• Title, Summary, Keyword: Angelica dahurica

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Neuroprotective Effect of Scopoletin from Angelica dahurica on Oxygen and Glucose Deprivation-exposed Rat Organotypic Hippocampal Slice Culture

  • Son, Dong-Wook;Lee, Pyeong-Jae;Lee, Jong-Seok;Lee, Sang-Hyun;Choi, Sang-Yoon;Lee, Jong-Won;Kim, Sun-Yeou
    • Food Science and Biotechnology
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    • v.16 no.4
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    • pp.632-635
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    • 2007
  • This study examined the neuroprotective effect of scopoletin from Angelica dahurica against oxygen and glucose deprivation-induced neurotoxicity in a rat organotypic hippocampal slice culture. Scopoletin reduced the propidium iodide (PI) uptake, which is an indication of impaired cell membrane integrity. In addition, it inhibited the loss of NeuN, which represents the viability of neuronal cells. The results suggests that scopoletin from A. dahurica protects neuronal cells from the damage caused by oxygen and glucose deprivation.

Antifungal Activities of Essential Oil from the Roots of Angelica dahurica Bentham et Hooker f. (구릿대 뿌리 정유의 항진균 효과)

  • Rho, Junghyun;Shin, Eunji;Shin, Seungwon
    • YAKHAK HOEJI
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    • v.58 no.1
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    • pp.58-61
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    • 2014
  • The essential oil was extracted from the roots of Angelica dahurica Bentham et Hooker f. by steam distillation and its composition was analyzed by GC-MS. The antifungal activities were evaluated by micro-dilution method against five Aspergillus and three Trichophyton species. The most abundant component was ${\alpha}$-pinene (17.21%) among 40 compounds identified in this oil. The essential oil fraction of A. dahurica and ${\alpha}$-pinene exhibited marked inhibiting activities against the tested Aspergillus and Trichophyton species with MICs (minimum inhibitory concentrations) between 0.12 mg/ml and 8 mg/ml.

Antithrombotic Effect of the BuOH Soluble Fraction of Angelica dahurica Root (백지 BuOH 가용분획의 항혈전 활성에 관한 연구)

  • Kim, Chang-Min;Kwon, Yong-Soo;YunChoi, Hye-Sook
    • Korean Journal of Pharmacognosy
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    • v.26 no.1
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    • pp.74-77
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    • 1995
  • Several coumarins isolated from Angelica sp. were described to show inhibitory effects against human platelet aggregation. The anti-thrombotic and anti-platelet potential was evaluated, in this paper, with the BuOH soluble fraction of Angelica dahurica root. The BuOH fraction was divided into five subfractions fr. A - E and tested in the mouse model of thrombosis. Survival was enhanced to 35% with fr. A or fr. E treated (500 mg/Kg, p.o.) group of mice compared with 5% survival of the control group. However, none of the 8 coumarin glycosides obtained from fr. A, at the conc. of 0.5 mg/ml, showed inhibitory effects against rat platelet aggregation induced by ADP or collagen.

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Anti-bacterial and Anti-inflammatory Effects of Angelica dahurica Extracts in Helicobacter pylori-infected Human Gastric Epithelial AGS Cells (백지(Angelica dahurica) 추출물의 Helicobacter pylori에 대한 항균력 및 H. pylori로 유도한 염증반응에 대한 항염 효과)

  • Choi, Min Kyeong;Yim, Dongsool;Choi, SungSook
    • Korean Journal of Pharmacognosy
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    • v.49 no.3
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    • pp.255-261
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    • 2018
  • The aim of this study was to evaluate the anti-helicobacter activity and anti-inflammatory activity of Angelica dahurica (AD). The minimum inhibitory concentration(MIC) of AD against Helicobacter pylori(H. pylori), expression of the H. pylori cagA gene in the presence of AD was determined. Inhibition of H. pylori urease by AD, inhibition of nitric oxide (NO) production in AGS cells was measured. IL-8 mRNA expression in AGS cells which were infected with H. pylori and IL-8 level was measured. The MIC of MeOH Ex. of AD was $250{\mu}g/mL$ and the expression of cagA gene was decreased about 88% in the presence of AD. The activity of H. pylori urease was inhibited 70% by AD. mRNA expression of IL-8 and the production of NO and IL-8 were significantly decreased in the presence of AD. In conclusion, AD showed anti-Helicobacter activity and has potent anti-inflammatory effect on H. pylori-induced inflammation in human gastric epithelial AGS cells.

Furanocoumarins from the Root of Angelica dahurica

  • Baek, Nam-In;Ahn, Eun-Mi;Kim, Hae-Yeong;Park, Young-Doo
    • Archives of Pharmacal Research
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    • v.23 no.5
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    • pp.467-470
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    • 2000
  • Five furanocoumarins including a new one were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were determined to be isoimperatorin (1), oxypeucedanin hydrate-3"-butyl ether (2), imperatorin (3), knidilin (4), and oxypeucedanin hydrate (5). This represents the first study in which the compound 2 has been isolated and identified, The long-range coupling ($^{5}J$) in the $^1H$-NMR spectrum observed in the linear furanocoumarin skeleton was also investigated in detail.

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Acetylcholinesterase Inhibitors from the Roots of Angelica dahurica

  • Kim, Dae-Keun;Lim, Jong-Pil;Yang, Jae-Heon;Eom, Dong-Ok;Eun, Jae-Soon;Leem, Kang-Hyun
    • Archives of Pharmacal Research
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    • v.25 no.6
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    • pp.856-859
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    • 2002
  • In the course of finding Korean natural products for acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the roots of Angelica dahurica showed significant inhibitory effects on AChE. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of three furanocoumarins, isoimperatorin (1), imperatorin (2) and oxypeucedanin (3), as active principles. These compounds inhibited AChE activity in a dosedependent manner, and the $IC_{50}$ values of compounds 1-3 were 74.6, 63.7 and 89.1 uM, respectively.

Estrogenic Activity of Furanocoumarins Isolated from Angelica dahurica

  • Piao, Xiang-Lan;Yoo, Hye-Hyun;Kim, Hyun-Young;Kang, Tak-Lim;Hwang, Gwi-Seo;Park, Jeong-Hill
    • Archives of Pharmacal Research
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    • v.29 no.9
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    • pp.741-745
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    • 2006
  • In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with $EC_{50}$ values of 1.1 and $0.8\;{\mu}g/mL$, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.

Isolation and Structure Determination of Coumarin Derivatives from the Roots of Angelica dahurica

  • Kim, Ji-Yeon;Son, Jong-Keun;Song, Dong-Keun
    • Journal Of Oriental Pharmacy
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    • v.3 no.1
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    • pp.35-41
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    • 2010
  • From the roots of Angelica dahurica Bentham et Hooker (Umbelliferae), three known coumarin derivatives have been isolated and identified as 8-(2-hydroxy-3-methoxy-3-methylbutyloxy) psoralen, 5,8-di(2,3-dihydroxy-3-methylbutyloxy) psoralen, 9-[3-($\beta$-D-glucopyranosyloxy)-2-hydroxy-3-methylbutoxy]-7H-furo[3,2-g][1]benzopyran-7-one. This is the first report of the occurrence of these compounds in this plant. These three compounds were tested for activity in septic shock model. Among these compounds, 2 showed relatively strong preventive activity against septic shock.

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Promoting Synthesis of Collagen from Angelica dahurica Root (백지의 콜라겐 생성 촉진 물질)

  • Jung, Min-Hwan;Lim, Young-Hee;Lee, Sang-Hwa;Kang, Sang-Jin;Cho, Wan-Goo;Jin, Mu-Hyun
    • Korean Journal of Pharmacognosy
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    • v.35 no.4
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    • pp.315-319
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    • 2004
  • Three coumarin derivatives, which stimulate collagen biosynthesis in human fibroblasts were isolated from Angelica dahurica root which has been used in traditional medicine for cold, headache, discharging blood and women's diseases. Three coumarin derivatives were identified as 5-benzofuranacrylic acid, $6,7-dihydroxy-4-(3-methyl-2-butenyl)-{\delta}-lactone\;(prangenidin)$, 5-benzofuranacrylic acid, $6,7-dihydroxy-4-methoxy-{\delta}-lactone\;(8-hydroxybergapten)$ and 5-benzofuranacrylic acid, 8-hydroxypsoralen(xanthotoxol) from their spectral data.

Cytotoxic Coumarins from the Root of Angelica dahurica

  • Thanh, Pham Ngoc;Jin, Wen-Yi;Song, Gyu-Yong;Bae, Ki-Hwan;Kang , Sam-Sik
    • Archives of Pharmacal Research
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    • v.27 no.12
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    • pp.1211-1215
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    • 2004
  • Ten coumarins were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, oxypeucedanin hydrate acetonide (7) was isolated for the first time from this plant. Cytotoxicity of coumarins isolated were determined in vitro against L1210, HL-60, K562, and B16F10 tumor cell lines by MTT method. Pangelin (5) and oxypeucedanin hydrate acetonide (7) showed a potent cytotoxic activity with the $IC_{50}$ values of 8.6 to 14.6 ${\mu}g$ /mL against four kinds of tumor cell lines. Other compounds showed the moderate cytotoxic activity or no activity against the tumor cell lines.