• Title, Summary, Keyword: Apolipoprotein AI

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Correlationship researches of Apolipoprotein A1 in body mass index (체질량지수에 따른 Apolipoprotein A1 상관성연구)

  • Kim, Jean-Soo;Lee, Dong-Yeop
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.11
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    • pp.5345-5349
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    • 2012
  • Recently obesity from the child until being early in the adult, there is to an increase tendency. The obesity influences to various metabolicdisease and there is a possibility of an effect in relationship disease of the heart, brain vascular system etc. This research analyzed the interrelation -ship of apolipoprotein AI consistency and body mass index. It used spss 19.0 with t-test and a regression analysis. Analytical result the interrelationship of apolipoprotein AI and body mass index was -0.484 (p=0.01). The high density cholesterol was 0.89 (p=0.01). The trigriceride was -0.88 (p=0.01). Free fatty acid were not interrelationship. Conclusively, interrelationship of apolipoprotein AI and body mass index was not high. Encourage to examine trigriceride or cholesterol and prevent Arteriosclerosis.

The Pst 1 Polymorphism of the Human Apolipoprotein AI Gene in Korean Elite Athletes

  • Kang, Byung-Yong;Kim, Hyun-Hee;Lee, Kang-Oh
    • Animal cells and systems
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    • v.7 no.1
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    • pp.69-73
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    • 2003
  • Serum lipid and lipoprotein levels are influenced by genetic factors, and exorcise increases the concentrations of cardio-protective parameters such as high-density lipoprotein cholesterol (HDL-cholesterol) and apolipoproteinAI (apoAI) in human serum. In the present study, we tested the effect of adaptation to endurance exercise on the association of a genetic polymorphism (Pst 1 RFLP) in the apoAI gene with these biochemical parameters. The genotype and allele frequencies for the Pst 1 RFLP were not significantly different between the elite athletes and sedentary controls (P>0.05). There were also no significant associations between the Pst 1 RFLP of the apoAI gene and the biochemical parameters in elite athletic group. Thus, our results suggest that the Pst 1 RFLP of the apoAI gene was not significantly associated with the serum apoAI and HDL-cholesterol concentrations as well as athletic performance in Koreans.

Msp I RFLP of the Human Apolipoprotein AI Gene in Korean Elite Athletes

  • Kang, Byung-Yong;Lee, Kang-Oh;Oh, Sang-Duk;Bae, Joon-Seol;Yoon, Tae-Joong;Jeong, Han-Min;Kim, Ki-Tae
    • Environmental Mutagens and Carcinogens
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    • v.22 no.4
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    • pp.243-247
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    • 2002
  • Prolonged exercise is known to increase steady-state serum high-density lipoprotein cholesterol (HDL-cholesterol) and apolipoprotein AI(apo AI) concentrations. We investigated the effect of adaptation to endurance exercise on the association of the genetic polymorphism in the apo AI gene with these biochemical parameters. 108 male subjects were randomly selected from a group of elite athletes, and 65 male samples used as sedentary control group from Korean general population. The genetic polymorphism in the apo AI gene locus was detected by polymerase chain reaction(PCR) and DNA digestion with Msp I restriction endonuclease. The genotype frequency for the Msp I RFLP was significantly different between the elite athletes and sedentary controls(P<0.05). There were, however, no significant associations between the Msp I RFLP of the apo AI gene and the biochemical parameters in elite athletic group. Therefore, our findings indicate that the Msp I RFLP of the apo AI gene was not associated with the serum apo AI and HDL-cholesterol concentrations in Korean male elite athletes.

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Association among Serum Lipid, Apolipoprotein Levels and Related Factors in Healthy Adults (중.장년층의 혈청 지질 및 아포지단백질의 농도와 관련된 요인 분석)

  • Lee, Hoe-Seon;Kim, Gyeong-Eup;Park, Mi-Young;Youn, Hee-Shang;Choi, Sun-Young;Kim, Sung-Hee
    • Journal of the East Asian Society of Dietary Life
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    • v.18 no.6
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    • pp.949-958
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    • 2008
  • This study was carried out to examine the association of age, nutrient intake, alcohol drinking and smoking on serum lipid and apolipoprotein levels in 100 healthy adults (54 males and 46 females). The serum total cholesterol, low density lipoprotein cholesterol (LDL-C) (p<0.05), apolipoprotein B (Apo B) levels, LDL-C:high density lipoprotein cholesterol (HDL-C) ratio, Apo B:apolipoprotein(Apo A-I) ratio and atherogenic index (AI) (p<0.001) were significantly higher in males than females, but HDL-cholesterol level was significantly lower (p<0.01) in males than females. The plasma ascorbic acid concentration had no difference in both genders. Most of nutrient intakes except Ca, vitamin A and vitamin $B_2$ were higher than RI (Recommended intake) in both males and females. The meal frequency per day was significantly higher (p<0.01) in males than females, while meal speed, the heaviest meal, meal quantity and meal regularity had no significant differences. The rates of drinking and smoking were significantly higher (p<0.01) in males (59.3%, 37.2%) than females (17.3%, 6.9%). The age was positively correlated with triglyceride level in males (p<0.05), and with total cholesterol (p<0.001), LDL-cholesterol (p<0.001), Apo B (p<0.01), LDL-C:HDL-C ratio (p<0.01), Apo B:Apo A-I ratio (p<0.05) and AI (p<0.01) in females. The levels of serum lipid and apolipoprotein were more correlated with protein intake than other macronutrient intakes in males, while those in females were more correlated energy, carbohydrate and lipid intakes than protein intake. The effect of drinking on serum lipid and apolipoprotein levels was bigger in males than females, while the effect of smoking on those was bigger in females than males. The plasma ascorbic acid concentration was positively correlated with HDL-cholesterol (p<0.05), Apo A-I levels (p<0.001), whereas negatively correlated with Apo B:Apo A-I ratio (p<0.05) in males. And that was positively correlated with HDL-cholesterol (p<0.05) in females. These results suggest that moderate macronutrient intake, less alcohol consumption and non-smoking were necessary to maintain healthy lipid profile with aging in adults.

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A Study on the Serum Lipid, Apolipoprotein Levels and Their Correlations in Healthy Adults of Gyeongnam Area (경남지역 중${\cdot}$장년층의 혈청지질, 아포지단백질의 농도 및 상호관련성에 관한 연구)

  • Lee, Hoe-Seon;Park, Mi-Young;Kim, Gyeong-Eup;Cheong, Hyo-Sook;Kim, Sung-Hee
    • Journal of Nutrition and Health
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    • v.40 no.6
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    • pp.526-530
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    • 2007
  • The purpose of this study was investigating serum lipid, apolipoprotein levels and their correlations in healthy adults of Gyeongnam area. The BMI (body mass index) was significantly higher (p < 0.001) in male (25.2 ${\pm}$ 2.7 $kg/m^2$) than female (23.8 ${\pm}$ 1.5 $kg/m^2$), however PBF (percent body fat) was significantly higher (p < 0.001) in female (29.6 ${\pm}$ 4.3%) than male (22.7 ${\pm}$ 5.0%). The WHR (waist to hip ratio) and blood pressure in the groups showed there was no significant differences. The levels of serum total cholesterol, LDL-cholesterol and apolipoprotein B were significantly higher (p < 0.01) in male (208.7 ${\pm}$ 27.7 mg/dl, 129.0 ${\pm}$ 26.9 mg/dl, 1.0 ${\pm}$ 0.2 g/L) than female (193.6 ${\pm}$ 29.1 mg/dl, 112.5 ${\pm}$ 29.5 mg/dl, 0.9 ${\pm}$ 0.2 g/L, but HDL-cholesterol level was significantly higher (p < 0.01) in female (54.9 ${\pm}$ 6.6 mg/dl) than male (49.9 ${\pm}$ 7.3 mg/dl). The LDL-C/HDL-C, Apo B/Apo A-I and AI (atherogenic index) were significantly higher (p < 0.001) in male (2.6 ${\pm}$ 0.6, 0.8 ${\pm}$ 0.2, 3.3 ${\pm}$ 0.7) than female (2.1 ${\pm}$ 0.5, 0.6 ${\pm}$ 0.2, 2.6 ${\pm}$ 0.5). The triglyceride level was positively correlated with apolipoprotein B concentration (p < 0.05) and negatively correlated with HDL-cholesterol concentration (p < 0.05), however no significant correlation was found with apolipoprotein A-I. According to these results, we conclude that male adults are expecting higher incidence of cardiovascular disease than female adults and we suggest the serum triglyceride should be kept normal level for the prevention of these diseases.

Apolipoprotein E Phenotypes and the Relationship Among Lipid Levels, Nutrient Intakes, Lifestyles and Risk Factors Between Subjects with and without Hyperlipidemic Risk (Apolipoprotein E 다형성과 고지혈증 위험 유무에 따른 혈중 지질농도, 영양소 섭취, 생활습관 및 위험요인과의 관계)

  • Lee, Jae-Eun;Cho, Sang-Woon;Kang, Ji-Yeon;Paek, Yun-Mi;Choi, Chang-Sun;Park, Yoo-Kyoung;Choi, Tae-In
    • Journal of Nutrition and Health
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    • v.41 no.5
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    • pp.402-413
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    • 2008
  • This study was performed to investigate Apolipoprotein E phenotypes and the relationship among lipid levels, nutrient intakes, lifestyles and risk factors between subjects with and without hyperlipidemic risk. The data were collected from 675 industrial male workers who had completed annual medical examination. Compared to the normal group, the hyperlipidemic risk group in Apo E3 and E4 had significantly higher BMI (p < 0.05) and showed significantly higher body fat (%), waist circumference and WHR in all types of Apo E (p < 0.05). In addition, the hyperlipidemic risk group had significantly higher total cholesterol, LDL-cholesterol, triglyceride and AI than the normal group in all types of Apo E (p < 0.05). Intakes of protein, calcium, phosphorus, iron, vitamin A, vitamin B1, vitamin B2, vitamin C and niacin in Apo E3 were significantly lower in the hyperlipidemic risk group than in the normal group (p < 0.05). In the logistic regression analysis, after adjustment for other factors, Apo E2 + E4, waist and WHR were the significant risk factors associated with hyperlipidemia, but protein intakes were associated with significantly lower risks of hyperlipidemia (p < 0.05). In conclusion, genetic factor (Apo E2 or Apo E4), anthropometric index and nutrient intake seem to influence hyperlidemic risk. Further studies and efforts will be needed to evaluate the independent relationships among hyperlipidemic risk factors.

New Normalization Methods using Support Vector Machine Regression Approach in cDNA Microarray Analysis

  • Sohn, In-Suk;Kim, Su-Jong;Hwang, Chang-Ha;Lee, Jae-Won
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • pp.51-56
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    • 2005
  • There are many sources of systematic variations in cDNA microarray experiments which affect the measured gene expression levels like differences in labeling efficiency between the two fluorescent dyes. Print-tip lowess normalization is used in situations where dye biases can depend on spot overall intensity and/or spatial location within the array. However, print-tip lowess normalization performs poorly in situation where error variability for each gene is heterogeneous over intensity ranges. We proposed the new print-tip normalization methods based on support vector machine regression(SVMR) and support vector machine quantile regression(SVMQR). SVMQR was derived by employing the basic principle of support vector machine (SVM) for the estimation of the linear and nonlinear quantile regressions. We applied our proposed methods to previous cDNA micro array data of apolipoprotein-AI-knockout (apoAI-KO) mice, diet-induced obese mice, and genistein-fed obese mice. From our statistical analysis, we found that the proposed methods perform better than the existing print-tip lowess normalization method.

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Age-related Circulating Inflammatory Markers and Cardiovascular Disease Risk Factors in Korean Women (한국 성인 여성에서 연령에 따른 혈중 염증 표지자와 심혈관계 질환 위험 요인에 대한 연구)

  • Kwak, Ho-Kyung;Kim, Mi-Joung
    • Korean Journal of Community Nutrition
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    • v.14 no.4
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    • pp.451-461
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    • 2009
  • The purpose of this study was to investigate the age-related changes of cardiovascular disease risk factors and inflammatory markers in non-obese Korean women. Subjects were 112 women over 20 years old with body mass index (BMI) less than $30 kg/m^2$ and were divided into 3 groups (< 40 years, $40{\sim}59$ years, ${\ge}60$ years). Mean weight and BMI in the oldest group were significantly higher than those in the other 2 younger groups (p < 0.05). Mean total cholesterol, triglyceride, LDL-cholesterol and apolipoprotein B/apolipoprotein A1 ratio (BAR) in the oldest group were significantly higher than those in the youngest group (p < 0.05), and mean HDL-cholesterol of the oldest group was significantly lower than that of the youngest group (p < 0.05). The older-aged group showed significantly higher mean values of atherogenic index (AI) and LDL/HDL ratio (p < 0.05) than the respective younger-aged group, and AI was significantly correlated with age, nitric oxide and thiobarbituric acid reactive substances (p < 0.01). In addition, mean vascular cell adhesion molecule-l (VCAM-1) tended to be higher in the older-aged group than the younger group. Tumor necrosis factor-${\alpha}$, a proinflammatory maker, was significantly positively correlated with serum homocysteine, a cardiovascular disease risk factor (p < 0.01). In addition, a significantly positive correlation was observed between C-reactive protein and BAR (p < 0.01). Overall results suggested that the aging might affect the increase of cardiovascular disease risk factors including the serum lipid profiles, weight and BMI, and age-related increases of weight and BMI might play a role in changes in certain biomarkers of inflammation. (Korean J Community Nutrition 14(4) : 451${\sim}$461, 2009)