• Title, Summary, Keyword: 이질성검증

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Identification of Heterogeneous Prognostic Genes and Prediction of Cancer Outcome using PageRank (페이지랭크를 이용한 암환자의 이질적인 예후 유전자 식별 및 예후 예측)

  • Choi, Jonghwan;Ahn, Jaegyoon
    • Journal of KIISE
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    • v.45 no.1
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    • pp.61-68
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    • 2018
  • The identification of genes that contribute to the prediction of prognosis in patients with cancer is one of the challenges in providing appropriate therapies. To find the prognostic genes, several classification models using gene expression data have been proposed. However, the prediction accuracy of cancer prognosis is limited due to the heterogeneity of cancer. In this paper, we integrate microarray data with biological network data using a modified PageRank algorithm to identify prognostic genes. We also predict the prognosis of patients with 6 cancer types (including breast carcinoma) using the K-Nearest Neighbor algorithm. Before we apply the modified PageRank, we separate samples by K-Means clustering to address the heterogeneity of cancer. The proposed algorithm showed better performance than traditional algorithms for prognosis. We were also able to identify cluster-specific biological processes using GO enrichment analysis.

Development of an Integrated Software for Medical Image-Based Quantification and Its Clinical Application in Liver Disease (의료영상 기반 간 질환 정량분석 통합소프트웨어 개발과 간 질환 환자 데이터 임상 적용)

  • Kim, Ji-Eon;Kim, Seung-Jin;No, Si-Hyeong;Lee, Chung Sub;Kim, Tae-Hoon;Jeong, Chang-Won
    • Proceedings of the Korea Information Processing Society Conference
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    • pp.365-367
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    • 2020
  • 현재 의료영상 진단검사는 간 질환의 진단을 위해 실제 임상에서 사용하고 있는 중요한 검사 방법이며 의료영상을 기반으로 한 정량분석 소프트웨어 개발 연구가 활발히 진행되고 있다. 특히, 의료영상을 기반으로 간 질환을 정량화 하는 방법 가운데 간 결절 점수와 간세포 이질성 점수를 이용하여 간질환에 대한 정량적 평가를 진행한 결과 간 결절 점수와 간세포 이질성 점수에 따른 간 질환 중증도의 상관관계가 증명되었으나 많은 문제점이 제기되었다. 의료영상에는 서로 상반되는 의료영상조건들을 가지고 있기 때문에 의료영상조건에 따른 영상처리 기술들이 필요하였으며 간 결절 점수와 간 세포 이질성 점수는 수식에 의한 계산법을 기반으로 산출하기 때문에 수식 결과에 대한 검증 과정이 필요하였다. 따라서, 본 연구는 기존의 문제점을 해결하기 위해 의료영상에 따른 의료영상처리 기술을 자동화 할 수 있도록 개발하였으며 간염, 간질환, 간 경변등 간 질환 중증도에 따른 정량적인 분석을 수행할 뿐만 아니라 분석 결과에 대한 리포트 결과까지 제공함으로써 간 질환을 진단하기 위한 정량적인 진단 지표가 될 수 있는 소프트웨어 기반의 간 질환 진단 기술을 제안하고자 한다.

Outbound Air Travel Demand Forecasting Model with Unobserved Regional Characteristics (미관찰 지역 특성을 고려한 내국인 국제선 항공수요 추정 모형)

  • YU, Jeong Whon;CHOI, Jung Yoon
    • Journal of Korean Society of Transportation
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    • v.36 no.2
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    • pp.141-154
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    • 2018
  • In order to meet the ever-increasing demand for international air travel, several plans are underway to open new airports and expand existing provincial airports. However, existing air demand forecasts have been based on the total air demand in Korea or the air demand among major cities. There is not much forecast of regional air demand considering local characteristics. In this study, the outbound air travel demand in the southeastern region of Korea was analyzed and the fixed-effects model using panel data was proposed as an optimal model that can reflect the inherent characteristics of metropolitan areas which are difficult to observe in reality. The results of model validation show that panel data analysis effectively addresses the spurious regression and unobserved heterogeneity that are difficult to handle in a model using only a few macroeconomic indicators with time series characteristics. Various statistical validation and conformance tests suggest that the fixed-effects model proposed in this study is superior to other econometric models in predicting demand for international demand in the southeastern region.

Conservation Values of Major Resources in the Korean DMZ and Its Vicinity (DMZ일원 주요 자원의 보전에 대한 지불의사액 추정 연구: 응답자의 지리적 이질성에 대한 검증)

  • Choi, Andy S.;Park, Eun-Jin
    • Environmental and Resource Economics Review
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    • v.19 no.2
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    • pp.303-340
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    • 2010
  • The Demilitarized Zone (DMZ) of Korea has been crucial not only for its buffering role between two Koreas, but also for the conservation of various resources across its premises. The objectives of this study is threefold. The first objective is to identify major resources that determine economic values of the DMZ and its vicinity. The second and third objectives are respectively to estimate conservation values of those resources using Choice Modeling and to test whether or not respondents living in different geographical locations have significantly different willingness to pay for the conservation. In a very conservative estimation, results showed that Korean adults have about 55,000 Won on average for conserving five major resources : the DMZ area, endangered species, cultural heritage items and sites, the Truce Village, and villages in the Civilian Conroal Zone. This equals the aggregate economic value of about 2,07 trillion Won. Moreover, significant regional differences were found in public benefits from conserving these major resources.

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A Simulation Study to Investigate Climatic Controls on Net Primary Production (NPP) of a Rugged Forested Landscape in the Mid-Western Korean Peninsula (기복이 심한 한반도 중서부 산림경관에서 기후가 순일차생산(NPP)에 미치는 영향에 대한 모사연구)

  • Eum Sungwon;Kang Sinkyu;Lee Dowon
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.7 no.1
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    • pp.66-77
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    • 2005
  • We have investigated microclimatic controls on the spatiotemporal variations of net primary production (NPP) of a rugged forested watershed using the process-based biogeochemical model (BIOME-BGC). To validate the model simulation of water and carbon cycles at the plot scale, we have conducted field survey over deciduous broadleaf forest (DBF) and evergreen needleleaf forest (ENF) since 2000. The modeled values of soil temperature, soil moisture and soil respiration showed high correlation with those from the field measurements. The modeled seasonal changes of NPP showed high correlation with air temperature but no significant correlation with water related parameters. The precipitation frequency turned out to be the best climatic factor to explain the annual variation of NPP. Furthermore, NPP of ENF was more sensitive to precipitation frequency than that of DBF. With changes in vegetation cover and topography, the spatial distribution of NPP was of great heterogeneity, which was negatively correlated with the magnitude of NPP. Despite the annual precipitation of 1,400mm, NPP at the study site was constrained by the amount of water available for the vegetation. Such a modeling result should be verified by the field measurements.

Differentiation of Entomoeba histolyticn and Entcmoeba dispor in cyst-passers by immunoblot (면역이적법을 이용한 아질아메바와 동형아메바의 감별진단)

  • 이미정;홍성태
    • The Korean Journal of Parasitology
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    • v.34 no.4
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    • pp.247-254
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    • 1996
  • Differentiation of invasive strains of Entamoebn histolytica according to their pathogenicity has been a topic of long debate, but now the pathogenic species only is regarded as E. histolytica while the non-pathogenic species is E. dispar. The present study applied immunoblot to differentiale infections of the two species among microscopically- detected cyst-passers in Korea. The crude extract of 5. histolyticn separated in 5-20% gradient gels, revealed many fractions of 94. 81. 71, 50. 44, 38.5. 37.5, 29, 19. and 18 kDa when the cysteine proteinase inhibitor. E64, was supplemented. The serum IgG antibody of 3 proven E. histolytirc cases reacted loth the antigenic fractions of 117. 110. 99.68,66,60.54.52, 46. and 45 kDa. Sera of PCR confirmed 3 cases of E. disper reacted only to the 117 kDa fraction or the E. histolytica crude extract which was regarded as non specific. To the antitigen of monoxenic E. dispar. sera or E. dispar and E. histolytica cases showed the same immunoblot reactions. The serum IgG antibody reacted with several antigenic fractions of both E. histolytica and E. dispar. but IgM and IgE antibodies showed no reaction to either antigen. Sera of 24 symptomless amebic cyst-passers were screened with the E. histolytica alltigen; two were found to be infected by E. histolytica and 22 were by E. dispar. The present findings suggest that in Korea most of asymptomatic cyst passers of E. histolytica are carriers of E. dispar. Immunoblot using E. histolytica antigen is a good technique for the differentiation of E. histolytica and E. dispar infections.

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Adjustment of heterogeneous variance by milk production level of dairy herd (젖소군의 유생산 수준별 이질성 분산 보정)

  • Cho, Kwang-Hyun;Lee, Joon-Ho;Park, Kyung-Do
    • Journal of the Korean Data and Information Science Society
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    • v.25 no.4
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    • pp.737-743
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    • 2014
  • This experiment was conducted to compare heterogeneity for the variance in dairy cattle population and to induce homogeneity of variance using 502,228 performance test records of dairy cattle. The estimates of heritability for milk yields, fat yields and protein yields were 0.28, 0.26 and 0.24, respectively and the estimate of average breeding value by birth year was lower in HV (heterogenous variance) model than in animal model, collectively. The average breeding values of milk yields, fat yields and protein yields for 545 sire bulls applicable to the criteria of interbull MACE programme were 453.54kg, 10.75kg and 14.33kg, respectively and when the heterogeneity was adjusted they were 432.06kg, 10.15kg and 13.40kg, respectively, which were lower in all milk traits collectively. In animal model, coefficients of phenotypic correlation between dataset I and II were 0.839 in milk yields, 0.821 in fat yields, and 0.837 in protein yields, while in HV model, they were 0.841 in milk yields, 0.820 in fat yields, and 0.836 in protein yields, showing similar results in 2 models. When compared using animal model and HV model, the regression coefficient for ratio of number of daughters by calving year of milk yields increased from 15.157 to 16.105 and that of fat yields increased from =0.227 to =0.196, but that of protein yields decreased from 0.630 to 0.586.

A Study on Verification Tests according to Connection Design Methods of Steel Plate Concrete Structures (강판 콘크리트 구조 접합부의 설계방식에 따른 검증실험 연구)

  • Hwang, Kyeong Min;Lee, Kyung Jin;Yang, Hyun Jung;Kim, Won Ki
    • Journal of Korean Society of Steel Construction
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    • v.26 no.1
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    • pp.1-10
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    • 2014
  • In this study, out-of-plane flexural test was performed to analyze behavior properties for a beam specimen which imitated a structure with connection member between reinforced concrete and steel plate concrete part. Tie bars between a upper and a lower steel plate, and tie wide flange shapes between upper and lower ribs were designed to prevent the steel plate or the ribs from breakaway in the connection of the specimen. As a result of the test, ductile failure behavior of the specimen and the functionality of the tie members were conformed as originally intended. Also, tension tests were performed to evaluate the design appropriateness of two specimens produced to anchor and connect mechanically #14 bars. The two test results showed that the anchorage connection system behaves in elastic limit during the main bars yielded, and the integrity of the designed system was verified.

A Study on XMDR-DSM System Design for Cooperative (협업을 위한 XMDR-DSM 시스템 설계에 관한 연구)

  • Moon, Seok-Jae;Jung, Kye-Dong;Choi, Young-Keun
    • The KIPS Transactions:PartD
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    • v.16D no.5
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    • pp.701-714
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    • 2009
  • In the enterprises the data integration based on service requires integrated data management as the change in the environment of enterprises accelerates. Cooperation among enterprises is accomplished through accessing distributed database using business process. As this approach is performed based on the global query, problems such as data heterogeneity, schema heterogeneity, and verification of validity have to be solved in advance for the interoperability among the heterogeneous system. Thus, cooperation requires dynamic and reliable construction. In this paper, we propose XMDR-DSM (eXtended MetaData Registry-Data Service Mediator) system for cooperation. XMDR-DSM, which is comprised of XMDR-DS, XMDR-DQP, and XMDR-DAI, supports the mapping between global schema and local schema and provides data access and integration service. Therefore, XMDR-DSM enables the mutual support of business operations among heterogeneous database. In addition, it can secure information as reusable asset and the standardization of interchange. Also it can manage unified information since it provides business process based on workflow; therefore, it will be able to increase the life span of information and reduce the cost.

Effect of Cognitive Behavioral Therapy (CBT) for Perinatal Depression: A Systematic Review and Meta-Analysis (산전우울 임부를 위한 인지행동치료 프로그램의 효과: 체계적 문헌고찰 및 메타분석)

  • Shin, Hyeon-Hee;Shin, Yeong-Hee;Kim, Ga-Eun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.11
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    • pp.271-284
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    • 2016
  • This study was carried out to evaluate the efficacy of CBT for perinatal depression through systematic literature review and meta-analysis. The following databases were used to search the literature: CINAHL, PubMed, EMBASE, Koreamed, Library of Korean Congress, KISS, and Korean Academic Publication Database. Keywords included 'perinatal depression,' 'pregnant women,' and 'cognitive behavioral therapy,' and the evaluated articles were published up to May 2016. Using the R program, the effect size of perinatal depression and anxiety were calculated by random-effects model. The heterogeneity of the effect size was analyzed by data moderator analysis using the meta-ANOVA. Furthermore, the funnel plot, Egger's regression test, fail-safe N, trim-and-fill test, and publication bias analysis were conducted and used to verify the results. Out of the 180 selected articles, 16 clinical trial studies were meta-analyzed. Each articles were evaluated for the risk of bias by the checklist of SIGN; the overall risk of bias was low. The effect size of CBT for perinatal depression was Hedges' g=-0.55 (95% CI: -0.76~-0.33), which was a moderate level, while for anxiety reduction, Hedges' g=-0.20 (95% CI: -0.48~-0.08) and it was not statistically significant. Heterogeneity or risk of publication bias were low. This meta-analytic study found that CBT is moderately effective in reducing perinatal depression in pregnant women.