• Title, Summary, Keyword: ALT

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Clinical Study of Liver Function Tests (AST/ALT) of 121 HPV Disease Patients taking Herbal Medicine over 6 Months (HPV감염질환으로 6개월 이상 한약을 복용한 환자 121명의 간기능검사(AST/ALT)에 대한 후향적 고찰)

  • Lee, Eun;Lee, Kyoung Yeob;Yu, Byung Kook
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.32 no.5
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    • pp.347-353
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    • 2018
  • There are some controversies about the safety of herbal medicine. In order to examine the safety of herbal medicine, this study investigated the level of liver function test(AST/ALT) in patients taking herbal medicine for more than 6 months We checked liver function in 121 patients who took herbal medicine for more than 6 months. AST/ALT were measured before treatment and every 3 months (from 3 month to 9 month). In 121 patients taking herbal medicine for more than 6 months, mean AST level after 6 months was lower than before treatment and mean ALT level after 6 months was lower than before treatment. In 20 patients with abnormal AST/ALT before herbal treatment, 18 patients's AST/ALT changed to normal after 6 month herbal treatment. 2 patients's AST/ALT was slightly higher than normal. One woman patient met the criteria for herb-induced liver injury(HILI) with RUCAM scores 4 after taking herbal medicine for 6 months. Although her RUCAM score decreased to zero after taking herbal medicine for 9 months. This study suggests that long-term herbal medicine for 6 months or longer is very unlikely to injury liver function. Individual-specific liver damage may occur, it can be recovered.

Relationship between Elevated Serum Alanine Aminotransferase Concentration and Metabolic Syndrome in Korean Adults (한국 성인에서 혈청 Alanine Aminotransferase 농도의 상승과 대사증후군과의 관계)

  • Kim, Ji-Hye
    • Journal of Nutrition and Health
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    • v.42 no.8
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    • pp.732-739
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    • 2009
  • Metabolic syndrome has been strongly associated with elevated alanine aminotransferase (ALT), a surrogate of nonalcoholic fatty liver disease. We investigated the relationship between metabolic syndrome and elevated ALT in the general Korean population. The study sample was comprised of 4,781 Korean adults who had participated in the 2005 Korean National Health and Nutrition Examination Survey. Metabolic syndrome was defined by National Cholesterol Education Program for Adult Treatment Panel III. Elevated ALT was defined as an enzyme activity > 40 IU/L for men, and > 31 IU/L for women. ALT was measured by enzymatic methods. Among participants, 425 (8.9%) subjects displayed elevated ALT. The odds ratios (ORs) for elevated ALT increased in subjects with obesity or one of components of metabolic syndrome such as abdominal obesity, high blood pressure, high fasting glucose, high triglyceride, and low HDL cholesterol after adjusting for age and sex. The unadjusted OR for elevated ALT increased according to the number of components of metabolic syndrome (OR = 1.5, 95% CI: 0.96-2.32 for 1 component; OR = 3.0, 95% CI: 1.98-4.61 for 2 components; OR = 6.3, 95% CI: 4.29-9.35 for ${\geq}3$ components; p for trend < 0.0001). This trend did not differ after adjustments for putative risk factors including age, sex, BMI, smoking status, and alcohol intake. Metabolic syndrome is implicated as a strong risk factor of elevated ALT in Korean adults.

Analysis of Glucose, Cholesterol, AST and ALT in Sera of Man Workers in Jeonbuk Area (전북지역 남자 근로자의 혈청 Glucose, Cholesterol, AST, ALT 농도 분석)

  • Kim, Chong-Ho;Shin, Yong-Sub;Park, Seok-Tae;Jung, Mi-Ra
    • Korean Journal of Clinical Laboratory Science
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    • v.40 no.1
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    • pp.26-30
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    • 2008
  • We determined the concentration of glucose, cholesterol, AST and ALT in sera of man workers (n=3,247) had health check-up at hospitls in Jeonbuk area. The mean of concentration of glucose, cholesterol and AST of all workers were increased by 0.1%, 14.9% and 33.0% over than the mean of reference, but the mean of ALT was decreased by 0.8% from it. The rate of workers showed abnormal value of glucose, cholesterol, AST and ALT were 9.7%, 25.4%, 23.7% and 5.5%, respectively. The mean of glucose, cholesterol and AST in each age group were increased over than reference, but the mean of ALT was decreased except in fifties. The rate of the workers in each age group showed an abnormal concentration of glucose, cholesterol, AST and ALT were in 5.6~6.7%, 14.9~31.1%, 20.4~29.2% and 5.2~6.0%, respectively. These data suggest that many workers in Jeonbuk area are opened in possibility of getting diabetes, liver disease and heart disease.

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Effects of Ginseng Saponin on Serum Alanine Aminotransferase Activity in Trained Rats (인삼 사포닌이 훈련된 흰 쥐의 혈청 Alanine Aminotransferase 활성에 미치는 영향)

  • 김희경;남상열
    • The Korean Journal of Zoology
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    • v.33 no.3
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    • pp.297-302
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    • 1990
  • The effects of ginseng saponin on the activity of serum alanine aminoiransferase (ALT) in trained rats were examined. The trained group was given a chronic swimming bout (approx. 90 min/day) for 50 days, and ginseng group was given an oral administration of ginseng saponin (150mg/kg/day) for 2 weeks. Ginseng treated-trained group was given an oral administration of ginseng saponin for 2 weeks prior to the termination of a swimming bout. In this experiment, male rats of Sprague-Dawley strain (250 $\pm$ 20 g) were used. The activities of serum ALT in trained and in ginseng groups increased 72.89% (P < 0.01) and 57.14% (P < 0.01) than in control groups, respectively. Also, the activities of serum ALT increased 69.66% (P <0.01) in saline treated-trained group, and 79.31% (P < 0.01) in ginseng treated-trained group than in control groups which were given saline solution and kept sedentary. The effect of ginseng saponin, as revealed by comparing the ginseng treated-trained group with the saline treated-trained group, was not significant. The present study suggests that training and ginseng saponin significantly increased the activity of serum ALT in rats, but that, in ginseng treated-trained group, ginseng saponin did not raise any further the increased activity of serum ALT by training.

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Dose-Response Relationship between Alanine Aminotransferase Levels within the Reference Interval and Metabolic Syndrome in Chinese Adults

  • Wu, Peipei;Chen, Qicai;Chen, Lili;Zhang, Pengpeng;Xiao, Juan;Chen, Xiaoxiao;Liu, Meng;Wang, Shumei
    • Yonsei Medical Journal
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    • v.58 no.1
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    • pp.158-164
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    • 2017
  • Purpose: Elevation in serum alanine aminotransferase (ALT) levels is a biomarker for metabolic syndrome (MS); however, the relationship has not been fully investigated within the reference interval of ALT levels. Our objective was to explore the relationship between serum ALT levels within the reference interval and MS in Chinese adults. Materials and Methods: This cross-sectional study included 16028 adults, who attended routine health check-ups at Shengli Oilfield Central Hospital from January 2006 to March 2012. The reference interval of serum ALT level was defined as less than 40 U/L. Logistic regression models and restricted cubic spline were used to evaluate the association of ALT with MS. Results: The prevalence of MS in the total population was 13.7% (6.4% for females and 18.4% for males). Multiple logistic regression showed that ALT levels were positively associated with MS after adjustment for potential confounding factors. The odds ratio of MS in the top quartile was 4.830 [95% confidence interval (CI): 2.980-7.829] in females and 3.168 (95% CI: 2.649-3.790) in males, compared with the ALT levels in the bottom quartile. The restricted cubic spline models revealed a positive non-linear dose-response relationship between ALT levels and the risk of MS in women (p for nonlinearity was 0.0327), but a positive linear dose-response relationship in men (p for nonlinearity was 0.0659). Conclusion: Serum ALT levels within the reference interval are positively associated with MS in a dose-response manner. Elevated ALT levels, even within the reference interval, may reflect early dysmetabolic changes.

Generating Method of an Unambiguous Correlation Function for AltBOC Signal Tracking (AltBOC의 코드 추적을 위한 비모호 상관함수 생성 기법)

  • Woo, Sunghyuk;Chae, Keunhong;Lee, Seong Ro;Park, Soonyoung;Yoon, Seokho
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.40 no.5
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    • pp.957-963
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    • 2015
  • The autocorrelation of an alternative binary offset carrier (AltBOC) signal provides an improved positioning accuracy because of its narrow main-peak. However, The AltBOC signal has a disadvantage that the autocorrelation of the AltBOC signal has multiple side-peaks which incur a severe positioning error. In this paper, we propose a generating method of an unambiguous correlation function for AltBOC signal tracking. Specifically, we first obtain symmetric partial correlation functions, and subsequently, we obtain an unambiguous correlation function by combining them. In numerical results, it is confirmed that the proposed correlation function provides better tracking error standard devation (TESD) performances comparing with the conventional correlation functions.

Optical Properties of Poly(N-arylcarbazole-alt-aniline) Copolymers For Polymer Light Emitting Devices

  • Wang, Hui;Ryu, Jeong-Tak;Kim, Yeon-Bo;Kwon, Young-Hwan
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • pp.55-60
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    • 2006
  • Thermally stable and solution-processable poly(N-arylcarbazole-alt-aniline) copolymers with high structural integrity were synthesized in good yields via palladium-catalyzed polycondensation of aniline with corresponding N-arylcarbazole monomers such as N-(2-ethylhexyloxyphenyl)-3,6-dibromocarbazole,bis[6-bromo-N-(2-ethylhexyloxyphenyl)carbazole-3-yl] and N-(4-(2-ethylhexyl)-3,5-dibromomethylene-phenyl) carbazole, respectively. The optical and electrochemical properties of these copolymers were measured and compared with those of poly(N-alkylcarbazole-alt-aniline) copolymer. All synthesized poly(N-arylcarbazole-alt-aniline) copolymers showed maximum UV-Vis absorption peaks at around 300 nm in THF solution, and exhibited maximum photoluminescence peaks in the blue emission range from 430 to 460 nm. It was also found that poly(N-arylcarbazole-alt-aniline) copolymers had wider band gap energy than poly(N-alkylcarbazole-alt-aniline) copolymer.

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Drug Interaction of Warfarin with Simvastatin / Gemfibrozil : high levels of ALT/AST, rhabdomyolysis and acute renal failure (Warfarin과 Simvastatin/Gemfibrozil의 약물 상호 작용 : 높은 수치의 ALT/AST, 횡문근 융해와 급성 신장 장애)

  • Yoon, Hyon-Ok;Osun, Babatunde
    • Korean Journal of Clinical Pharmacy
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    • v.21 no.3
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    • pp.270-275
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    • 2011
  • 이 증례는 드물게 보는 경우로 simvastatin과 gemfibrozil을 오랫동안 함께 복용했음에도, 특이한 문제가 발현되지 않았지만, 이들을 warfarin와 함께 치료하는 경우, 아주 높은 alanine aminotransferase (ALT), aspartate aminotransferase(AST) 혈중 농도, rhabdomyolysis, 급성 신장 장애가 발생하였다. 그 후, Simvastatin와 gemfibrozil을 복용 중단시켰더니, ALT/AST는 빠르게 정상수치로 돌아온 경우이다. 이 증례 보고서는 의료인들에게 simvastatin과 gemfibrozil을 함께 혹은 따로 warfarin과 함께 복용시켜 치료할 경우, creatine phosphokinase (CPK) 와 creatinine 혈중 수치들을 포함하여 ALT/AST 농도들을 주의 깊게 모니터하도록 경각심을 주고자 한다.

Drastic Growth of ALT/AST Level after First Doses of Intravenous Injection of Linezolid, Moxifloxacin and Aztreonam for a Patient with Community Acquired Pneumonia & Severe Sepsis: A Case Report (지역사회 획득성 폐렴 및 중증 패혈증이 있는 한 환자에게 Linezolid, Moxifloxacin과 Aztreonam을 초회 정맥 주사 후 ALT/AST 수치의 큰 폭 증가 증례 보고)

  • Yoon, Hyon-Ok;Osun, Babatunde
    • Korean Journal of Clinical Pharmacy
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    • v.21 no.4
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    • pp.394-399
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    • 2011
  • 이 증례는 알코올 중독증을 앓은 병력을 가졌으나 간 기능에 특이한 증후가 없던 환자가, 지역 사회 획득성 폐렴으로부터 유발된 중증 패혈증 치료를 받기 위해서 linezolid, moxifloxacin 과 함께 aztreonam을 초회 정맥주사 맞은 후, 아주 높은 수치의 alanine aminotransferase (ALT), aspartate aminotransferase (AST) 혈중 농도가 검출된 경우이다. 후속 치료에서 상기 3가지 항생제 대신 vancomycin과 ceftazidime을 주사했더니, ALT/AST가 빠르게 정상화됨이 관찰되었다. 이 증례 보고는 linzolid, moxifloxacin과 aztreonam을 함께 사용할 경우, 각별한 주의 관찰이 필요하며, 알코올 중독증을 앓은 병력을 가진 환자에게 투여 시 특별한 주의와 함께 AST/ALT혈중 수치를 검사토록 권하기 위한 것이다.

Asynchronous Multilevel Search Strategy for Fast Acquisition of AltBOC Signals

  • Kim, Binhee;Kong, Seung-Hyun
    • Journal of Positioning, Navigation, and Timing
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    • v.4 no.4
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    • pp.161-171
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    • 2015
  • Alternative binary offset carrier (AltBOC) signals can be approximated by four synchronized direct sequence spread spectrum (DSSS) signals, each pair of which is a quadrature phase shift keyed (QPSK) signal at a different frequency. Therefore, depending on the strength of an incoming AltBOC signal, an acquisition technique can reduce the mean acquisition time (MAT) by searching the four DSSS signals asynchronously; the search for each of the four DSSS signals can start at one of the evenly separated hypotheses on the two-dimensional hypothesis space. And detection sensitivity can be improved by multiple levels when different numbers of search results for the same hypothesis are combined. In this paper, we propose a fast AltBOC acquisition technique that has an asynchronous search strategy and efficiently utilizes the output of the four search results to increase the sensitivity level when sensitivity improvement is needed. We provide a complete theoretical analysis and demonstrate with numerous Monte Carlo simulations that the MAT of the proposed technique is much smaller than conventional AltBOC acquisition techniques.