The purpose of the present study was to compare and analyze differences in job satisfaction and quality of life in relation to the use of movement assisters among workers with severe and slight external physical disabilities and to analyze the effect of job satisfaction on the quality of life of disabled persons who use movement assisters. First, severely disabled persons who used movement assisters showed higher degrees of satisfaction with their work content, working environments, working hours, possibilities for development, communication, and human relations. On the other hand, slightly disabled persons who used movement assisters showed higher degrees of satisfaction only with their working environments. Second, severely disabled persons who used movement assisters perceived a higher quality of life in the areas of family, residence, and work. Slightly disabled persons who used movement assisters perceived a higher quality of life only in the area of family. Third, workers with external physical disabilities who used movement assisters had positive effects on their quality of life arising from job satisfaction in relation to income, job stability, working environments, working hours, possibilities for job development, communication, and human relations that is, a higher job satisfaction was correlated with a higher perceived quality of life.