Since the number of social enterprises have been increased more than double over the past five years, the determinant of their growth by regional comparison is examined in this paper. In terms of the sale determinant, experimental results show that the total number of workers, business history, and capital intensity in Seoul metropolitan area, the total number of workers, business history, and capital intensity in Gyeongsang area, the total number workers, business history, and the dependence on government subsidies in Chungcheong area, the total number of workers, and the capital intensity in Jeolla/Jeju area have showed positive effects. In terms of asset determinants, experimental results show that the total number of workers, business history, and capital in Seoul metropolitan area, the capital in Gangwon area, the total number of workers, business history, and capital in Gyeongsang area, the total number of workers, business history, and capital intensity in Chungcheong area, the total number of workers, capital, and capital intensity in Jeolla/Jeju area have showed positive effect.