• Title, Summary, Keyword: Allograft transplantation

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Outcomes of Meniscal Allograft Transplantation (동종 반월상 연골 이식술의 결과)

  • Cho, Chong-Hyuk;Choi, Yun-Jin
    • Journal of the Korean Arthroscopy Society
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    • v.15 no.1
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    • pp.36-41
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    • 2011
  • Treatment options are limited for young, meniscal-deficient patients with pain. This patient population is not age appropriate for total joint replacement, but the loss of the meniscus leaves them at significant risk for the development of osteoarthritis. One increasingly popular option is the use of allograft meniscal transplantation. However, many questions still surround allograft meniscus transplantation. Furthermore, most reports in the literature on the results of meniscal transplantation describe small case series using clinical outcome measures and/or incomplete direct evaluation of the meniscus. Therefore, the results of meniscal allograft transplantation have been difficult to interpret and compare due to many confounding variables. In this study, we reviewed the current research of concerns on the results of meniscal allograft transplantation.

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Allograft Immune Reaction of Kidney Transplantation Part 1. Mechanism of Allograft Rejection (신이식 후 면역반응의 이해 - 1부. 이식 거부 반응의 기전 -)

  • Kang, Hee-Gyung
    • Childhood Kidney Diseases
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    • v.12 no.1
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    • pp.23-29
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    • 2008
  • Kidney allograft transplantation is the most effective method of renal replacement for end stage renal disease patients. Still, it is another kind of 'disease', requiring immunosuppression to keep the allograft from rejection(allograft immune reaction). Immune system of the allograft recipient recognizes the graft as a 'pathogen (foreign or danger)', and the allograft-recognizing commanderin-chief of adaptive immune system, T cell, recruits all the components of immune system for attacking the graft. Proper activation and proliferation of T cell require signals from recognizing proper epitope(processed antigen by antigen presenting cell) via T cell receptor, costimulatory stimuli, and cytokines(IL-2). Thus, most of the immunosuppressive agents suppress the process of T cell activation and proliferation.

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Indication and Pre-operative Planning of Meniscal Allograft Transplantation (연골판 이식술의 적응증과 수술 전 계획)

  • Kim, Tae-Hyung;Choi, Nam-Hong
    • Journal of the Korean Arthroscopy Society
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    • v.15 no.1
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    • pp.32-35
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    • 2011
  • Meniscal allograft transplantation is considered to restore important functions of the meniscus after total and subtotal meniscectomy. There are patients who need meniscal allograft transplantation have concomitant lesions; chronic anterior cruciate ligament tear, chondral defect, and malalignment of the knee. Therefore proper selection of the patients and thorough preparation of operative procedure are imperative to get satisfactory results.

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Complications After Meniscus Allograft Transplantation (동종 반월상 연골 이식술 후 합병증)

  • Chun, Churl-Hong;Bae, Kyu-Hwan
    • Journal of the Korean Arthroscopy Society
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    • v.15 no.1
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    • pp.42-49
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    • 2011
  • Recently, meniscal allograft transplantation has been regarded as a successful procedure in terms of pain relief and functional improvement for the symptomatic patients previously underwent subtotal or total meniscectomy. However, the likelihood of a successful outcome would be reduced by various complications including graft tear, shrinkage, extrusion, infection, progressive chondral injury, and granuloma due to nonabsorbable suture material. Therefore, knee surgeons need to be all aware of the complications and to make an effort to minimize them. The purpose of this article is to review the current literatures regarding clinical results and complications after meniscus allograft transplantation.

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Quilty Lesions in the Endomyocardial Biopsies after Heart Transplantation

  • Cho, Haeyon;Choi, Jin-Oh;Jeon, Eun-Seok;Kim, Jung-Sun
    • Journal of Pathology and Translational Medicine
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    • v.53 no.1
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    • pp.50-56
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    • 2019
  • Background: The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients. Methods: A total of 1190 EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions, acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy was diagnosed by computed tomography coronary angiography. Clinical information, including the patients' survival was retrieved by a review of medical records. Results: Eighty-eight patients (75.2%) were diagnosed with Quilty lesions, which were significantly associated with acute cellular rejection, but not with acute cellular rejection ≥ 2R or antibody-mediated rejection. In patients diagnosed with both Quilty lesions and acute cellular rejection, the time-to-onset of Quilty lesions from transplantation was longer than that of acute cellular rejections. We found a significant association between Quilty lesions and cardiac allograft vasculopathy. No significant relationship was found between Quilty lesions and the patients' survival. Conclusions: Quilty lesion may be an indicator of previous acute cellular rejection rather than a predictor for future acute cellular rejection.

Effect of Pretransplant Donor-specific Blood Transfusion on Cardiac Allograft Survival in Rats (실험쥐모델에서 이식전 제공자 전혈 수혈이 이식심장의 생존에 미치는 영향)

  • 서충헌;박만실
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.32 no.11
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    • pp.984-988
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    • 1999
  • Background: Donor-specific blood transfusion(DSBT) before organ transplantation has been demonstrated to prolong allograft survival; the mechanism of this effect has remained unclear. Only a few researches have been performed on this subject in our country. Material and Method: To investigate the effect of DSBT, we selected 5 donor recipient combinations using rats of pure strain such as PVG, ACI, and LEW. One ml of donor whole blood was transfused to each recipient through the femoral vein 7 days prior to transplantation. The donor heart was transplanted to the recipient's abdominal vessels heterotopically using modified Ono and Lindsey's microsurgical technique. Five transplantations were done for each combination. Postoperatively, donor heart beat was palpated everyday through the recipent's abdominal wall. Rejection was defined as complete cessation of donor heart beat. Result: The allogeneic heart grafts transplanted from PVG strain to ACI strain(PVG ACI) without DSBT were acutely rejected(mean survival 10.2 days). With pretransplant DSBT, the cardiac allografts in PVG ACI and LEW PVG combinations survived indefinitely(more than 100 days), those in ACI PVG combination survived 12 to 66 days(mean 31.8 days), those in PVG LEW survived 8 to 11 days(mean 10.0 days), and those in ACI LEW survived 7 to 9 days(mean 8.0 days). In brief, DSBT prior to heart transplantation was definitely effective in PVG ACI and LEW PVG combinations and moderately effective in ACI PVG combination, but not effective in PVG LEW and ACI LEW combinations. Conclusion: DSBT prior to heart transplantation showed variable effects, but might prolong cardiac allograft survival indefinitely in some donor recipient strain combinations. The mechanism of this effect should be further investigated.

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Association of Foxp3 Polymorphism With Allograft Outcome in Kidney Transplantation

  • Park, Hyewon;Lee, Nuri;In, Ji Won;Roh, Eun Youn;Park, Kyoung Un;Shin, Sue;Yang, Jaeseok;Song, Eun Young
    • Annals of Laboratory Medicine
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    • v.37 no.5
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    • pp.420-425
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    • 2017
  • Background: Forkhead box P3 (Foxp3) is the most reliable marker for regulatory T cells, which play an important role in maintaining renal allograft tolerance. Recently, Foxp3 polymorphisms have been reported to be associated with graft outcome in kidney transplantation. We analyzed the association of Foxp3 polymorphisms with renal allograft outcome. Methods: Foxp3 polymorphisms (rs3761548 A/C, rs2280883 C/T, rs5902434 del/ATT, and rs2232365 A/G) were tested by PCR with sequence-specific primers (PCR-SSP) in 231 adult kidney transplantation recipients from 1996-2004 at Seoul National University Hospital. Results: Patients with the rs3761548 CC genotype showed better graft survival than those with the AC or AA genotype (log rank test, P =0.03). Patients with the rs3761548 CC genotype also showed a lower rate of recurrence of the original glomerular disease than those with the AC or AA genotype (P =0.01). The frequency of acute rejection (AR) in patients with the rs2280883 TT genotype was lower than that in patients with the rs2280883 CT or CC genotype (26.9% vs 53.3%, P =0.038). Patients with the rs2280883 TT genotype also showed better graft survival than those with the CT or CC genotype (P =0.03). Conclusions: Foxp3 rs3761548 CC and rs2280883 TT genotypes were associated with superior graft outcome of kidney transplantation. Further studies involving a larger number of patients are needed.

Acute Rejection after Renal Allograft in a Dog (개의 신장 동종이식 후 발생된 급성 거부반응)

  • Nam Hyun sook;Uhm Ji Yong;Yoon Byung IL;Woo Heung Myung
    • Journal of Veterinary Clinics
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    • v.22 no.4
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    • pp.439-443
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    • 2005
  • Rejection is one of the life-threatening complications after organ transplantation. An eight-month-old, intact male, mixed breed dog was presented with acute rejection after renal allograft. The heterotopic renal transplantation with bilateral nephrectomy was performed in the dog. The triple drug protocol for immunosuppression was applied for prevention of the acute rejection. Postoperative care was done according to the transplantation protocol of VMTH, Kangwon National University. The dog was euthanized when the serum creatinine concentration exceeded 5 mg/dL followed by tile signs of illness. The transplanted kidney was enlarged. The renal cortex lesions were characterized by necrosis of the renal tubules and the glomeruli. Interstitial lesions were characterized by hemorrhage and severe infiltration of lymphoid cells. Intrarenal arteries showed necrosis of the walls and infiltration of perivascular lymphoid cells. In immunohistochemical (IHC) findings, infiltration of the CD4 and the CD8 positive T lymphocytes was examined. In this case, acute rejection was shown by humoral and cellular immunity on the basis of histopathologic and IHC evaluation.

Arthroscopic Treatment of an Acute Septic Arthritis after Meniscal Allograft Transplantation - A Case Report - (반월상 연골 동종 이식술 후 발생한 화농성 관절염의 관절경적 치료 - 증례 보고 -)

  • Kim, Yeub;Yoon, Jung-Ro;Suh, Dong-Hoon;Jang, Hyoung-Won
    • Journal of the Korean Arthroscopy Society
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    • v.13 no.1
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    • pp.63-67
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    • 2009
  • We report the case of a 21-year-old man with acute septic arthritis of the knee after meniscal allograft transplantation, which was successfully treated with repeated arthroscopic debridement and irrigations. Our procedures included arthroscopic debridement and irrigation with 10L normal saline, repeated arthroscopic irrigations (5 times), and intravenous antibiotics. Our decision to repeat the debridement was based on clinical and laboratory results. The significance of this case is that early aggressive arthroscopic debridement and repeated irrigations as part of a treatment protocol of acute septic arthritis after meniscal allograft transplantation can be an effective treatment option in selected cases.

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