• Title, Summary, Keyword: BMI1

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The Role of Bmi1 in Pilocarpine-induced Status Epilepticus in Mice (Pilocarpine에 의해 유도된 생쥐 경련중첩증에서 Bmi1의 역할)

  • Pyeon, Hae-In;Bak, Jia;Choi, Yun-Sik
    • Journal of Life Science
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    • v.30 no.6
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    • pp.513-521
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    • 2020
  • B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) is a polycomb group protein and a core component of polycomb repressive complex 1. Initial research into Bmi1 has focused on its role in tumorigenesis, and it is generally accepted that it is important for the proliferation and survival of cancer cells. However, more recent studies have revealed that Bmi1 is downregulated in brains with neurodegenerative disease and that it regulates the function of mitochondria and reactive oxygen species levels. In this study, we tested the therapeutic potential of Bmi1 in pilocarpine-induced seizures in Bmi1-knockout mice. Bmi1 expression transiently increased in the hippocampal CA1 and CA3 and the dentate gyrus following pilocarpine-induced status epilepticus (SE). In terms of seizure behavior, SE induction was 43.14% and 53.57% for Bmi1+/+ and Bmi1+/- mice, respectively. However, there was no significant difference in mortality or hippocampal damage between the two groups. Two months after SE induction, the frequency of epileptic seizures in the Bmi1+/- mice was 50% lower than in the control group, although the difference was not statistically significant. In addition, mossy fiber outgrowth in the Bmi1+/- mice was significantly higher than in their wild-type littermates. Taken together, these data indicate that reduced Bmi1 activity increases pilocarpine-induced seizure probability and mossy fiber outgrowth.

Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study

  • Bang, Ki Bae;Park, Jung Ho
    • Gut and Liver
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    • v.12 no.6
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    • pp.633-640
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    • 2018
  • Background/Aims: Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI reduction could resolve EE. Methods: A retrospective cohort study was performed to assess the natural course of EE according to changes in BMI. Participants undergoing health check-ups from 2006 to 2012 were enrolled, and 1,126 subjects with EE were included. The degree of esophagitis was measured by upper endoscopy and serially checked over a 5-year follow-up. Logistic regression and Cox proportional hazards models were used to investigate the association between BMI reduction and EE resolution. Results: Substantial weight loss is associated with EE resolution. The adjusted odds ratio for EE resolution was 1.44 (95% confidence interval [CI], 1.09 to 1.92) among participants with a decrease in BMI compared to those with no decrease in BMI. The EE resolution rate was related to the degree of BMI reduction. The effect of weight loss on EE resolution was higher among subjects who lost more weight. Compared with subjects with no decrease in BMI, the hazard ratios for EE resolution were 1.09 (95% CI, 0.89 to 1.35), 1.31 (95% CI, 1.01 to 1.72) and 2.12 (95% CI, 1.44 to 3.12) in subjects with BMI reductions of ${\leq}1$, 1-2, and >$2kg/m^2$, respectively. Conclusions: EE resolution is associated with a decrease in BMI, and weight loss is potentially an effective GERD treatment.

Non-linear Relationship Between Body Mass Index and Lower Urinary Tract Symptoms in Korean Males

  • Choi, Chang Kyun;Kim, Sun A;Jeong, Ji-An;Kweon, Sun-Seog;Shin, Min-Ho
    • Journal of Preventive Medicine and Public Health
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    • v.52 no.3
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    • pp.147-153
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    • 2019
  • Objectives: The purpose of this study was to evaluate the association between body mass index (BMI) and severe lower urinary tract symptoms (LUTS) in Korean males. Methods: This study was conducted on males aged ${\geq}50years$ who participated in the 2011 Korean Community Health Survey. LUTS severity was assessed using the Korean version of the International Prostate Symptom Score (IPSS) questionnaire, and was dichotomized as severe (IPSS >19) and non-severe ($IPSS{\leq}19$). BMI was divided into 6 categories: <18.5, 18.5-22.9, 23.0-24.9, 25.0-27.4, 27.5-29.9, and ${\geq}30.0kg/m^2$. To evaluate the relationship between BMI and LUTS, a survey-weighted multivariate Poisson regression analysis was performed to estimate prevalence rate ratios (PRRs). Age, smoking status, alcohol intake, physical activity, educational level, household income, and comorbidities were adjusted for in the multivariate model. Results: A U-shaped relationship was detected between BMI and severe LUTS. Compared with a BMI of $23.0-24.9kg/m^2$, the PRR for a BMI < $18.5kg/m^2$ was 1.65 (95% confidence interval [CI], 1.35 to 2.02), that for a BMI of $18.5-22.9kg/m^2$ was 1.25 (95% CI, 1.09 to 1.44), that for a BMI of $25.0-27.4kg/m^2$ was 1.20 (95% CI, 1.00 to 1.45), that for a BMI of $27.5-29.9kg/m^2$ was 1.11 (95% CI, 0.83 to 1.47), and that for a BMI ${\geq}30.0kg/m^2$ was 1.85 (95% CI, 1.18 to 2.88). Conclusions: This study showed that both high and low BMI were associated with severe LUTS.

According to the BMI of Children and Adolescents, Eating-Lifestyle Habits, and Recognized Study (아동·청소년의 BMI에 따른 식생활습관 및 인식 연구)

  • Lee, Yeo Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.1
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    • pp.265-274
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    • 2013
  • The purpose of this study was to investigate the dietary habits of the relevant factors according to the obesity status of children and adolescents. Services research studies conducted in the Ministry of Health, Welfare and Family Affairs of the '2009 Children and Youth Online Games and Family Activity Survey findings utilizing data. Study, the subjects utilized 9,462 elementary school students 2,778 people, 3,385 middle school students, high school students a total of 3,299 people were enrolled in the study. Were grouped according to the BMI of the study subjects. After dinner snack intake 18.5>BMI groups disagree 38.8%, 18.5${\leq}$BMI<23.0 group it was 41.1%, 23.5${\leq}$BMI<25.0 group it was 40.1%, $25{\leq}BMI$ groups disagree 37.4% response was highest(p=0.001). Investigate whether regular exercise every day, results showed that a high BMI index groups do not exercise more. Aggressiveness in time, such as physical education, the survey showed that a low BMI index group more likely to exercise vigorously. BMI index group of people around you and the speed of eating more meals were faster. If you let more to allow time to practice proper education of children and youth, health and enrich lives of the appropriation will be able to Services to live a healthy and happy life than to correct perceptions and lifestyles of children and adolescents. To do this, there is a need to educate parents, children and youth, as well as.

BMI-1026 treatment can induce SAHF formation by activation of Erk1/2

  • Seo, Hyun-Joo;Park, Hye-Jeong;Choi, Hyung-Su;Hwang, So-Yoon;Park, Jeong-Soo;Seong, Yeon-Sun
    • BMB Reports
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    • v.41 no.7
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    • pp.523-528
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    • 2008
  • BMI-1026 is a synthetic aminopyrimidine compound that targets cyclin dependent kinases (cdks) and was initially designed as a potential anticancer drug. Even though it has been well documented that BMI-1026 is a potent cdk inhibitor, little is known about the cellular effects of this compound. In this study, we examined the effects of BMI-1026 treatment on inducing premature senescence and then evaluated the biochemical features of BMI-1026-induced premature senescence. From these experiments we determined that BMI-1026 treatment produced several biochemical features of premature senescence and also stimulated expression of mitogen activated protein kinase (MAPK) family proteins. BMI-1026 treatment caused nuclear translocation of activated Erk1/2 and the formation of senescence associated heterochromatin foci in 5 days. The heterochromatin foci formation was perturbed by inhibition of Erk1/2 activation.

Relationship between body mass index(BMI) and periodontal disease in Korean adult: The fifth Korea National Health and Nutrition Examination Survey(KNHANES V-1) (한국 성인의 체질량지수와 치주질환의 관련성: 제5기 1차년도 국민건강영양조사)

  • Lee, Min-Kyung;Jin, Hye-Jung
    • Journal of Korean society of Dental Hygiene
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    • v.15 no.6
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    • pp.991-997
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    • 2015
  • Objectives: The purpose of the study is to investigate the relationship between body mass index(BMI) and periodontal disease in Korean adult from the data of the fifth Korea National Health and Nutrition Examination Survey(KNHANES). Methods: The subjects were 3,309 adults from 25 ro 45 years old in the fifth KNHANES. The subjects were divided into three BMI categories: normal weight 1,549(BMI ${\leq}22.9kg/m^2$), overweight 792(BMI $23.0-25.0kg/m^2$) and obesity 968(BMI ${\geq}25.0kg/m^2$). Periodontal disease was assessed by community periodontal index(CPI) and periodontitis was defined as ${\geq}$ code 3. Results: Increased BMI adults had no significantly higher prevalence of periodontitis than those having normal body weight after adjusting for variables; the odds ratio(OR) was 1.06 in overweight and 1.23 in obesity. BMI and periodontitis had no significant relation to increased age, but the age increase tended to have high odds ratio. Women had a higher OR than men. Conclusions: Through this study, it is necessary to analyze the relationship between the obesity index and periodontitis in the further study.

The Clinicopathological Significance of Bmi-1 Expression in Pathogenesis and Progression of Gastric Carcinomas

  • Lu, Hang;Sun, Hong-Zhi;Li, Hua;Cong, Ming
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.7
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    • pp.3437-3441
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    • 2012
  • Background: Oncogenic Bmi-1 (B-lymphoma Moloney murine leukemia virus insertion region-1) belongs to the Polycomb-group (PcG) family of proteins and plays an important role in the regulation of proliferation, senescence, cell cycle and apoptosis, chromosome stability, activation of gene transcription. Methods: To clarify the roles of Bmi-1 in tumourigenesis and progression of gastric carcinomas, it was examined by immunohistochemistry (IHC) and real-time RT-PCR in gastric carcinomas, dysplasia, intestinal metaplasia (IM), and gastritis with a comparison of its expression with clinicopathological parameters of carcinomas. Results: There was gradually increased Bmi-1 protein expression from gastritis, IM, dyplasia to carcinoma (p<0.001). Bmi-1 expression was positively linked to tumor size, depth of invasion, lymph node metastasis and worse prognosis of carcinomas (p<0.001), but not to age or sex of carcinoma patients (p>0.05). There was higher Bmi-1 protein expression in intestinal-type carcinomas than diffuse-type ones (p<0.001). At mRNA level, Bmi-1 protein expression was increased from gastritis, IM, dysplasia and carcinoma (p<0.001). Bmi-1 overexpression was observed in gastric carcinoma with larger diameter, deeper invasion, lymph node metastasis, and intestinal-type carcinoma (p<0.05). Conclusion: These findings indicate that up-regulated Bmi-1 expression is positively linked to pathogenesis, growth, invasion, metastasis and differentiation of gastric carcinomas. It was considered as a promising marker to indicate the aggressive behaviors and prognosis of gastric carcinomas.

Effects of BMI-1026, A Potent CDK Inhibitor, on Murine Oocyte Maturation and Metaphase II Arrest

  • Choi, Tae-Saeng
    • Reproductive and Developmental Biology
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    • v.31 no.2
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    • pp.71-76
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    • 2007
  • Previous studies have shown that BMI-1026 is a potent inhibitor of the cyclin-dependent kinases (cdk). In cell culture, the compound also arrests G2/M strongly and G1/S and S weakly. Two key kinases, cdk1 (p34cdc2 kinase) and mitogen-activated protein (MAP) kinase (erk1 and 2), perform crucial roles during oocyte maturation and, later, metaphase II (MII) arrest. In mammalian oocytes, both kinases are activated gradually around the time of germinal vesicle breakdown (GVBD) and maintain high activity in eggs arrested at metaphase II. In this study, we examined the effects of BMI-1026 on GVBD and MII arrest in mouse oocytes. BMI-1026 inhibited GVBD of immature oocytes and activated MII-arrested oocytes in a concentration-dependent manner, with more than 90% of oocytes exhibiting GVBD inhibition and MII activation at 100 nM This is approximately 500$\sim$1,000 times more potent than the activity reported for the cdk inhibitors roscovitine (${\sim}50{\mu}M$) and butyrolactone (${\sim}100{\mu}M$). Based on the results of previous in vitro kinase assays, we expected BMI-1026 to inhibit only cdk1 activation in oocytes and eggs, not MAP kinase. However, in our cell-based system, it inhibited the activity of both kinases. We also found that the effect of BMI-1026 is reversible. Our results suggest that BMI-1026 inhibits GVBD and activates MII-arrested oocytes efficiently and reversibly and that it also inhibits both cdk1/histone HI kinase and MAP kinase in mouse oocytes.

BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

  • Rajabpour, Fatemeh Vand;Raoofian, Reza;Youssefian, Leila;Vahidnezhad, Hassan;Shahshahani, Mostafa Mirshams;Fathi, Hamidreza;Noormohammadpour, Pedram;Hesari, Kambiz Kamyab;Hashemzadeh-Chaleshtori, Morteza;Tabrizi, Mina
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.8
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    • pp.3797-3800
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    • 2014
  • Background: BMI1, TWIST1 and SNAI2/SLUG have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma and BMI1 expression could identify subtypes of Merkel cell carcinoma (MCC). However, BMI1, TWIST1 and SNAI2 expression levels in basal cell carcinomas (BCCs) have not been elucidated. We hypothesized BCC could be a good model system to decipher mechanisms which inhibit processes that drive tumor metastasis. The aim of this study was to examine the mRNA expression level of BMI1, TWIST1, and SNAI2 in BCCs. Materials and Methods: Thirty-five fresh non-metastatic BCC tissue samples and seven fresh normal skin tissue samples were evaluated by real-time RT-PCR. Results: BMI1 and TWIST1 demonstrated marked down-regulation (p<0.00l, p=0.00l respectively), but SNAI2 showed no significant change (p=0.12). Conclusions: Previous literature has clearly demonstrated a positive association between BMI1 and TWIST1 expression and metastatic BCC, aggressive SCC and melanoma. Here, we demonstrated a negative association between BMI1 and TWIST1 mRNA expression level and BCC.

Relationship Between BMI, Body image, and Smoking in Korean Women as Determined by Urine Cotinine: Results of a Nationwide Survey

  • Jang, So-Young;Kim, Jin-Hyeong;Lim, Min-Kyung;Kim, Hee-Jin;Jee, Sun-Ha;NamKoong, Kee;Cho, Woo-Hyun;Park, Eun-Cheol;Lee, Sang-Gyu
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.3
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    • pp.1003-1010
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    • 2012
  • Background: This study examined the influence of body mass index (BMI), subjective body perception (SBP), and the differences between BMI and SBP influence on smoking among women. Methods: This study used the Korea National Health and Nutrition Examination Survey IV-2, 3 2008-2009. A urinary cotinine test was administered to 5485 women at least 19 years of age. Individuals whose cotinine level was at least 50 ng/mL were categorized as smokers. A multiple logistic regression analysis was performed to estimate the extent to which body-related variables affect female smoking. Results: Women with a lower BMI who perceived themselves to be normal or very fat were 2.09 times (1.14-3.83) more likely to smoke than women with a normal BMI and SBP. Women who were never married with a low BMI and thin SBP were 3.11 times (1.47-6.55) more likely to smoke than women with a normal BMI and SBP. Married women with a high BMI who considered themselves very fat were 0.63 times (0.43-0.94) less likely to smoke than women with a normal BMI and SBP. In contrast, divorced and widowed women with a low or normal BMI who considered themselves very fat were 26.1 times (1.35-507.3) more likely to smoke. Conclusions: Discrepancies between the objective physical condition (BMI) and the subjective body image (SBP) influence the female smoking rate. To reduce the number of female smokers, public education on the association between smoking behavior and weight issues is needed, especially among women with low BMI and distorted weight perception.