Using Full Thickness Skin Graft in C57BL/6 Mouse (C57BL/6 마우스의 등에 시행한 자가 전층피부이식편을 이용한 색소침착 동물모델)

  • Lee, Hong-Ki;Park, Jong-Lim;Heo, Eun-Ju;Kim, Suk-Wha
    • Archives of Plastic Surgery
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    • v.38 no.6
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    • pp.725-732
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    • 2011
  • Purpose: Skin grafting is one of the most commonly used methods in reconstructive plastic surgery field, but complications such as color change, contracture or hypertrophy are common problems. However, pathophysiology of the color change after skin graft is not yet determined and no animal model is established. Methods: Full thickness skin grafts were performed on the dorsum of C57BL/6 mice. Serial chronological gross inspection for color change and pigmentation were examined. Melanin pigments were traced by Fontana-Masson staining and semi-quantitative analysis was performed. In addition, immunohistochemical staining of S-100, Micropthalmia related Transcription Factor (MITF) and Melan-A antibodies were also performed to observe melanocytes and their changes. Results: After skin graft, color change and pigment spots were observed in the graft. Fontana-Masson staining showed melanin pigments in the epidermal and dermal layers in all mice. Immunohistochemistry staining to S-100, MITF, Melan-A antibodies showed melanocytes at the basal layer of epidermis and dermis. Conclusion: In conclusion, we have established an animal model for skin pigmentation after skin graft. We believe this study may be useful in understanding of the behavior of melanocytes after skin graft.

Effects of Rhus verniciflua Stokes (RVS) Extract on Diet-induced Obesity in C57BL/6 mouse (옻나무 추출물이 식이에 의한 비만유도 C57BL/6 mouse에 미치는 영향)

  • Kim, Jung-Hee;Lee, Hye-Won;Ko, Byoung-Seop;Kim, Ho-Kyoung;Jeon, Won-Kyung
    • Korean Journal of Pharmacognosy
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    • v.34 no.4
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    • pp.339-343
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    • 2003
  • We investigated the effects of Rhus verniciflua Stokes (RVS) on high fat diet- induced obesity in C57BL/6 that received ad libitum exposure to a high fat diet for 8 weeks. Male C57BL/6 mice weighing $20.1{\pm}0.95\;g$ were divided into four groups and the body weight and food intake were weighed for 8 weeks. After the administration of RVS extract, the liver, subcutaneous and retroperitoneal adipose tissue in the mice were weighed and common blood count in whole blood and biochemical parameters in plasma were measured. It was founded that body weight increase was significantly suppressed by the oral administration of RVS extract in group with high fat diet. Weight of subcutaneous adipose tissue and concentration of triglyceride in plasma from mice which were administrated RVS extract were lower than obesity control group. These results suggest that RVS extract may effect on inhibition of diet-induced obesity.

Strains Difference of Ovulatory Response in Mice to Superovulation-treatment (과배란처리(過排卵處理)에 대(對)한 Mouse의 배란반응(排卵反應)의 계통차(系統差))

  • Jeon, Chang Ge;Ishijima, Yoshiro
    • Korean Journal of Agricultural Science
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    • v.5 no.2
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    • pp.77-79
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    • 1978
  • The Present study was examined the response of mice of 5 strains to superovulation treatment. Female mice of CF#1, C57BL/6, ICR, dd and CHN strains, aged 60 days were used. Superovulation was induced by the subcutaneous injection of 5 IU PMS and followed 48 hours later by the subcutaneous injection of 5 IU HeG. All females were killed 24 hours after RCG and then ova in the oviduct were counted under a microscope. The average number of ova ovulated in CF#1, C57BL/6, ICR, dd and CHN were 21.3, 17.9, 20.7, 21.0 and 20.5, respectively.

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The Study of the Changes of Obesity-Relating Biomarkers in High Fat Fed-Induced C57BL/6 Mice (고지방 식이로 비만이 유도된 C57BL/6 마우스에서 식이 기간에 따른 비만 관련 지표 변화에 대한 연구)

  • Song, Mi-Young
    • Journal of Korean Medicine for Obesity Research
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    • v.16 no.1
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    • pp.19-26
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    • 2016
  • Objectives: The prevalence of obesity continues rise and obesity and metabolic syndrome is a major problem in global health care. Animal models are used in the drug discovery of novel treatment for obesity. One of common models of obesity is a high fat diet induced obesity in a C5BL/6 mouse, and the development of obesity and glucose tolerance in mouse model is different according to period of diet. Therefore, this study was performed to observe the development of obesity and glucose tolerance during a high fat diet (HFD). Methods: Male C57BL/6 mice, 5 weeks of age, were fed on a standard chow diet as a normal diet (18 kcal% fat) or a HFD (60 kcal% fat) for up to 16 weeks. The various factors related with obesity and insulin resistance were measured at 8, 12, and 16 weeks. Results: The weights of body and epididymal fat were gradually increased for 8~16 weeks, however the change of hyperglycaemia and glucose tolerance have shown different with that of body weight. Blood glucose, oral glucose tolerance and insulin tolerance were increased more clearly at week 12 and 16 than week 8. Lipid accumulation of liver and body temperature were also significantly increased at week 16, compared with normal group. Conclusions: The developments of obesity and related factors were different by a HFD period in a C57BL/6 obese mice. This result suggests that the development of obesity with glucose tolerance and liver lipid may induce clearly by a HFD for 16 weeks.