• Title, Summary, Keyword: C-reactive protein

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Molecular Chaperonic Function of C-Reactive Protein Induced by Heating in HT-29 Human Colon Carcinoma Cells

  • Lee, Soo-Young;Jung, Hyun-Jung;Kim, Hyun-Soo;Lee, Seung-Chul;Lee, Si-Back;Joe, Jae-Hoon;Kim, You-Mie
    • BMB Reports
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    • v.33 no.5
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    • pp.407-411
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    • 2000
  • The effects of heat shock, or all-trans retinoic acid, on the expression of the C-reactive protein mRNA in the HT-29 human colon carcinoma cells, as well as the functional role of the C-reactive protein as a molecular chaperone, were studied. The expression level of the C-reactive protein mRNA in the HT-29 cells was increased time-dependently when exposed to heat-shock, and dose-dependently when treated with all-trans retinoic acid. The activities of transglutaminase C and K in the HT-29 cells were significantly increased when treated with all-trans retinoic acid. The C-reactive protein prevented thermal aggregation of the citrate synthase and stabilized the target enzyme, citrate synthase. The C-reactive protein promoted functional refolding of the urea-denatured citrate synthase up to 40-70%. These results suggest that the C-reactive protein, which is induced in human colon carcinoma cells, when heated or treated with all-trans retinoic acid has in a part functional activity of the molecular chaperone.

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Association between periodontal disease, number of remaining teeth and high-sensitivity C-reactive protein in Korean adults aged 40 and older: Based on data from 2015 Korea National Health and Nutrition Examination Survey (한국 40세 이상 성인의 치주질환, 잔존 치아 수와 고감도 C-반응성 단백의 연관성: 2015 국민건강영양조사 제6기 자료)

  • Cho, Youn-Young
    • Journal of Korean society of Dental Hygiene
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    • v.20 no.3
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    • pp.303-312
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    • 2020
  • Objectives: The purpose of this study was to investigate the relationship between periodontal disease, number of remaining teeth with high-sensitivity C-Reactive protein in Korean adults aged 40 and older. Methods: The study used the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3), 2015. The study sample consisted of 3,883 aged 40 years or older who had completed the health survey and the health examination. Logistic regression analyses were performed to examine the odds ratios of high-sensitivity C-Reactive protein by periodontal disease and number of remaining teeth, adjusting for demographic characteristics, chronic diseases and oral health behavior-related variables. Results: When the demographic and chronic diseases were adjusted, the risk of high-sensitivity C-Reactive protein (hs-CRP) average 1.23 mg/L or higher was 1.36 times higher in patients with periodontal disease between the ages of 40 and 49, but it was not significant (OR=1.36; 95% CI=0.82-2.23). In addition, in the group of 0~23 remaining teeth aged 40~49 years, the risk of higher than the average 1.23 mg/L of high-sensitivity C-Reactive protein was 2.03 times higher (OR=2.03; 95% CI=1.10-3.74), and 1.49 times higher in 60~69 years (OR=1.07; 95% CI=1.04-2.76). Conclusions: This study found that periodontal disease and tooth loss in Korean adults aged 40 and older was significantly associated with high-sensitivity C-reactive protein.

Comparison of the Demographic and Laboratory Profiles of Patients with Aseptic Meningitis and Encephalitis: Significance of Age and C-reactive Protein (무균성수막염과 뇌염환자 사이의 인구학과 검사소견의 비교: 나이와 C-반응단백질의 중요성)

  • Park, Kang Min;Shin, Kyong Jin;Ha, Sam Yeol;Park, Jin Se;Park, Bong Soo;Kim, Sung Eun
    • Annals of Clinical Neurophysiology
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    • v.16 no.2
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    • pp.55-61
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    • 2014
  • Background: Viruses can cause either meningitis or encephalitis. It is unclear why some people suffer from aseptic meningitis, and others acquire aseptic encephalitis when infected with the same viral pathogens. The aim of this study was to compare demographic and laboratory factors between patients with aseptic meningitis and encephalitis. Methods: The demographic and laboratory differences were analyzed according to age, sex, diabetes, hypertension, C-reactive protein in the blood, white blood cell and protein in the cerebrospinal fluid, and glucose ratio (cerebrospinal fluid/blood). Additionally, we analyzed the nation-wide differencesin age between the patients with aseptic meningitis and those with encephalitis in Korea. Results: The patients with aseptic encephalitis were older, more likely to have hypertension, and had higher levels of C-reactive protein than did the patients with aseptic meningitis. However, the numbers of white blood cells in the cerebrospinal fluid were significantly higher in the patients with meningitis than in the patients with encephalitis. Multivariable analysis revealed that age >49 years, hypertension and a C-reactive protein level >5.81 mg/dL were independent and significant variables in the prediction of aseptic encephalitis. Additionally, the patients with aseptic encephalitis were older than those with aseptic meningitis in the nation-wide Korean database. Conclusions: Older age, hypertension, and higher levels of C-reactive protein are useful factors for the prediction of aseptic encephalitis.

C-Reactive Protein in Pregnancy and Labor (임신주령과 진통에 따른 임부 혈청 C-Reactive Protein의 동태)

  • Kim, Jong-Ho;Kim, Byung-Suk;Lee, Jae-Yul;Lee, Young-Gi;Lee, Tae-Hyung;Lee, Seung-Ho
    • Yeungnam University Journal of Medicine
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    • v.10 no.2
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    • pp.298-305
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    • 1993
  • In order to evaluate the clinical usefulness of maternal serum C-reactive protein measurement in early detection of infectious morbidity at term laboring women, serum C-reactive protein levels were measured in 521 healthy pregnant women ; 64 who were not in labor before term, 55 who were in labor before term, 71 who were not in labor at term and 331 who were in labor at term. The frequencies of elevated serum C-reactive protein level were compared in relation to the gestational weeks, the presence or absence of labor, the status of amniotic membranes and the degree of cervical dilation. The obtained results were as follows. 1. The frequencies of women with elevated serum C-reactive protein, 0.8mg/dl or higher and 2.0mg/dl or higher, in 521 health pregnant women were 12% and 4%, respectively. 2. C-reactive pretein levels of 0.8mg/dl or higher were more frequent in the group of women in labor than those not in labor(5.93%, vs. 13.73%, p<0.05), but the frequencies of C-reactive protein level of 2.0mg/dl or higher were not statistically different between both groups. The frequencies of C-reactive protein level of 0.8mg/dl or higher and 2.0mg/dl or higher were not statistically different between the groups before term and at term, intact and ruptured membranes, latent phase and active phase of labor, respectively. 3. Before term, C-reactive protein levels of 0.8mg/dl or higher and 2.0mg/dl or higher were more frequent in the group of women in labor than those not in labor(23.64 vs. 4.69, p<0.001 and 12.73% vs. 3.13%, p<0.05, respectively), but those statistical differences were not seen between both group at term. Above results and review of literature suggest that serum C-reactive protein level of 2.0mg/dl or higher may be reliable in early detection of infectious morbidity at term laboring women as well as laboring women before term, and the presence of subclinical infection should be suspected in the laboring women before term with serum C-reactive protein level of 0.8mg/dl or higher.

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Comparison of the lipids levels, C-reactive protein and adiponectin in adolescent male by fat intake (청년기 남성의 지방 섭취 수준에 따른 혈중지질 함량, C-반응성 단백질 및 아디포넥틴 비교)

  • Lee, Sung-Hye;Park, Mi-Young;Kim, Soon-Kyung;Min, Young-Ki
    • Journal of Nutrition and Health
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    • v.45 no.4
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    • pp.303-314
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    • 2012
  • The purpose of this study was to investigate the relationship between dietary fat intake, anthropometric data, blood lipids, C-reactive protein, and adiponectin in Korean male college students. Forty-eight subjects were divided into 2 groups based on dietary fat intake: UERF (under 30% of energy ratio for fat source), AERF (above 30% of energy ratio for fat souce). We collected dietary intake data using 24-hour dietary recall for 3 days. Anthropometric and biochemical parameters were measured by using standard methods. Segmental body composition analysis was carried out using an 8-electrode multifrequency bioelectrical impedance method of body fat estimation. There was no significant difference in anthropometric data and serum lipid profile between UERF and AERF group. Serum C-reactive protein level was significantly higher in the AERF group compared to the UERF group. Although there was no significant difference in serum adiponectin level between UERF and AERF groups, subjects had lower adiponectin levels. Correlation data show that serum adiponectin level was positively correlated with vegetable intake (p < 0.05). In addition, dietary fat intake had a positive correlation with meat (p < 0.01), whereas a negative correlation with grain (p < 0.01), vegetables (p < 0.05), and fish (p < 0.05). These results suggest that the increased fat intake of non-obese Korean male college students is associated with their increased serum C-reactive protein concentration. Therefore, proper guidelines on fat intake and nutrition education are necessary for the prevention and management of metabolic syndromes.

THE CHANGES OF SERUM C-REACTIVE PROTEIN IN THE HEAD AND NECK INFECTION (두경부 감염 환자에서 혈청 내 C-Reactive Protein의 변화)

  • Lee, Ju-Hyun;Kim, Chin-Soo;Lee, Sang-Han;Kim, Chul-Hwan
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.29 no.1
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    • pp.5-13
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    • 2003
  • The purpose of this study is to determine the value of serum concentration of C-reactive protein(CRP) in comparison with ESR and leukocyte as the tools for diagnosis and follow-up study of infection. For this study, thirty-one patients with head and neck infection and thirty-two patients performed the orthognathic surgery were selected for experimental and control groups each other. we analyzed the blood sample daily to measure CRP, ESR and leukocytosis. The results of this study are as the following : 1. Serum C-Reactive Protein levels in the experimental group were higher than control group and the pattern of CRP changes continued to decline in both groups(P<0.001). 2. ESR changes in both groups were scattered without any special pattern. 3. Correlation between CRP and Leukocyte was higher than others(r=0.664, P<0.01). 4. In the Receiver Operating Characteristic(ROC) Curve of experimental group, rapid increase of CRP curve and Area under the curve(AUC) value, 0.774, indicate the high accuracy of estimation. 5. In experimental group, sensitivity of CRP, ESR, and Leukocytosis on recovery day were 83%, 17% and 71%. Based on the results of this study, we could conclude that determination of CRP is more useful method to diagnosis and follow-up study of infection than other commonly used variables in oral and maxillofacial region.

Glass Slide-based Immunosensing for C-Reactive Protein Using Quantum Dot-Antibody Conjugate

  • Kim, Namsoo;Oh, Sun Mi;Kim, Chong-Tai;Cho, Yong Jin
    • Food Engineering Progress
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    • v.14 no.1
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    • pp.21-26
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    • 2010
  • C-Reactive protein (CRP), which is an 118 kDa pentameric protein, was secreted by the liver is an important biomarker for coronary disease, hypertension and inflammation. In this study, a method for CRP detection exploiting quantum dot (Qdot)-antibody conjugate was developed according to an indirect-competitive immunosensing protocol. For this purpose, a streptavidin-bound $Qdot_{605}$ was linked with a separately prepared biotinylated monoclonal antirat CRP antibody to produce a Qdot-antibody conjugate. The immunosensing was performed at 0.1 and 20 nM of the coating antigen and conjugate, respectively. The current method was found very sensitive in CRP detection, judging from the concentration-dependent fluorescence emission.

Effects of Brisk Walking and Brisk Walking Plus Diet on C-reactive Protein in Obese Women with Hypertriglycemia (건강걷기, 건강걷기와 식이 교육이 고중성지방혈증 비만 여성의 C-reactive protein에 미치는 영향)

  • Lee, Mi Ra;Kim, Wan Soo
    • Korean Journal of Adult Nursing
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    • v.18 no.4
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    • pp.660-667
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    • 2006
  • Purpose: The purpose of this study was to investigate the effects of 12-week brisk walking and brisk walking plus diet program on C-Reactive Protein(CRP) in middle-aged obese hypertriglycemic($triglyceride{\geq}150mg/d{\ell}$) Korean women. Method: The subjects were 16 obese ($BMI{\geq}25$) hypertriglycemic middle-aged women (7 for brisk walking group, 9 for brisk walking plus diet group) who participated in a health promotion program at one public health center. Initially the brisk walking intervention consisted of walking for 20 minutes/day at an intensity of 40 to 50% of heart rate reserve(HRR) for 3 days/week and progressed to 50 minutes/day, 60 to 70% of their HRR, and 6 days/week. The diet intervention consisted of 60 minutes of group education and 20 to 30 minutes of individual counseling with a nutritionist every week. Data were analyzed with SPSS PC program. Results: There was no significant reduction in CRP levels in both brisk walking (Z=-1.70, p=0.088) and brisk walking plus diet group(Z=-0.31, p=0.752). In brisk walking only group, CRP levels were increased after the intervention. Conclusion: Brisk walking could increase the level of CRP when it is in the course of progression and diet could decrease the acute phase inflammatory response.

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C-Reactive Protein and Respiratory Viral Infection (호흡기 바이러스 감염과 C-Reactive Protein)

  • Jeon, Jae-Sik;Rheem, Insoo;Kim, Jae Kyung
    • Korean Journal of Clinical Laboratory Science
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    • v.49 no.1
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    • pp.15-21
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    • 2017
  • C-reactive protein (CRP) levels are not generally associated with viral infections. This study investigated the changes in the CRP level caused by an infection from respiratory virus (RV). Nasopharyngeal samples from hospitalized patients with suspected RV infection were used to measure the CRP levels, virus load, virus-virus co-infection, age, sex, and length of hospital stay (LOS). Abnormal CRP levels were detected in 62.3% (3,608 out of 5,788) of all RV-positive samples. The percentage of patients with abnormal CRP levels tended to increase with age. Furthermore, LOS in patients with abnormal CRP levels was significantly longer than that in patients with normal CRP levels. The frequency of elevated CRP levels differed according to the causative virus and the frequency of abnormal levels increased with age. Moreover, LOS was longer in those with abnormal CRP levels. These data provide important insights into the role of CRP levels in RV infection.